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The map label for this gene is 119386259

Identifier: 119386259

GI number: 119386259

Start: 696400

End: 697605

Strand: Direct

Name: 119386259

Synonym: Pden_3548

Alternate gene names: NA

Gene position: 696400-697605 (Clockwise)

Preceding gene: 119386258

Following gene: 119386260

Centisome position: 40.25

GC content: 68.66

Gene sequence:

>1206_bases
GTGGCTCTATTGCGGTCCTGGCTCGAAAGCGCCAATCAGGCGGATTGCCCGTTTCCCCTGAACAACCTGCCCTATGGGGT
GTTCTCCGTGTCGGGCGATGCGCCGCGCTGCGGGGTGGCCATCGGCGACATGATCCTGGATCTGGCCGAATGCGAGGCGC
GCGGGCTGGTCGACGCGGGCGGCACGTTCGCGCAGCCGCGGCTCAACGATTTCATCGCGCTGGGGCGGGCGAAATGGGAC
GAGATCCGCGCCCGGCTGACCGCGCTGCTGGCCGAGGAGGGCGATCGCAGCCTGCCGCTGGTCGCCATGGCCGAGGCACA
GCTGCACCTGCCGATCCGGGTCACGGAGTTCACCGATTTCTACGCCTCGAAGAACCATGCCTTCAATGTGGGCGTGCTGT
TTCGCGGCCCCGAGAACGCCCTGCCGCCGCAATGGACGCATATGCCCATCGGCTATAACGGGCGGGCGTCCTCGGTCGTG
GTCTCGGGCACGCCGATCCGCCGTCCGATGGGCCAGTTGAAGGGCGAGGCCGGGCCGGAATGGGCGCCCTGCCGCAGGCT
GGACCTGGAGCTTGAGCTGGGCGCCATCGTTGGCGCGGACAGCGTGATGGGCCAGCGCCTGAGCGTTGAGGAGGCAGAGC
AGGCGATCTTCGGCTATGTGCTGCTGAACGACTGGTCGGCGCGCGATGTGCAAGCCTGGGAATACCAGCCGCTGGGCCCG
TTCCAGTCCAAGGCGCTTGGCACCACAATCGGTGCATGGATCGTGACCCAGGCGGCGCTGGAGCCGTTTCGCTGCGCGGG
TGCCGAGCGGGCGAACCCGCTGCTGCCCTATCTGCACGAGCGGCGGCCGGGGCTTTACGACCTGGAGATCGGCTGGACCA
TGAACGGCCAGGTCATGGGGCGGACGAATTACGGCGTCATGTATTACTCCAGCGCCCAGCAACTGGCGCATCACACCAGT
TCCGGCTGCCCGATGCGGGTCGGCGACCTGCTGGGCTCGGGCACGATCTCGGGGCCGGAGCGCGAGCAGACCGGGGCGCT
GCTGGAGATGACCGGGGGCGGCAAGGTGCCGGTCACGGTCAATGGCGCGCCCCGCACCTTCATCGAGGACGGCGACGAGA
TCGGGCTGTTCGCCCAGGCGCGGGGCGAGGGCTATCGCATCGGCTTCGGCCCCTGCACCGGGCAGGTCCTGCCTGCGCTG
CCATGA

Upstream 100 bases:

>100_bases
TCGACGGAACGCCAGGCGTCAAGTGAGGCCCCAAGGTCGAAGGCCGAGGGCCGAGGGCCGAGAGCCGGGGATATTTGCAC
AAGAAAGAAGGAGGCCGGAT

Downstream 100 bases:

>100_bases
CGGTCGTGCTGCACGACTACTGGCGATCCTCCGCATCCTACCGGGTGCGGATCGCGCTGGCGCTGAAGGGTATTGCCTAC
GACCGGGTGGCGGTGGATCT

Product: fumarylacetoacetase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; 2-Hydroxyhepta-2 4-Diene-1 7-Dioate Isomerase; Fumarylacetoacetate Hydrolase Domain-Containing; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MALLRSWLESANQADCPFPLNNLPYGVFSVSGDAPRCGVAIGDMILDLAECEARGLVDAGGTFAQPRLNDFIALGRAKWD
EIRARLTALLAEEGDRSLPLVAMAEAQLHLPIRVTEFTDFYASKNHAFNVGVLFRGPENALPPQWTHMPIGYNGRASSVV
VSGTPIRRPMGQLKGEAGPEWAPCRRLDLELELGAIVGADSVMGQRLSVEEAEQAIFGYVLLNDWSARDVQAWEYQPLGP
FQSKALGTTIGAWIVTQAALEPFRCAGAERANPLLPYLHERRPGLYDLEIGWTMNGQVMGRTNYGVMYYSSAQQLAHHTS
SGCPMRVGDLLGSGTISGPEREQTGALLEMTGGGKVPVTVNGAPRTFIEDGDEIGLFAQARGEGYRIGFGPCTGQVLPAL
P

Sequences:

>Translated_401_residues
MALLRSWLESANQADCPFPLNNLPYGVFSVSGDAPRCGVAIGDMILDLAECEARGLVDAGGTFAQPRLNDFIALGRAKWD
EIRARLTALLAEEGDRSLPLVAMAEAQLHLPIRVTEFTDFYASKNHAFNVGVLFRGPENALPPQWTHMPIGYNGRASSVV
VSGTPIRRPMGQLKGEAGPEWAPCRRLDLELELGAIVGADSVMGQRLSVEEAEQAIFGYVLLNDWSARDVQAWEYQPLGP
FQSKALGTTIGAWIVTQAALEPFRCAGAERANPLLPYLHERRPGLYDLEIGWTMNGQVMGRTNYGVMYYSSAQQLAHHTS
SGCPMRVGDLLGSGTISGPEREQTGALLEMTGGGKVPVTVNGAPRTFIEDGDEIGLFAQARGEGYRIGFGPCTGQVLPAL
P
>Mature_400_residues
ALLRSWLESANQADCPFPLNNLPYGVFSVSGDAPRCGVAIGDMILDLAECEARGLVDAGGTFAQPRLNDFIALGRAKWDE
IRARLTALLAEEGDRSLPLVAMAEAQLHLPIRVTEFTDFYASKNHAFNVGVLFRGPENALPPQWTHMPIGYNGRASSVVV
SGTPIRRPMGQLKGEAGPEWAPCRRLDLELELGAIVGADSVMGQRLSVEEAEQAIFGYVLLNDWSARDVQAWEYQPLGPF
QSKALGTTIGAWIVTQAALEPFRCAGAERANPLLPYLHERRPGLYDLEIGWTMNGQVMGRTNYGVMYYSSAQQLAHHTSS
GCPMRVGDLLGSGTISGPEREQTGALLEMTGGGKVPVTVNGAPRTFIEDGDEIGLFAQARGEGYRIGFGPCTGQVLPALP

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=408, Percent_Identity=46.8137254901961, Blast_Score=373, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17568863, Length=419, Percent_Identity=44.8687350835322, Blast_Score=351, Evalue=3e-97,
Organism=Drosophila melanogaster, GI24657182, Length=401, Percent_Identity=42.3940149625935, Blast_Score=334, Evalue=6e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 43301; Mature: 43170

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLRSWLESANQADCPFPLNNLPYGVFSVSGDAPRCGVAIGDMILDLAECEARGLVDAG
CHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
GTFAQPRLNDFIALGRAKWDEIRARLTALLAEEGDRSLPLVAMAEAQLHLPIRVTEFTDF
CCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEEEEEEHHHH
YASKNHAFNVGVLFRGPENALPPQWTHMPIGYNGRASSVVVSGTPIRRPMGQLKGEAGPE
HCCCCCEEEEEEEEECCCCCCCCCCEEECCCCCCCCCEEEEECCCCCCCHHHHCCCCCCC
WAPCRRLDLELELGAIVGADSVMGQRLSVEEAEQAIFGYVLLNDWSARDVQAWEYQPLGP
CCCCEEEEEEEEECEEECCHHHHCCCCCHHHHHHHHEEEEEEECCCCCCCCCEECCCCCC
FQSKALGTTIGAWIVTQAALEPFRCAGAERANPLLPYLHERRPGLYDLEIGWTMNGQVMG
HHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHCCCCEEEEEECEEECCEEEE
RTNYGVMYYSSAQQLAHHTSSGCPMRVGDLLGSGTISGPEREQTGALLEMTGGGKVPVTV
ECCCCEEEECCHHHHHHHCCCCCCEEHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEE
NGAPRTFIEDGDEIGLFAQARGEGYRIGFGPCTGQVLPALP
CCCCCHHHCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
ALLRSWLESANQADCPFPLNNLPYGVFSVSGDAPRCGVAIGDMILDLAECEARGLVDAG
HHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
GTFAQPRLNDFIALGRAKWDEIRARLTALLAEEGDRSLPLVAMAEAQLHLPIRVTEFTDF
CCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEEEEEEHHHH
YASKNHAFNVGVLFRGPENALPPQWTHMPIGYNGRASSVVVSGTPIRRPMGQLKGEAGPE
HCCCCCEEEEEEEEECCCCCCCCCCEEECCCCCCCCCEEEEECCCCCCCHHHHCCCCCCC
WAPCRRLDLELELGAIVGADSVMGQRLSVEEAEQAIFGYVLLNDWSARDVQAWEYQPLGP
CCCCEEEEEEEEECEEECCHHHHCCCCCHHHHHHHHEEEEEEECCCCCCCCCEECCCCCC
FQSKALGTTIGAWIVTQAALEPFRCAGAERANPLLPYLHERRPGLYDLEIGWTMNGQVMG
HHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHCCCCEEEEEECEEECCEEEE
RTNYGVMYYSSAQQLAHHTSSGCPMRVGDLLGSGTISGPEREQTGALLEMTGGGKVPVTV
ECCCCEEEECCHHHHHHHCCCCCCEEHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEE
NGAPRTFIEDGDEIGLFAQARGEGYRIGFGPCTGQVLPALP
CCCCCHHHCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA