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The map label for this gene is zitB [H]

Identifier: 119386067

GI number: 119386067

Start: 508469

End: 509425

Strand: Direct

Name: zitB [H]

Synonym: Pden_3353

Alternate gene names: 119386067

Gene position: 508469-509425 (Clockwise)

Preceding gene: 119386066

Following gene: 119386068

Centisome position: 29.39

GC content: 67.71

Gene sequence:

>957_bases
ATGTCCGCAATCGACATCTCCGCCCATACCCACGGGCACGACTTTCTCGGGCGGCACCACCGGCGCAACGAACGCCGGGT
CTGGCTGGTCATCGCCCTGACGGCCGCGATGATGGTGGCCGAGATCGCCGCCGGCACGCTCTACGGCTCGATGGCGCTGG
TGGCCGATGGCTGGCACATGTCCACCCATGCCGGGGCGATGCTGATCACGGCGCTGGCCTATGTCTATGCCCGCCGCCAT
GTCGGCGATGCCCGTTTCAGCTTCGGCACCGGCAAACTGGGCGATCTCGGCGGCTTCGCCAGCGCCGTCGTGCTGGCCCT
GATCGCGCTGCTGATCGGCTGGGAGAGTTTGGTGCGGCTGGCCAACCCGGTCGAGATCCGCTTCGGCCAGGCCATCGCGG
TCGCTGTGGTCGGGCTGGTGGTCAATCTGGCCTGCGCCTGGCTGCTGAGGGGCGACCATTCCCATCACCATCACGGGCAT
GGACGTCACCACGATCACGACCATGATCATCACCACGGTCATGCCCGGGACAACAACCTGCGCGCCGCCTATCTGCATGT
GCTGGCGGATGCGCTGACCTCGATCCTGGCCATCGTGGCGCTGCTGGCCGGGCGCAGCTATGGCTGGACCTGGGCCGATC
CGGCCATGGGCGTCGTCGGCGCGCTGGTGATCGCACGTTGGTCCTGGGGGCTGATCCGCGATTCCGCTGCCGTGTTGCTG
GACCGGACCCCGCAGGACGCGGATCTGCCGCAAGAAATCCGCACGGCGATCGAGACCGGGACCGACCGGATCGCCGATCT
GCATGTCTGGCAGGTCGGGCCGGGCCATCATGCCGCCATCGTCTCGCTGGTGTCGAGCGACCCGCAGGCGCCCTCGCATT
ACAAGTCGCGCCTGGCGCGGATCCACGCGCTTTCCCATGTTACCGTCGAGGTCGAGCGGGTGAGTGCCGCTTCCTGA

Upstream 100 bases:

>100_bases
GCATGTGCTGCAGGCCGAAACCGATGCCGAGCGCCGGCAGGGCGGCGAGGAACTGATCGAAATCATCCGCACCTACATGA
AATAGCCCTGGAGGGGGCCC

Downstream 100 bases:

>100_bases
AAGGACCATGGCGGGTTGGCGAGGCTGCAACCCGTTGCGGCCATTCGCCGGCCTGTGCGAAGCTGGTCCATGCTCCAACC
CTTGCCCCGACAGACCCATG

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MSAIDISAHTHGHDFLGRHHRRNERRVWLVIALTAAMMVAEIAAGTLYGSMALVADGWHMSTHAGAMLITALAYVYARRH
VGDARFSFGTGKLGDLGGFASAVVLALIALLIGWESLVRLANPVEIRFGQAIAVAVVGLVVNLACAWLLRGDHSHHHHGH
GRHHDHDHDHHHGHARDNNLRAAYLHVLADALTSILAIVALLAGRSYGWTWADPAMGVVGALVIARWSWGLIRDSAAVLL
DRTPQDADLPQEIRTAIETGTDRIADLHVWQVGPGHHAAIVSLVSSDPQAPSHYKSRLARIHALSHVTVEVERVSAAS

Sequences:

>Translated_318_residues
MSAIDISAHTHGHDFLGRHHRRNERRVWLVIALTAAMMVAEIAAGTLYGSMALVADGWHMSTHAGAMLITALAYVYARRH
VGDARFSFGTGKLGDLGGFASAVVLALIALLIGWESLVRLANPVEIRFGQAIAVAVVGLVVNLACAWLLRGDHSHHHHGH
GRHHDHDHDHHHGHARDNNLRAAYLHVLADALTSILAIVALLAGRSYGWTWADPAMGVVGALVIARWSWGLIRDSAAVLL
DRTPQDADLPQEIRTAIETGTDRIADLHVWQVGPGHHAAIVSLVSSDPQAPSHYKSRLARIHALSHVTVEVERVSAAS
>Mature_317_residues
SAIDISAHTHGHDFLGRHHRRNERRVWLVIALTAAMMVAEIAAGTLYGSMALVADGWHMSTHAGAMLITALAYVYARRHV
GDARFSFGTGKLGDLGGFASAVVLALIALLIGWESLVRLANPVEIRFGQAIAVAVVGLVVNLACAWLLRGDHSHHHHGHG
RHHDHDHDHHHGHARDNNLRAAYLHVLADALTSILAIVALLAGRSYGWTWADPAMGVVGALVIARWSWGLIRDSAAVLLD
RTPQDADLPQEIRTAIETGTDRIADLHVWQVGPGHHAAIVSLVSSDPQAPSHYKSRLARIHALSHVTVEVERVSAAS

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=330, Percent_Identity=27.8787878787879, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI222080086, Length=310, Percent_Identity=24.8387096774194, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI40255009, Length=310, Percent_Identity=24.8387096774194, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI21359890, Length=278, Percent_Identity=24.8201438848921, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI52352805, Length=302, Percent_Identity=21.8543046357616, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI21361112, Length=307, Percent_Identity=24.4299674267101, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1786966, Length=254, Percent_Identity=34.6456692913386, Blast_Score=114, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI32564488, Length=350, Percent_Identity=27.4285714285714, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI193210990, Length=321, Percent_Identity=28.6604361370716, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17555794, Length=312, Percent_Identity=29.4871794871795, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17555796, Length=299, Percent_Identity=29.4314381270903, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320411, Length=194, Percent_Identity=25.7731958762887, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323899, Length=183, Percent_Identity=29.5081967213115, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24645863, Length=313, Percent_Identity=25.8785942492013, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24656728, Length=280, Percent_Identity=27.5, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656724, Length=280, Percent_Identity=27.5, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656720, Length=280, Percent_Identity=27.5, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656715, Length=280, Percent_Identity=27.5, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357035, Length=280, Percent_Identity=27.5, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 34390; Mature: 34258

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIDISAHTHGHDFLGRHHRRNERRVWLVIALTAAMMVAEIAAGTLYGSMALVADGWHM
CCCEEECCCCCCHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHEEECCCCC
STHAGAMLITALAYVYARRHVGDARFSFGTGKLGDLGGFASAVVLALIALLIGWESLVRL
CHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ANPVEIRFGQAIAVAVVGLVVNLACAWLLRGDHSHHHHGHGRHHDHDHDHHHGHARDNNL
CCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
RAAYLHVLADALTSILAIVALLAGRSYGWTWADPAMGVVGALVIARWSWGLIRDSAAVLL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHCCHHHEE
DRTPQDADLPQEIRTAIETGTDRIADLHVWQVGPGHHAAIVSLVSSDPQAPSHYKSRLAR
ECCCCCCCCHHHHHHHHHCCCCHHEEEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHH
IHALSHVTVEVERVSAAS
HHHHHHHEEEEECCCCCC
>Mature Secondary Structure 
SAIDISAHTHGHDFLGRHHRRNERRVWLVIALTAAMMVAEIAAGTLYGSMALVADGWHM
CCEEECCCCCCHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHEEECCCCC
STHAGAMLITALAYVYARRHVGDARFSFGTGKLGDLGGFASAVVLALIALLIGWESLVRL
CHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ANPVEIRFGQAIAVAVVGLVVNLACAWLLRGDHSHHHHGHGRHHDHDHDHHHGHARDNNL
CCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
RAAYLHVLADALTSILAIVALLAGRSYGWTWADPAMGVVGALVIARWSWGLIRDSAAVLL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHCCHHHEE
DRTPQDADLPQEIRTAIETGTDRIADLHVWQVGPGHHAAIVSLVSSDPQAPSHYKSRLAR
ECCCCCCCCHHHHHHHHHCCCCHHEEEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHH
IHALSHVTVEVERVSAAS
HHHHHHHEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]