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The map label for this gene is livM [H]

Identifier: 119385780

GI number: 119385780

Start: 237648

End: 238664

Strand: Direct

Name: livM [H]

Synonym: Pden_3058

Alternate gene names: 119385780

Gene position: 237648-238664 (Clockwise)

Preceding gene: 119385779

Following gene: 119385781

Centisome position: 13.74

GC content: 59.0

Gene sequence:

>1017_bases
ATGACTGCCATGCGTCGTGATCTTCTTCTTTGCGGCCTCTTCGCCTGTGTTGCGCTTTTCTGGCCTATGATTTCTGGGAT
GCGTTACTCGATAACCCAGACCACCTTTTTCTTTATTTGGGCCACGGTGGTGGTGCAGTGGAATCTGGTCTTCGGGATCG
GCGGGATCTTCTCGCTGGCCCAGGTCGCGATCTTTGCCATCGGCGCCTATGTGACCGCGATGCTTGGCTATTACCTCGGT
ACATCTATGCTGCTGGCAATGCCTGCAGGCGCGGTTGTGGCAGTGGTCGCGAGTATCATCCTCGGCATCGCCTGCCTGAG
GCTCTACGGCCCCTATGTCGCGCTGCTGACGATCTGCGTTTCGCAGGTCCTCTATGTGCTGATCGTGAATGATACCGATT
GTTTTACCAATCCGCCGGCGGGCTGTATGCCGCTGATGGGCGGGGTGCGCGGCTTTTCCCGCTTTGGCGATCTGGGGTTT
CGCGACTGGCTGGGCGCGGGCTTCTATGTCGGCAACTACTATGTTGGGCTTTTGTTGCTGAGCGCCGCGATCCTCTTCTC
GATCATGATCATCCACAGTCCTATGGGGCTCGCCTTCCGGGCCTTGCGCGACAACCCGGTCTATGCCGCTGCCCGGGGCG
TTGACCGCTTCCGCTATCAACTCTGGATCTTCGGTCTCTCGGCCTTCTTTACCGGCCTTGCCGGTGCCTTCTATGCGGTC
AATACGGGCGTGGTCGGCCCGGTGGTGTTTTCCTTCCAGCACCTGCTCTTTTTGCTATCGATGATCATCGTGGGCGGAAT
AGGCACGGTCTGGGGGCCGGTGATTGGCGCGGCCGTGCTGATGCTGGCGGATGAGGCTATGCGCGAACTTGGGGACTTCC
GCGATATCGGCATGGGGCTGATCCTCGTTGCCTGTGTCGTGTTGATGCCCAGGGGCCTGACCGGCCTGTTCCACGACATC
TCGACACGTCTTGCAAAGTCATCTGGGACCGAAGGAGAGAAATCATGTCAGCGCTGA

Upstream 100 bases:

>100_bases
TCGGGGTTCGCTTCAGCTTTGCGCTTTTGCTTCTTCTCGTCATCGTGGTGCTGATCTGGAAGCCTCAGGGCGTGTTCGGG
CGCCAACAGGGGGTTCGTCT

Downstream 100 bases:

>100_bases
AGCCCGTGACCATGACAGAGCAGCTCCGCCAGCTGCGCAGCGGTGAGACGACTGCAGAGGCCATGATGACCCGCGCGATC
CGGCGGGCCGGAGATTTAGG

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MTAMRRDLLLCGLFACVALFWPMISGMRYSITQTTFFFIWATVVVQWNLVFGIGGIFSLAQVAIFAIGAYVTAMLGYYLG
TSMLLAMPAGAVVAVVASIILGIACLRLYGPYVALLTICVSQVLYVLIVNDTDCFTNPPAGCMPLMGGVRGFSRFGDLGF
RDWLGAGFYVGNYYVGLLLLSAAILFSIMIIHSPMGLAFRALRDNPVYAAARGVDRFRYQLWIFGLSAFFTGLAGAFYAV
NTGVVGPVVFSFQHLLFLLSMIIVGGIGTVWGPVIGAAVLMLADEAMRELGDFRDIGMGLILVACVVLMPRGLTGLFHDI
STRLAKSSGTEGEKSCQR

Sequences:

>Translated_338_residues
MTAMRRDLLLCGLFACVALFWPMISGMRYSITQTTFFFIWATVVVQWNLVFGIGGIFSLAQVAIFAIGAYVTAMLGYYLG
TSMLLAMPAGAVVAVVASIILGIACLRLYGPYVALLTICVSQVLYVLIVNDTDCFTNPPAGCMPLMGGVRGFSRFGDLGF
RDWLGAGFYVGNYYVGLLLLSAAILFSIMIIHSPMGLAFRALRDNPVYAAARGVDRFRYQLWIFGLSAFFTGLAGAFYAV
NTGVVGPVVFSFQHLLFLLSMIIVGGIGTVWGPVIGAAVLMLADEAMRELGDFRDIGMGLILVACVVLMPRGLTGLFHDI
STRLAKSSGTEGEKSCQR
>Mature_337_residues
TAMRRDLLLCGLFACVALFWPMISGMRYSITQTTFFFIWATVVVQWNLVFGIGGIFSLAQVAIFAIGAYVTAMLGYYLGT
SMLLAMPAGAVVAVVASIILGIACLRLYGPYVALLTICVSQVLYVLIVNDTDCFTNPPAGCMPLMGGVRGFSRFGDLGFR
DWLGAGFYVGNYYVGLLLLSAAILFSIMIIHSPMGLAFRALRDNPVYAAARGVDRFRYQLWIFGLSAFFTGLAGAFYAVN
TGVVGPVVFSFQHLLFLLSMIIVGGIGTVWGPVIGAAVLMLADEAMRELGDFRDIGMGLILVACVVLMPRGLTGLFHDIS
TRLAKSSGTEGEKSCQR

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=329, Percent_Identity=27.355623100304, Blast_Score=116, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 36450; Mature: 36319

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAMRRDLLLCGLFACVALFWPMISGMRYSITQTTFFFIWATVVVQWNLVFGIGGIFSLA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVAIFAIGAYVTAMLGYYLGTSMLLAMPAGAVVAVVASIILGIACLRLYGPYVALLTICV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQVLYVLIVNDTDCFTNPPAGCMPLMGGVRGFSRFGDLGFRDWLGAGFYVGNYYVGLLLL
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHH
SAAILFSIMIIHSPMGLAFRALRDNPVYAAARGVDRFRYQLWIFGLSAFFTGLAGAFYAV
HHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NTGVVGPVVFSFQHLLFLLSMIIVGGIGTVWGPVIGAAVLMLADEAMRELGDFRDIGMGL
CCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILVACVVLMPRGLTGLFHDISTRLAKSSGTEGEKSCQR
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHCCC
>Mature Secondary Structure 
TAMRRDLLLCGLFACVALFWPMISGMRYSITQTTFFFIWATVVVQWNLVFGIGGIFSLA
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH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HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]