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The map label for this gene is icd [H]

Identifier: 119385686

GI number: 119385686

Start: 129721

End: 130935

Strand: Direct

Name: icd [H]

Synonym: Pden_2961

Alternate gene names: 119385686

Gene position: 129721-130935 (Clockwise)

Preceding gene: 119385685

Following gene: 119385687

Centisome position: 7.5

GC content: 61.89

Gene sequence:

>1215_bases
ATGTCGAAGATCAAGGTAGAGAACCCCGTCGTCGAACTCGACGGCGACGAGATGACCCGGATCATCTGGGATTTCATCAA
GAAGAAGCTGATCCTTCCCTATCTGGACCTCGACCTGAAATATTACGACCTGGGCATCGAGGAGCGCGACGCGACCTCGG
ACCAGATCACCGTGGACGCGGCCGAGGCGATCAAGCAATACGGCGTCGGCGTGAAATGCGCCACCATCACCCCCGACGAG
GCGCGGGTCGAGGAATTCGGCCTGAAGAAGATGTGGAAATCGCCCAACGGCACCATCCGCAACATCCTGGGCGGCGTGAT
CTTCCGCGAGCCGATCATCTGCAAGAACGTGCCGCGCCTGGTCCCCGGCTGGACCCAGCCCATCGTCGTCGGCCGCCACG
CCTTCGGCGACCAGTACAAGGCCACCGATTTCCGCTTTCCGGGCAAGGGCAAGCTGACGATCAAGTTCGTCGGCGAGGAT
GGCGAGACCATCGAGCACGAGGTCTATCAGGCCCCCGGCGCCGGCGTCGCCATGGCGATGTACAACCTCGACCAGTCGAT
CATCGACTTCGCCCGCGCCTCGATGAATTACGGGCTGAACCGCGGCTACCCGGTCTATCTCTCGACCAAGAACACCATCC
TGAAAGCCTATGACGGCCGCTTCAAGGACCTGTTCCAGAAGGTCTACGAGGAAGAATTCGAGGCCGAGTTCAAGAAGAAG
GGCATCCATTACGAGCATCGCCTGATCGACGACATGGTCGCCTCGGCGATGAAATGGTCGGGCGGCTATGTCTGGGCCTG
CAAGAACTACGACGGCGACGTGCAGTCGGATACGGTTGCGCAGGGCTTCGGCAGCCTGGGGCTGATGACCTCGGTGCTGA
TGACGCCGGACGGGAAGATCGTCGAGTCCGAGGCCGCGCATGGCACGGTGACGCGCCACTATCGCGAGCACCAGAAGGGC
AACCAGACCTCGACCAACTCGATCGCCTCGATCTTTGCCTGGACCGGCGGGCTGAAGCACCGCGCCAAGCTGGACGACAA
CGCGGCGCTGCTGAACTTTGCCCAGACGCTGGAGCGGGTCACCGTGCAGGCGGTCGAGGACGGCTTCATGACCAAGGATC
TGGCGCTGCTGGTGGGCCCGGACCAGAAATGGCTGACCACCATGGGCTATCTGGAAAAGGTCGACGAATACCTGAACAAG
GCGCTGGCGGGCTGA

Upstream 100 bases:

>100_bases
GCGGGGCGGCAATCGGTATGCAATCGCATACCGGGCTTTCCTTTCGCGGCGAATGCGGCTATAGCGCGGCCGAGCCGAAT
CCTAATCGAAGGGACCACCC

Downstream 100 bases:

>100_bases
ACTGCCGGACAGGGTTGCGAAGGGCCGGGGGAAACCCCGGCCCTTTTCGCTTGCGGCGCTGCCTTTGAGTGTTTGGGAAA
CGGCGAAACCGCCGGGTGAT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MSKIKVENPVVELDGDEMTRIIWDFIKKKLILPYLDLDLKYYDLGIEERDATSDQITVDAAEAIKQYGVGVKCATITPDE
ARVEEFGLKKMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPIVVGRHAFGDQYKATDFRFPGKGKLTIKFVGED
GETIEHEVYQAPGAGVAMAMYNLDQSIIDFARASMNYGLNRGYPVYLSTKNTILKAYDGRFKDLFQKVYEEEFEAEFKKK
GIHYEHRLIDDMVASAMKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKIVESEAAHGTVTRHYREHQKG
NQTSTNSIASIFAWTGGLKHRAKLDDNAALLNFAQTLERVTVQAVEDGFMTKDLALLVGPDQKWLTTMGYLEKVDEYLNK
ALAG

Sequences:

>Translated_404_residues
MSKIKVENPVVELDGDEMTRIIWDFIKKKLILPYLDLDLKYYDLGIEERDATSDQITVDAAEAIKQYGVGVKCATITPDE
ARVEEFGLKKMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPIVVGRHAFGDQYKATDFRFPGKGKLTIKFVGED
GETIEHEVYQAPGAGVAMAMYNLDQSIIDFARASMNYGLNRGYPVYLSTKNTILKAYDGRFKDLFQKVYEEEFEAEFKKK
GIHYEHRLIDDMVASAMKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKIVESEAAHGTVTRHYREHQKG
NQTSTNSIASIFAWTGGLKHRAKLDDNAALLNFAQTLERVTVQAVEDGFMTKDLALLVGPDQKWLTTMGYLEKVDEYLNK
ALAG
>Mature_403_residues
SKIKVENPVVELDGDEMTRIIWDFIKKKLILPYLDLDLKYYDLGIEERDATSDQITVDAAEAIKQYGVGVKCATITPDEA
RVEEFGLKKMWKSPNGTIRNILGGVIFREPIICKNVPRLVPGWTQPIVVGRHAFGDQYKATDFRFPGKGKLTIKFVGEDG
ETIEHEVYQAPGAGVAMAMYNLDQSIIDFARASMNYGLNRGYPVYLSTKNTILKAYDGRFKDLFQKVYEEEFEAEFKKKG
IHYEHRLIDDMVASAMKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKIVESEAAHGTVTRHYREHQKGN
QTSTNSIASIFAWTGGLKHRAKLDDNAALLNFAQTLERVTVQAVEDGFMTKDLALLVGPDQKWLTTMGYLEKVDEYLNKA
LAG

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=407, Percent_Identity=64.3734643734644, Blast_Score=553, Evalue=1e-157,
Organism=Homo sapiens, GI28178825, Length=410, Percent_Identity=63.9024390243902, Blast_Score=546, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17540874, Length=402, Percent_Identity=67.1641791044776, Blast_Score=557, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17550822, Length=400, Percent_Identity=65.75, Blast_Score=555, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6320137, Length=408, Percent_Identity=64.9509803921569, Blast_Score=547, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6323203, Length=405, Percent_Identity=61.7283950617284, Blast_Score=516, Evalue=1e-147,
Organism=Saccharomyces cerevisiae, GI6324319, Length=407, Percent_Identity=58.968058968059, Blast_Score=506, Evalue=1e-144,
Organism=Drosophila melanogaster, GI21356561, Length=397, Percent_Identity=64.9874055415617, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24660856, Length=397, Percent_Identity=64.9874055415617, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI221330987, Length=397, Percent_Identity=64.9874055415617, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI221330985, Length=397, Percent_Identity=64.9874055415617, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI28574947, Length=397, Percent_Identity=64.9874055415617, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24660849, Length=397, Percent_Identity=64.9874055415617, Blast_Score=544, Evalue=1e-155,
Organism=Drosophila melanogaster, GI221330983, Length=397, Percent_Identity=64.9874055415617, Blast_Score=543, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24660868, Length=397, Percent_Identity=64.9874055415617, Blast_Score=543, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24660860, Length=397, Percent_Identity=64.9874055415617, Blast_Score=543, Evalue=1e-154,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45288; Mature: 45157

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIKVENPVVELDGDEMTRIIWDFIKKKLILPYLDLDLKYYDLGIEERDATSDQITVDA
CCCEECCCCEEEECCHHHHHHHHHHHHHHHCCCEECCCEEEEECCCCCCCCCCCEEEEHH
AEAIKQYGVGVKCATITPDEARVEEFGLKKMWKSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTQPIVVGRHAFGDQYKATDFRFPGKGKLTIKFVGEDGETIEHEVYQAPGAGVAMAM
CCCCCCCEEEECHHCCCCCCCCCEECCCCCEEEEEEECCCCCHHHHHHHCCCCCCHHHHH
YNLDQSIIDFARASMNYGLNRGYPVYLSTKNTILKAYDGRFKDLFQKVYEEEFEAEFKKK
HHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHC
GIHYEHRLIDDMVASAMKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKI
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCE
VESEAAHGTVTRHYREHQKGNQTSTNSIASIFAWTGGLKHRAKLDDNAALLNFAQTLERV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
TVQAVEDGFMTKDLALLVGPDQKWLTTMGYLEKVDEYLNKALAG
HHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKIKVENPVVELDGDEMTRIIWDFIKKKLILPYLDLDLKYYDLGIEERDATSDQITVDA
CCEECCCCEEEECCHHHHHHHHHHHHHHHCCCEECCCEEEEECCCCCCCCCCCEEEEHH
AEAIKQYGVGVKCATITPDEARVEEFGLKKMWKSPNGTIRNILGGVIFREPIICKNVPRL
HHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTQPIVVGRHAFGDQYKATDFRFPGKGKLTIKFVGEDGETIEHEVYQAPGAGVAMAM
CCCCCCCEEEECHHCCCCCCCCCEECCCCCEEEEEEECCCCCHHHHHHHCCCCCCHHHHH
YNLDQSIIDFARASMNYGLNRGYPVYLSTKNTILKAYDGRFKDLFQKVYEEEFEAEFKKK
HHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHC
GIHYEHRLIDDMVASAMKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKI
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCE
VESEAAHGTVTRHYREHQKGNQTSTNSIASIFAWTGGLKHRAKLDDNAALLNFAQTLERV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH
TVQAVEDGFMTKDLALLVGPDQKWLTTMGYLEKVDEYLNKALAG
HHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]