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The map label for this gene is bioF [C]

Identifier: 119385642

GI number: 119385642

Start: 80228

End: 81343

Strand: Direct

Name: bioF [C]

Synonym: Pden_2917

Alternate gene names: 119385642

Gene position: 80228-81343 (Clockwise)

Preceding gene: 119385641

Following gene: 119385643

Centisome position: 4.64

GC content: 74.37

Gene sequence:

>1116_bases
ATGAGCTTTTCGCGGCACGGGGCGGCGCTGGAGGCGATGGCGCGGCGCGGACGGCTGCGCCGGGTGGCGCCGGCGGCGGG
TGCCGATTTCGCCTCGAACGACTATCTGGGGCTGGCGGGGTCGGAATTGCTGGCCCGGGCTGCGCGGGAGGCGCTGGCGC
GCGGCGTGCCGGTGGGCGCGGGGGGGTCGCGGCTGTTGCGCGGCAACCATCCCGAGCATCAGGCGCTGGAGGCCGAGGCG
GCGGCGTTCTTCGGCGCCGAGGCGGCGCTTTACATGGGCGGCGGGTTCCAGGCCAACCAGGCGATCTTTTCGGCGCTGCC
GATGCAGGGCGACCTGGTGGTCCATGATGCGCTGGTCCATGCCAGCGCGCATGAGGGGATGCGGCTGGGCCGGGCCGAAT
GCCGCGGCTTTGCCCATAACGATGCCGGCGACGCGGCGCGGGTGATCGCGGAATGGCGCGCCTCGGGCGGGCGCGGCCGG
ATCTGGATCGCAGTCGAGAGCGTCTATTCCATGGAGGGCGACCGCGCGCCGCTGGAGGCGCTGGCGGCGCTGGCCGCGCG
CGAGGACGGGGTTCTGGTGGTGGACGAGGCGCATGCGACCGGCGTTTTCGGCCCGCAGGGCAGGGGGCTGGCGCATCGGC
TGGCCTGCCCGCTGGTGAGCCTGCATACCGGGGGCAAGGGGCTGGGCGCCTCGGGCGCGCTGGTCTGCGCCGACCGGGTG
CTGGTCGAGACGCTGGTGAACAAGGCGCGGCCGTTCATCTATGCCACGGCGCCGGCGCCCCTGTCGGCGGCGGTGCTGCG
CGGCGCCTTGCGGACGCTGGAGGAGGTGCCGGCGCTGGTCGAGGGCGCGCGGGCGCGCATGGCGCAGGCGGCAGAGGCGG
CGCGGCGTTGCGGCATAGTGGCGCAGAGCCAGATCGTGCCGGTGATCGTCGGCGAGGATTTCCGGGCGCTGGAGATGGCC
GGAGCCTTGCAGGCGCAGGGTTTCGACATCCGCGCCATCCGGCCGCCGACGGTGCCGAAGGGGACGGCGCGGCTGCGGGT
CTCGGTCACCGGCAATGTCGGGGCGGGCGAGATCGCGGCGCTGTTTGCCGCGCTGGAGGCAGCATGGGTGCGGTGA

Upstream 100 bases:

>100_bases
TGACCGCCGGGAACCCGGACGAGGACAAGGACGCGCTGCTGTTCGCCAAGCTGGGGCTGCGGGCCGAGGTGCCGGAGGCG
TCGCAGGAGGGCTGCGCGGC

Downstream 100 bases:

>100_bases
TCGTCGTGGGCACCGATACGGGCATCGGCAAGACCGTGTTCAGCGCCGGGCTGGCCCGCGCGCTGGGCGCGAGTTATTGG
AAGCCGGTGCAGGCGGGGCT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MSFSRHGAALEAMARRGRLRRVAPAAGADFASNDYLGLAGSELLARAAREALARGVPVGAGGSRLLRGNHPEHQALEAEA
AAFFGAEAALYMGGGFQANQAIFSALPMQGDLVVHDALVHASAHEGMRLGRAECRGFAHNDAGDAARVIAEWRASGGRGR
IWIAVESVYSMEGDRAPLEALAALAAREDGVLVVDEAHATGVFGPQGRGLAHRLACPLVSLHTGGKGLGASGALVCADRV
LVETLVNKARPFIYATAPAPLSAAVLRGALRTLEEVPALVEGARARMAQAAEAARRCGIVAQSQIVPVIVGEDFRALEMA
GALQAQGFDIRAIRPPTVPKGTARLRVSVTGNVGAGEIAALFAALEAAWVR

Sequences:

>Translated_371_residues
MSFSRHGAALEAMARRGRLRRVAPAAGADFASNDYLGLAGSELLARAAREALARGVPVGAGGSRLLRGNHPEHQALEAEA
AAFFGAEAALYMGGGFQANQAIFSALPMQGDLVVHDALVHASAHEGMRLGRAECRGFAHNDAGDAARVIAEWRASGGRGR
IWIAVESVYSMEGDRAPLEALAALAAREDGVLVVDEAHATGVFGPQGRGLAHRLACPLVSLHTGGKGLGASGALVCADRV
LVETLVNKARPFIYATAPAPLSAAVLRGALRTLEEVPALVEGARARMAQAAEAARRCGIVAQSQIVPVIVGEDFRALEMA
GALQAQGFDIRAIRPPTVPKGTARLRVSVTGNVGAGEIAALFAALEAAWVR
>Mature_370_residues
SFSRHGAALEAMARRGRLRRVAPAAGADFASNDYLGLAGSELLARAAREALARGVPVGAGGSRLLRGNHPEHQALEAEAA
AFFGAEAALYMGGGFQANQAIFSALPMQGDLVVHDALVHASAHEGMRLGRAECRGFAHNDAGDAARVIAEWRASGGRGRI
WIAVESVYSMEGDRAPLEALAALAAREDGVLVVDEAHATGVFGPQGRGLAHRLACPLVSLHTGGKGLGASGALVCADRVL
VETLVNKARPFIYATAPAPLSAAVLRGALRTLEEVPALVEGARARMAQAAEAARRCGIVAQSQIVPVIVGEDFRALEMAG
ALQAQGFDIRAIRPPTVPKGTARLRVSVTGNVGAGEIAALFAALEAAWVR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=348, Percent_Identity=32.4712643678161, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI284448556, Length=331, Percent_Identity=32.6283987915408, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI83977440, Length=356, Percent_Identity=29.4943820224719, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI83977444, Length=356, Percent_Identity=29.4943820224719, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI83977442, Length=356, Percent_Identity=29.4943820224719, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4502025, Length=359, Percent_Identity=28.133704735376, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI40316939, Length=359, Percent_Identity=28.133704735376, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4758668, Length=242, Percent_Identity=31.8181818181818, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI119220554, Length=277, Percent_Identity=29.2418772563177, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI5454084, Length=278, Percent_Identity=24.4604316546763, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1786993, Length=348, Percent_Identity=38.5057471264368, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1790046, Length=334, Percent_Identity=33.8323353293413, Blast_Score=152, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71994529, Length=355, Percent_Identity=31.5492957746479, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI32566772, Length=362, Percent_Identity=25.414364640884, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17560914, Length=243, Percent_Identity=29.6296296296296, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560912, Length=243, Percent_Identity=29.6296296296296, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71982625, Length=268, Percent_Identity=24.6268656716418, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71982617, Length=197, Percent_Identity=26.3959390862944, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320438, Length=352, Percent_Identity=30.3977272727273, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320267, Length=356, Percent_Identity=26.4044943820225, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323954, Length=224, Percent_Identity=27.6785714285714, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24662918, Length=331, Percent_Identity=31.1178247734139, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI17137420, Length=359, Percent_Identity=29.8050139275766, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI17136286, Length=304, Percent_Identity=27.9605263157895, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653280, Length=286, Percent_Identity=25.1748251748252, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24653276, Length=286, Percent_Identity=25.1748251748252, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24653278, Length=286, Percent_Identity=25.1748251748252, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 38399; Mature: 38268

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSRHGAALEAMARRGRLRRVAPAAGADFASNDYLGLAGSELLARAAREALARGVPVGA
CCCCCCHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
GGSRLLRGNHPEHQALEAEAAAFFGAEAALYMGGGFQANQAIFSALPMQGDLVVHDALVH
CCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCCCEEEHHHHHH
ASAHEGMRLGRAECRGFAHNDAGDAARVIAEWRASGGRGRIWIAVESVYSMEGDRAPLEA
HHHHCCHHHCHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEHHHCCCCCCHHHH
LAALAAREDGVLVVDEAHATGVFGPQGRGLAHRLACPLVSLHTGGKGLGASGALVCADRV
HHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHCCCEEEECCCCCCCCCCHHHHHHHH
LVETLVNKARPFIYATAPAPLSAAVLRGALRTLEEVPALVEGARARMAQAAEAARRCGIV
HHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
AQSQIVPVIVGEDFRALEMAGALQAQGFDIRAIRPPTVPKGTARLRVSVTGNVGAGEIAA
ECCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEECCCCCHHHHH
LFAALEAAWVR
HHHHHHHHHCC
>Mature Secondary Structure 
SFSRHGAALEAMARRGRLRRVAPAAGADFASNDYLGLAGSELLARAAREALARGVPVGA
CCCCCHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
GGSRLLRGNHPEHQALEAEAAAFFGAEAALYMGGGFQANQAIFSALPMQGDLVVHDALVH
CCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCCCEEEHHHHHH
ASAHEGMRLGRAECRGFAHNDAGDAARVIAEWRASGGRGRIWIAVESVYSMEGDRAPLEA
HHHHCCHHHCHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEEEEHHHCCCCCCHHHH
LAALAAREDGVLVVDEAHATGVFGPQGRGLAHRLACPLVSLHTGGKGLGASGALVCADRV
HHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHCCCEEEECCCCCCCCCCHHHHHHHH
LVETLVNKARPFIYATAPAPLSAAVLRGALRTLEEVPALVEGARARMAQAAEAARRCGIV
HHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
AQSQIVPVIVGEDFRALEMAGALQAQGFDIRAIRPPTVPKGTARLRVSVTGNVGAGEIAA
ECCCEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEEECCCCCHHHHH
LFAALEAAWVR
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]