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The map label for this gene is pyrD [H]

Identifier: 119385609

GI number: 119385609

Start: 48031

End: 49089

Strand: Direct

Name: pyrD [H]

Synonym: Pden_2884

Alternate gene names: 119385609

Gene position: 48031-49089 (Clockwise)

Preceding gene: 119385608

Following gene: 119385635

Centisome position: 2.78

GC content: 72.24

Gene sequence:

>1059_bases
ATGACCCCCATCGAGCGGCTGGGCCTTGCCGCATTGCATCGCCTCGACCCCGAGCGCGCGCATGATCTCTCGATCCTCGC
CCTGCGGCATGGCCTCGTGCCCCTGCCCGGCCGGCCCGTCACCTCCGACCGGCTGCGCATCCGCATCTCGGGGCTCGACC
TGCCGAACCCTGTCGGCCTTGCCGCCGGCTACGACAAGAACGCCCGCGCCCTGCCCGCATTGATGCGCGCCGGCTTCGGC
TTCGTCGAGATCGGCGCCGCCACCCCGCGCCCGCAGCCGGGCAACCCAAGGCCGCGCCTGTTCCGCCTGACCCCGGACCG
CGCCATCATCAACCGCTTCGGCTTCAACAACGAGGGCGCGCAGGCCATCGCCGACCGCCTCGCGCAGCGTCCCGCCGGCA
TCCCGGTCGGGCTGAACATCGGCGCGAACAAGGACAGCGCCGACCGCAGCGCCGATTTCGCGCAGGTCGTGCGCATCGCC
GGCGCCCATGCCGATTTCCTGACCGTCAACGTCTCCTCGCCGAATACCGAGAAGCTGCGCGACCTTCAGGGACCCGAGGC
ATTGTCGGCCCTTCTGCAAGGCGTGCTGGCCGCGCGCGACGCGCTGCCGAACCGCCCGCCCGTGTTCATCAAGATCGCCC
CCGACCTCGACGACACCGCACTCGCCGACATCGCCGCCGTGGCGCTGGCCGCCCCGGTCGATGCGATCATCGCCACCAAC
ACCACGCTGTCCCGCGACGGCCTCGCCTCGCCGCACGCCAACGAGGCCGGCGGCCTTTCCGGCGCGCCGCTTTTCGACCG
CGCCACCCGCATCCTCGCCCGGCTCTACCGCGAGACCGGGGGGCGTGTGCCGCTGATCGGCGTCGGCGGCATCGGCTCGG
CCGAGCAGGCCTGGCAAAAGCTGCGCGCCGGCGCCTCGGCCGTCCAGATCTACTCCGCGCTGGTCTACCAGGGCTTCTCG
CTCGCCGCGCAGATCGCCCGCGACCTCGACGAACGGCTCGCGCGCGAAAACGTCACGCTGGCGGAGCTGACCGGCAGCGG
CAACGCGGACTGGCTCTAG

Upstream 100 bases:

>100_bases
ATCTCTTTCCGCATCTCTACCGCGAATTGCGCATGGACGACGTGCTCTGGAGCCGCGCCCTGCCCCTCGGCCCCGGCGGC
CACGACATCGGAGACATCGC

Downstream 100 bases:

>100_bases
AACAGGTCCTCGTGACCCAGAAGCTGGTTCATGGTGTTCGAGGGATCCGAGCAGCCGGCATCGCCCACGATCCGCGCCGG
CACCCCGGCCACGGTCTTGC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MTPIERLGLAALHRLDPERAHDLSILALRHGLVPLPGRPVTSDRLRIRISGLDLPNPVGLAAGYDKNARALPALMRAGFG
FVEIGAATPRPQPGNPRPRLFRLTPDRAIINRFGFNNEGAQAIADRLAQRPAGIPVGLNIGANKDSADRSADFAQVVRIA
GAHADFLTVNVSSPNTEKLRDLQGPEALSALLQGVLAARDALPNRPPVFIKIAPDLDDTALADIAAVALAAPVDAIIATN
TTLSRDGLASPHANEAGGLSGAPLFDRATRILARLYRETGGRVPLIGVGGIGSAEQAWQKLRAGASAVQIYSALVYQGFS
LAAQIARDLDERLARENVTLAELTGSGNADWL

Sequences:

>Translated_352_residues
MTPIERLGLAALHRLDPERAHDLSILALRHGLVPLPGRPVTSDRLRIRISGLDLPNPVGLAAGYDKNARALPALMRAGFG
FVEIGAATPRPQPGNPRPRLFRLTPDRAIINRFGFNNEGAQAIADRLAQRPAGIPVGLNIGANKDSADRSADFAQVVRIA
GAHADFLTVNVSSPNTEKLRDLQGPEALSALLQGVLAARDALPNRPPVFIKIAPDLDDTALADIAAVALAAPVDAIIATN
TTLSRDGLASPHANEAGGLSGAPLFDRATRILARLYRETGGRVPLIGVGGIGSAEQAWQKLRAGASAVQIYSALVYQGFS
LAAQIARDLDERLARENVTLAELTGSGNADWL
>Mature_351_residues
TPIERLGLAALHRLDPERAHDLSILALRHGLVPLPGRPVTSDRLRIRISGLDLPNPVGLAAGYDKNARALPALMRAGFGF
VEIGAATPRPQPGNPRPRLFRLTPDRAIINRFGFNNEGAQAIADRLAQRPAGIPVGLNIGANKDSADRSADFAQVVRIAG
AHADFLTVNVSSPNTEKLRDLQGPEALSALLQGVLAARDALPNRPPVFIKIAPDLDDTALADIAAVALAAPVDAIIATNT
TLSRDGLASPHANEAGGLSGAPLFDRATRILARLYRETGGRVPLIGVGGIGSAEQAWQKLRAGASAVQIYSALVYQGFSL
AAQIARDLDERLARENVTLAELTGSGNADWL

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=333, Percent_Identity=47.7477477477478, Blast_Score=291, Evalue=9e-79,
Organism=Homo sapiens, GI119943098, Length=332, Percent_Identity=25, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1787177, Length=335, Percent_Identity=40.8955223880597, Blast_Score=228, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17509475, Length=342, Percent_Identity=41.5204678362573, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI281361352, Length=357, Percent_Identity=42.5770308123249, Blast_Score=270, Evalue=8e-73,
Organism=Drosophila melanogaster, GI17137316, Length=357, Percent_Identity=42.5770308123249, Blast_Score=270, Evalue=8e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 37111; Mature: 36980

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPIERLGLAALHRLDPERAHDLSILALRHGLVPLPGRPVTSDRLRIRISGLDLPNPVGL
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
AAGYDKNARALPALMRAGFGFVEIGAATPRPQPGNPRPRLFRLTPDRAIINRFGFNNEGA
CCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHCCCCCCHH
QAIADRLAQRPAGIPVGLNIGANKDSADRSADFAQVVRIAGAHADFLTVNVSSPNTEKLR
HHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHH
DLQGPEALSALLQGVLAARDALPNRPPVFIKIAPDLDDTALADIAAVALAAPVDAIIATN
HCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCC
TTLSRDGLASPHANEAGGLSGAPLFDRATRILARLYRETGGRVPLIGVGGIGSAEQAWQK
CEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHH
LRAGASAVQIYSALVYQGFSLAAQIARDLDERLARENVTLAELTGSGNADWL
HHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
>Mature Secondary Structure 
TPIERLGLAALHRLDPERAHDLSILALRHGLVPLPGRPVTSDRLRIRISGLDLPNPVGL
CCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
AAGYDKNARALPALMRAGFGFVEIGAATPRPQPGNPRPRLFRLTPDRAIINRFGFNNEGA
CCCCCCCCHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHCCCCCCHH
QAIADRLAQRPAGIPVGLNIGANKDSADRSADFAQVVRIAGAHADFLTVNVSSPNTEKLR
HHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHH
DLQGPEALSALLQGVLAARDALPNRPPVFIKIAPDLDDTALADIAAVALAAPVDAIIATN
HCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCC
TTLSRDGLASPHANEAGGLSGAPLFDRATRILARLYRETGGRVPLIGVGGIGSAEQAWQK
CEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHH
LRAGASAVQIYSALVYQGFSLAAQIARDLDERLARENVTLAELTGSGNADWL
HHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA