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The map label for this gene is glmS [H]

Identifier: 119358440

GI number: 119358440

Start: 3068534

End: 3070402

Strand: Reverse

Name: glmS [H]

Synonym: Cpha266_2676

Alternate gene names: 119358440

Gene position: 3070402-3068534 (Counterclockwise)

Preceding gene: 119358441

Following gene: 119358439

Centisome position: 97.97

GC content: 55.27

Gene sequence:

>1869_bases
ATGAAACAAGATCCGAAAAGTCTTATGTGTGGAATTGTAGGTTATATCGGCAAAAGAGATGCGGCAACGGTGCTGCTTAA
CGGCCTCAAGCGACTTGAATACCGCGGGTACGACTCCGCAGGCATCGCCGTCCTTAACGGAGCCCTTTCGGTCATCAAAC
AGAAAGGAAGCGTCGGCGCTCTGGAGCGAGCCGTCGCCGACTCGTCGGGCCTCCTCAAAGGAGGAACCATCGGCATCGGA
CATACCCGCTGGGCAACCCATGGCGACCCGAGCGACCGCAATGCCCACCCGCACCTCAACGCGGCAGGCGATATTGCCCT
GATACACAACGGCATTATCGAGAACCACACGGCGCTTCGTCAGGAGCTGAGCAGCCAGGGCTACACCTTTCTGAGCGATA
CCGATACGGAAGTGCTTGTTCATCTCATCGACCGAATCTGGAACGAAGAGCGGCATCTCACCCTTGAAGGGGTCGTTCGA
AGGGCGCTGCACTACATCGAAGGAGCTTACGGGATCTGCGTCATATCCTCGCGCGAACCGGAGACGCTCATCGTTGCCCG
GATGGGAAGTCCCCTCGTACTCGGTATCGGCGAACAGGAATATTTTATAGCCTCCGACGCCGCGCCGATAATCGAATACA
CCAAAAAAGTGATCTATCTGGCCGACGGCGAGATGGCCGTCATGAACCGCGAAGGGTTTGCCGTAAAAACAGATAAAAAC
GAAGAGGCCGAAAAAAACGTCACCGAGCTCGATTTCAAGCTTGAAGAGATAGAAAAAGGGGGGTTCGAGCACTTCATGCT
CAAGGAGATCTTTGAACAGCCCAGCGTCATGCAGGATGTCATGCGCGGAAGAATTCATCTCGAAGACAACACGCTCCATC
TCGGCGGTGTAAAAGATCACCTCGAAAAGCTCCGCAAGGCGAAACGAATCATTATCTGTGCCTGCGGAACCAGTTGGCAT
GCGGGACTGATCGGCGAGTACCTCATCGAAGAGTTTGCCCGTATTCCGGTTGAAGTCGATTACGCATCGGAGTTCAGATA
TCGCACCCCGATCATCTCGCCCGACGATGTGGTCATGGTGATTTCGCAATCCGGAGAGACCGCCGACACCCTTGCCGCGC
TTCGAATGGCAAAAGAAAAAGGCGCGCTGGTAATGGGCATCTGCAATGTCGTCGGCTCCACGATTGCCCGCGAAACCACC
TGCGGGATGTACACCCATGCCGGCCCGGAAATCGGAGTCGCATCGACAAAAGCCTTTACCGCCCAGGTTATTGTGCTCTA
CATGCTGGCGCTTGCGCTCAGTATCGGGCGAACCATCAAGGATGAAGAGATAGCGCTCTATCTCAAAGAACTTTCAGAAG
CGCCCCAAAAAGCCGCAAGCATCATCGCGCAGCATGCCGACATCCGCGCGATAGCCAAAGTATACAAGGATGCGCGCAAC
TTTCTCTACCTTGGCCGCGGCTTCAACTTTCCCGTCGCCCTCGAAGGCGCATTGAAACTCAAGGAGATCTCCTACATCCA
TGCCGAAGGCTACCCGGCAGCCGAAATGAAGCATGGCCCGATCGCCCTGATCGACAAGGATATGCCGGTGATTTTTATTG
CCACGCGCGACAGCACCTACACCAAGATACTCAGCAATATCGAAGAGGTTCGCACCCGAAAAGGCAAGATTATCGCCATT
GCCACCGAGGGGGACCAGGAGATCAGCAATCTCGCCGACCATGTGATCTATATTCCCTATGCGGCCGCGCCGGTCACGCC
GCTCCTGACGGTCATCCCCCTGCAGTTGCTCTCCTATTACATCGCCACCGAACGAGGGTGCAACGTAGACCGTCCCAGAA
ATCTCGCCAAATCCGTTACGGTCGAGTAA

Upstream 100 bases:

>100_bases
CTGCATCTGGCCATGAAACGTGCCATGTAACGTCGTTACGGCAGCTCCCGTCAGTCAGCAGACAGCATAAATCATCATGC
AAAAGCAGGAAATTTATTGC

Downstream 100 bases:

>100_bases
CCGGGCAAGAGAGGGGGAATTATTAGGCGGCTCTGTTTATTGTGTTGAGAGAGCGGGGTATCCGGGATCAACGGAACAAC
CGGATCGCCGCATCATAACG

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 622; Mature: 622

Protein sequence:

>622_residues
MKQDPKSLMCGIVGYIGKRDAATVLLNGLKRLEYRGYDSAGIAVLNGALSVIKQKGSVGALERAVADSSGLLKGGTIGIG
HTRWATHGDPSDRNAHPHLNAAGDIALIHNGIIENHTALRQELSSQGYTFLSDTDTEVLVHLIDRIWNEERHLTLEGVVR
RALHYIEGAYGICVISSREPETLIVARMGSPLVLGIGEQEYFIASDAAPIIEYTKKVIYLADGEMAVMNREGFAVKTDKN
EEAEKNVTELDFKLEEIEKGGFEHFMLKEIFEQPSVMQDVMRGRIHLEDNTLHLGGVKDHLEKLRKAKRIIICACGTSWH
AGLIGEYLIEEFARIPVEVDYASEFRYRTPIISPDDVVMVISQSGETADTLAALRMAKEKGALVMGICNVVGSTIARETT
CGMYTHAGPEIGVASTKAFTAQVIVLYMLALALSIGRTIKDEEIALYLKELSEAPQKAASIIAQHADIRAIAKVYKDARN
FLYLGRGFNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDKDMPVIFIATRDSTYTKILSNIEEVRTRKGKIIAI
ATEGDQEISNLADHVIYIPYAAAPVTPLLTVIPLQLLSYYIATERGCNVDRPRNLAKSVTVE

Sequences:

>Translated_622_residues
MKQDPKSLMCGIVGYIGKRDAATVLLNGLKRLEYRGYDSAGIAVLNGALSVIKQKGSVGALERAVADSSGLLKGGTIGIG
HTRWATHGDPSDRNAHPHLNAAGDIALIHNGIIENHTALRQELSSQGYTFLSDTDTEVLVHLIDRIWNEERHLTLEGVVR
RALHYIEGAYGICVISSREPETLIVARMGSPLVLGIGEQEYFIASDAAPIIEYTKKVIYLADGEMAVMNREGFAVKTDKN
EEAEKNVTELDFKLEEIEKGGFEHFMLKEIFEQPSVMQDVMRGRIHLEDNTLHLGGVKDHLEKLRKAKRIIICACGTSWH
AGLIGEYLIEEFARIPVEVDYASEFRYRTPIISPDDVVMVISQSGETADTLAALRMAKEKGALVMGICNVVGSTIARETT
CGMYTHAGPEIGVASTKAFTAQVIVLYMLALALSIGRTIKDEEIALYLKELSEAPQKAASIIAQHADIRAIAKVYKDARN
FLYLGRGFNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDKDMPVIFIATRDSTYTKILSNIEEVRTRKGKIIAI
ATEGDQEISNLADHVIYIPYAAAPVTPLLTVIPLQLLSYYIATERGCNVDRPRNLAKSVTVE
>Mature_622_residues
MKQDPKSLMCGIVGYIGKRDAATVLLNGLKRLEYRGYDSAGIAVLNGALSVIKQKGSVGALERAVADSSGLLKGGTIGIG
HTRWATHGDPSDRNAHPHLNAAGDIALIHNGIIENHTALRQELSSQGYTFLSDTDTEVLVHLIDRIWNEERHLTLEGVVR
RALHYIEGAYGICVISSREPETLIVARMGSPLVLGIGEQEYFIASDAAPIIEYTKKVIYLADGEMAVMNREGFAVKTDKN
EEAEKNVTELDFKLEEIEKGGFEHFMLKEIFEQPSVMQDVMRGRIHLEDNTLHLGGVKDHLEKLRKAKRIIICACGTSWH
AGLIGEYLIEEFARIPVEVDYASEFRYRTPIISPDDVVMVISQSGETADTLAALRMAKEKGALVMGICNVVGSTIARETT
CGMYTHAGPEIGVASTKAFTAQVIVLYMLALALSIGRTIKDEEIALYLKELSEAPQKAASIIAQHADIRAIAKVYKDARN
FLYLGRGFNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDKDMPVIFIATRDSTYTKILSNIEEVRTRKGKIIAI
ATEGDQEISNLADHVIYIPYAAAPVTPLLTVIPLQLLSYYIATERGCNVDRPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=682, Percent_Identity=40.0293255131965, Blast_Score=498, Evalue=1e-141,
Organism=Homo sapiens, GI205277386, Length=684, Percent_Identity=39.327485380117, Blast_Score=486, Evalue=1e-137,
Organism=Escherichia coli, GI1790167, Length=618, Percent_Identity=46.4401294498382, Blast_Score=544, Evalue=1e-156,
Organism=Escherichia coli, GI1788651, Length=251, Percent_Identity=29.4820717131474, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532899, Length=431, Percent_Identity=44.3155452436195, Blast_Score=363, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17532897, Length=431, Percent_Identity=44.3155452436195, Blast_Score=363, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17539970, Length=432, Percent_Identity=45.1388888888889, Blast_Score=360, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6322745, Length=431, Percent_Identity=44.3155452436195, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323731, Length=429, Percent_Identity=36.5967365967366, Blast_Score=273, Evalue=5e-74,
Organism=Saccharomyces cerevisiae, GI6323730, Length=206, Percent_Identity=35.4368932038835, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6323958, Length=228, Percent_Identity=28.0701754385965, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21357745, Length=683, Percent_Identity=40.7027818448023, Blast_Score=523, Evalue=1e-148,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 68314; Mature: 68314

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQDPKSLMCGIVGYIGKRDAATVLLNGLKRLEYRGYDSAGIAVLNGALSVIKQKGSVGA
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHH
LERAVADSSGLLKGGTIGIGHTRWATHGDPSDRNAHPHLNAAGDIALIHNGIIENHTALR
HHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHH
QELSSQGYTFLSDTDTEVLVHLIDRIWNEERHLTLEGVVRRALHYIEGAYGICVISSREP
HHHHHCCCEEECCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCEEEEECCCCC
ETLIVARMGSPLVLGIGEQEYFIASDAAPIIEYTKKVIYLADGEMAVMNREGFAVKTDKN
CEEEEEECCCCEEEEECCCCEEEECCCCHHHHHCCEEEEEECCCEEEEECCCEEEECCCC
EEAEKNVTELDFKLEEIEKGGFEHFMLKEIFEQPSVMQDVMRGRIHLEDNTLHLGGVKDH
CHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCEEEEECCEEEECCHHHH
LEKLRKAKRIIICACGTSWHAGLIGEYLIEEFARIPVEVDYASEFRYRTPIISPDDVVMV
HHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEECCCCCEECCCCCCCCCEEEE
ISQSGETADTLAALRMAKEKGALVMGICNVVGSTIARETTCGMYTHAGPEIGVASTKAFT
EECCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCHHHH
AQVIVLYMLALALSIGRTIKDEEIALYLKELSEAPQKAASIIAQHADIRAIAKVYKDARN
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FLYLGRGFNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDKDMPVIFIATRDSTY
EEEECCCCCCCEEECCCEEEEHEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEECCCHH
TKILSNIEEVRTRKGKIIAIATEGDQEISNLADHVIYIPYAAAPVTPLLTVIPLQLLSYY
HHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHH
IATERGCNVDRPRNLAKSVTVE
HHHCCCCCCCCCHHHHHHCCCC
>Mature Secondary Structure
MKQDPKSLMCGIVGYIGKRDAATVLLNGLKRLEYRGYDSAGIAVLNGALSVIKQKGSVGA
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHH
LERAVADSSGLLKGGTIGIGHTRWATHGDPSDRNAHPHLNAAGDIALIHNGIIENHTALR
HHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHH
QELSSQGYTFLSDTDTEVLVHLIDRIWNEERHLTLEGVVRRALHYIEGAYGICVISSREP
HHHHHCCCEEECCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCEEEEECCCCC
ETLIVARMGSPLVLGIGEQEYFIASDAAPIIEYTKKVIYLADGEMAVMNREGFAVKTDKN
CEEEEEECCCCEEEEECCCCEEEECCCCHHHHHCCEEEEEECCCEEEEECCCEEEECCCC
EEAEKNVTELDFKLEEIEKGGFEHFMLKEIFEQPSVMQDVMRGRIHLEDNTLHLGGVKDH
CHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHCCEEEEECCEEEECCHHHH
LEKLRKAKRIIICACGTSWHAGLIGEYLIEEFARIPVEVDYASEFRYRTPIISPDDVVMV
HHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEECCCCCEECCCCCCCCCEEEE
ISQSGETADTLAALRMAKEKGALVMGICNVVGSTIARETTCGMYTHAGPEIGVASTKAFT
EECCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCHHHH
AQVIVLYMLALALSIGRTIKDEEIALYLKELSEAPQKAASIIAQHADIRAIAKVYKDARN
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
FLYLGRGFNFPVALEGALKLKEISYIHAEGYPAAEMKHGPIALIDKDMPVIFIATRDSTY
EEEECCCCCCCEEECCCEEEEHEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEECCCHH
TKILSNIEEVRTRKGKIIAIATEGDQEISNLADHVIYIPYAAAPVTPLLTVIPLQLLSYY
HHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHH
IATERGCNVDRPRNLAKSVTVE
HHHCCCCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]