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The map label for this gene is glpK [H]

Identifier: 119358358

GI number: 119358358

Start: 2966456

End: 2967907

Strand: Reverse

Name: glpK [H]

Synonym: Cpha266_2590

Alternate gene names: 119358358

Gene position: 2967907-2966456 (Counterclockwise)

Preceding gene: 119358359

Following gene: 119358357

Centisome position: 94.7

GC content: 55.99

Gene sequence:

>1452_bases
ATGGCTATTCTTGCGATTGATCAGGGAACGACGGGAACAACCTGCGTGCTCTATAATGAAAAGGCTGAGGTTCTCGGGAA
GGCTTACCGGGAGCTGAGGCAGATTTATCCCTGCGAGGGTTGGGTTGAGCACGATCCGGAAGAGATCTGGCAGAGCGTTG
TGCTTTGTGTCCGGGAGCTTCTTGAGCGATGCCCGGTGACGATTGCCGCTCTGGGTATAACGAATCAGCGGGAAACAACG
ATTGTCTGGGAGCGGGCAAGCGGTCGTCCGGTGTATCATGCGATTGTCTGGCAGTGCAGACGCACGACGGAGCTTTGCCG
GCGATTTGAGCAGGAAAAAGGGATGATCGCAGAAAAGACGGGGCTGCCGCTTGATGCGTATTTCAGCGCAACGAAAATCC
GCTGGATTCTCGATACCTGTTCTCATCTTTCTCCGGATGCTCTTCTTTTCGGTACGGTTGACAGTTGGCTGGTGTGGAAA
CTGACCGGCGGCGGGGTTCATGCGACCGATTTTACCAATGCGTCGAGAACGATGCTTTATAATATCAGGGAGAAGCGGTG
GGATGGGGAGCTTCTCGATCTGTTTGGAATTCCTGGTTCGATGTTGCCGGAGGTTCGTCCGTCAATGGATGATTTTGGCC
GGGTGAGCGCTCTTGATGAGCTGGCGGGGGTGCCGGTGCTTGCGGTTGCCGGCGATCAGCAGGCCGCTCTGTTCGGGCAG
TGCTGTTTTGAGCCGGGCTCTATCAAGAATACCTATGGCACGGGTTGTTTTATGGTTATGAATACCGGCGATGCATGTAT
CCGTTCGCATAACGGTCTTCTGACGACGTTGGCTATTGATGCCGGAGGGCGTCCCTGTTATGCTCTTGAGGGTTCTGTTT
TTATCGGCGGCGCGGTGGTTCAGTGGTTGCGCGACGAGTTGCAGTTGATGAAGCATGCTTCGGAGTCTGAGGCGATGGCA
AGAGCGGCGGGTTCAAATGGAGGGGTTTATCTTGTTCCTGCTTTTGTCGGCCTCGGGGCGCCTCATTGGCAGATGGAGGC
GCGGGGAACGATTGTCGGGTTGACGAGGGGTACGAATAAAAATCATATTGTGCGGGCCGCTCTGGAGTCCATTGCTTTTG
AGTCGTACGATGTGTTCAGGGCCATGGTTGCGGATTCGGGAATCTCGCCTGATGCGTTGGCTGTCGATGGCGGGGCGGCG
GATAACGGGTTTCTTATGCAGTTTCAGGCGGATCTGCTTGGCATTCCGGTTCTGAAGGCGGCGAATATCGAGTCGACTTC
GCTTGGCGCGGCTTTTCTCTGCGGGTTGCGGGCCGGCATCTGGAAGTCAGATGGGGAGTTGCGCATGGTTAATCGGCATG
CGCAGGCCTGTTATCCTTCCATGGAGCCCGAGACGAGGGATGCTCTGCTTTGCGGCTGGCAAAAGGCTCTCCGCCAGACG
CTGGTGAGGTAG

Upstream 100 bases:

>100_bases
GCTCCTCTTCCCGTCTGTTTTTTTGCTTGCGTGTGATGGGTTTGTTTCTCTTTTTTCCGGGGTGTATGTCCGGTGTTGGC
GTAACAGTGATGCTCAGGCG

Downstream 100 bases:

>100_bases
GGGGCGATGCCTTGTGGTTTCTCAATGGTTTATTCGAGGGTTTTGTAAACGTAATGACGATTATGACAACTGACCATGAA
GTGAAGAGCAGCGGCGAGAG

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MAILAIDQGTTGTTCVLYNEKAEVLGKAYRELRQIYPCEGWVEHDPEEIWQSVVLCVRELLERCPVTIAALGITNQRETT
IVWERASGRPVYHAIVWQCRRTTELCRRFEQEKGMIAEKTGLPLDAYFSATKIRWILDTCSHLSPDALLFGTVDSWLVWK
LTGGGVHATDFTNASRTMLYNIREKRWDGELLDLFGIPGSMLPEVRPSMDDFGRVSALDELAGVPVLAVAGDQQAALFGQ
CCFEPGSIKNTYGTGCFMVMNTGDACIRSHNGLLTTLAIDAGGRPCYALEGSVFIGGAVVQWLRDELQLMKHASESEAMA
RAAGSNGGVYLVPAFVGLGAPHWQMEARGTIVGLTRGTNKNHIVRAALESIAFESYDVFRAMVADSGISPDALAVDGGAA
DNGFLMQFQADLLGIPVLKAANIESTSLGAAFLCGLRAGIWKSDGELRMVNRHAQACYPSMEPETRDALLCGWQKALRQT
LVR

Sequences:

>Translated_483_residues
MAILAIDQGTTGTTCVLYNEKAEVLGKAYRELRQIYPCEGWVEHDPEEIWQSVVLCVRELLERCPVTIAALGITNQRETT
IVWERASGRPVYHAIVWQCRRTTELCRRFEQEKGMIAEKTGLPLDAYFSATKIRWILDTCSHLSPDALLFGTVDSWLVWK
LTGGGVHATDFTNASRTMLYNIREKRWDGELLDLFGIPGSMLPEVRPSMDDFGRVSALDELAGVPVLAVAGDQQAALFGQ
CCFEPGSIKNTYGTGCFMVMNTGDACIRSHNGLLTTLAIDAGGRPCYALEGSVFIGGAVVQWLRDELQLMKHASESEAMA
RAAGSNGGVYLVPAFVGLGAPHWQMEARGTIVGLTRGTNKNHIVRAALESIAFESYDVFRAMVADSGISPDALAVDGGAA
DNGFLMQFQADLLGIPVLKAANIESTSLGAAFLCGLRAGIWKSDGELRMVNRHAQACYPSMEPETRDALLCGWQKALRQT
LVR
>Mature_482_residues
AILAIDQGTTGTTCVLYNEKAEVLGKAYRELRQIYPCEGWVEHDPEEIWQSVVLCVRELLERCPVTIAALGITNQRETTI
VWERASGRPVYHAIVWQCRRTTELCRRFEQEKGMIAEKTGLPLDAYFSATKIRWILDTCSHLSPDALLFGTVDSWLVWKL
TGGGVHATDFTNASRTMLYNIREKRWDGELLDLFGIPGSMLPEVRPSMDDFGRVSALDELAGVPVLAVAGDQQAALFGQC
CFEPGSIKNTYGTGCFMVMNTGDACIRSHNGLLTTLAIDAGGRPCYALEGSVFIGGAVVQWLRDELQLMKHASESEAMAR
AAGSNGGVYLVPAFVGLGAPHWQMEARGTIVGLTRGTNKNHIVRAALESIAFESYDVFRAMVADSGISPDALAVDGGAAD
NGFLMQFQADLLGIPVLKAANIESTSLGAAFLCGLRAGIWKSDGELRMVNRHAQACYPSMEPETRDALLCGWQKALRQTL
VR

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=442, Percent_Identity=48.6425339366516, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI4504007, Length=442, Percent_Identity=48.6425339366516, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI42794763, Length=447, Percent_Identity=47.8747203579418, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI41393575, Length=442, Percent_Identity=47.5113122171946, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI88196792, Length=506, Percent_Identity=32.4110671936759, Blast_Score=284, Evalue=1e-76,
Organism=Escherichia coli, GI1790361, Length=493, Percent_Identity=50.709939148073, Blast_Score=501, Evalue=1e-143,
Organism=Escherichia coli, GI1789987, Length=461, Percent_Identity=25.5965292841649, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787789, Length=480, Percent_Identity=24.7916666666667, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1789168, Length=478, Percent_Identity=22.3849372384937, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790005, Length=483, Percent_Identity=22.9813664596273, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17535599, Length=496, Percent_Identity=37.9032258064516, Blast_Score=332, Evalue=3e-91,
Organism=Caenorhabditis elegans, GI71986140, Length=515, Percent_Identity=24.0776699029126, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71986147, Length=299, Percent_Identity=29.0969899665552, Blast_Score=118, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6321755, Length=478, Percent_Identity=36.6108786610879, Blast_Score=280, Evalue=4e-76,
Organism=Drosophila melanogaster, GI24655555, Length=497, Percent_Identity=39.2354124748491, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI24655560, Length=497, Percent_Identity=39.2354124748491, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI24655570, Length=497, Percent_Identity=39.2354124748491, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI24655574, Length=497, Percent_Identity=39.2354124748491, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI24655565, Length=497, Percent_Identity=39.2354124748491, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI17864214, Length=501, Percent_Identity=40.1197604790419, Blast_Score=349, Evalue=3e-96,
Organism=Drosophila melanogaster, GI24654573, Length=431, Percent_Identity=42.4593967517401, Blast_Score=329, Evalue=3e-90,
Organism=Drosophila melanogaster, GI19922058, Length=525, Percent_Identity=32.9523809523809, Blast_Score=278, Evalue=4e-75,
Organism=Drosophila melanogaster, GI24652871, Length=491, Percent_Identity=32.3828920570265, Blast_Score=262, Evalue=4e-70,
Organism=Drosophila melanogaster, GI24656367, Length=503, Percent_Identity=29.6222664015905, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI21357867, Length=522, Percent_Identity=29.1187739463602, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI24656372, Length=344, Percent_Identity=31.6860465116279, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI45552909, Length=247, Percent_Identity=31.9838056680162, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 52748; Mature: 52617

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILAIDQGTTGTTCVLYNEKAEVLGKAYRELRQIYPCEGWVEHDPEEIWQSVVLCVREL
CEEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
LERCPVTIAALGITNQRETTIVWERASGRPVYHAIVWQCRRTTELCRRFEQEKGMIAEKT
HHHCCEEEEEEECCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCEEECC
GLPLDAYFSATKIRWILDTCSHLSPDALLFGTVDSWLVWKLTGGGVHATDFTNASRTMLY
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCEEECCCCCCCHHEEE
NIREKRWDGELLDLFGIPGSMLPEVRPSMDDFGRVSALDELAGVPVLAVAGDQQAALFGQ
EHHHHCCCCCCCEEECCCHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
CCFEPGSIKNTYGTGCFMVMNTGDACIRSHNGLLTTLAIDAGGRPCYALEGSVFIGGAVV
HHCCCCCCCCCCCCEEEEEEECCCHHHHCCCCEEEEEEEECCCCEEEEECCCEEECHHHH
QWLRDELQLMKHASESEAMARAAGSNGGVYLVPAFVGLGAPHWQMEARGTIVGLTRGTNK
HHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEHHHHCCCCCEEEECCCEEEEEECCCCC
NHIVRAALESIAFESYDVFRAMVADSGISPDALAVDGGAADNGFLMQFQADLLGIPVLKA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCEEEEEEHHHHCCCEEEE
ANIESTSLGAAFLCGLRAGIWKSDGELRMVNRHAQACYPSMEPETRDALLCGWQKALRQT
CCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LVR
HCC
>Mature Secondary Structure 
AILAIDQGTTGTTCVLYNEKAEVLGKAYRELRQIYPCEGWVEHDPEEIWQSVVLCVREL
EEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
LERCPVTIAALGITNQRETTIVWERASGRPVYHAIVWQCRRTTELCRRFEQEKGMIAEKT
HHHCCEEEEEEECCCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCEEECC
GLPLDAYFSATKIRWILDTCSHLSPDALLFGTVDSWLVWKLTGGGVHATDFTNASRTMLY
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCEEECCCCCCCHHEEE
NIREKRWDGELLDLFGIPGSMLPEVRPSMDDFGRVSALDELAGVPVLAVAGDQQAALFGQ
EHHHHCCCCCCCEEECCCHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHH
CCFEPGSIKNTYGTGCFMVMNTGDACIRSHNGLLTTLAIDAGGRPCYALEGSVFIGGAVV
HHCCCCCCCCCCCCEEEEEEECCCHHHHCCCCEEEEEEEECCCCEEEEECCCEEECHHHH
QWLRDELQLMKHASESEAMARAAGSNGGVYLVPAFVGLGAPHWQMEARGTIVGLTRGTNK
HHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEHHHHCCCCCEEEECCCEEEEEECCCCC
NHIVRAALESIAFESYDVFRAMVADSGISPDALAVDGGAADNGFLMQFQADLLGIPVLKA
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCEEEEEEHHHHCCCEEEE
ANIESTSLGAAFLCGLRAGIWKSDGELRMVNRHAQACYPSMEPETRDALLCGWQKALRQT
CCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
LVR
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA