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The map label for this gene is lysC [C]

Identifier: 119358351

GI number: 119358351

Start: 2957696

End: 2959111

Strand: Reverse

Name: lysC [C]

Synonym: Cpha266_2583

Alternate gene names: 119358351

Gene position: 2959111-2957696 (Counterclockwise)

Preceding gene: 119358355

Following gene: 119358350

Centisome position: 94.42

GC content: 54.1

Gene sequence:

>1416_bases
ATGGCGGTGATGAAATTCGGTGGGACCTCTGTAGGTACCGCCCGGGCTATGCAGCAGGCTATAACCATTGTTGCGACGAA
AAAAAAGGAACGGGCCCCTCTTGTGGTGCTCAGCGCGTGCAGCGGCATTACCAATAAATTGATCCGGATTGCCGATGCTG
CGGGTTTGAGCCGTCTTGACGAGGCTATGGCGATTGCCGGAGAGGTGCGCAGGCATCATCTCGACCTTCTTGATGAGCTC
GTGAAGAGCCCGGCGGTGAAGGAGGAGCTGACGGTTGCGGTGAATCTGCTGGTGGGCGAGCTTGAGCTGCTTGTCAAGGG
GGTTGATATCGTCGGGGAGCTGACTGCCAGATCCATGGATATGTTCTGCTCTTTCGGGGAACTGCTTTCGACAACGGTGT
TTGCAGCCGCGATGAAGGAGCAGGGGCATGACGCGTTGTGGGTTGACGTGCGCAAGGTGATGGTTACCGATGATAATTTC
GGATTTGCCCGACCGATTCAGGCTTTGTGCGAGGCGAATGCTCTTTCGATGATCAAGCCGTTGCTCGATGCCGGTACGAC
GGTGATTACCCAGGGGTATATCGGATCTTCAAAAGCCGGTAAGACTACGACGCTTGGTCGCGGGGGTTCCGATTTTTCGG
CGGCTCTGCTCGGGGCCTGGCTTGATGAAAACGCTATTGAGATATGGACCGACGTTGATGGCGTTATGACCTGCGATCCT
CGGCTTGTTCCGGAGGCGCGCAGTATCAGGGTCATGACCTTTACGGAGGCGGCGGAACTTGCCTATCTTGGCGCCAAGGT
GCTTCATCCGGATACTATTGCTCCTGCCGTGCTGAAGAATATTCCGGTTTATGTGCTGAACTCGCTTCATCCCCAGGCAA
AGGGTACCCTGATTACCGATGATCCACGGATGCTTTCGGGTATGAGCTACGGCGGACTGGTGAAGTCGATTGCCGTCAAG
AAGGGGCAGTGCATCATCAATGTGCGGTCGAATCGTATGTTCGGTCGTCACGGGTTTATGAATGAGTTGTTTGACGTTTT
TTCGCGTTATGGCGTTTCGGTTGAGATGATTTCAACCAGCGAGGTTTCGATTTCGGTTACCGTCGACGACAGGAGTTTCA
ACGAGGAGCTTATTCGTGAGTTGAAAACGTTCAGCGATGTTGAAATCGAGCATAATGTGGCAACGGTGAGCGTGGTCGGA
GATAATCTGCGGATGTCGCGAGGGGTTGCCGGCAGGATTTTCAGTTCGCTGAAGGATGTCAATCTTCGAATGATCTCCCA
GGGGGCTTCGGAGATCAATGTGGGCTTTGTCGTTGAGGAGCACGATGTGGCCATTGCGGTCAATACGCTGCATCGTGAGT
TTTTTTCCGGTCAGGAGACGGCCGGTATTTTTGAAATTCCAGCGGGCAGCCGGTAG

Upstream 100 bases:

>100_bases
CCTGTATGCATGAGGAATCGGTTGGGCGGTTGTTGTTGGTTATGAGTGAAGTAAGCTAAAAAAAAACGATGACGGAAATT
TTTAACGATTTGGCGGATTT

Downstream 100 bases:

>100_bases
ATGGAGCTGTTTTTCGTCTGACGAGTTAACCCATATAAAAACAGTGAGGCAGCATGGATTATAAAAAAGCCGGAGTGGAT
ATCAGTGCAGGCGAGGAGTT

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MAVMKFGGTSVGTARAMQQAITIVATKKKERAPLVVLSACSGITNKLIRIADAAGLSRLDEAMAIAGEVRRHHLDLLDEL
VKSPAVKEELTVAVNLLVGELELLVKGVDIVGELTARSMDMFCSFGELLSTTVFAAAMKEQGHDALWVDVRKVMVTDDNF
GFARPIQALCEANALSMIKPLLDAGTTVITQGYIGSSKAGKTTTLGRGGSDFSAALLGAWLDENAIEIWTDVDGVMTCDP
RLVPEARSIRVMTFTEAAELAYLGAKVLHPDTIAPAVLKNIPVYVLNSLHPQAKGTLITDDPRMLSGMSYGGLVKSIAVK
KGQCIINVRSNRMFGRHGFMNELFDVFSRYGVSVEMISTSEVSISVTVDDRSFNEELIRELKTFSDVEIEHNVATVSVVG
DNLRMSRGVAGRIFSSLKDVNLRMISQGASEINVGFVVEEHDVAIAVNTLHREFFSGQETAGIFEIPAGSR

Sequences:

>Translated_471_residues
MAVMKFGGTSVGTARAMQQAITIVATKKKERAPLVVLSACSGITNKLIRIADAAGLSRLDEAMAIAGEVRRHHLDLLDEL
VKSPAVKEELTVAVNLLVGELELLVKGVDIVGELTARSMDMFCSFGELLSTTVFAAAMKEQGHDALWVDVRKVMVTDDNF
GFARPIQALCEANALSMIKPLLDAGTTVITQGYIGSSKAGKTTTLGRGGSDFSAALLGAWLDENAIEIWTDVDGVMTCDP
RLVPEARSIRVMTFTEAAELAYLGAKVLHPDTIAPAVLKNIPVYVLNSLHPQAKGTLITDDPRMLSGMSYGGLVKSIAVK
KGQCIINVRSNRMFGRHGFMNELFDVFSRYGVSVEMISTSEVSISVTVDDRSFNEELIRELKTFSDVEIEHNVATVSVVG
DNLRMSRGVAGRIFSSLKDVNLRMISQGASEINVGFVVEEHDVAIAVNTLHREFFSGQETAGIFEIPAGSR
>Mature_470_residues
AVMKFGGTSVGTARAMQQAITIVATKKKERAPLVVLSACSGITNKLIRIADAAGLSRLDEAMAIAGEVRRHHLDLLDELV
KSPAVKEELTVAVNLLVGELELLVKGVDIVGELTARSMDMFCSFGELLSTTVFAAAMKEQGHDALWVDVRKVMVTDDNFG
FARPIQALCEANALSMIKPLLDAGTTVITQGYIGSSKAGKTTTLGRGGSDFSAALLGAWLDENAIEIWTDVDGVMTCDPR
LVPEARSIRVMTFTEAAELAYLGAKVLHPDTIAPAVLKNIPVYVLNSLHPQAKGTLITDDPRMLSGMSYGGLVKSIAVKK
GQCIINVRSNRMFGRHGFMNELFDVFSRYGVSVEMISTSEVSISVTVDDRSFNEELIRELKTFSDVEIEHNVATVSVVGD
NLRMSRGVAGRIFSSLKDVNLRMISQGASEINVGFVVEEHDVAIAVNTLHREFFSGQETAGIFEIPAGSR

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=474, Percent_Identity=38.3966244725738, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1786183, Length=474, Percent_Identity=32.7004219409283, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1790376, Length=296, Percent_Identity=30.4054054054054, Blast_Score=113, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320893, Length=508, Percent_Identity=31.496062992126, Blast_Score=225, Evalue=1e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 50841; Mature: 50710

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVMKFGGTSVGTARAMQQAITIVATKKKERAPLVVLSACSGITNKLIRIADAAGLSRLD
CEEEEECCCCCHHHHHHHHHHHHEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
EAMAIAGEVRRHHLDLLDELVKSPAVKEELTVAVNLLVGELELLVKGVDIVGELTARSMD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MFCSFGELLSTTVFAAAMKEQGHDALWVDVRKVMVTDDNFGFARPIQALCEANALSMIKP
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCHHHHHHHHCCCHHHHHHH
LLDAGTTVITQGYIGSSKAGKTTTLGRGGSDFSAALLGAWLDENAIEIWTDVDGVMTCDP
HHHCCCEEEEECCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCEEECCC
RLVPEARSIRVMTFTEAAELAYLGAKVLHPDTIAPAVLKNIPVYVLNSLHPQAKGTLITD
CCCCCCCCEEEEEECCHHHHHHHCHHHCCCCCHHHHHHHCCCHHHHHCCCCCCCCCEEEC
DPRMLSGMSYGGLVKSIAVKKGQCIINVRSNRMFGRHGFMNELFDVFSRYGVSVEMISTS
CCHHHCCCCCCHHHHHHHHCCCCEEEEEECCCEECCCCHHHHHHHHHHHHCCEEEEEECC
EVSISVTVDDRSFNEELIRELKTFSDVEIEHNVATVSVVGDNLRMSRGVAGRIFSSLKDV
CEEEEEEECCCCCCHHHHHHHHHHCCCEEECCEEEEEEECCCCCHHCCHHHHHHHHHHHC
NLRMISQGASEINVGFVVEEHDVAIAVNTLHREFFSGQETAGIFEIPAGSR
CHHEECCCCCCCEEEEEEECCCEEEEHHHHHHHHHCCCCCCCEEECCCCCC
>Mature Secondary Structure 
AVMKFGGTSVGTARAMQQAITIVATKKKERAPLVVLSACSGITNKLIRIADAAGLSRLD
EEEEECCCCCHHHHHHHHHHHHEEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
EAMAIAGEVRRHHLDLLDELVKSPAVKEELTVAVNLLVGELELLVKGVDIVGELTARSMD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MFCSFGELLSTTVFAAAMKEQGHDALWVDVRKVMVTDDNFGFARPIQALCEANALSMIKP
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCCCCHHHHHHHHCCCHHHHHHH
LLDAGTTVITQGYIGSSKAGKTTTLGRGGSDFSAALLGAWLDENAIEIWTDVDGVMTCDP
HHHCCCEEEEECCCCCCCCCCCEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCEEECCC
RLVPEARSIRVMTFTEAAELAYLGAKVLHPDTIAPAVLKNIPVYVLNSLHPQAKGTLITD
CCCCCCCCEEEEEECCHHHHHHHCHHHCCCCCHHHHHHHCCCHHHHHCCCCCCCCCEEEC
DPRMLSGMSYGGLVKSIAVKKGQCIINVRSNRMFGRHGFMNELFDVFSRYGVSVEMISTS
CCHHHCCCCCCHHHHHHHHCCCCEEEEEECCCEECCCCHHHHHHHHHHHHCCEEEEEECC
EVSISVTVDDRSFNEELIRELKTFSDVEIEHNVATVSVVGDNLRMSRGVAGRIFSSLKDV
CEEEEEEECCCCCCHHHHHHHHHHCCCEEECCEEEEEEECCCCCHHCCHHHHHHHHHHHC
NLRMISQGASEINVGFVVEEHDVAIAVNTLHREFFSGQETAGIFEIPAGSR
CHHEECCCCCCCEEEEEEECCCEEEEHHHHHHHHHCCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]