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The map label for this gene is purM [H]

Identifier: 119358350

GI number: 119358350

Start: 2956653

End: 2957642

Strand: Reverse

Name: purM [H]

Synonym: Cpha266_2582

Alternate gene names: 119358350

Gene position: 2957642-2956653 (Counterclockwise)

Preceding gene: 119358351

Following gene: 119358349

Centisome position: 94.38

GC content: 53.54

Gene sequence:

>990_bases
ATGGATTATAAAAAAGCCGGAGTGGATATCAGTGCAGGCGAGGAGTTTGTGCGTCTGATCAAGCCAGAGGTTCGCAAGAC
CTTTACCCCGGGCGTTATAACGGATATTGGCGCTTTCGGAGGTTTTTTTCAGCCGGATTTTTCGGGATATACCCGACCTG
TTCTTGTGAGCAGTATCGATGGCGTCGGTACAAAACTGAAAATCGCCATAGAGCTTGAGCGTTATGATACGGTCGGTTCG
TGTCTGATCAATCACTGCGTTAACGATATTCTTGTTTGTGGCGCCAGACCGCTGTTTTTTCTTGACTATTATGCCTGCGG
CAGGCTGACCCCGTCCATTGCGGCTGCGGTGGTAACCGGGATGGTGAAGGCGTGCAGGGAGAACGGCTGCGCTCTTATCG
GGGGTGAAACCGCCGAGATGCCCGGCGTGTATGATGTCGCGGATTTTGATCTCGCCGGTACGGTTGTCGGGGTGGTCGAT
CATGAGAAAATCGTTAACGGTTCTGCAATTGAAGCCGGGGATGTGCTGCTGGGGCTTCCTTCGACAGGGTTGCATACCAA
CGGCTATTCGCTTGCAAGAAAGGTGCTCGAGGGGAGAATGCACGAGCGTTTCGAGGGGCTTGATGGTTCGGCGGGCGAGG
AGTTGCTGAAGGTCCATCGTTCCTATCTCAAGGTTATCGAGCCGTTTTTCGGTTCTCCCGAGCTGCGGGGGCTGGCGCAT
ATTACCGGCGGAGGTCTTATGGGCAATACCATGCGGATCGTTCCCGAGGGTCTGACGCTTGACGTTGACTGGCAGGCCTG
GCCCGAGCCGGTTATTTTTGACATTATCCGCAGGGAGGGCGAGGTTCCCGAGGAGGATATGCGGCGGACCTTTAATCTCG
GTATCGGGCTCGTTCTGGTTGTCGAAAAAAGCGCGGCAGACGGGATGATGAGCAGGTTGAAATCTAATGGAGAAAATGCT
TATATTATAGGTTCGATCTCAAAACTCTGA

Upstream 100 bases:

>100_bases
GTCAGGAGACGGCCGGTATTTTTGAAATTCCAGCGGGCAGCCGGTAGATGGAGCTGTTTTTCGTCTGACGAGTTAACCCA
TATAAAAACAGTGAGGCAGC

Downstream 100 bases:

>100_bases
TTTTTTTGTCATCAACACAGCCATTTTACTGTATATGCTGACACTCATAGCCATTTTAGCGATAAGTTACCTTGTCGGAG
CCATTCCCACCGGTATCATG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MDYKKAGVDISAGEEFVRLIKPEVRKTFTPGVITDIGAFGGFFQPDFSGYTRPVLVSSIDGVGTKLKIAIELERYDTVGS
CLINHCVNDILVCGARPLFFLDYYACGRLTPSIAAAVVTGMVKACRENGCALIGGETAEMPGVYDVADFDLAGTVVGVVD
HEKIVNGSAIEAGDVLLGLPSTGLHTNGYSLARKVLEGRMHERFEGLDGSAGEELLKVHRSYLKVIEPFFGSPELRGLAH
ITGGGLMGNTMRIVPEGLTLDVDWQAWPEPVIFDIIRREGEVPEEDMRRTFNLGIGLVLVVEKSAADGMMSRLKSNGENA
YIIGSISKL

Sequences:

>Translated_329_residues
MDYKKAGVDISAGEEFVRLIKPEVRKTFTPGVITDIGAFGGFFQPDFSGYTRPVLVSSIDGVGTKLKIAIELERYDTVGS
CLINHCVNDILVCGARPLFFLDYYACGRLTPSIAAAVVTGMVKACRENGCALIGGETAEMPGVYDVADFDLAGTVVGVVD
HEKIVNGSAIEAGDVLLGLPSTGLHTNGYSLARKVLEGRMHERFEGLDGSAGEELLKVHRSYLKVIEPFFGSPELRGLAH
ITGGGLMGNTMRIVPEGLTLDVDWQAWPEPVIFDIIRREGEVPEEDMRRTFNLGIGLVLVVEKSAADGMMSRLKSNGENA
YIIGSISKL
>Mature_329_residues
MDYKKAGVDISAGEEFVRLIKPEVRKTFTPGVITDIGAFGGFFQPDFSGYTRPVLVSSIDGVGTKLKIAIELERYDTVGS
CLINHCVNDILVCGARPLFFLDYYACGRLTPSIAAAVVTGMVKACRENGCALIGGETAEMPGVYDVADFDLAGTVVGVVD
HEKIVNGSAIEAGDVLLGLPSTGLHTNGYSLARKVLEGRMHERFEGLDGSAGEELLKVHRSYLKVIEPFFGSPELRGLAH
ITGGGLMGNTMRIVPEGLTLDVDWQAWPEPVIFDIIRREGEVPEEDMRRTFNLGIGLVLVVEKSAADGMMSRLKSNGENA
YIIGSISKL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=332, Percent_Identity=43.9759036144578, Blast_Score=285, Evalue=3e-77,
Organism=Homo sapiens, GI209869995, Length=332, Percent_Identity=43.9759036144578, Blast_Score=285, Evalue=3e-77,
Organism=Homo sapiens, GI209869993, Length=332, Percent_Identity=43.9759036144578, Blast_Score=285, Evalue=3e-77,
Organism=Escherichia coli, GI1788845, Length=328, Percent_Identity=43.9024390243902, Blast_Score=275, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17567511, Length=335, Percent_Identity=39.7014925373134, Blast_Score=228, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6321203, Length=337, Percent_Identity=41.2462908011869, Blast_Score=242, Evalue=5e-65,
Organism=Drosophila melanogaster, GI24582400, Length=314, Percent_Identity=37.2611464968153, Blast_Score=187, Evalue=9e-48,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 35461; Mature: 35461

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKKAGVDISAGEEFVRLIKPEVRKTFTPGVITDIGAFGGFFQPDFSGYTRPVLVSSID
CCCCCCCCCCCCCHHHHHHHCHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCEEECCC
GVGTKLKIAIELERYDTVGSCLINHCVNDILVCGARPLFFLDYYACGRLTPSIAAAVVTG
CCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHH
MVKACRENGCALIGGETAEMPGVYDVADFDLAGTVVGVVDHEKIVNGSAIEAGDVLLGLP
HHHHHHHCCCEEECCCCCCCCCCEEECCCCCCCEEEEEECHHHHCCCCCEECCCEEEECC
STGLHTNGYSLARKVLEGRMHERFEGLDGSAGEELLKVHRSYLKVIEPFFGSPELRGLAH
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
ITGGGLMGNTMRIVPEGLTLDVDWQAWPEPVIFDIIRREGEVPEEDMRRTFNLGIGLVLV
ECCCCCCCCEEEEEECCCEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEE
VEKSAADGMMSRLKSNGENAYIIGSISKL
EECCHHHHHHHHHHCCCCCEEEEEECCCC
>Mature Secondary Structure
MDYKKAGVDISAGEEFVRLIKPEVRKTFTPGVITDIGAFGGFFQPDFSGYTRPVLVSSID
CCCCCCCCCCCCCHHHHHHHCHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCEEECCC
GVGTKLKIAIELERYDTVGSCLINHCVNDILVCGARPLFFLDYYACGRLTPSIAAAVVTG
CCCCEEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHH
MVKACRENGCALIGGETAEMPGVYDVADFDLAGTVVGVVDHEKIVNGSAIEAGDVLLGLP
HHHHHHHCCCEEECCCCCCCCCCEEECCCCCCCEEEEEECHHHHCCCCCEECCCEEEECC
STGLHTNGYSLARKVLEGRMHERFEGLDGSAGEELLKVHRSYLKVIEPFFGSPELRGLAH
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
ITGGGLMGNTMRIVPEGLTLDVDWQAWPEPVIFDIIRREGEVPEEDMRRTFNLGIGLVLV
ECCCCCCCCEEEEEECCCEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEE
VEKSAADGMMSRLKSNGENAYIIGSISKL
EECCHHHHHHHHHHCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA