Click here to switch to the map view.

The map label for this gene is guaD [H]

Identifier: 119358266

GI number: 119358266

Start: 2864849

End: 2865442

Strand: Direct

Name: guaD [H]

Synonym: Cpha266_2498

Alternate gene names: 119358266

Gene position: 2864849-2865442 (Clockwise)

Preceding gene: 119358265

Following gene: 119358267

Centisome position: 91.41

GC content: 51.68

Gene sequence:

>594_bases
ATGACATTGATGCACATATCTCTTCCTGACATTATTCTCCCTCCACATATACGGGACTTTATCGAATCCGGACCTCAAGC
ATTCGCTTCTCCAGAAGAGAGAGTGCGTTTTACCATTGAACTTGCCCGCCTGAACACGGTCGAAAAAACCGGTGGACCAT
TCGGCGCGGCTGTTTTCGAAAGCCGTTCTGGAAAACTTGTTGCCGCAGGAGTTAATGTTGTTGTTACAAGCTCCTGCTCC
CATGCACATGCTGAAATGGTCGCAATCCTCCTCGCCCAGCAGAAGCTCTCTACCTACGACCTCGGATTGAGCTCGCTTCC
CGATCATGAACTGGTCAGTTCATGCGAACCCTGTGCGATGTGTTTCGGAGCGATCATCTGGTCGGGAGTCAAAAAACTTG
TCTTTGGCGCAACCGGTAAAACTGCCAAAGCCGCAGGATTCGATGAGGGACCCAAACCGCGACTATGGATACGCGCATTA
GAGCAACGAGGCATCGAGGTTACCCCCAGGGTCTGCTGTAAAGAGGCCGAGGCCATCCTTGAAAACTATGCCGCATCGGG
CGGATTGATCTACAATGCCAGAAAATCCCGCTGA

Upstream 100 bases:

>100_bases
AACCATCTCCTGTTCCTGCAGCAATGGATCGCTACGGTCTATGATGAATGGAAACCTTACCTTTTCATGAGTTGAATAAC
CTCTCTCGCGCACCTCATAC

Downstream 100 bases:

>100_bases
TTCGATAAAAAAAAGGCGAAGCTCTCTGGGTCAAACACCCATTATACCGATTCATCTCTTTTTTTTGTATCCTTGAAGAA
AATCACTACCGGGCACACCC

Product: CMP/dCMP deaminase, zinc-binding

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MTLMHISLPDIILPPHIRDFIESGPQAFASPEERVRFTIELARLNTVEKTGGPFGAAVFESRSGKLVAAGVNVVVTSSCS
HAHAEMVAILLAQQKLSTYDLGLSSLPDHELVSSCEPCAMCFGAIIWSGVKKLVFGATGKTAKAAGFDEGPKPRLWIRAL
EQRGIEVTPRVCCKEAEAILENYAASGGLIYNARKSR

Sequences:

>Translated_197_residues
MTLMHISLPDIILPPHIRDFIESGPQAFASPEERVRFTIELARLNTVEKTGGPFGAAVFESRSGKLVAAGVNVVVTSSCS
HAHAEMVAILLAQQKLSTYDLGLSSLPDHELVSSCEPCAMCFGAIIWSGVKKLVFGATGKTAKAAGFDEGPKPRLWIRAL
EQRGIEVTPRVCCKEAEAILENYAASGGLIYNARKSR
>Mature_196_residues
TLMHISLPDIILPPHIRDFIESGPQAFASPEERVRFTIELARLNTVEKTGGPFGAAVFESRSGKLVAAGVNVVVTSSCSH
AHAEMVAILLAQQKLSTYDLGLSSLPDHELVSSCEPCAMCFGAIIWSGVKKLVFGATGKTAKAAGFDEGPKPRLWIRALE
QRGIEVTPRVCCKEAEAILENYAASGGLIYNARKSR

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17555996, Length=99, Percent_Identity=43.4343434343434, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17554608, Length=115, Percent_Identity=35.6521739130435, Blast_Score=77, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 21183; Mature: 21052

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLMHISLPDIILPPHIRDFIESGPQAFASPEERVRFTIELARLNTVEKTGGPFGAAVFE
CEEEEECCCCEECCHHHHHHHHCCCHHHCCHHHHEEEEEEEEHHCHHHHCCCCCCHHHEE
SRSGKLVAAGVNVVVTSSCSHAHAEMVAILLAQQKLSTYDLGLSSLPDHELVSSCEPCAM
CCCCEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHH
CFGAIIWSGVKKLVFGATGKTAKAAGFDEGPKPRLWIRALEQRGIEVTPRVCCKEAEAIL
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
ENYAASGGLIYNARKSR
HHHCCCCCEEECCCCCC
>Mature Secondary Structure 
TLMHISLPDIILPPHIRDFIESGPQAFASPEERVRFTIELARLNTVEKTGGPFGAAVFE
EEEEECCCCEECCHHHHHHHHCCCHHHCCHHHHEEEEEEEEHHCHHHHCCCCCCHHHEE
SRSGKLVAAGVNVVVTSSCSHAHAEMVAILLAQQKLSTYDLGLSSLPDHELVSSCEPCAM
CCCCEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHH
CFGAIIWSGVKKLVFGATGKTAKAAGFDEGPKPRLWIRALEQRGIEVTPRVCCKEAEAIL
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHH
ENYAASGGLIYNARKSR
HHHCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]