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The map label for this gene is manC [H]

Identifier: 119358161

GI number: 119358161

Start: 2781389

End: 2782501

Strand: Reverse

Name: manC [H]

Synonym: Cpha266_2393

Alternate gene names: 119358161

Gene position: 2782501-2781389 (Counterclockwise)

Preceding gene: 119358163

Following gene: 119358159

Centisome position: 88.79

GC content: 43.31

Gene sequence:

>1113_bases
ATGAACGAGGTTGATAACAAGCGTGTGTATGCTGTCATCATGGCAGGTGGAACCGGAAAGTTGCTATGGCCGCTTGCAAG
AAAAAAAACTCCGAAACAGTTCGTCGATCTCTTTGATAAGAAAACGATGATCGACAAAACGATTCAGCGAATTGCGGGAA
TCGTAAACACCGAAAACATCTTCATTATCACCAATGAGCAGGGCAAGGTGATGTTGTTACAATCAGATTGCCGAATCGAC
CCTGAGAATATCATCGTTGAACCGATGAGCCGCAATACCGCCCCCTGTATAGCGCTTGCAACTGCATACATCAAAAAAAA
GGACCCTGATGCCGTTACGATAATTCTGCCCTCCGACCATCTGGTCATTGACGAGGAGAAATTTCTCGAAATACTCCAGG
CAGGTATCAGAATAGCTGCAAAAAAAACATCCCTTGTCACTATAGGAATTAATCCCGATCATCCAGAGACAAACTATGGA
TACATTCAGGCAGACAGGGAGCTTTATATTGATCCATCTGATTGCGGTGATTACCGACTGTACAAGGTCAAGACCTTTGC
GGAAAAACCGGATTATGCAACTGCAGTACAGTTTCTCGAAAGCAAGGATTTTTTCTGGAACAGCGGAATGTTTATCTGGC
ATATCGACATGTTCAGCAAAGAGATAGAACGATCACTTCCGGATTTGCACAGAGATTTTCTCAATATATATGAAAACATC
GATACTCATAACGAATCAGAGATAATAGAGGATGTCTATAGTTGGATCCATCCGATATCTGTGGATTACGGTATTATGGA
AAAGGCCGAATCGGTTTATATGCTGGAAGGAGAGTTCGGTTGGACAGATCTTGGTAACTGGGATCAGGTAGCCAAAGTAT
CAGTGCAACCGCCATATTCTGCCGCCTCAAGAGAGAAGGGCATTGTCATGATAGACTGCGAGCAAATGTATATCAGAAAG
CCAAAGGATAAGGTTGTCTGTTTGATCGGAACAAGCAACCTTATCGTTGTCGATACAGGTGACGCACTGCTTATTTGCAA
TAAAGGGGATTCGCATAAAGTTGGCACTGCCTTTGATCAACTCCGTCGAGACGATTTTGACAGCTATCTTTAA

Upstream 100 bases:

>100_bases
TGTTCAATGTGCAAATAAATAATTGTAAATTCAGTCAAAAACCTTCCGCTGATGCTGTTCTGTGGTTTGCTTTGCCAATG
ATCATAATAAGAGAAGTGCG

Downstream 100 bases:

>100_bases
CGGTTTGAAACCTTGGACCAGCTTGCACCATCTTTTGTGTCTTTGACCTCGATTCCCGCTTCAAGAAGCCTGTCTCTTAT
GGTATCGCTGAGTGGATAGT

Product: mannose-1-phosphate guanylyltransferase (GDP)

Products: NA

Alternate protein names: GDP-mannose pyrophosphorylase; GMP; GMPP [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MNEVDNKRVYAVIMAGGTGKLLWPLARKKTPKQFVDLFDKKTMIDKTIQRIAGIVNTENIFIITNEQGKVMLLQSDCRID
PENIIVEPMSRNTAPCIALATAYIKKKDPDAVTIILPSDHLVIDEEKFLEILQAGIRIAAKKTSLVTIGINPDHPETNYG
YIQADRELYIDPSDCGDYRLYKVKTFAEKPDYATAVQFLESKDFFWNSGMFIWHIDMFSKEIERSLPDLHRDFLNIYENI
DTHNESEIIEDVYSWIHPISVDYGIMEKAESVYMLEGEFGWTDLGNWDQVAKVSVQPPYSAASREKGIVMIDCEQMYIRK
PKDKVVCLIGTSNLIVVDTGDALLICNKGDSHKVGTAFDQLRRDDFDSYL

Sequences:

>Translated_370_residues
MNEVDNKRVYAVIMAGGTGKLLWPLARKKTPKQFVDLFDKKTMIDKTIQRIAGIVNTENIFIITNEQGKVMLLQSDCRID
PENIIVEPMSRNTAPCIALATAYIKKKDPDAVTIILPSDHLVIDEEKFLEILQAGIRIAAKKTSLVTIGINPDHPETNYG
YIQADRELYIDPSDCGDYRLYKVKTFAEKPDYATAVQFLESKDFFWNSGMFIWHIDMFSKEIERSLPDLHRDFLNIYENI
DTHNESEIIEDVYSWIHPISVDYGIMEKAESVYMLEGEFGWTDLGNWDQVAKVSVQPPYSAASREKGIVMIDCEQMYIRK
PKDKVVCLIGTSNLIVVDTGDALLICNKGDSHKVGTAFDQLRRDDFDSYL
>Mature_370_residues
MNEVDNKRVYAVIMAGGTGKLLWPLARKKTPKQFVDLFDKKTMIDKTIQRIAGIVNTENIFIITNEQGKVMLLQSDCRID
PENIIVEPMSRNTAPCIALATAYIKKKDPDAVTIILPSDHLVIDEEKFLEILQAGIRIAAKKTSLVTIGINPDHPETNYG
YIQADRELYIDPSDCGDYRLYKVKTFAEKPDYATAVQFLESKDFFWNSGMFIWHIDMFSKEIERSLPDLHRDFLNIYENI
DTHNESEIIEDVYSWIHPISVDYGIMEKAESVYMLEGEFGWTDLGNWDQVAKVSVQPPYSAASREKGIVMIDCEQMYIRK
PKDKVVCLIGTSNLIVVDTGDALLICNKGDSHKVGTAFDQLRRDDFDSYL

Specific function: Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS O9 antigen [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=367, Percent_Identity=32.6975476839237, Blast_Score=178, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 42200; Mature: 42200

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEVDNKRVYAVIMAGGTGKLLWPLARKKTPKQFVDLFDKKTMIDKTIQRIAGIVNTENI
CCCCCCCEEEEEEEECCCCCEEEHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCEE
FIITNEQGKVMLLQSDCRIDPENIIVEPMSRNTAPCIALATAYIKKKDPDAVTIILPSDH
EEEECCCCCEEEEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCC
LVIDEEKFLEILQAGIRIAAKKTSLVTIGINPDHPETNYGYIQADRELYIDPSDCGDYRL
EEECHHHHHHHHHHHHEEEEECCEEEEEECCCCCCCCCCCEEEECCEEEECCCCCCCEEE
YKVKTFAEKPDYATAVQFLESKDFFWNSGMFIWHIDMFSKEIERSLPDLHRDFLNIYENI
EEEEECCCCCCHHHHHHHHHCCCCEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCC
DTHNESEIIEDVYSWIHPISVDYGIMEKAESVYMLEGEFGWTDLGNWDQVAKVSVQPPYS
CCCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCC
AASREKGIVMIDCEQMYIRKPKDKVVCLIGTSNLIVVDTGDALLICNKGDSHKVGTAFDQ
CCCCCCCEEEEECHHHHHCCCCCCEEEEEECCCEEEEECCCEEEEECCCCCCCCHHHHHH
LRRDDFDSYL
HHHCCCCCCC
>Mature Secondary Structure
MNEVDNKRVYAVIMAGGTGKLLWPLARKKTPKQFVDLFDKKTMIDKTIQRIAGIVNTENI
CCCCCCCEEEEEEEECCCCCEEEHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCEE
FIITNEQGKVMLLQSDCRIDPENIIVEPMSRNTAPCIALATAYIKKKDPDAVTIILPSDH
EEEECCCCCEEEEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCC
LVIDEEKFLEILQAGIRIAAKKTSLVTIGINPDHPETNYGYIQADRELYIDPSDCGDYRL
EEECHHHHHHHHHHHHEEEEECCEEEEEECCCCCCCCCCCEEEECCEEEECCCCCCCEEE
YKVKTFAEKPDYATAVQFLESKDFFWNSGMFIWHIDMFSKEIERSLPDLHRDFLNIYENI
EEEEECCCCCCHHHHHHHHHCCCCEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCC
DTHNESEIIEDVYSWIHPISVDYGIMEKAESVYMLEGEFGWTDLGNWDQVAKVSVQPPYS
CCCCHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCC
AASREKGIVMIDCEQMYIRKPKDKVVCLIGTSNLIVVDTGDALLICNKGDSHKVGTAFDQ
CCCCCCCEEEEECHHHHHCCCCCCEEEEEECCCEEEEECCCEEEEECCCCCCCCHHHHHH
LRRDDFDSYL
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7515042; 9004408 [H]