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The map label for this gene is lpxA

Identifier: 119358141

GI number: 119358141

Start: 2757448

End: 2758242

Strand: Reverse

Name: lpxA

Synonym: Cpha266_2373

Alternate gene names: 119358141

Gene position: 2758242-2757448 (Counterclockwise)

Preceding gene: 119358142

Following gene: 119358140

Centisome position: 88.01

GC content: 51.19

Gene sequence:

>795_bases
ATGAACACCATACATGCAACAGCAATAATTGATCCCGGAGTAACGCTTGGCGACAAGGTTACCATTGGACCTTATACCGT
TATTGAGGATGATGTTGAAATCGGCGAAGGTACCCGAATCGGTCCTCATGTGCATATCGCCAGTGGCGCCCGCATCGGCA
GCGCATGCAGGATTCATGCAGGGGCTGTTCTCGCAACCGAGCCTCAGGATCTGAAATATGCCGGAGAAAAAACTCAACTC
ATTGTTGGCGACCGGACGGTTATCAGAGAGTGTGTCACGCTGAACCGGGGAACAAAAGCAAGCGGCAGAACGGTCGTTGG
CTCCGATACTCTTGTCATGTCCTATGTTCATGCCGGTCACGATTGCGTGATCGGAAACCACGTTGTTATTGCCAACTCCG
TTCAGTTTGGCGGACATTGTGAAGTGGGCGACTACGCAGTTATTGGCGGGCTTACCGGTGTGCACCAGTTTGTCAGGATC
GGGCGTTACTCCATGGTTGGCGGTATCGCACGAGCTTCGCTTGACGTACCGCCTTTCGTTATGGCAGGAGGTCACGCTTC
GTTTCGTTATGAAGGGCTCAACTCCCTCGGGCTGAAGCGTCGAGGTTTCACGGCCGAAAAGATCAGTATGATCAAGGATG
TGTACCGGATTATTTTTCAGTCCGGTTTACTGCTCTCAAATGCGCTTGAAAAGGTTAGAACGGACTTTCCTGCCGAGCCC
GAAATTGTTGAAATACTCCGTTTTTTTGATTCCGGTACGCACGGAAGGAAATTCCTCAGGCCGTTCAACAGTTAA

Upstream 100 bases:

>100_bases
AAGAGAGCAGGACGCATTGCGGGTCATTACATTGCTTTCCCGTGAATTACAGGAGCCTCGCCTGCTGGAGGAATTTGAAA
AAATGAAAGAATAACAACGT

Downstream 100 bases:

>100_bases
CCTGAATCATGCAGAGAGATATGTTTCGATGGGCTATAGGTATTGATCTTGGTGGTACGGCAATCAAGGGCGCAGTCATT
GGTGAGCAGGAGGGTATTGT

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MNTIHATAIIDPGVTLGDKVTIGPYTVIEDDVEIGEGTRIGPHVHIASGARIGSACRIHAGAVLATEPQDLKYAGEKTQL
IVGDRTVIRECVTLNRGTKASGRTVVGSDTLVMSYVHAGHDCVIGNHVVIANSVQFGGHCEVGDYAVIGGLTGVHQFVRI
GRYSMVGGIARASLDVPPFVMAGGHASFRYEGLNSLGLKRRGFTAEKISMIKDVYRIIFQSGLLLSNALEKVRTDFPAEP
EIVEILRFFDSGTHGRKFLRPFNS

Sequences:

>Translated_264_residues
MNTIHATAIIDPGVTLGDKVTIGPYTVIEDDVEIGEGTRIGPHVHIASGARIGSACRIHAGAVLATEPQDLKYAGEKTQL
IVGDRTVIRECVTLNRGTKASGRTVVGSDTLVMSYVHAGHDCVIGNHVVIANSVQFGGHCEVGDYAVIGGLTGVHQFVRI
GRYSMVGGIARASLDVPPFVMAGGHASFRYEGLNSLGLKRRGFTAEKISMIKDVYRIIFQSGLLLSNALEKVRTDFPAEP
EIVEILRFFDSGTHGRKFLRPFNS
>Mature_264_residues
MNTIHATAIIDPGVTLGDKVTIGPYTVIEDDVEIGEGTRIGPHVHIASGARIGSACRIHAGAVLATEPQDLKYAGEKTQL
IVGDRTVIRECVTLNRGTKASGRTVVGSDTLVMSYVHAGHDCVIGNHVVIANSVQFGGHCEVGDYAVIGGLTGVHQFVRI
GRYSMVGGIARASLDVPPFVMAGGHASFRYEGLNSLGLKRRGFTAEKISMIKDVYRIIFQSGLLLSNALEKVRTDFPAEP
EIVEILRFFDSGTHGRKFLRPFNS

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=253, Percent_Identity=42.2924901185771, Blast_Score=201, Evalue=3e-53,
Organism=Escherichia coli, GI1786376, Length=167, Percent_Identity=30.5389221556886, Blast_Score=78, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_CHLPD (A1BIY4)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_912785.1
- ProteinModelPortal:   A1BIY4
- SMR:   A1BIY4
- STRING:   A1BIY4
- GeneID:   4569283
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_2373
- NMPDR:   fig|290317.7.peg.2489
- eggNOG:   COG1043
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- ProtClustDB:   PRK05289
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 28342; Mature: 28342

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTIHATAIIDPGVTLGDKVTIGPYTVIEDDVEIGEGTRIGPHVHIASGARIGSACRIHA
CCCEEEEEEECCCCCCCCEEEECCEEEEECCCCCCCCCCCCCEEEEECCCCCCCEEEEEC
GAVLATEPQDLKYAGEKTQLIVGDRTVIRECVTLNRGTKASGRTVVGSDTLVMSYVHAGH
CEEEEECCCHHHCCCCCEEEEECCHHHHHHHHHCCCCCCCCCCEEECCCCEEEHHHHCCC
DCVIGNHVVIANSVQFGGHCEVGDYAVIGGLTGVHQFVRIGRYSMVGGIARASLDVPPFV
CEEECCEEEEEECEECCCCCCCCCEEEECCHHHHHHHHHHCCHHHHHHHHHCCCCCCCEE
MAGGHASFRYEGLNSLGLKRRGFTAEKISMIKDVYRIIFQSGLLLSNALEKVRTDFPAEP
EECCCCEEEECCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCH
EIVEILRFFDSGTHGRKFLRPFNS
HHHHHHHHHCCCCCCHHHHCCCCC
>Mature Secondary Structure
MNTIHATAIIDPGVTLGDKVTIGPYTVIEDDVEIGEGTRIGPHVHIASGARIGSACRIHA
CCCEEEEEEECCCCCCCCEEEECCEEEEECCCCCCCCCCCCCEEEEECCCCCCCEEEEEC
GAVLATEPQDLKYAGEKTQLIVGDRTVIRECVTLNRGTKASGRTVVGSDTLVMSYVHAGH
CEEEEECCCHHHCCCCCEEEEECCHHHHHHHHHCCCCCCCCCCEEECCCCEEEHHHHCCC
DCVIGNHVVIANSVQFGGHCEVGDYAVIGGLTGVHQFVRIGRYSMVGGIARASLDVPPFV
CEEECCEEEEEECEECCCCCCCCCEEEECCHHHHHHHHHHCCHHHHHHHHHCCCCCCCEE
MAGGHASFRYEGLNSLGLKRRGFTAEKISMIKDVYRIIFQSGLLLSNALEKVRTDFPAEP
EECCCCEEEECCCHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCH
EIVEILRFFDSGTHGRKFLRPFNS
HHHHHHHHHCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA