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The map label for this gene is ndk [H]

Identifier: 119358136

GI number: 119358136

Start: 2753396

End: 2753818

Strand: Direct

Name: ndk [H]

Synonym: Cpha266_2368

Alternate gene names: 119358136

Gene position: 2753396-2753818 (Clockwise)

Preceding gene: 119358121

Following gene: 119358146

Centisome position: 87.86

GC content: 51.3

Gene sequence:

>423_bases
ATGGAAAGAACATTGACCATTCTGAAACCGGACTGCGTAAAAAAGCAGCTCATCGGTGCAGTGACGGACAAGATCGAACG
CGCGGGGTTCCGGATTATCGCCATGAAAAAAACCAGACTGACAAAAGAGACCGCAGGTGAATTTTATGCGGTGCACCGGG
AAAGGCCGTTTTATGGCGAACTGGTCGAGTTCATGTCTTCAGGGCCATGCGTGCCGATGATTCTTGAAAAGGAAAATGCC
GTTGCCGATTTCCGTACGCTGATCGGAGCAACCGATCCAGCAGAGGCTGCTGAAGGCACCGTTCGCAAGCTCTATGCCGA
CAGCAAGGGCGAAAATATCGTTCACGGCTCAGACTCTGCCGAAAACGCAGCTATTGAAGCAGGATTCTTCTTTTCTGCCG
AAGAGGTTGTCCGCGTAAACTGA

Upstream 100 bases:

>100_bases
CTGGCGCTTTTGAATCGGAAAGCTCATTTTCATTTATCCGGCGAGTTTGTGTATCTTCGCTCGAACTTTTGTTTTCAGCA
ACACAAATACCTTTACGACA

Downstream 100 bases:

>100_bases
AACGACGCTCTGGCCGGTAAGATAACCCTCTCTGCCGGTCAGACTTCTTTGTTCCCCCTTACCTCATCGAGATAGTCACT
GAAGGCCTCTCCGTATATCT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MERTLTILKPDCVKKQLIGAVTDKIERAGFRIIAMKKTRLTKETAGEFYAVHRERPFYGELVEFMSSGPCVPMILEKENA
VADFRTLIGATDPAEAAEGTVRKLYADSKGENIVHGSDSAENAAIEAGFFFSAEEVVRVN

Sequences:

>Translated_140_residues
MERTLTILKPDCVKKQLIGAVTDKIERAGFRIIAMKKTRLTKETAGEFYAVHRERPFYGELVEFMSSGPCVPMILEKENA
VADFRTLIGATDPAEAAEGTVRKLYADSKGENIVHGSDSAENAAIEAGFFFSAEEVVRVN
>Mature_140_residues
MERTLTILKPDCVKKQLIGAVTDKIERAGFRIIAMKKTRLTKETAGEFYAVHRERPFYGELVEFMSSGPCVPMILEKENA
VADFRTLIGATDPAEAAEGTVRKLYADSKGENIVHGSDSAENAAIEAGFFFSAEEVVRVN

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=44.1176470588235, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=40.1459854014599, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=40.1459854014599, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=40.1459854014599, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=40.1459854014599, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=40.1459854014599, Blast_Score=119, Evalue=1e-27,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=39.7058823529412, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=39.7058823529412, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=41.9117647058824, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI7019465, Length=135, Percent_Identity=32.5925925925926, Blast_Score=89, Evalue=9e-19,
Organism=Homo sapiens, GI37574614, Length=135, Percent_Identity=32.5925925925926, Blast_Score=89, Evalue=9e-19,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=37.7777777777778, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=34.8148148148148, Blast_Score=80, Evalue=4e-16,
Organism=Homo sapiens, GI148839372, Length=126, Percent_Identity=37.3015873015873, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1788866, Length=136, Percent_Identity=52.2058823529412, Blast_Score=136, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=35.5555555555556, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=35.2941176470588, Blast_Score=106, Evalue=1e-24,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=41.1764705882353, Blast_Score=122, Evalue=9e-29,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=33.5820895522388, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24645457, Length=140, Percent_Identity=32.8571428571429, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15430; Mature: 15430

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTLTILKPDCVKKQLIGAVTDKIERAGFRIIAMKKTRLTKETAGEFYAVHRERPFYGE
CCCEEEEECCHHHHHHHHHHHHHHHHHCCEEEEEEECHHHCHHHCCCEEEEECCCCCHHH
LVEFMSSGPCVPMILEKENAVADFRTLIGATDPAEAAEGTVRKLYADSKGENIVHGSDSA
HHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCC
ENAAIEAGFFFSAEEVVRVN
CCCEEECCEEECCCEEEECC
>Mature Secondary Structure
MERTLTILKPDCVKKQLIGAVTDKIERAGFRIIAMKKTRLTKETAGEFYAVHRERPFYGE
CCCEEEEECCHHHHHHHHHHHHHHHHHCCEEEEEEECHHHCHHHCCCEEEEECCCCCHHH
LVEFMSSGPCVPMILEKENAVADFRTLIGATDPAEAAEGTVRKLYADSKGENIVHGSDSA
HHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCC
ENAAIEAGFFFSAEEVVRVN
CCCEEECCEEECCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA