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The map label for this gene is cbs [H]

Identifier: 119358052

GI number: 119358052

Start: 2612345

End: 2613724

Strand: Reverse

Name: cbs [H]

Synonym: Cpha266_2280

Alternate gene names: 119358052

Gene position: 2613724-2612345 (Counterclockwise)

Preceding gene: 119358059

Following gene: 119358051

Centisome position: 83.4

GC content: 48.7

Gene sequence:

>1380_bases
ATGTCGAATCACGATATCCTTGCTCTTGGAGCTGAAAGTCCTCTTGTGCTCATAAAGCAACTTGCCCGGCAGATCAAGCC
GAAAGTTATGGCAAAACTGGAGTATATGAATCCGGCATGCTCGCACTACTATCGGGTTGCTTCAGCCATTATTCTTGATG
CAGAGCAGCGAAACCTCATTCACCCCGGGATGACTCTTGTTGACTGGACATATGGCGACAGCGGTATTGCCCTTGCCATG
GCCGGTTTGAGGAAGGGATACAATCTCCTGCTTGTTGCTCCGGATAAAATCTCACGTGAAAAACAGGAGTTGCTCAAGGC
GCTTGGAGCGGAGACGGTTATTACCCCATCGGCGGCTCTTCCGGGAGAACCGCGTAGTTGTATGAATGTTGCGGAAAGTC
TTGTGAAAAAAATTTCCAATGCTTTTTTTGCCAACATGTATGAAAATCCTATAGGCATGGAGGTGCATCGTCAGTTCACT
TCGAGGGAGATTTTCGAACAGACTGACGGAGCCGTTACCCATGTGTTTGTGCCCATGGTTTCAGGCGCGATGATTTCCGG
GATCGGATCTTTTTTCAAGCAGAAAAAACCTTCGGTCAGGATTATCGGCGTCGAGCCTGAGGGTTCCATCTATTCAGGTC
TTTTCAGGGAAGGGACGCCTGGAAAAACCGGTTTTTATGAACTTGAAGAGATAGGAGCGGTCGCTCCTTCAGGGTTGTGG
GATTCTTCATTCATTGATGACATTGTGCAGGTAAGTGATTACGATGCGTTTAATTGCGGGCGTGAACTGCTCAGGGCTGA
ATCAGTATTCGCCGGCGGCTCCTCTGGCGCTGTTATGGCGGCGGTACTGCGTGCCGGACGGCACTACACTGAAGATGATT
GTGTTGTTGCCCTCATGAACGATTTCGGAGGTTTTTACCTCAGCAAGATGTATCGTGATGAATGGATGAAAGCGAAGGGG
CTGTATCGTAAGGCGAAATCGGCACTTGACCAGATTACCGCAGAAGATATTCTTCTGCTGAAAGGAAGCAAGGATCTTAT
TTTCGCTTATCCCGAGAACACGCTGGCCGAAGTTTTTGAGATGATGAAGCAGAGCGATGTTTCGCAGCTTCCCATTGTTT
CCTATGGAACTCCGATAGGCAGCATCAGCGAAAACAGGATTTTATCGATTCTTATTGAAAATGATGAGGCGATGAACTCG
AAGGTTGTGGGTTTCATGGAGCAGCCTTTCGCCGTTTGTCAGCCGGGAGCAACCATATCGGATCTCTCGTCCAAGCTTCA
GGAAAGTGCTTCAGGAGTACTTATTGCGCTGTCAGACGGGCGCTTGCAATTGCTCACGAAATCGGATCTTATTGACGCTT
TGACTCACAAGCAGGGTTGA

Upstream 100 bases:

>100_bases
GCTTCCGTTATGCGCAGATGCCCTGAAATGAGCAATTAATGTATATTATAAGATGAGTGTCTGCGGTGCAGGACTGTTAA
CCTATTTTTCGCGAACCAAT

Downstream 100 bases:

>100_bases
GAAAAATTAACCGTTGTTTTTTTGGGGGGATTTACTTATTTAAGCAAACCTGAATATTCTCTGGTTCCTTTTTATTATTC
GGGCCATGCGTAGGTGAAGC

Product: cysteine synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSNHDILALGAESPLVLIKQLARQIKPKVMAKLEYMNPACSHYYRVASAIILDAEQRNLIHPGMTLVDWTYGDSGIALAM
AGLRKGYNLLLVAPDKISREKQELLKALGAETVITPSAALPGEPRSCMNVAESLVKKISNAFFANMYENPIGMEVHRQFT
SREIFEQTDGAVTHVFVPMVSGAMISGIGSFFKQKKPSVRIIGVEPEGSIYSGLFREGTPGKTGFYELEEIGAVAPSGLW
DSSFIDDIVQVSDYDAFNCGRELLRAESVFAGGSSGAVMAAVLRAGRHYTEDDCVVALMNDFGGFYLSKMYRDEWMKAKG
LYRKAKSALDQITAEDILLLKGSKDLIFAYPENTLAEVFEMMKQSDVSQLPIVSYGTPIGSISENRILSILIENDEAMNS
KVVGFMEQPFAVCQPGATISDLSSKLQESASGVLIALSDGRLQLLTKSDLIDALTHKQG

Sequences:

>Translated_459_residues
MSNHDILALGAESPLVLIKQLARQIKPKVMAKLEYMNPACSHYYRVASAIILDAEQRNLIHPGMTLVDWTYGDSGIALAM
AGLRKGYNLLLVAPDKISREKQELLKALGAETVITPSAALPGEPRSCMNVAESLVKKISNAFFANMYENPIGMEVHRQFT
SREIFEQTDGAVTHVFVPMVSGAMISGIGSFFKQKKPSVRIIGVEPEGSIYSGLFREGTPGKTGFYELEEIGAVAPSGLW
DSSFIDDIVQVSDYDAFNCGRELLRAESVFAGGSSGAVMAAVLRAGRHYTEDDCVVALMNDFGGFYLSKMYRDEWMKAKG
LYRKAKSALDQITAEDILLLKGSKDLIFAYPENTLAEVFEMMKQSDVSQLPIVSYGTPIGSISENRILSILIENDEAMNS
KVVGFMEQPFAVCQPGATISDLSSKLQESASGVLIALSDGRLQLLTKSDLIDALTHKQG
>Mature_458_residues
SNHDILALGAESPLVLIKQLARQIKPKVMAKLEYMNPACSHYYRVASAIILDAEQRNLIHPGMTLVDWTYGDSGIALAMA
GLRKGYNLLLVAPDKISREKQELLKALGAETVITPSAALPGEPRSCMNVAESLVKKISNAFFANMYENPIGMEVHRQFTS
REIFEQTDGAVTHVFVPMVSGAMISGIGSFFKQKKPSVRIIGVEPEGSIYSGLFREGTPGKTGFYELEEIGAVAPSGLWD
SSFIDDIVQVSDYDAFNCGRELLRAESVFAGGSSGAVMAAVLRAGRHYTEDDCVVALMNDFGGFYLSKMYRDEWMKAKGL
YRKAKSALDQITAEDILLLKGSKDLIFAYPENTLAEVFEMMKQSDVSQLPIVSYGTPIGSISENRILSILIENDEAMNSK
VVGFMEQPFAVCQPGATISDLSSKLQESASGVLIALSDGRLQLLTKSDLIDALTHKQG

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=431, Percent_Identity=29.4663573085847, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI295821200, Length=431, Percent_Identity=29.4663573085847, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI4557415, Length=431, Percent_Identity=29.4663573085847, Blast_Score=186, Evalue=3e-47,
Organism=Escherichia coli, GI2367138, Length=298, Percent_Identity=33.2214765100671, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI1788754, Length=301, Percent_Identity=32.2259136212625, Blast_Score=133, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17562970, Length=306, Percent_Identity=33.9869281045752, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI32566674, Length=299, Percent_Identity=34.7826086956522, Blast_Score=168, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17535051, Length=316, Percent_Identity=36.0759493670886, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17534315, Length=320, Percent_Identity=32.1875, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI25147552, Length=326, Percent_Identity=31.2883435582822, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17561720, Length=309, Percent_Identity=33.6569579288026, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI115535073, Length=310, Percent_Identity=32.5806451612903, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32566672, Length=224, Percent_Identity=31.6964285714286, Blast_Score=105, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6321594, Length=503, Percent_Identity=30.8151093439364, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321449, Length=324, Percent_Identity=28.7037037037037, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24643623, Length=417, Percent_Identity=30.4556354916067, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI20129101, Length=417, Percent_Identity=30.4556354916067, Blast_Score=178, Evalue=6e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 50068; Mature: 49937

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNHDILALGAESPLVLIKQLARQIKPKVMAKLEYMNPACSHYYRVASAIILDAEQRNLI
CCCCCEEEECCCCHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHEECHHCCCC
HPGMTLVDWTYGDSGIALAMAGLRKGYNLLLVAPDKISREKQELLKALGAETVITPSAAL
CCCCEEEEEEECCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCEEECCCCCC
PGEPRSCMNVAESLVKKISNAFFANMYENPIGMEVHRQFTSREIFEQTDGAVTHVFVPMV
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEHHHHHH
SGAMISGIGSFFKQKKPSVRIIGVEPEGSIYSGLFREGTPGKTGFYELEEIGAVAPSGLW
HHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCEEHHHHCCCCCCCCC
DSSFIDDIVQVSDYDAFNCGRELLRAESVFAGGSSGAVMAAVLRAGRHYTEDDCVVALMN
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHH
DFGGFYLSKMYRDEWMKAKGLYRKAKSALDQITAEDILLLKGSKDLIFAYPENTLAEVFE
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHH
MMKQSDVSQLPIVSYGTPIGSISENRILSILIENDEAMNSKVVGFMEQPFAVCQPGATIS
HHHHCCCCCCCEEECCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCHHHCCCCCCHH
DLSSKLQESASGVLIALSDGRLQLLTKSDLIDALTHKQG
HHHHHHHHCCCCEEEEECCCCEEEEEHHHHHHHHHCCCC
>Mature Secondary Structure 
SNHDILALGAESPLVLIKQLARQIKPKVMAKLEYMNPACSHYYRVASAIILDAEQRNLI
CCCCEEEECCCCHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHHEECHHCCCC
HPGMTLVDWTYGDSGIALAMAGLRKGYNLLLVAPDKISREKQELLKALGAETVITPSAAL
CCCCEEEEEEECCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCEEECCCCCC
PGEPRSCMNVAESLVKKISNAFFANMYENPIGMEVHRQFTSREIFEQTDGAVTHVFVPMV
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEHHHHHH
SGAMISGIGSFFKQKKPSVRIIGVEPEGSIYSGLFREGTPGKTGFYELEEIGAVAPSGLW
HHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHCCCCCCCCCCEEHHHHCCCCCCCCC
DSSFIDDIVQVSDYDAFNCGRELLRAESVFAGGSSGAVMAAVLRAGRHYTEDDCVVALMN
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHH
DFGGFYLSKMYRDEWMKAKGLYRKAKSALDQITAEDILLLKGSKDLIFAYPENTLAEVFE
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHH
MMKQSDVSQLPIVSYGTPIGSISENRILSILIENDEAMNSKVVGFMEQPFAVCQPGATIS
HHHHCCCCCCCEEECCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHCCHHHCCCCCCHH
DLSSKLQESASGVLIALSDGRLQLLTKSDLIDALTHKQG
HHHHHHHHCCCCEEEEECCCCEEEEEHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]