Click here to switch to the map view.

The map label for this gene is menE [H]

Identifier: 119357885

GI number: 119357885

Start: 2426536

End: 2427993

Strand: Direct

Name: menE [H]

Synonym: Cpha266_2093

Alternate gene names: 119357885

Gene position: 2426536-2427993 (Clockwise)

Preceding gene: 119357884

Following gene: 119357890

Centisome position: 77.43

GC content: 53.84

Gene sequence:

>1458_bases
ATGGACATTATAAACCAGGCCGCTCTCCGGTTCGCCGATTCGCCTCTGCTTGTCACAAGGGAAAAAACACTCTCTTTCAG
GGAGTGTTCTGTAAAAGCCTCACAAATCGCCAACACCCTTTTCAAAAAAGGGTATCGTCCGGGTGACATTGCAGCCCTTC
TGCTTCCCGGTTCGCCCGAGTATGTGCTGATCCTCCTCGGACTGCTCAAAGCAGGCCTGATCAGCGCGCCCCTGAACAAC
CGTTTTCCGGAGAAACAGCTTTCGCTTGCTCTTGAACAACTGCAACCCCCGCTTCTCCTGACGGAGGCTGATTCGGGGAT
GCAGAAAAACCGCATGACGACGCTCTCGATCCACGACCTGCTCAAGGAAGCCGAAAGCGCATCCCCGGAGCCGGAGTTTC
CTGTCAATGAGAGCCGCGAGCGCCCTGTAACCATCATTCACACCTCGGCAAGCTCGGGAAAACCGAAAGCCGCAGTACAC
AGTTTCAGCAATCACTGGTTCAGCGCTCTTGGATCGGCCTCTAATCTGCCGCTTGAAAAGGGGGACTGCTGGCTCCTCTC
CCTGCCGCTCTTTCATATCGGCGGCTATGCCGTGCTCTTCAAAGCCCTGCTTTCAGGTTCATCGGTTGCCCTGCCGGATC
CGTCTGACTCTCTTGAAGAGTGTTTGCGGATGTTCTCTCTGACCCATCTCTCGCTGGTACCGACCCAGTTGTACCGCCTG
CTGCGACAACCGTCGATCATCCCTGCCCTTGCTTCGCTCAAAGCGCTCCTGCTCGGAGGAAGTCCGATACCCCCTGCCCT
GCTTGCCGACACGATCCGCAAAGGCATTCCGGTCTATCTCAGCTACGGATCGACCGAGATGAGCTCTCAAATCGCAACCA
CGCCGAATCCGGCAGACTCCATGCAGGAAAACAGCGGCAGAATACTTCCCTTTCGCGAAGTTATGACCGATGCTGAGGGA
GAGATACTTTGCAAAGGAGAGTGCCTCTTTCAGGGTTATCTGCAAAATGGCCGGATTGAACCGCAAACAGACGGCGACGG
CTGGTTTCATACGAACGATATCGGGAGAATCGATGAGAAAGGAATGATAACCGTACTGGGAAGAAAAGACAATATGTTCA
TCTCCGGAGGCGAAAACATCCATCCTGAAGAGATAGAAAAAGCTCTTCTCGATATGGAGGGAATCCTCCAGGCGGTCGTT
GTGCCCGTTATCGACAAAGAGTACGGAAGCCGACCTGCGGCGTTCATTCAGACAGAGGAGAGTGAAAAACCCGATGATGA
AGCCATTGCCGGATACATACGCAAAAAGCTCGGGAAACTGAAAACGCCGGTAAAGATTACCAGAACCCTTCAGTGGGAAA
CTCTTGCGGGTTCACAAAAAATCGACAGAAAGCAATACCGCCAACTTGCCGGAGAGGCTCTTGTGCCGACTATCGAGCCT
TCGCCGCCTGACGTTTGA

Upstream 100 bases:

>100_bases
TCGATCTCCCTTTCGGAAGTTCATCCGACACGCTCACGCCTCAGGAACTCTACTGGAATGGCCACAAGGTCGCAACCTCG
CACCTCAAGCCTTCATCAAT

Downstream 100 bases:

>100_bases
GTCTGAAAACCATAAATATCCCCCCCAGACCTGTAACTGGCGCATATAAACCTGCAGAAACCACGATCCAGACAAGAAGA
TCTTTCAGATTGATATCCGG

Product: O-succinylbenzoate-CoA ligase

Products: NA

Alternate protein names: OSB-CoA synthetase; o-succinylbenzoyl-CoA synthetase [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MDIINQAALRFADSPLLVTREKTLSFRECSVKASQIANTLFKKGYRPGDIAALLLPGSPEYVLILLGLLKAGLISAPLNN
RFPEKQLSLALEQLQPPLLLTEADSGMQKNRMTTLSIHDLLKEAESASPEPEFPVNESRERPVTIIHTSASSGKPKAAVH
SFSNHWFSALGSASNLPLEKGDCWLLSLPLFHIGGYAVLFKALLSGSSVALPDPSDSLEECLRMFSLTHLSLVPTQLYRL
LRQPSIIPALASLKALLLGGSPIPPALLADTIRKGIPVYLSYGSTEMSSQIATTPNPADSMQENSGRILPFREVMTDAEG
EILCKGECLFQGYLQNGRIEPQTDGDGWFHTNDIGRIDEKGMITVLGRKDNMFISGGENIHPEEIEKALLDMEGILQAVV
VPVIDKEYGSRPAAFIQTEESEKPDDEAIAGYIRKKLGKLKTPVKITRTLQWETLAGSQKIDRKQYRQLAGEALVPTIEP
SPPDV

Sequences:

>Translated_485_residues
MDIINQAALRFADSPLLVTREKTLSFRECSVKASQIANTLFKKGYRPGDIAALLLPGSPEYVLILLGLLKAGLISAPLNN
RFPEKQLSLALEQLQPPLLLTEADSGMQKNRMTTLSIHDLLKEAESASPEPEFPVNESRERPVTIIHTSASSGKPKAAVH
SFSNHWFSALGSASNLPLEKGDCWLLSLPLFHIGGYAVLFKALLSGSSVALPDPSDSLEECLRMFSLTHLSLVPTQLYRL
LRQPSIIPALASLKALLLGGSPIPPALLADTIRKGIPVYLSYGSTEMSSQIATTPNPADSMQENSGRILPFREVMTDAEG
EILCKGECLFQGYLQNGRIEPQTDGDGWFHTNDIGRIDEKGMITVLGRKDNMFISGGENIHPEEIEKALLDMEGILQAVV
VPVIDKEYGSRPAAFIQTEESEKPDDEAIAGYIRKKLGKLKTPVKITRTLQWETLAGSQKIDRKQYRQLAGEALVPTIEP
SPPDV
>Mature_485_residues
MDIINQAALRFADSPLLVTREKTLSFRECSVKASQIANTLFKKGYRPGDIAALLLPGSPEYVLILLGLLKAGLISAPLNN
RFPEKQLSLALEQLQPPLLLTEADSGMQKNRMTTLSIHDLLKEAESASPEPEFPVNESRERPVTIIHTSASSGKPKAAVH
SFSNHWFSALGSASNLPLEKGDCWLLSLPLFHIGGYAVLFKALLSGSSVALPDPSDSLEECLRMFSLTHLSLVPTQLYRL
LRQPSIIPALASLKALLLGGSPIPPALLADTIRKGIPVYLSYGSTEMSSQIATTPNPADSMQENSGRILPFREVMTDAEG
EILCKGECLFQGYLQNGRIEPQTDGDGWFHTNDIGRIDEKGMITVLGRKDNMFISGGENIHPEEIEKALLDMEGILQAVV
VPVIDKEYGSRPAAFIQTEESEKPDDEAIAGYIRKKLGKLKTPVKITRTLQWETLAGSQKIDRKQYRQLAGEALVPTIEP
SPPDV

Specific function: Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl- CoA (OSB-CoA) [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=521, Percent_Identity=25.7197696737044, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI38505220, Length=498, Percent_Identity=26.1044176706827, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI122937307, Length=434, Percent_Identity=25.5760368663594, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI115511026, Length=498, Percent_Identity=25.9036144578313, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI58082049, Length=513, Percent_Identity=25.3411306042885, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI42544132, Length=501, Percent_Identity=24.1516966067864, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI157311624, Length=511, Percent_Identity=25.2446183953033, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI157311622, Length=511, Percent_Identity=25.2446183953033, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI227499619, Length=514, Percent_Identity=23.3463035019455, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI40807491, Length=511, Percent_Identity=20.9393346379648, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI57165410, Length=165, Percent_Identity=29.6969696969697, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI57165412, Length=165, Percent_Identity=29.6969696969697, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI42794756, Length=162, Percent_Identity=30.2469135802469, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI42794760, Length=162, Percent_Identity=30.2469135802469, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI42794758, Length=162, Percent_Identity=30.2469135802469, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1788595, Length=448, Percent_Identity=33.9285714285714, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI145693145, Length=459, Percent_Identity=27.8867102396514, Blast_Score=142, Evalue=7e-35,
Organism=Escherichia coli, GI221142682, Length=462, Percent_Identity=24.8917748917749, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786810, Length=511, Percent_Identity=24.6575342465753, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1786801, Length=439, Percent_Identity=23.9179954441913, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788107, Length=506, Percent_Identity=22.5296442687747, Blast_Score=101, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17558820, Length=472, Percent_Identity=27.3305084745763, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI32563687, Length=460, Percent_Identity=23.695652173913, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17560308, Length=494, Percent_Identity=23.4817813765182, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71994703, Length=541, Percent_Identity=21.2569316081331, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71994694, Length=541, Percent_Identity=21.2569316081331, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71994690, Length=541, Percent_Identity=21.2569316081331, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17557194, Length=518, Percent_Identity=22.3938223938224, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17538037, Length=490, Percent_Identity=23.8775510204082, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17559526, Length=496, Percent_Identity=24.7983870967742, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17551278, Length=448, Percent_Identity=23.6607142857143, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17531443, Length=482, Percent_Identity=23.8589211618257, Blast_Score=93, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71996755, Length=457, Percent_Identity=23.1947483588621, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17560140, Length=465, Percent_Identity=23.8709677419355, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17510401, Length=163, Percent_Identity=29.4478527607362, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17564090, Length=371, Percent_Identity=24.2587601078167, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17556356, Length=273, Percent_Identity=28.9377289377289, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=455, Percent_Identity=23.5164835164835, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24581924, Length=512, Percent_Identity=25.78125, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24583465, Length=525, Percent_Identity=24.3809523809524, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24583463, Length=525, Percent_Identity=24.3809523809524, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281364798, Length=525, Percent_Identity=24.3809523809524, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21355181, Length=457, Percent_Identity=24.2888402625821, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI20130357, Length=338, Percent_Identity=24.2603550295858, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI18859661, Length=440, Percent_Identity=23.6363636363636, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356947, Length=372, Percent_Identity=23.1182795698925, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21358303, Length=456, Percent_Identity=21.4912280701754, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24648260, Length=314, Percent_Identity=24.203821656051, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24653035, Length=451, Percent_Identity=22.1729490022173, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI161076582, Length=458, Percent_Identity=21.8340611353712, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19921316, Length=141, Percent_Identity=32.6241134751773, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24648253, Length=491, Percent_Identity=19.959266802444, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24648255, Length=457, Percent_Identity=20.3501094091904, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010192
- InterPro:   IPR023015 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.26 [H]

Molecular weight: Translated: 53041; Mature: 53041

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIINQAALRFADSPLLVTREKTLSFRECSVKASQIANTLFKKGYRPGDIAALLLPGSPE
CCCHHHHHHHHCCCCEEEEHHHCCCHHHHHCCHHHHHHHHHHCCCCCCCEEEEEECCCCH
YVLILLGLLKAGLISAPLNNRFPEKQLSLALEQLQPPLLLTEADSGMQKNRMTTLSIHDL
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHCCCEEHHHHHH
LKEAESASPEPEFPVNESRERPVTIIHTSASSGKPKAAVHSFSNHWFSALGSASNLPLEK
HHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
GDCWLLSLPLFHIGGYAVLFKALLSGSSVALPDPSDSLEECLRMFSLTHLSLVPTQLYRL
CCEEEEECHHHHHCCHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LRQPSIIPALASLKALLLGGSPIPPALLADTIRKGIPVYLSYGSTEMSSQIATTPNPADS
HHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCCCHHH
MQENSGRILPFREVMTDAEGEILCKGECLFQGYLQNGRIEPQTDGDGWFHTNDIGRIDEK
HHCCCCCEEEHHHHHCCCCCCEEECCHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCC
GMITVLGRKDNMFISGGENIHPEEIEKALLDMEGILQAVVVPVIDKEYGSRPAAFIQTEE
CEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
SEKPDDEAIAGYIRKKLGKLKTPVKITRTLQWETLAGSQKIDRKQYRQLAGEALVPTIEP
CCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEHHHCCCHHHHHHHHHHHHCCCCCCCCCC
SPPDV
CCCCC
>Mature Secondary Structure
MDIINQAALRFADSPLLVTREKTLSFRECSVKASQIANTLFKKGYRPGDIAALLLPGSPE
CCCHHHHHHHHCCCCEEEEHHHCCCHHHHHCCHHHHHHHHHHCCCCCCCEEEEEECCCCH
YVLILLGLLKAGLISAPLNNRFPEKQLSLALEQLQPPLLLTEADSGMQKNRMTTLSIHDL
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHCCCEEHHHHHH
LKEAESASPEPEFPVNESRERPVTIIHTSASSGKPKAAVHSFSNHWFSALGSASNLPLEK
HHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
GDCWLLSLPLFHIGGYAVLFKALLSGSSVALPDPSDSLEECLRMFSLTHLSLVPTQLYRL
CCEEEEECHHHHHCCHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LRQPSIIPALASLKALLLGGSPIPPALLADTIRKGIPVYLSYGSTEMSSQIATTPNPADS
HHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEECCCHHHHCCCCCCCCCHHH
MQENSGRILPFREVMTDAEGEILCKGECLFQGYLQNGRIEPQTDGDGWFHTNDIGRIDEK
HHCCCCCEEEHHHHHCCCCCCEEECCHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCC
GMITVLGRKDNMFISGGENIHPEEIEKALLDMEGILQAVVVPVIDKEYGSRPAAFIQTEE
CEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
SEKPDDEAIAGYIRKKLGKLKTPVKITRTLQWETLAGSQKIDRKQYRQLAGEALVPTIEP
CCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEHHHCCCHHHHHHHHHHHHCCCCCCCCCC
SPPDV
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA