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The map label for this gene is menB [H]

Identifier: 119357883

GI number: 119357883

Start: 2424657

End: 2425478

Strand: Direct

Name: menB [H]

Synonym: Cpha266_2091

Alternate gene names: 119357883

Gene position: 2424657-2425478 (Clockwise)

Preceding gene: 119357882

Following gene: 119357884

Centisome position: 77.37

GC content: 54.5

Gene sequence:

>822_bases
ATGGGCACAATCTCATGGATACCTGCCGCTGAATTTACCGATATTCTCTATCACAAGGCCGACGGGATTGCTAAAATAAC
CATCAATCGCCCGGAAGTCCGCAACGCGTTCCGGCCGCAAACCGTCGAAGAGATGATCAAGGCTCTTTCGGATGCAAGAA
ATGACGAGAAAATCGGCGTCGTGATTCTTACCGGTGCCGGCGACCTTGCGTTCTGCTCAGGGGGCGACCAGAAAATCCGC
GGATATGCCGGCTATGCTGATGCCAAAGGGGTAAACCGGCTCAATGTGCTTGATTTCCAGCGCGATATCAGAACCTGTCC
CAAACCGGTCATTGCCATGGTAGCAGGCTATGCGATCGGAGGCGGCCATGTGCTCCACATGCTGTGCGATCTTACCATTG
CCGCCGACAACGCCATTTTCGGTCAGACCGGGCCGAAAGTAGGCTCTTTTGACGGAGGCTGGGGCGCAAGCTACATGGCC
AGACTTGTAGGTCAGAAAAAGGCCAGGGAGATCTGGTATCTCTGCCGCCAGTACAATGCTGCCGACGCTCTTGCCATGGG
ACTGGTCAATACCGTTGTTCCGCTTGCCCGGCTTGAAGAAGAGACCGTTCAGTGGTGCCGCGAAATTCTCGAAAATTCCC
CTCTGGCCATCCGCTGCCTGAAATCGGCCCTCAATGCGGATTGCGATGGACAGGCCGGCCTGCAGGAGCTTGCCGGAAAC
GCCACCATGCTCTACTATATGAGCGAAGAGGCTCAGGAGGGAAAAAATGCATTCGTCGAAAAAAGAAAGCCTGATTTCAC
TAAATTCCCGAAACGCCCTTGA

Upstream 100 bases:

>100_bases
AGATCTTTGCCGATTGCGGCCACGCCCTGCATATTGAAAACAGGGAGGAGTTTACCAGCCGCCTGAAGGTTTTTTTCAAA
CAGTAAGAACATCAATCACT

Downstream 100 bases:

>100_bases
ATGCGTCATTTTTACACCTTTACCGGTATAGCATCCCTTTCAATGAGCCGGTTACCGTAAGAAACCATCGGCTTCTGAAC
AGAGAGGGGATAATTATCGC

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MGTISWIPAAEFTDILYHKADGIAKITINRPEVRNAFRPQTVEEMIKALSDARNDEKIGVVILTGAGDLAFCSGGDQKIR
GYAGYADAKGVNRLNVLDFQRDIRTCPKPVIAMVAGYAIGGGHVLHMLCDLTIAADNAIFGQTGPKVGSFDGGWGASYMA
RLVGQKKAREIWYLCRQYNAADALAMGLVNTVVPLARLEEETVQWCREILENSPLAIRCLKSALNADCDGQAGLQELAGN
ATMLYYMSEEAQEGKNAFVEKRKPDFTKFPKRP

Sequences:

>Translated_273_residues
MGTISWIPAAEFTDILYHKADGIAKITINRPEVRNAFRPQTVEEMIKALSDARNDEKIGVVILTGAGDLAFCSGGDQKIR
GYAGYADAKGVNRLNVLDFQRDIRTCPKPVIAMVAGYAIGGGHVLHMLCDLTIAADNAIFGQTGPKVGSFDGGWGASYMA
RLVGQKKAREIWYLCRQYNAADALAMGLVNTVVPLARLEEETVQWCREILENSPLAIRCLKSALNADCDGQAGLQELAGN
ATMLYYMSEEAQEGKNAFVEKRKPDFTKFPKRP
>Mature_272_residues
GTISWIPAAEFTDILYHKADGIAKITINRPEVRNAFRPQTVEEMIKALSDARNDEKIGVVILTGAGDLAFCSGGDQKIRG
YAGYADAKGVNRLNVLDFQRDIRTCPKPVIAMVAGYAIGGGHVLHMLCDLTIAADNAIFGQTGPKVGSFDGGWGASYMAR
LVGQKKAREIWYLCRQYNAADALAMGLVNTVVPLARLEEETVQWCREILENSPLAIRCLKSALNADCDGQAGLQELAGNA
TMLYYMSEEAQEGKNAFVEKRKPDFTKFPKRP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=271, Percent_Identity=32.4723247232472, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI31542718, Length=260, Percent_Identity=29.2307692307692, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI45643119, Length=221, Percent_Identity=29.4117647058824, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI260275230, Length=221, Percent_Identity=29.4117647058824, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI260274832, Length=221, Percent_Identity=29.4117647058824, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI4502327, Length=260, Percent_Identity=29.2307692307692, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI25453481, Length=264, Percent_Identity=25.7575757575758, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI51538573, Length=264, Percent_Identity=25.7575757575758, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4757966, Length=215, Percent_Identity=26.5116279069767, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI51538581, Length=215, Percent_Identity=26.5116279069767, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI4757968, Length=264, Percent_Identity=26.5151515151515, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI49355787, Length=264, Percent_Identity=26.5151515151515, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI70995211, Length=220, Percent_Identity=29.0909090909091, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI37594469, Length=154, Percent_Identity=26.6233766233766, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI37594471, Length=154, Percent_Identity=26.6233766233766, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1788597, Length=273, Percent_Identity=78.3882783882784, Blast_Score=451, Evalue=1e-128,
Organism=Escherichia coli, GI1787659, Length=257, Percent_Identity=30.7392996108949, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI87082183, Length=251, Percent_Identity=30.6772908366534, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI221142681, Length=254, Percent_Identity=31.1023622047244, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1787660, Length=265, Percent_Identity=29.811320754717, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1788682, Length=205, Percent_Identity=27.8048780487805, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=250, Percent_Identity=33.6, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17540714, Length=220, Percent_Identity=35, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17554946, Length=247, Percent_Identity=31.5789473684211, Blast_Score=113, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17535521, Length=210, Percent_Identity=26.1904761904762, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17549921, Length=210, Percent_Identity=24.7619047619048, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17536985, Length=222, Percent_Identity=25.6756756756757, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25144160, Length=221, Percent_Identity=27.6018099547511, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI25144157, Length=221, Percent_Identity=27.6018099547511, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17534483, Length=216, Percent_Identity=25.9259259259259, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560910, Length=190, Percent_Identity=28.4210526315789, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI20129971, Length=244, Percent_Identity=34.8360655737705, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653477, Length=244, Percent_Identity=34.8360655737705, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24653139, Length=281, Percent_Identity=28.8256227758007, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24654903, Length=200, Percent_Identity=28.5, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24650670, Length=184, Percent_Identity=29.8913043478261, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21357171, Length=191, Percent_Identity=28.7958115183246, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI19922422, Length=258, Percent_Identity=24.031007751938, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 29838; Mature: 29706

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTISWIPAAEFTDILYHKADGIAKITINRPEVRNAFRPQTVEEMIKALSDARNDEKIGV
CCCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHCCCCHHHHHHHHHHHCCCCCCCEEE
VILTGAGDLAFCSGGDQKIRGYAGYADAKGVNRLNVLDFQRDIRTCPKPVIAMVAGYAIG
EEEECCCCEEEECCCCHHHCEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCC
GGHVLHMLCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARLVGQKKAREIWYLCRQYNA
CHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCH
ADALAMGLVNTVVPLARLEEETVQWCREILENSPLAIRCLKSALNADCDGQAGLQELAGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHCCC
ATMLYYMSEEAQEGKNAFVEKRKPDFTKFPKRP
CEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
GTISWIPAAEFTDILYHKADGIAKITINRPEVRNAFRPQTVEEMIKALSDARNDEKIGV
CCCCCCCCHHHHHHHHHCCCCEEEEEECCHHHHHCCCCHHHHHHHHHHHCCCCCCCEEE
VILTGAGDLAFCSGGDQKIRGYAGYADAKGVNRLNVLDFQRDIRTCPKPVIAMVAGYAIG
EEEECCCCEEEECCCCHHHCEECCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCC
GGHVLHMLCDLTIAADNAIFGQTGPKVGSFDGGWGASYMARLVGQKKAREIWYLCRQYNA
CHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCH
ADALAMGLVNTVVPLARLEEETVQWCREILENSPLAIRCLKSALNADCDGQAGLQELAGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHCCC
ATMLYYMSEEAQEGKNAFVEKRKPDFTKFPKRP
CEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]