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The map label for this gene is cqsS [H]

Identifier: 119357751

GI number: 119357751

Start: 2269700

End: 2272255

Strand: Direct

Name: cqsS [H]

Synonym: Cpha266_1957

Alternate gene names: 119357751

Gene position: 2269700-2272255 (Clockwise)

Preceding gene: 119357743

Following gene: 119357753

Centisome position: 72.42

GC content: 42.57

Gene sequence:

>2556_bases
ATGCAGAAACTGAAGTCTTTATCCAAAAGAATTATTGAACATGCTGAGCCGAACCTTGGCATTATAGGGATCTTCACCAC
TCTCGGGTATCCCGTTTATTACATTATCTGGACGTTCCTTTTTCCTCAGCCATATGAGAATCTGATGCTGCGAATCTTCT
GCGCATTCATAAGCATTCCCTGTATACTGTATCGTCACATTCCTGTTTCTCTGAAAAAGTTTTTTCCTTTCTATTTCTAT
CTCACATTTTTTATTGATGTTCCCTACTTTTTCAGCTTTATGCTGCTGAAAAATGAGTGTTCAACCGTATGGACAATGTC
CCTCTTGACAGGGATATTCATGCTGATTCTGATTCTGTCGAACTGGATGGTTGTCAGTATTATGACCATTCTGGGTTTCA
TAACCGCTTATGCAACGGTTATGTTTCTTGACGGCGAGGTATCGTTTGCCTTTTTTCAGCTTGAGTATATTCCTGTTTTC
CTGTTTTCGTTCATTGGAAGCATTATTGCAAACCATAACCGGCAACTGGCCCACCAGACAAAAATCTCGCTCCTGAAAAG
CCTTAGCGGCAGTATTGCTCATGAAATGAGAAACCCTCTGAACGCAATTACTAACGCGATAGGTTCGGTTCACGCTACGC
TGCCAAAAAAAGCTGACATCAATACAGAGTCGAAAAGCTATTCTGTCAGCCATTCCTGCCTGATGAACATTCATCAGGTT
ATCGAGGAGAGTTCAAATACGCTGAACAGAGCCAATAAAATCATCGACTCGATACTTGCAAGCATGCGCGGCGATGAAGT
ATCAACAGGAATGTTTATCCGTATCAGCGTTGTCGACGCGATTGAGGCGGCTGTCAACAGTTTCCCCTTTAATGACGCTG
AGGAAAAAAAGTTGATCGGCATCAACAACATCCAGAATTTCAATTTTCTGGGTGATTGCGATCTGTTTCATTATGTCCTT
TTCAACCTCCTGAAAAACTCGCTTTACTACAGAAACAAAAAGAACTTCTGCATTACCATAACCACCGATTCAACGCTTGC
TGAAAACACCATCAAGTTCAGGGATACAGGCCCAGGCATACCGGCAAATAAAAGAGAACTGGTATTCGACAGCTTCTATA
CCTCCGATAAAAAAGGTGGAAACGGTTTGGGATTATCATTCTGCAGAAGGGTTATCAATGCTTTTGGAGGCACAATCGTC
TGTAATTCGAAGGAAGGCGAATGGACAGAGTTCATTATCACTCTGCCAAAATATGACTCCAAAAAGGTCAGGGAGATTAA
AAACAACATTCTGCAGGAAAAAAGAGTTCTTGTCACCGAAGACCAACCCGCCAACCGCCTTCTTTTGTCAAAATTCCTCT
CGGAGATAAACTGCCAGTACGAGATGGCTGAAAACGGCATGCGCGCTATAGAACTGCTTTCGGAAAAACGGTATGACCTT
ATTTTCATGGATTTCGAAATGCAAATCCTCAATGGCGATGCAACCGTAAAACATATCAGATCGGCAGATGGTATGGATCC
TTCACTTGCCATCCACTATCTCGATGTCCCTGTAGTCGGCCTGACATCCCTGCCCAGAAAAGAAGCTTTGGAAAGGGCCA
GAGAGTGCGGGATGAATGAAGTCCTTATAAAACCACTCAAAAGAACTGATTTCAGAAAAATCATTGAAAAGTATTTTTTT
TCAGGAGTTAAATCAATCCGGCATGTCAAGGAAGAGCTCATTTCCGGAAAACGTATTCTTCTGGTGGACGATAACGAGAC
AAGCTTGAAATTCATGAGCATAATGCTTGACCACCTCGGCTGCAATGTTGATCACGCATTACATGGAAAAGAGGCAATCG
ATCTTCTTGAAAAAGAAGATTTCGATCTGGTGCTGATGGATTTGGAAATGCCGGTCATGGACGGTATCGAAGCGACCATG
GCCATTCGGGCAGGAACACATTTCCATCGCTTCCATTCCTTCAGGACCATACCCATTATTGCCCTTACCGGAAATGACGA
TGAGCAAAACAAACAGAACATAAAGAACGCAGGCATGAACTATCATCTCTGCAAACCTGTTTTCACGGATGAACTTATTT
CTGCCATAACGCTTGTACTGAACAACAATTCTGAAGAAAACGAGACGATTCCTGCCAACAACAAAAAAGAGCGACCCGTT
ACAAACAGCGCCACATTCTGGAATACCCTCTACAATGAAAATATTCTTGACGCCGCAACCATCAACAGCCTTATAGAGAT
CGGAGGCGACGAACTGCTTGAAAGTCTTTTCGGGAATTTTTCAACTGATACAGACCAACTGATCGGCAAACTGGAGAAAA
GCGTTACAACAAAGGATTTGAAACAGTATGATTTCATCATACACACCATCAAGGGATCTTCGGGATGTATCGGAGCCCAT
AAAATGTTTGTGCTTTGCAGATATATCAATGAATATTCCCGCAAAGGAGAGTGGCCTGACAACAGTACATGGATGGAAAT
ACTGAAAACAGTTTATGCTGAAACAAAACATGAACTGCAAATCCTTATCAATCCCGAAACAACGCCGTCATCCTGA

Upstream 100 bases:

>100_bases
GGATATCAAGCCCCTCCAGAGCGAAAAGACTCTGGCGATGAACAAGTGAATGGAGATACTGACAAGTTATAACAGCCTCT
TTTACGGTGTATAGTTTTCA

Downstream 100 bases:

>100_bases
TACCCTCCAAACCGTTCAGGAAATGGCTCCGGAAAAATACCGATACCACTGCAGATTGTTATCTGCCTGCATATTCCCCG
GAACTGAACCCTTAAAATGC

Product: multi-sensor hybrid histidine kinase

Products: NA

Alternate protein names: Cholerae quorum-sensing sensor [H]

Number of amino acids: Translated: 851; Mature: 851

Protein sequence:

>851_residues
MQKLKSLSKRIIEHAEPNLGIIGIFTTLGYPVYYIIWTFLFPQPYENLMLRIFCAFISIPCILYRHIPVSLKKFFPFYFY
LTFFIDVPYFFSFMLLKNECSTVWTMSLLTGIFMLILILSNWMVVSIMTILGFITAYATVMFLDGEVSFAFFQLEYIPVF
LFSFIGSIIANHNRQLAHQTKISLLKSLSGSIAHEMRNPLNAITNAIGSVHATLPKKADINTESKSYSVSHSCLMNIHQV
IEESSNTLNRANKIIDSILASMRGDEVSTGMFIRISVVDAIEAAVNSFPFNDAEEKKLIGINNIQNFNFLGDCDLFHYVL
FNLLKNSLYYRNKKNFCITITTDSTLAENTIKFRDTGPGIPANKRELVFDSFYTSDKKGGNGLGLSFCRRVINAFGGTIV
CNSKEGEWTEFIITLPKYDSKKVREIKNNILQEKRVLVTEDQPANRLLLSKFLSEINCQYEMAENGMRAIELLSEKRYDL
IFMDFEMQILNGDATVKHIRSADGMDPSLAIHYLDVPVVGLTSLPRKEALERARECGMNEVLIKPLKRTDFRKIIEKYFF
SGVKSIRHVKEELISGKRILLVDDNETSLKFMSIMLDHLGCNVDHALHGKEAIDLLEKEDFDLVLMDLEMPVMDGIEATM
AIRAGTHFHRFHSFRTIPIIALTGNDDEQNKQNIKNAGMNYHLCKPVFTDELISAITLVLNNNSEENETIPANNKKERPV
TNSATFWNTLYNENILDAATINSLIEIGGDELLESLFGNFSTDTDQLIGKLEKSVTTKDLKQYDFIIHTIKGSSGCIGAH
KMFVLCRYINEYSRKGEWPDNSTWMEILKTVYAETKHELQILINPETTPSS

Sequences:

>Translated_851_residues
MQKLKSLSKRIIEHAEPNLGIIGIFTTLGYPVYYIIWTFLFPQPYENLMLRIFCAFISIPCILYRHIPVSLKKFFPFYFY
LTFFIDVPYFFSFMLLKNECSTVWTMSLLTGIFMLILILSNWMVVSIMTILGFITAYATVMFLDGEVSFAFFQLEYIPVF
LFSFIGSIIANHNRQLAHQTKISLLKSLSGSIAHEMRNPLNAITNAIGSVHATLPKKADINTESKSYSVSHSCLMNIHQV
IEESSNTLNRANKIIDSILASMRGDEVSTGMFIRISVVDAIEAAVNSFPFNDAEEKKLIGINNIQNFNFLGDCDLFHYVL
FNLLKNSLYYRNKKNFCITITTDSTLAENTIKFRDTGPGIPANKRELVFDSFYTSDKKGGNGLGLSFCRRVINAFGGTIV
CNSKEGEWTEFIITLPKYDSKKVREIKNNILQEKRVLVTEDQPANRLLLSKFLSEINCQYEMAENGMRAIELLSEKRYDL
IFMDFEMQILNGDATVKHIRSADGMDPSLAIHYLDVPVVGLTSLPRKEALERARECGMNEVLIKPLKRTDFRKIIEKYFF
SGVKSIRHVKEELISGKRILLVDDNETSLKFMSIMLDHLGCNVDHALHGKEAIDLLEKEDFDLVLMDLEMPVMDGIEATM
AIRAGTHFHRFHSFRTIPIIALTGNDDEQNKQNIKNAGMNYHLCKPVFTDELISAITLVLNNNSEENETIPANNKKERPV
TNSATFWNTLYNENILDAATINSLIEIGGDELLESLFGNFSTDTDQLIGKLEKSVTTKDLKQYDFIIHTIKGSSGCIGAH
KMFVLCRYINEYSRKGEWPDNSTWMEILKTVYAETKHELQILINPETTPSS
>Mature_851_residues
MQKLKSLSKRIIEHAEPNLGIIGIFTTLGYPVYYIIWTFLFPQPYENLMLRIFCAFISIPCILYRHIPVSLKKFFPFYFY
LTFFIDVPYFFSFMLLKNECSTVWTMSLLTGIFMLILILSNWMVVSIMTILGFITAYATVMFLDGEVSFAFFQLEYIPVF
LFSFIGSIIANHNRQLAHQTKISLLKSLSGSIAHEMRNPLNAITNAIGSVHATLPKKADINTESKSYSVSHSCLMNIHQV
IEESSNTLNRANKIIDSILASMRGDEVSTGMFIRISVVDAIEAAVNSFPFNDAEEKKLIGINNIQNFNFLGDCDLFHYVL
FNLLKNSLYYRNKKNFCITITTDSTLAENTIKFRDTGPGIPANKRELVFDSFYTSDKKGGNGLGLSFCRRVINAFGGTIV
CNSKEGEWTEFIITLPKYDSKKVREIKNNILQEKRVLVTEDQPANRLLLSKFLSEINCQYEMAENGMRAIELLSEKRYDL
IFMDFEMQILNGDATVKHIRSADGMDPSLAIHYLDVPVVGLTSLPRKEALERARECGMNEVLIKPLKRTDFRKIIEKYFF
SGVKSIRHVKEELISGKRILLVDDNETSLKFMSIMLDHLGCNVDHALHGKEAIDLLEKEDFDLVLMDLEMPVMDGIEATM
AIRAGTHFHRFHSFRTIPIIALTGNDDEQNKQNIKNAGMNYHLCKPVFTDELISAITLVLNNNSEENETIPANNKKERPV
TNSATFWNTLYNENILDAATINSLIEIGGDELLESLFGNFSTDTDQLIGKLEKSVTTKDLKQYDFIIHTIKGSSGCIGAH
KMFVLCRYINEYSRKGEWPDNSTWMEILKTVYAETKHELQILINPETTPSS

Specific function: Senses the quorum-sensing autoinducer CAI-1 ((S)-3- hydroxytridecan-4-one) which probably functions as an intragenus signal. The sensory signal is then relayed to luxU and luxO [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=667, Percent_Identity=24.287856071964, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1788713, Length=375, Percent_Identity=25.3333333333333, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI48994928, Length=265, Percent_Identity=27.1698113207547, Blast_Score=90, Evalue=6e-19,
Organism=Escherichia coli, GI1788549, Length=255, Percent_Identity=27.0588235294118, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1790436, Length=252, Percent_Identity=23.4126984126984, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87081816, Length=509, Percent_Identity=22.3968565815324, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI145693157, Length=120, Percent_Identity=34.1666666666667, Blast_Score=66, Evalue=9e-12,
Organism=Escherichia coli, GI87082012, Length=148, Percent_Identity=24.3243243243243, Blast_Score=63, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=123, Percent_Identity=40.650406504065, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 96892; Mature: 96892

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLKSLSKRIIEHAEPNLGIIGIFTTLGYPVYYIIWTFLFPQPYENLMLRIFCAFISIP
CCHHHHHHHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
CILYRHIPVSLKKFFPFYFYLTFFIDVPYFFSFMLLKNECSTVWTMSLLTGIFMLILILS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NWMVVSIMTILGFITAYATVMFLDGEVSFAFFQLEYIPVFLFSFIGSIIANHNRQLAHQT
HHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHH
KISLLKSLSGSIAHEMRNPLNAITNAIGSVHATLPKKADINTESKSYSVSHSCLMNIHQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
IEESSNTLNRANKIIDSILASMRGDEVSTGMFIRISVVDAIEAAVNSFPFNDAEEKKLIG
HHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCEEEE
INNIQNFNFLGDCDLFHYVLFNLLKNSLYYRNKKNFCITITTDSTLAENTIKFRDTGPGI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCHHHHCCEEEECCCCCC
PANKRELVFDSFYTSDKKGGNGLGLSFCRRVINAFGGTIVCNSKEGEWTEFIITLPKYDS
CCCCCCEEEHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCCC
KKVREIKNNILQEKRVLVTEDQPANRLLLSKFLSEINCQYEMAENGMRAIELLSEKRYDL
HHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHCCCCCE
IFMDFEMQILNGDATVKHIRSADGMDPSLAIHYLDVPVVGLTSLPRKEALERARECGMNE
EEEEEEEEEECCCHHHHHHHHCCCCCCCEEEEEECCCEECCCCCCHHHHHHHHHHCCCHH
VLIKPLKRTDFRKIIEKYFFSGVKSIRHVKEELISGKRILLVDDNETSLKFMSIMLDHLG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHC
CNVDHALHGKEAIDLLEKEDFDLVLMDLEMPVMDGIEATMAIRAGTHFHRFHSFRTIPII
CCCCHHHCCHHHHHHHCCCCCCEEEEECCCCHHCCCHHHHHHHCCCHHHHHHCCCEEEEE
ALTGNDDEQNKQNIKNAGMNYHLCKPVFTDELISAITLVLNNNSEENETIPANNKKERPV
EEECCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
TNSATFWNTLYNENILDAATINSLIEIGGDELLESLFGNFSTDTDQLIGKLEKSVTTKDL
CCCHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
KQYDFIIHTIKGSSGCIGAHKMFVLCRYINEYSRKGEWPDNSTWMEILKTVYAETKHELQ
HHHCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEE
ILINPETTPSS
EEECCCCCCCC
>Mature Secondary Structure
MQKLKSLSKRIIEHAEPNLGIIGIFTTLGYPVYYIIWTFLFPQPYENLMLRIFCAFISIP
CCHHHHHHHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
CILYRHIPVSLKKFFPFYFYLTFFIDVPYFFSFMLLKNECSTVWTMSLLTGIFMLILILS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NWMVVSIMTILGFITAYATVMFLDGEVSFAFFQLEYIPVFLFSFIGSIIANHNRQLAHQT
HHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHH
KISLLKSLSGSIAHEMRNPLNAITNAIGSVHATLPKKADINTESKSYSVSHSCLMNIHQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
IEESSNTLNRANKIIDSILASMRGDEVSTGMFIRISVVDAIEAAVNSFPFNDAEEKKLIG
HHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCEEEE
INNIQNFNFLGDCDLFHYVLFNLLKNSLYYRNKKNFCITITTDSTLAENTIKFRDTGPGI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCHHHHCCEEEECCCCCC
PANKRELVFDSFYTSDKKGGNGLGLSFCRRVINAFGGTIVCNSKEGEWTEFIITLPKYDS
CCCCCCEEEHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCCC
KKVREIKNNILQEKRVLVTEDQPANRLLLSKFLSEINCQYEMAENGMRAIELLSEKRYDL
HHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHCCCCCE
IFMDFEMQILNGDATVKHIRSADGMDPSLAIHYLDVPVVGLTSLPRKEALERARECGMNE
EEEEEEEEEECCCHHHHHHHHCCCCCCCEEEEEECCCEECCCCCCHHHHHHHHHHCCCHH
VLIKPLKRTDFRKIIEKYFFSGVKSIRHVKEELISGKRILLVDDNETSLKFMSIMLDHLG
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHC
CNVDHALHGKEAIDLLEKEDFDLVLMDLEMPVMDGIEATMAIRAGTHFHRFHSFRTIPII
CCCCHHHCCHHHHHHHCCCCCCEEEEECCCCHHCCCHHHHHHHCCCHHHHHHCCCEEEEE
ALTGNDDEQNKQNIKNAGMNYHLCKPVFTDELISAITLVLNNNSEENETIPANNKKERPV
EEECCCCHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
TNSATFWNTLYNENILDAATINSLIEIGGDELLESLFGNFSTDTDQLIGKLEKSVTTKDL
CCCHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
KQYDFIIHTIKGSSGCIGAHKMFVLCRYINEYSRKGEWPDNSTWMEILKTVYAETKHELQ
HHHCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEE
ILINPETTPSS
EEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]