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The map label for this gene is hpt [H]

Identifier: 119357713

GI number: 119357713

Start: 2224547

End: 2225080

Strand: Direct

Name: hpt [H]

Synonym: Cpha266_1917

Alternate gene names: 119357713

Gene position: 2224547-2225080 (Clockwise)

Preceding gene: 119357712

Following gene: 119357714

Centisome position: 70.98

GC content: 49.81

Gene sequence:

>534_bases
ATGAACCCGAATTACAACGCCGTTACCGAGTTTATTTCGGCTGAACGTCTCCACAACCGCATCTGCGAACTGGGATGCGA
TATATCGAGGGATTATGCGGGAATTCCGACGCCGCTCGTAATAATCGGCGTGCTGAAAGGGGCATTCGTCGTCTTCGCCG
ATCTCGTCAGGGCAATAACCATTCCATGTACGATTGACTTTCTTCATGCATCAAGCTATGGTTCGAAAACGGTCTCTTCA
GGAACCGTCACCATCCGGCACAAACTCTCCTCCATTCAAAATCGACATGTTCTGCTTGTCGAAGACATTATCGACAGCGG
ACTTACGATGCAGCGCATAACCGATGATCTTCAGCAAATGCATCCTGCGTCCATGAAGATTTTCACACTGCTCGACAAAC
CGGAAAGCCGTAAACACCCCGTTGCTATTGCCTACACCGGGTTTGTTGTCCCCGACAAATTCATTGTCGGCTACGGGATC
GACTTTAATGAACAGTACCGGGAACTCCCCGCTATCGGCATTATCAACCCGTGA

Upstream 100 bases:

>100_bases
CATTTGAAGCCTCTGTATTAAGCAATGTCCAGAAAAAACTCTACCTACAGAAACTGGATCATTACGTAGACTCGTTTATT
CAGTAACCCTGATTATCACG

Downstream 100 bases:

>100_bases
ACCGACCGCCATCCAACCCCCGCTGAACAGTTGCGGATATGCGCGTCAGCGACATCCTCCCTGCACGTCCTTCAGATACC
TGAAATAACACAATAATGTC

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MNPNYNAVTEFISAERLHNRICELGCDISRDYAGIPTPLVIIGVLKGAFVVFADLVRAITIPCTIDFLHASSYGSKTVSS
GTVTIRHKLSSIQNRHVLLVEDIIDSGLTMQRITDDLQQMHPASMKIFTLLDKPESRKHPVAIAYTGFVVPDKFIVGYGI
DFNEQYRELPAIGIINP

Sequences:

>Translated_177_residues
MNPNYNAVTEFISAERLHNRICELGCDISRDYAGIPTPLVIIGVLKGAFVVFADLVRAITIPCTIDFLHASSYGSKTVSS
GTVTIRHKLSSIQNRHVLLVEDIIDSGLTMQRITDDLQQMHPASMKIFTLLDKPESRKHPVAIAYTGFVVPDKFIVGYGI
DFNEQYRELPAIGIINP
>Mature_177_residues
MNPNYNAVTEFISAERLHNRICELGCDISRDYAGIPTPLVIIGVLKGAFVVFADLVRAITIPCTIDFLHASSYGSKTVSS
GTVTIRHKLSSIQNRHVLLVEDIIDSGLTMQRITDDLQQMHPASMKIFTLLDKPESRKHPVAIAYTGFVVPDKFIVGYGI
DFNEQYRELPAIGIINP

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=177, Percent_Identity=34.4632768361582, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI9910262, Length=168, Percent_Identity=30.3571428571429, Blast_Score=88, Evalue=4e-18,
Organism=Escherichia coli, GI87081689, Length=169, Percent_Identity=41.4201183431953, Blast_Score=136, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17510817, Length=170, Percent_Identity=31.1764705882353, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19630; Mature: 19630

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPNYNAVTEFISAERLHNRICELGCDISRDYAGIPTPLVIIGVLKGAFVVFADLVRAIT
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
IPCTIDFLHASSYGSKTVSSGTVTIRHKLSSIQNRHVLLVEDIIDSGLTMQRITDDLQQM
CCCEEEEEECCCCCCCCCCCCEEEEEEHHHHHCCCCEEEEHHHHCCCCCHHHHHHHHHHH
HPASMKIFTLLDKPESRKHPVAIAYTGFVVPDKFIVGYGIDFNEQYRELPAIGIINP
CCCCEEEEEEECCCCCCCCCEEEEEECEECCCCEEEEECCCCCHHHHHCCCCCCCCC
>Mature Secondary Structure
MNPNYNAVTEFISAERLHNRICELGCDISRDYAGIPTPLVIIGVLKGAFVVFADLVRAIT
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
IPCTIDFLHASSYGSKTVSSGTVTIRHKLSSIQNRHVLLVEDIIDSGLTMQRITDDLQQM
CCCEEEEEECCCCCCCCCCCCEEEEEEHHHHHCCCCEEEEHHHHCCCCCHHHHHHHHHHH
HPASMKIFTLLDKPESRKHPVAIAYTGFVVPDKFIVGYGIDFNEQYRELPAIGIINP
CCCCEEEEEEECCCCCCCCCEEEEEECEECCCCEEEEECCCCCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663927 [H]