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The map label for this gene is menA [H]

Identifier: 119357700

GI number: 119357700

Start: 2212215

End: 2213069

Strand: Reverse

Name: menA [H]

Synonym: Cpha266_1904

Alternate gene names: 119357700

Gene position: 2213069-2212215 (Counterclockwise)

Preceding gene: 119357701

Following gene: 119357699

Centisome position: 70.62

GC content: 52.28

Gene sequence:

>855_bases
ATGCTTGCCGTACGTCCAAAAACTCTTCCGGCGGGCGCCGTGCCGGTGTTGCTTGGTTCCGCGCTTGCGGCTGCTGATGA
CCGCTTCAGTCTGTTCTCTGCTTTGATTGCTCTTTTCTGCGCGCTGGGCATTCAGATAGCAACCAATTTCATCAACGAGA
TATACGATTTTCGCAAAGGGGCAGATACGGTTCAGAGGCTCGGCCCAACAAGAACCGTTGCTGCCGGAATTATCAGCGAA
AAGACCATGATTCGTGTATCGGCCACCCTTCTGATATCTGTTTTTCTGCTGGGACTCGTTCTTGTGTACAGCGCCGGCTG
GCCGATTTTACTGGTAGGTTTGCTCTCTATGCTTTTCGCCTGGGCTTATACCGGCGGACCTTATCCGATTGCCTATTCAG
GGCTTGGGGATGTTTTTGTTTTTATTTTTTTCGGACTGGTTGCGACAGGAGGTACCTACTATGTGCAGGCGCTTGAGCTG
CATTCCTCAATACTTCTTGCTGCGGCGGCTCCAGGAGCTTTTTCTGTCAATATTCTTCTGGTTAACAATATCCGGGATAT
CGACACCGACCGTACTGTCGGCAAGATGACGTTGCCAGCCCGTATCGGTGCTGCGTCGGCAAGAAAGCTCTATGTTCTGC
TGACTGTGCTCGCATATCTTGTTCCGGTGGCGGTATGGATGAATGGCTACTCCGTTTGGAGTCTGCTCTCACTCCTCTCT
TTTCCTCTTGCGGTCGGCATGATCCGTGCGCTCTACGCTTCCGGGGGCAGGGCGTTGAACGATGTTCTTGCCGGTACGGG
AAAAGTCATGACTATTCACGGCCTTCTTTTTGCCGCGGGGCTTCTCATTCACTAA

Upstream 100 bases:

>100_bases
AAGCACACCTTCAGCAGTGTTAAAATGGCCAGGGAAAAAAAGAATGCAAAATGAGATTTCGTCAACCCCTGCTCCCGCAT
TGACTCCGTTCGGGGCATGG

Downstream 100 bases:

>100_bases
CAACGATGATATCAATGCCGTCGGAAACAGTTACCATCGCACTTCTTCAAACAACATCGTCAGAAAGACCGGAAGAGAAC
CTCGCCGAAGCGGATCGCCT

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MLAVRPKTLPAGAVPVLLGSALAAADDRFSLFSALIALFCALGIQIATNFINEIYDFRKGADTVQRLGPTRTVAAGIISE
KTMIRVSATLLISVFLLGLVLVYSAGWPILLVGLLSMLFAWAYTGGPYPIAYSGLGDVFVFIFFGLVATGGTYYVQALEL
HSSILLAAAAPGAFSVNILLVNNIRDIDTDRTVGKMTLPARIGAASARKLYVLLTVLAYLVPVAVWMNGYSVWSLLSLLS
FPLAVGMIRALYASGGRALNDVLAGTGKVMTIHGLLFAAGLLIH

Sequences:

>Translated_284_residues
MLAVRPKTLPAGAVPVLLGSALAAADDRFSLFSALIALFCALGIQIATNFINEIYDFRKGADTVQRLGPTRTVAAGIISE
KTMIRVSATLLISVFLLGLVLVYSAGWPILLVGLLSMLFAWAYTGGPYPIAYSGLGDVFVFIFFGLVATGGTYYVQALEL
HSSILLAAAAPGAFSVNILLVNNIRDIDTDRTVGKMTLPARIGAASARKLYVLLTVLAYLVPVAVWMNGYSVWSLLSLLS
FPLAVGMIRALYASGGRALNDVLAGTGKVMTIHGLLFAAGLLIH
>Mature_284_residues
MLAVRPKTLPAGAVPVLLGSALAAADDRFSLFSALIALFCALGIQIATNFINEIYDFRKGADTVQRLGPTRTVAAGIISE
KTMIRVSATLLISVFLLGLVLVYSAGWPILLVGLLSMLFAWAYTGGPYPIAYSGLGDVFVFIFFGLVATGGTYYVQALEL
HSSILLAAAAPGAFSVNILLVNNIRDIDTDRTVGKMTLPARIGAASARKLYVLLTVLAYLVPVAVWMNGYSVWSLLSLLS
FPLAVGMIRALYASGGRALNDVLAGTGKVMTIHGLLFAAGLLIH

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=296, Percent_Identity=31.0810810810811, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1790365, Length=290, Percent_Identity=35.1724137931034, Blast_Score=145, Evalue=2e-36,
Organism=Drosophila melanogaster, GI17737429, Length=284, Percent_Identity=29.5774647887324, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 30026; Mature: 30026

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAVRPKTLPAGAVPVLLGSALAAADDRFSLFSALIALFCALGIQIATNFINEIYDFRKG
CCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ADTVQRLGPTRTVAAGIISEKTMIRVSATLLISVFLLGLVLVYSAGWPILLVGLLSMLFA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
WAYTGGPYPIAYSGLGDVFVFIFFGLVATGGTYYVQALELHSSILLAAAAPGAFSVNILL
HHHCCCCCCEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCEEEEEEE
VNNIRDIDTDRTVGKMTLPARIGAASARKLYVLLTVLAYLVPVAVWMNGYSVWSLLSLLS
EECCCCCCCCCCCCCEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
FPLAVGMIRALYASGGRALNDVLAGTGKVMTIHGLLFAAGLLIH
HHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLAVRPKTLPAGAVPVLLGSALAAADDRFSLFSALIALFCALGIQIATNFINEIYDFRKG
CCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ADTVQRLGPTRTVAAGIISEKTMIRVSATLLISVFLLGLVLVYSAGWPILLVGLLSMLFA
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
WAYTGGPYPIAYSGLGDVFVFIFFGLVATGGTYYVQALELHSSILLAAAAPGAFSVNILL
HHHCCCCCCEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCEEEEEEE
VNNIRDIDTDRTVGKMTLPARIGAASARKLYVLLTVLAYLVPVAVWMNGYSVWSLLSLLS
EECCCCCCCCCCCCCEECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
FPLAVGMIRALYASGGRALNDVLAGTGKVMTIHGLLFAAGLLIH
HHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]