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The map label for this gene is proA [H]

Identifier: 119357661

GI number: 119357661

Start: 2161179

End: 2162435

Strand: Direct

Name: proA [H]

Synonym: Cpha266_1865

Alternate gene names: 119357661

Gene position: 2161179-2162435 (Clockwise)

Preceding gene: 119357660

Following gene: 119357662

Centisome position: 68.96

GC content: 51.07

Gene sequence:

>1257_bases
ATGCAGAGAATCATTACGGAAAAGCTCAAGGCGGTCCGGGAGGCAAGCCGAAAGATCATTACTCTTGATGACAAGGCTAT
CAACGCTCTCCTTCTTGACCTTGCCGCTCATATTCCCCTTCACAGCCCGGCCATTCTTGAGGCGAACCAGAGGGATCTTG
AGCTGATGGATCCTGCTGATCCGAAATATGACCGCCTGCTTCTGACAAAAGAAAGGCTTGAAGCCATTGCCGGAGATATC
AGAAATGTAGCCGCCCTCTCCTCCCCTCTTGATCTTGTGCTTGAACAGCGAATCCTGAAGAACGGCATCAGCCTGCATAA
GGTAACCGTTCCTCTCGGAGTTATCGGCATCATCTATGAATCGCGGCCCAATGTTACCTTTGACGTTTTCGCGCTCTCTT
TGAAATCCGGCAATGCAACCGTGCTCAAAGGGGGAAGCGATGCCATGCATTCGAATATCGCAATCGTTGACCTCATCCAT
ACCGTCCTTCAGAAACACGGAATCAATACCGATACCATCTACCTGCTACCCGCCCGGCGAGAAGCAGCCGCCGTGATGCT
CAATGCTGTCGGAGCCATTGACGTTATTATTCCTCGGGGAAGTCAGCAGCTTATTGATTTTGTAAGAAAAAACTCGACTG
TACCGGTCATTGAAACCGGTGCGGGCATTGTGCACACCTATTTCGACAAAAGCGGCAACCTTGCGATGGGACAGGCAATC
GTGTTCAACGCAAAAACACGACGCCCAAGTGTCTGCAATGCACTTGATACGCTGATCATCCACAGCGATCGCCTTTGTGA
CCTTTCAGAACTCCTGCAACCGCTCCAGGAAAAAAAGGTGGTGATCTTTGCAGACAGCAGCGCATATCCTGAACTCGTCG
GCAATTACCCCGAAGAGCTCCTTCAGCATGCCGAACCGGAGCATTTCGGCACGGAGTTTCTTTCCTTGAAAATGTCGGTA
AAAACGGTTGGAAACCTTGAAGAAGCCCTCAGCCACATTGCCACCTACAGCTCGCAGCACAGTGAAGCCATTATAGCCGA
TGACCCTGCTGTTAAAGCCGAGTTTCTCAAGCGTGTCGATGCAGCCGTGGTCTATGCCAACACCTCGACAGCATTCACTG
ACGGCGCACAGTTCGGACTTGGAGCGGAAATCGGCATCAGCACCCAGAAGCTGCACGCAAGAGGCCCTATGGCACTCAAA
GAGCTATGCAGTTACAAATGGATTCTTGAAGGAAACGGACAAACAAGGCCTGTATAA

Upstream 100 bases:

>100_bases
CTTATGGGTCAACAGGATCAGAAGCCGCTGATTCACTACGATTATCTCTATATCACGCACTGAAAAGCAGAACAACAGAA
CCTATCTGATAAACGAACCA

Downstream 100 bases:

>100_bases
TGATACTCGAGGTAAAAAAAATCTGCAAATCATACGCACTCCCCTCCAGAGACGCCATTCCGATTCTCAGAGGAATTGAT
ATGGTCGTCGGCGAAGGCGA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MQRIITEKLKAVREASRKIITLDDKAINALLLDLAAHIPLHSPAILEANQRDLELMDPADPKYDRLLLTKERLEAIAGDI
RNVAALSSPLDLVLEQRILKNGISLHKVTVPLGVIGIIYESRPNVTFDVFALSLKSGNATVLKGGSDAMHSNIAIVDLIH
TVLQKHGINTDTIYLLPARREAAAVMLNAVGAIDVIIPRGSQQLIDFVRKNSTVPVIETGAGIVHTYFDKSGNLAMGQAI
VFNAKTRRPSVCNALDTLIIHSDRLCDLSELLQPLQEKKVVIFADSSAYPELVGNYPEELLQHAEPEHFGTEFLSLKMSV
KTVGNLEEALSHIATYSSQHSEAIIADDPAVKAEFLKRVDAAVVYANTSTAFTDGAQFGLGAEIGISTQKLHARGPMALK
ELCSYKWILEGNGQTRPV

Sequences:

>Translated_418_residues
MQRIITEKLKAVREASRKIITLDDKAINALLLDLAAHIPLHSPAILEANQRDLELMDPADPKYDRLLLTKERLEAIAGDI
RNVAALSSPLDLVLEQRILKNGISLHKVTVPLGVIGIIYESRPNVTFDVFALSLKSGNATVLKGGSDAMHSNIAIVDLIH
TVLQKHGINTDTIYLLPARREAAAVMLNAVGAIDVIIPRGSQQLIDFVRKNSTVPVIETGAGIVHTYFDKSGNLAMGQAI
VFNAKTRRPSVCNALDTLIIHSDRLCDLSELLQPLQEKKVVIFADSSAYPELVGNYPEELLQHAEPEHFGTEFLSLKMSV
KTVGNLEEALSHIATYSSQHSEAIIADDPAVKAEFLKRVDAAVVYANTSTAFTDGAQFGLGAEIGISTQKLHARGPMALK
ELCSYKWILEGNGQTRPV
>Mature_418_residues
MQRIITEKLKAVREASRKIITLDDKAINALLLDLAAHIPLHSPAILEANQRDLELMDPADPKYDRLLLTKERLEAIAGDI
RNVAALSSPLDLVLEQRILKNGISLHKVTVPLGVIGIIYESRPNVTFDVFALSLKSGNATVLKGGSDAMHSNIAIVDLIH
TVLQKHGINTDTIYLLPARREAAAVMLNAVGAIDVIIPRGSQQLIDFVRKNSTVPVIETGAGIVHTYFDKSGNLAMGQAI
VFNAKTRRPSVCNALDTLIIHSDRLCDLSELLQPLQEKKVVIFADSSAYPELVGNYPEELLQHAEPEHFGTEFLSLKMSV
KTVGNLEEALSHIATYSSQHSEAIIADDPAVKAEFLKRVDAAVVYANTSTAFTDGAQFGLGAEIGISTQKLHARGPMALK
ELCSYKWILEGNGQTRPV

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=414, Percent_Identity=35.2657004830918, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI62912457, Length=414, Percent_Identity=35.2657004830918, Blast_Score=227, Evalue=2e-59,
Organism=Escherichia coli, GI1786438, Length=412, Percent_Identity=40.0485436893204, Blast_Score=285, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17569969, Length=419, Percent_Identity=36.2768496420048, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI17569967, Length=419, Percent_Identity=36.2768496420048, Blast_Score=238, Evalue=5e-63,
Organism=Saccharomyces cerevisiae, GI6324899, Length=424, Percent_Identity=34.1981132075472, Blast_Score=236, Evalue=4e-63,
Organism=Drosophila melanogaster, GI21357643, Length=376, Percent_Identity=35.3723404255319, Blast_Score=221, Evalue=5e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: NA

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45539; Mature: 45539

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRIITEKLKAVREASRKIITLDDKAINALLLDLAAHIPLHSPAILEANQRDLELMDPAD
CCHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHCCCCCCCEECCCCCCCEEECCCC
PKYDRLLLTKERLEAIAGDIRNVAALSSPLDLVLEQRILKNGISLHKVTVPLGVIGIIYE
CCHHHEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCEEEEEEEE
SRPNVTFDVFALSLKSGNATVLKGGSDAMHSNIAIVDLIHTVLQKHGINTDTIYLLPARR
CCCCCEEEEEEEEECCCCEEEEECCCHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCC
EAAAVMLNAVGAIDVIIPRGSQQLIDFVRKNSTVPVIETGAGIVHTYFDKSGNLAMGQAI
HHHHHHHHHCCEEEEEECCCHHHHHHHHHCCCCCCEEECCCCEEEEEECCCCCEEECEEE
VFNAKTRRPSVCNALDTLIIHSDRLCDLSELLQPLQEKKVVIFADSSAYPELVGNYPEEL
EEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEEEEECCCCCHHHHCCCHHHH
LQHAEPEHFGTEFLSLKMSVKTVGNLEEALSHIATYSSQHSEAIIADDPAVKAEFLKRVD
HHHCCCCHHCCHHHEEEEHHHHHCCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHC
AAVVYANTSTAFTDGAQFGLGAEIGISTQKLHARGPMALKELCSYKWILEGNGQTRPV
EEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHCEEEEEECCCCCCCC
>Mature Secondary Structure
MQRIITEKLKAVREASRKIITLDDKAINALLLDLAAHIPLHSPAILEANQRDLELMDPAD
CCHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHCCCCCCCEECCCCCCCEEECCCC
PKYDRLLLTKERLEAIAGDIRNVAALSSPLDLVLEQRILKNGISLHKVTVPLGVIGIIYE
CCHHHEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEECCEEEEEEEE
SRPNVTFDVFALSLKSGNATVLKGGSDAMHSNIAIVDLIHTVLQKHGINTDTIYLLPARR
CCCCCEEEEEEEEECCCCEEEEECCCHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEECCC
EAAAVMLNAVGAIDVIIPRGSQQLIDFVRKNSTVPVIETGAGIVHTYFDKSGNLAMGQAI
HHHHHHHHHCCEEEEEECCCHHHHHHHHHCCCCCCEEECCCCEEEEEECCCCCEEECEEE
VFNAKTRRPSVCNALDTLIIHSDRLCDLSELLQPLQEKKVVIFADSSAYPELVGNYPEEL
EEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEEEEECCCCCHHHHCCCHHHH
LQHAEPEHFGTEFLSLKMSVKTVGNLEEALSHIATYSSQHSEAIIADDPAVKAEFLKRVD
HHHCCCCHHCCHHHEEEEHHHHHCCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHC
AAVVYANTSTAFTDGAQFGLGAEIGISTQKLHARGPMALKELCSYKWILEGNGQTRPV
EEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA