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The map label for this gene is yvaE [H]

Identifier: 119357659

GI number: 119357659

Start: 2159678

End: 2160049

Strand: Direct

Name: yvaE [H]

Synonym: Cpha266_1863

Alternate gene names: 119357659

Gene position: 2159678-2160049 (Clockwise)

Preceding gene: 119357653

Following gene: 119357660

Centisome position: 68.91

GC content: 44.62

Gene sequence:

>372_bases
ATGAAGCGCAATTATTATACCAATAATCAGAACCCCAATCGACCGATGCCCTGGCTCTATCTTGTACTCGCCATTATCTT
CGAAGTTTCCGGCACGACATGCATGAAGCTTTCGGAAGGTTTCACCAGAATTGTACCGACACTTTTTATCTTTATCTTTT
ATGCGGTGAGTTTTACCTTTGTAACGCTGACCGTGAAAGTGCTGCCGTTAGGACTGACCTATGCAGTCTGGTCGGCTATC
GGTACAGCCTCCATCACGATAGTCGGAATTTTCTGGTTTGGCGAAGGAATCAACATCGTTAAAACAATTTCCCTGCTTTT
TATTATTATCGGTGTGGTCGGGCTGCATTTCAGTCAGGAACACCTCCAATGA

Upstream 100 bases:

>100_bases
ATGACCCATTTCAATGAGAACCCGGACCGGGCCATAGCGTTGAATACTGTAATCTGTTGCTAAATATGCATATCTTTTGG
ATTATGACAAAAAGACAAGC

Downstream 100 bases:

>100_bases
CTTATGAATAATCAGGAACTACTGTACAAAAAAATAGTTGTCAAAGTCGGAACCAATGTCATCACGGACAAACATGGCGA
CCTCGATCTTGACATTCTTA

Product: small multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 123; Mature: 123

Protein sequence:

>123_residues
MKRNYYTNNQNPNRPMPWLYLVLAIIFEVSGTTCMKLSEGFTRIVPTLFIFIFYAVSFTFVTLTVKVLPLGLTYAVWSAI
GTASITIVGIFWFGEGINIVKTISLLFIIIGVVGLHFSQEHLQ

Sequences:

>Translated_123_residues
MKRNYYTNNQNPNRPMPWLYLVLAIIFEVSGTTCMKLSEGFTRIVPTLFIFIFYAVSFTFVTLTVKVLPLGLTYAVWSAI
GTASITIVGIFWFGEGINIVKTISLLFIIIGVVGLHFSQEHLQ
>Mature_123_residues
MKRNYYTNNQNPNRPMPWLYLVLAIIFEVSGTTCMKLSEGFTRIVPTLFIFIFYAVSFTFVTLTVKVLPLGLTYAVWSAI
GTASITIVGIFWFGEGINIVKTISLLFIIIGVVGLHFSQEHLQ

Specific function: Multidrug Transporter. Confers Resistance To A Wide Range Of Toxic Compounds By Removing Them For The Cells. The Efflux Is Coupled To An Influx Of Protons. Probably Prevents The Incorporation Of Methyl VIologen Into Cells. Involved In Ethidium Bromide Ef

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=97, Percent_Identity=39.1752577319588, Blast_Score=73, Evalue=6e-15,
Organism=Escherichia coli, GI87082378, Length=105, Percent_Identity=35.2380952380952, Blast_Score=72, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 13885; Mature: 13885

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRNYYTNNQNPNRPMPWLYLVLAIIFEVSGTTCMKLSEGFTRIVPTLFIFIFYAVSFTF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTLTVKVLPLGLTYAVWSAIGTASITIVGIFWFGEGINIVKTISLLFIIIGVVGLHFSQE
HHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHH
HLQ
HCC
>Mature Secondary Structure
MKRNYYTNNQNPNRPMPWLYLVLAIIFEVSGTTCMKLSEGFTRIVPTLFIFIFYAVSFTF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTLTVKVLPLGLTYAVWSAIGTASITIVGIFWFGEGINIVKTISLLFIIIGVVGLHFSQE
HHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHH
HLQ
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]