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The map label for this gene is wecG [H]

Identifier: 119357627

GI number: 119357627

Start: 2087046

End: 2088818

Strand: Reverse

Name: wecG [H]

Synonym: Cpha266_1831

Alternate gene names: 119357627

Gene position: 2088818-2087046 (Counterclockwise)

Preceding gene: 119357628

Following gene: 119357626

Centisome position: 66.65

GC content: 45.8

Gene sequence:

>1773_bases
ATGATGAAAACAAAGTGTTCTGCAGATCATGTTCCGGGATATGAGTTTTTCTCAAAAGCTCTTGTTCTTGGAAGAAAAGA
GAGCGTTGCCGAACTGTTCCGTTTGCTTGAAAGGAGCTATCAGCAGGTGATGCTTGCAGAAAATACAGGAGAACTGGAAG
ATCTAAAGCCTGAAAAACATTTGTTCAGGCTTGCAGTCATGACTGACAGTTTTTCTGAAACGCTGAGTTTGGGACTGGTT
AACCGTGTGAGGCAGAACTTTGGTCCTGAAAACATGATCTGCCTTTCGACCGATGACGATCAGGAAAAAGAGCGCGTTCT
TCGTTCAGCAGGTTTGATTTATTTTGGTAGTTACGGGAGTTTTTCTGCTTTTGCGGAAAAGATTATCAACCAAACGTTGA
CCGGCCATCAAAACCGGTCGAGGACTGCAATGGAGTCGAGAACAGATAGTGCGAGGGCTCTTGAAAAAAGACTTACAGAC
CGTTCGTTATCGATGAAAAGTATCTTTAAAAGGGTACTCTTCAGGATTGGTGCTCTAACGGCGGAAGTACTGGAAAGAGT
CATTGAATTCGTGGTTGCGTTTGTTATGACGCTATTGCTCACCGTTCCATTGCTTGGTATTCTCTTGTTCAGGAAGCTTT
TTACCGGTACACCGGTTTTTGTCAAACGGACAGTAGAAGGTGCTTTTGCAAAACCTTTAATGGTTTTCCGGTTCAGGGAT
TTGCCTGCTCCTTTTTGTGATTTGCCTCTTTTTCTTGAGCTTTTTACCGGAAGGCTTGCTCTTGCAGGTACGGCAATCAA
AAGCTGGAGCGAACGTTCAGCCGTTCCTGAAAATGCCTATATTCGTCTGGTTAAACCCGGTATTGTCTCGCTTTGGGATA
TTCGCAATTCCAGCAAAACCGCTCATGAGGGGCAGCAGGCGATTGAATGGGAGTATGTTTTCAAAAAACGCCTGTTTTAC
GATTTCATGCTGATATTGCGCGCTTTACCGGTGATGCTGTACAGTGAAAACAGCGGTATTTCATCAGCGATCTTTCCTCT
GCTTGGTCTCAATCTCAACAATCTGACCATGGATGAAGCGATTTCTGTCATGCAGAGAACCCTTGAGGAGAAAAAGCAGA
GCGCAATTTATTTTGTAAATCCAGACTGTCTCAATAAAATGGTCTCCGACAGGAAGTATTTCAACACGCTCAAAACAGGC
GATTATGTGTTTCCTGACGGGATAGGCCTGAGTATTGCGGGGAAAATGCTTGGAACGCCTCTCAGAGAAAATATCAACGG
TACCGATATGCTTCCTTATCTTTGCAGAATGGCCGCAGCTGAAGGGTACCCGGTTTTTCTCCTGGGAGGCAAACCCGGAA
TTGCTGAAAAGGCCGGACAAAACATCAGCAAAACGTATGGGGTGACCATAGCAGGCAGCGCTGACGGTTATTTTGATCAT
CAGCATGATAGCGATGCTGTTATTGAGCAGATAAATAGTTCGGGAGCCGCAATTCTTCTGGTGGCTTTCGGGGCTCCACT
GCAAGAGATCTGGATTGCAAGGCACCGTCAAAAACTTTCGCCGAGGGTGTTGATGGGCGTAGGCGGTCTGTTCGACTTTT
ATTCCGGCACCATCAGGCGTGCGCCGCGCTGGATACGTGAGATCGGGTTTGAGTGGGTATACAGAATTCTCCAGGAGCCG
GGCAGGATGTGGAGGCGGTATGTTATAGGTAATCCTCTTTTTCTCTACAGGGTAATGAAATGGAAAGTGTTTACACAAAG
TAATAGTCTGTAA

Upstream 100 bases:

>100_bases
CTTTGGCCTGTTGTGCCGTGACGGCATGATGTTCTGGCATCGTTATTGCATAAGAATTCGTAAAACACGTTTTTTTATGG
ACGATCCGGATTCTGTCATC

Downstream 100 bases:

>100_bases
TTCTCATGGAGCTTGATCCAACAGTACGAAAAGAACTGATACGCAAAATAAGCGACTCTATCAGCCCCGGATTCCGATAC
AGAAGGAGACTTAAGGTCAT

Product: N-acetylmannosaminyltransferase

Products: C55-PP-GlcNAc-ManNAcA; UDP [C]

Alternate protein names: UDP-ManNAcA transferase [H]

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MMKTKCSADHVPGYEFFSKALVLGRKESVAELFRLLERSYQQVMLAENTGELEDLKPEKHLFRLAVMTDSFSETLSLGLV
NRVRQNFGPENMICLSTDDDQEKERVLRSAGLIYFGSYGSFSAFAEKIINQTLTGHQNRSRTAMESRTDSARALEKRLTD
RSLSMKSIFKRVLFRIGALTAEVLERVIEFVVAFVMTLLLTVPLLGILLFRKLFTGTPVFVKRTVEGAFAKPLMVFRFRD
LPAPFCDLPLFLELFTGRLALAGTAIKSWSERSAVPENAYIRLVKPGIVSLWDIRNSSKTAHEGQQAIEWEYVFKKRLFY
DFMLILRALPVMLYSENSGISSAIFPLLGLNLNNLTMDEAISVMQRTLEEKKQSAIYFVNPDCLNKMVSDRKYFNTLKTG
DYVFPDGIGLSIAGKMLGTPLRENINGTDMLPYLCRMAAAEGYPVFLLGGKPGIAEKAGQNISKTYGVTIAGSADGYFDH
QHDSDAVIEQINSSGAAILLVAFGAPLQEIWIARHRQKLSPRVLMGVGGLFDFYSGTIRRAPRWIREIGFEWVYRILQEP
GRMWRRYVIGNPLFLYRVMKWKVFTQSNSL

Sequences:

>Translated_590_residues
MMKTKCSADHVPGYEFFSKALVLGRKESVAELFRLLERSYQQVMLAENTGELEDLKPEKHLFRLAVMTDSFSETLSLGLV
NRVRQNFGPENMICLSTDDDQEKERVLRSAGLIYFGSYGSFSAFAEKIINQTLTGHQNRSRTAMESRTDSARALEKRLTD
RSLSMKSIFKRVLFRIGALTAEVLERVIEFVVAFVMTLLLTVPLLGILLFRKLFTGTPVFVKRTVEGAFAKPLMVFRFRD
LPAPFCDLPLFLELFTGRLALAGTAIKSWSERSAVPENAYIRLVKPGIVSLWDIRNSSKTAHEGQQAIEWEYVFKKRLFY
DFMLILRALPVMLYSENSGISSAIFPLLGLNLNNLTMDEAISVMQRTLEEKKQSAIYFVNPDCLNKMVSDRKYFNTLKTG
DYVFPDGIGLSIAGKMLGTPLRENINGTDMLPYLCRMAAAEGYPVFLLGGKPGIAEKAGQNISKTYGVTIAGSADGYFDH
QHDSDAVIEQINSSGAAILLVAFGAPLQEIWIARHRQKLSPRVLMGVGGLFDFYSGTIRRAPRWIREIGFEWVYRILQEP
GRMWRRYVIGNPLFLYRVMKWKVFTQSNSL
>Mature_590_residues
MMKTKCSADHVPGYEFFSKALVLGRKESVAELFRLLERSYQQVMLAENTGELEDLKPEKHLFRLAVMTDSFSETLSLGLV
NRVRQNFGPENMICLSTDDDQEKERVLRSAGLIYFGSYGSFSAFAEKIINQTLTGHQNRSRTAMESRTDSARALEKRLTD
RSLSMKSIFKRVLFRIGALTAEVLERVIEFVVAFVMTLLLTVPLLGILLFRKLFTGTPVFVKRTVEGAFAKPLMVFRFRD
LPAPFCDLPLFLELFTGRLALAGTAIKSWSERSAVPENAYIRLVKPGIVSLWDIRNSSKTAHEGQQAIEWEYVFKKRLFY
DFMLILRALPVMLYSENSGISSAIFPLLGLNLNNLTMDEAISVMQRTLEEKKQSAIYFVNPDCLNKMVSDRKYFNTLKTG
DYVFPDGIGLSIAGKMLGTPLRENINGTDMLPYLCRMAAAEGYPVFLLGGKPGIAEKAGQNISKTYGVTIAGSADGYFDH
QHDSDAVIEQINSSGAAILLVAFGAPLQEIWIARHRQKLSPRVLMGVGGLFDFYSGTIRRAPRWIREIGFEWVYRILQEP
GRMWRRYVIGNPLFLYRVMKWKVFTQSNSL

Specific function: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in ECA synthesis [H]

COG id: COG1922

COG function: function code M; Teichoic acid biosynthesis proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 26 family [H]

Homologues:

Organism=Escherichia coli, GI2367289, Length=195, Percent_Identity=33.8461538461538, Blast_Score=115, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023085
- InterPro:   IPR004629 [H]

Pfam domain/function: PF03808 Glyco_tran_WecB [H]

EC number: 2.4.1.- [C]

Molecular weight: Translated: 66777; Mature: 66777

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKTKCSADHVPGYEFFSKALVLGRKESVAELFRLLERSYQQVMLAENTGELEDLKPEKH
CCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEHHCCCCCHHHCCCHHH
LFRLAVMTDSFSETLSLGLVNRVRQNFGPENMICLSTDDDQEKERVLRSAGLIYFGSYGS
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCEEEEECCCC
FSAFAEKIINQTLTGHQNRSRTAMESRTDSARALEKRLTDRSLSMKSIFKRVLFRIGALT
HHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AEVLERVIEFVVAFVMTLLLTVPLLGILLFRKLFTGTPVFVKRTVEGAFAKPLMVFRFRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCHHHHHHHHC
LPAPFCDLPLFLELFTGRLALAGTAIKSWSERSAVPENAYIRLVKPGIVSLWDIRNSSKT
CCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCCCC
AHEGQQAIEWEYVFKKRLFYDFMLILRALPVMLYSENSGISSAIFPLLGLNLNNLTMDEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHCCCCCCCCHHHH
ISVMQRTLEEKKQSAIYFVNPDCLNKMVSDRKYFNTLKTGDYVFPDGIGLSIAGKMLGTP
HHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHCCC
LRENINGTDMLPYLCRMAAAEGYPVFLLGGKPGIAEKAGQNISKTYGVTIAGSADGYFDH
HHCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCCHHHCCEEEECCCCCCCCC
QHDSDAVIEQINSSGAAILLVAFGAPLQEIWIARHRQKLSPRVLMGVGGLFDFYSGTIRR
CCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHH
APRWIREIGFEWVYRILQEPGRMWRRYVIGNPLFLYRVMKWKVFTQSNSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEECCCCC
>Mature Secondary Structure
MMKTKCSADHVPGYEFFSKALVLGRKESVAELFRLLERSYQQVMLAENTGELEDLKPEKH
CCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEEHHCCCCCHHHCCCHHH
LFRLAVMTDSFSETLSLGLVNRVRQNFGPENMICLSTDDDQEKERVLRSAGLIYFGSYGS
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHCCEEEEECCCC
FSAFAEKIINQTLTGHQNRSRTAMESRTDSARALEKRLTDRSLSMKSIFKRVLFRIGALT
HHHHHHHHHHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
AEVLERVIEFVVAFVMTLLLTVPLLGILLFRKLFTGTPVFVKRTVEGAFAKPLMVFRFRD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCHHHHHHHHC
LPAPFCDLPLFLELFTGRLALAGTAIKSWSERSAVPENAYIRLVKPGIVSLWDIRNSSKT
CCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCCCCCC
AHEGQQAIEWEYVFKKRLFYDFMLILRALPVMLYSENSGISSAIFPLLGLNLNNLTMDEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHCCCCCCCCHHHH
ISVMQRTLEEKKQSAIYFVNPDCLNKMVSDRKYFNTLKTGDYVFPDGIGLSIAGKMLGTP
HHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHCCC
LRENINGTDMLPYLCRMAAAEGYPVFLLGGKPGIAEKAGQNISKTYGVTIAGSADGYFDH
HHCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCCHHHCCEEEECCCCCCCCC
QHDSDAVIEQINSSGAAILLVAFGAPLQEIWIARHRQKLSPRVLMGVGGLFDFYSGTIRR
CCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHH
APRWIREIGFEWVYRILQEPGRMWRRYVIGNPLFLYRVMKWKVFTQSNSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosaminuronic-acid; undecaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate [C]

Specific reaction: UDP-N-acetyl-D-mannosaminuronic-acid + undecaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate = C55-PP-GlcNAc-ManNAcA + UDP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA