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The map label for this gene is 119357569

Identifier: 119357569

GI number: 119357569

Start: 2013619

End: 2015016

Strand: Reverse

Name: 119357569

Synonym: Cpha266_1772

Alternate gene names: NA

Gene position: 2015016-2013619 (Counterclockwise)

Preceding gene: 119357570

Following gene: 119357568

Centisome position: 64.3

GC content: 50.29

Gene sequence:

>1398_bases
ATGGAACTTGAATTTTACGGCGCTACAGAACGGGTAACGGGTTCTTGTCATATTATCCGTACAAAACAAGCGACGATATT
GCTGGATTGCGGTCTTATTCAGGGATCTTCCGATGAGGAGCAATTGAACAGAGCCGCTTTTCCGTTTGATCCTGCAAGCA
TTGATGTCGTCGTTCTCAGTCACGGACATATTGATCATTCCGGAAGGCTTCCCCTGCTCGTACAGCGAGGTTTCAGTGGT
TCAATCTATACCCATGAGGCAACGCTTGATCTTTGCAGGGTTCTGCTGCTTGATTCGGCCAGCCTTGCCGAACGTGACGC
TGAGTATCAGAGAAAGCATCCGGTAACCCGTCAGGATAAACATGCCGAGCCATTGTATACTCGCAAAGAGGTGCTTCGTA
CTCTTGATCGCATGGTTGGTATACCGTATCACCGGCAGGCGGAAATAGTTCGTGGCATTACCCTTCGTCTCTCGGATGCC
GGTCATATTCTTGGTTCATCGCTGATTGAACTATGGATCAGAGATGAGGGTTACGAGCGTAAACTTGTTTTCAGCGGCGA
TCTGGGACAGTACGCAAGTCCTGTGCTTCAGGATCCGGAAACAATTGAAGAGGCCGATCTGGTGATAGTGGAGAGTACCT
ATGGCGACAGGCTTCATCGGGATTTCGAAGAGACTGCCCTTGAGTTAGGAACTATTATCCGGTCGGCATGCCGGGGTTGC
GGAAACATTCTGATACCGGCTTTTGCCATCGGCAGAAGTCAGGAGCTGCTCTATCTTTTTGCTCTGAACTATAAGGAGTG
GCAGCTTGACCGCTGGCAGATTTTTCTGGACAGTCCCATGGCAATCGAGGCCAGTCAGATCTACTGGGACTATCCGGAAC
TTGTTGACGTTGATGCGCGTGATTTTCGGGAACATCCCGAGAAGCTGCCCCCGCTCGGCAATCTGCATTTTACCCCGAAA
CCCGAGCAGTCCCGGGCAATAAACAGCTTGAAGAGCGGAGCTGTTATTATCGCAGGTAGCGGGATGTGCAATGGCGGCAG
GATTCTGCACCACCTGAAACAGAATATCCACAGGCATGAATGCAAGGTGATTATTACGGGATATCAGGCTGAAGGAACGC
TTGGCCGAAAACTTGTCGATGGAGATAAGGAGGTGTCGATTCATGGACGGAACTATGCTGTCGCGGCAACAGTTCATACC
GTTGGCGGTCTGTCAGCTCATGGCGATCAGGAAGACATGCTCCGCTGGCTTGGCGGTTTCAGGAGTAGGCCAAAGGTATT
TGTTGTTCATGGTGACGGTGATGTGAAAAAGGTTTTCAAGGCAAAGATTGAAGAGCGGTTTGACTTGAATGTGACGATTC
CGGAATCGGGGAGTTGTGTGAATTTGTTGCAACGGTGA

Upstream 100 bases:

>100_bases
TTGACGGAATTGTTTCGGAAACGTGATGGCAGTTTTTCTCCAGACCATTGCGTTGAAGTGCAGAGCTGTATCGCTGTAAT
TGTAAACAAAGGAGGGATCA

Downstream 100 bases:

>100_bases
TGAACGCAAGTGCACATTTCGTTATTGTTGATCGCGGTTTTTCATGGGGATGGTCGGAGTTCCGAATCGTCGGGATCCCG
ATCATTATGCCGACAGTTCG

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MELEFYGATERVTGSCHIIRTKQATILLDCGLIQGSSDEEQLNRAAFPFDPASIDVVVLSHGHIDHSGRLPLLVQRGFSG
SIYTHEATLDLCRVLLLDSASLAERDAEYQRKHPVTRQDKHAEPLYTRKEVLRTLDRMVGIPYHRQAEIVRGITLRLSDA
GHILGSSLIELWIRDEGYERKLVFSGDLGQYASPVLQDPETIEEADLVIVESTYGDRLHRDFEETALELGTIIRSACRGC
GNILIPAFAIGRSQELLYLFALNYKEWQLDRWQIFLDSPMAIEASQIYWDYPELVDVDARDFREHPEKLPPLGNLHFTPK
PEQSRAINSLKSGAVIIAGSGMCNGGRILHHLKQNIHRHECKVIITGYQAEGTLGRKLVDGDKEVSIHGRNYAVAATVHT
VGGLSAHGDQEDMLRWLGGFRSRPKVFVVHGDGDVKKVFKAKIEERFDLNVTIPESGSCVNLLQR

Sequences:

>Translated_465_residues
MELEFYGATERVTGSCHIIRTKQATILLDCGLIQGSSDEEQLNRAAFPFDPASIDVVVLSHGHIDHSGRLPLLVQRGFSG
SIYTHEATLDLCRVLLLDSASLAERDAEYQRKHPVTRQDKHAEPLYTRKEVLRTLDRMVGIPYHRQAEIVRGITLRLSDA
GHILGSSLIELWIRDEGYERKLVFSGDLGQYASPVLQDPETIEEADLVIVESTYGDRLHRDFEETALELGTIIRSACRGC
GNILIPAFAIGRSQELLYLFALNYKEWQLDRWQIFLDSPMAIEASQIYWDYPELVDVDARDFREHPEKLPPLGNLHFTPK
PEQSRAINSLKSGAVIIAGSGMCNGGRILHHLKQNIHRHECKVIITGYQAEGTLGRKLVDGDKEVSIHGRNYAVAATVHT
VGGLSAHGDQEDMLRWLGGFRSRPKVFVVHGDGDVKKVFKAKIEERFDLNVTIPESGSCVNLLQR
>Mature_465_residues
MELEFYGATERVTGSCHIIRTKQATILLDCGLIQGSSDEEQLNRAAFPFDPASIDVVVLSHGHIDHSGRLPLLVQRGFSG
SIYTHEATLDLCRVLLLDSASLAERDAEYQRKHPVTRQDKHAEPLYTRKEVLRTLDRMVGIPYHRQAEIVRGITLRLSDA
GHILGSSLIELWIRDEGYERKLVFSGDLGQYASPVLQDPETIEEADLVIVESTYGDRLHRDFEETALELGTIIRSACRGC
GNILIPAFAIGRSQELLYLFALNYKEWQLDRWQIFLDSPMAIEASQIYWDYPELVDVDARDFREHPEKLPPLGNLHFTPK
PEQSRAINSLKSGAVIIAGSGMCNGGRILHHLKQNIHRHECKVIITGYQAEGTLGRKLVDGDKEVSIHGRNYAVAATVHT
VGGLSAHGDQEDMLRWLGGFRSRPKVFVVHGDGDVKKVFKAKIEERFDLNVTIPESGSCVNLLQR

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=464, Percent_Identity=27.801724137931, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI33300633, Length=472, Percent_Identity=24.5762711864407, Blast_Score=139, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI32564696, Length=463, Percent_Identity=23.3261339092873, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI32566029, Length=454, Percent_Identity=25.5506607929515, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6323307, Length=458, Percent_Identity=24.6724890829694, Blast_Score=126, Evalue=6e-30,
Organism=Drosophila melanogaster, GI21358523, Length=470, Percent_Identity=25.7446808510638, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24648013, Length=469, Percent_Identity=24.0938166311301, Blast_Score=118, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 52175; Mature: 52175

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELEFYGATERVTGSCHIIRTKQATILLDCGLIQGSSDEEQLNRAAFPFDPASIDVVVLS
CEEEEECCCCCCCCCEEEEEECCEEEEEEECCCCCCCCHHHHHHCCCCCCCCCEEEEEEE
HGHIDHSGRLPLLVQRGFSGSIYTHEATLDLCRVLLLDSASLAERDAEYQRKHPVTRQDK
CCCCCCCCCCCEEEECCCCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
HAEPLYTRKEVLRTLDRMVGIPYHRQAEIVRGITLRLSDAGHILGSSLIELWIRDEGYER
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEEECCCCHHHHHHHHHEEECCCCCCE
KLVFSGDLGQYASPVLQDPETIEEADLVIVESTYGDRLHRDFEETALELGTIIRSACRGC
EEEEECCCCHHHCHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GNILIPAFAIGRSQELLYLFALNYKEWQLDRWQIFLDSPMAIEASQIYWDYPELVDVDAR
CCEEEEHEECCCCCCEEEEEEECCCCCCCEEEEEEECCCCEEEEEEEEECCHHHCCCCHH
DFREHPEKLPPLGNLHFTPKPEQSRAINSLKSGAVIIAGSGMCNGGRILHHLKQNIHRHE
HHHHCHHHCCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCE
CKVIITGYQAEGTLGRKLVDGDKEVSIHGRNYAVAATVHTVGGLSAHGDQEDMLRWLGGF
EEEEEEEEECCCCCCCEECCCCCEEEEECCCEEEEEEEEECCCCCCCCCHHHHHHHHHCC
RSRPKVFVVHGDGDVKKVFKAKIEERFDLNVTIPESGSCVNLLQR
CCCCEEEEEECCCCHHHHHHHHHHHHCCEEEECCCCCCHHHHHCC
>Mature Secondary Structure
MELEFYGATERVTGSCHIIRTKQATILLDCGLIQGSSDEEQLNRAAFPFDPASIDVVVLS
CEEEEECCCCCCCCCEEEEEECCEEEEEEECCCCCCCCHHHHHHCCCCCCCCCEEEEEEE
HGHIDHSGRLPLLVQRGFSGSIYTHEATLDLCRVLLLDSASLAERDAEYQRKHPVTRQDK
CCCCCCCCCCCEEEECCCCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCC
HAEPLYTRKEVLRTLDRMVGIPYHRQAEIVRGITLRLSDAGHILGSSLIELWIRDEGYER
CCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCEEEEECCCCHHHHHHHHHEEECCCCCCE
KLVFSGDLGQYASPVLQDPETIEEADLVIVESTYGDRLHRDFEETALELGTIIRSACRGC
EEEEECCCCHHHCHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCC
GNILIPAFAIGRSQELLYLFALNYKEWQLDRWQIFLDSPMAIEASQIYWDYPELVDVDAR
CCEEEEHEECCCCCCEEEEEEECCCCCCCEEEEEEECCCCEEEEEEEEECCHHHCCCCHH
DFREHPEKLPPLGNLHFTPKPEQSRAINSLKSGAVIIAGSGMCNGGRILHHLKQNIHRHE
HHHHCHHHCCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCCCE
CKVIITGYQAEGTLGRKLVDGDKEVSIHGRNYAVAATVHTVGGLSAHGDQEDMLRWLGGF
EEEEEEEEECCCCCCCEECCCCCEEEEECCCEEEEEEEEECCCCCCCCCHHHHHHHHHCC
RSRPKVFVVHGDGDVKKVFKAKIEERFDLNVTIPESGSCVNLLQR
CCCCEEEEEECCCCHHHHHHHHHHHHCCEEEECCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA