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The map label for this gene is lpd [H]

Identifier: 119357433

GI number: 119357433

Start: 1859760

End: 1861211

Strand: Reverse

Name: lpd [H]

Synonym: Cpha266_1632

Alternate gene names: 119357433

Gene position: 1861211-1859760 (Counterclockwise)

Preceding gene: 119357435

Following gene: 119357432

Centisome position: 59.39

GC content: 51.79

Gene sequence:

>1452_bases
ATGCATTTTCGTTATAGTATACTAAAACCATATGATTATCTGTTTATGCAACAGGGGAGTGCTGACGAGGGTTTTGCCTT
TGATCTTGCTGTTATCGGCTCAGGTCCTGGCGGTTATGAGGCTGCGCTGAAGGCCGCAAAGGCCGGTTTGAAAGTTTGTC
TTATCGAAAAAGGCGCGCTTGGAGGCGTTTGCGTCAACTGGGGGTGTATTCCGACCAAAGCCCTTCTCAGGAGTGCTGAA
ATAATTGATCTTGTCGCTCGATCGTCTTCATTTGGCATAATGGCTGAAAATGTCAGCTTCGATTTTCCGCAAGCTGTCAA
GCGGAGTCGCTCGGTAGTGCGTAAGCTTTCTAAAGGCATCGATTTCATGCTTCAGCGTGCAGGGGTGGAGGTGAAACAGG
GAGAAGCGCGATTTACCTCACCGCATGATCTCGATATTGTCCGTGACGGTATCGGTGTTGATCACATTCGTGCCCGATCA
GTGATTATTGCTACAGGAAGCATTCCCAGAGAGATTTCCGGACTCGAGCCTGACGGGAACCGTATCCTTGGAAGCAGGGA
TGCTCTCGCTCTTAAAACGCTCCCTTCTTCGATGATTGTTGTTGGTGGAGGCGCTATCGGCATTGAGATGGCATGGTTTT
ATGCCAAAGCAGGCACCGTGGTTACGCTTGTCGAAATGATGCCCCGGATTCTTCCTCTTGAAGACGCAGAGATCGCTCTT
GCGCTCAGGCGTTCACTTGAAAAAGCTGGTATCCTGATTTATACCGGAGCAAAACTGGAGCGCCTTTCTTCTGATGAGCG
TGGTGTCAACTGCAGGATTACCGTTGCAGAAGAGGATCCGATTGCTGTTCATGCCGAATGTCTCCTTGTCGCTGTTGGCG
TGACCGGTAATACCTGTGAACTCGGGCTTTCAAATGCGGGGGTAGAGTGCTCGGGAGGATATATTGTTACTGACGGCGAG
TGCCGAACTTCGGCAGATCATGTCTATGCTATCGGCGACGTACGCGGCGGTATGCTGCTGGCGCACAAGGCATCGGCTGA
AGCCGCTATTGCTGTTGCTTCGATTTCCGGCAAAACGAGTGAACCGCTTGACGATACGAAGATTCCCCGGTGCGTGTATG
TCGAACCATCTCTTGCGAGTGTGGGGTTGAGTGAGGAGCAGGCGGTGGCGAGCGGTTTCAGTGTCAGGATTGGTCGCGCC
ATGTTTGCTGCTTCAGGAAAGGCTAATGCATACGGAAATCTTGAAGGAATGGTGAAACTGATTTTCAGCTGCAAAACCGA
CAGACTGCTTGGTGCCCATGTACTCGGCCATGGAGCTGTCGAGTTGATTGGCGAGCTTTGTCTGGCCCGACAACTTGAGC
TGACGGCACGGGTGCTTGCAGGAACGGTGCATGCTCACCCGACTCTTTCGGAAACGATCAGGGAGGCTGCTGAAAACTCG
CTTGAAGCTTGA

Upstream 100 bases:

>100_bases
GCAAGCTTTTTGGGTTCCGGGGGCAGTTCCTGAACGTCAAGGGATTCGTTTTTTATCGGCTGATTTAGCATTTTTAAAGC
AATGAATAAGAGAGTGCGTT

Downstream 100 bases:

>100_bases
AGATAATGCTTTTCCGTGCCGGTAATCGCTATAGTGCGCAAGAGGATTGCGGTTCAACTTTATTGATTAAGAAAACCATT
TTCGAATGTCTTTCTAAAAG

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MHFRYSILKPYDYLFMQQGSADEGFAFDLAVIGSGPGGYEAALKAAKAGLKVCLIEKGALGGVCVNWGCIPTKALLRSAE
IIDLVARSSSFGIMAENVSFDFPQAVKRSRSVVRKLSKGIDFMLQRAGVEVKQGEARFTSPHDLDIVRDGIGVDHIRARS
VIIATGSIPREISGLEPDGNRILGSRDALALKTLPSSMIVVGGGAIGIEMAWFYAKAGTVVTLVEMMPRILPLEDAEIAL
ALRRSLEKAGILIYTGAKLERLSSDERGVNCRITVAEEDPIAVHAECLLVAVGVTGNTCELGLSNAGVECSGGYIVTDGE
CRTSADHVYAIGDVRGGMLLAHKASAEAAIAVASISGKTSEPLDDTKIPRCVYVEPSLASVGLSEEQAVASGFSVRIGRA
MFAASGKANAYGNLEGMVKLIFSCKTDRLLGAHVLGHGAVELIGELCLARQLELTARVLAGTVHAHPTLSETIREAAENS
LEA

Sequences:

>Translated_483_residues
MHFRYSILKPYDYLFMQQGSADEGFAFDLAVIGSGPGGYEAALKAAKAGLKVCLIEKGALGGVCVNWGCIPTKALLRSAE
IIDLVARSSSFGIMAENVSFDFPQAVKRSRSVVRKLSKGIDFMLQRAGVEVKQGEARFTSPHDLDIVRDGIGVDHIRARS
VIIATGSIPREISGLEPDGNRILGSRDALALKTLPSSMIVVGGGAIGIEMAWFYAKAGTVVTLVEMMPRILPLEDAEIAL
ALRRSLEKAGILIYTGAKLERLSSDERGVNCRITVAEEDPIAVHAECLLVAVGVTGNTCELGLSNAGVECSGGYIVTDGE
CRTSADHVYAIGDVRGGMLLAHKASAEAAIAVASISGKTSEPLDDTKIPRCVYVEPSLASVGLSEEQAVASGFSVRIGRA
MFAASGKANAYGNLEGMVKLIFSCKTDRLLGAHVLGHGAVELIGELCLARQLELTARVLAGTVHAHPTLSETIREAAENS
LEA
>Mature_483_residues
MHFRYSILKPYDYLFMQQGSADEGFAFDLAVIGSGPGGYEAALKAAKAGLKVCLIEKGALGGVCVNWGCIPTKALLRSAE
IIDLVARSSSFGIMAENVSFDFPQAVKRSRSVVRKLSKGIDFMLQRAGVEVKQGEARFTSPHDLDIVRDGIGVDHIRARS
VIIATGSIPREISGLEPDGNRILGSRDALALKTLPSSMIVVGGGAIGIEMAWFYAKAGTVVTLVEMMPRILPLEDAEIAL
ALRRSLEKAGILIYTGAKLERLSSDERGVNCRITVAEEDPIAVHAECLLVAVGVTGNTCELGLSNAGVECSGGYIVTDGE
CRTSADHVYAIGDVRGGMLLAHKASAEAAIAVASISGKTSEPLDDTKIPRCVYVEPSLASVGLSEEQAVASGFSVRIGRA
MFAASGKANAYGNLEGMVKLIFSCKTDRLLGAHVLGHGAVELIGELCLARQLELTARVLAGTVHAHPTLSETIREAAENS
LEA

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=467, Percent_Identity=35.5460385438972, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI50301238, Length=458, Percent_Identity=26.8558951965066, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI22035672, Length=459, Percent_Identity=27.8867102396514, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI33519430, Length=469, Percent_Identity=26.226012793177, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI33519428, Length=469, Percent_Identity=26.226012793177, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI33519426, Length=469, Percent_Identity=26.226012793177, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI148277065, Length=469, Percent_Identity=26.226012793177, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI148277071, Length=469, Percent_Identity=26.226012793177, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI291045266, Length=436, Percent_Identity=27.0642201834862, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI291045268, Length=437, Percent_Identity=25.629290617849, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1786307, Length=452, Percent_Identity=34.7345132743363, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI87082354, Length=465, Percent_Identity=30.3225806451613, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=31.359649122807, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1789915, Length=435, Percent_Identity=27.816091954023, Blast_Score=139, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI32565766, Length=453, Percent_Identity=34.2163355408389, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI71983429, Length=459, Percent_Identity=26.797385620915, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71983419, Length=459, Percent_Identity=26.797385620915, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17557007, Length=473, Percent_Identity=24.9471458773784, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71982272, Length=488, Percent_Identity=23.9754098360656, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321091, Length=468, Percent_Identity=34.8290598290598, Blast_Score=233, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6325240, Length=479, Percent_Identity=27.9749478079332, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=24.8927038626609, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI21358499, Length=456, Percent_Identity=34.6491228070175, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24640549, Length=485, Percent_Identity=27.0103092783505, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24640553, Length=478, Percent_Identity=26.5690376569038, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24640551, Length=472, Percent_Identity=26.6949152542373, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=25.5813953488372, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50969; Mature: 50969

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFRYSILKPYDYLFMQQGSADEGFAFDLAVIGSGPGGYEAALKAAKAGLKVCLIEKGAL
CCEEEECCCCCEEEEEECCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCC
GGVCVNWGCIPTKALLRSAEIIDLVARSSSFGIMAENVSFDFPQAVKRSRSVVRKLSKGI
CCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
DFMLQRAGVEVKQGEARFTSPHDLDIVRDGIGVDHIRARSVIIATGSIPREISGLEPDGN
HHHHHHCCCEEECCCCCCCCCCCCHHHHCCCCCCCEEEEEEEEEECCCCHHHCCCCCCCC
RILGSRDALALKTLPSSMIVVGGGAIGIEMAWFYAKAGTVVTLVEMMPRILPLEDAEIAL
EEECCCCCEEEEECCCCEEEEECCEEEEEEEEEEECCCHHHHHHHHHHHHCCCCCHHHHH
ALRRSLEKAGILIYTGAKLERLSSDERGVNCRITVAEEDPIAVHAECLLVAVGVTGNTCE
HHHHHHHHCCEEEEECCHHHHCCCCCCCCEEEEEEECCCCCEEEEEEEEEEEECCCCEEE
LGLSNAGVECSGGYIVTDGECRTSADHVYAIGDVRGGMLLAHKASAEAAIAVASISGKTS
ECCCCCCEEECCCEEEECCCCCCCCCEEEEEECCCCCEEEEEECCCCEEEEEEEECCCCC
EPLDDTKIPRCVYVEPSLASVGLSEEQAVASGFSVRIGRAMFAASGKANAYGNLEGMVKL
CCCCCCCCCEEEEECCCHHHCCCCHHHHHHCCCEEEECCEEEECCCCCCCCCCHHHHHHH
IFSCKTDRLLGAHVLGHGAVELIGELCLARQLELTARVLAGTVHAHPTLSETIREAAENS
HHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
LEA
CCC
>Mature Secondary Structure
MHFRYSILKPYDYLFMQQGSADEGFAFDLAVIGSGPGGYEAALKAAKAGLKVCLIEKGAL
CCEEEECCCCCEEEEEECCCCCCCEEEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCC
GGVCVNWGCIPTKALLRSAEIIDLVARSSSFGIMAENVSFDFPQAVKRSRSVVRKLSKGI
CCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
DFMLQRAGVEVKQGEARFTSPHDLDIVRDGIGVDHIRARSVIIATGSIPREISGLEPDGN
HHHHHHCCCEEECCCCCCCCCCCCHHHHCCCCCCCEEEEEEEEEECCCCHHHCCCCCCCC
RILGSRDALALKTLPSSMIVVGGGAIGIEMAWFYAKAGTVVTLVEMMPRILPLEDAEIAL
EEECCCCCEEEEECCCCEEEEECCEEEEEEEEEEECCCHHHHHHHHHHHHCCCCCHHHHH
ALRRSLEKAGILIYTGAKLERLSSDERGVNCRITVAEEDPIAVHAECLLVAVGVTGNTCE
HHHHHHHHCCEEEEECCHHHHCCCCCCCCEEEEEEECCCCCEEEEEEEEEEEECCCCEEE
LGLSNAGVECSGGYIVTDGECRTSADHVYAIGDVRGGMLLAHKASAEAAIAVASISGKTS
ECCCCCCEEECCCEEEECCCCCCCCCEEEEEECCCCCEEEEEECCCCEEEEEEEECCCCC
EPLDDTKIPRCVYVEPSLASVGLSEEQAVASGFSVRIGRAMFAASGKANAYGNLEGMVKL
CCCCCCCCCEEEEECCCHHHCCCCHHHHHHCCCEEEECCEEEECCCCCCCCCCHHHHHHH
IFSCKTDRLLGAHVLGHGAVELIGELCLARQLELTARVLAGTVHAHPTLSETIREAAENS
HHHCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
LEA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]