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The map label for this gene is polC [H]

Identifier: 119357378

GI number: 119357378

Start: 1791726

End: 1792385

Strand: Reverse

Name: polC [H]

Synonym: Cpha266_1576

Alternate gene names: 119357378

Gene position: 1792385-1791726 (Counterclockwise)

Preceding gene: 119357379

Following gene: 119357377

Centisome position: 57.19

GC content: 50.76

Gene sequence:

>660_bases
ATGCATCGGACAATGGCGGATAGTGTGGTGGTTCTTGATTTCGAGACAACAGGCTTGTCACCCCAGTACGGCGACAGGGC
TATCGAGATCGGTGCGGTGCTTGTGGAGCACGGGGAGATTGTCGATCGCTATCAGAAGCTTATGAATCCCGGTTTTCGGA
TCAGTCGGTTTATCGAGAGTTATACCGGTATTACCAATGAAATGCTGAGCGGCCAGCCTTGCTGCGAGGAAGTTATGACT
GAGTTTTCGGAGTTTATAGCCGGTCATAATATCGTTGCGCACAATGCGTCGTTCGACCGCCGTTTTCTGGATTTCGAGCT
GAAACGGGCGAAACGAGTGTATGAAGGCGCCTGTTGCTGCTCTTTGCTCGTTTCAAGAAGGATTTATCAGGACTCTCCGA
ACCATAAGCTGCAGACGCTTGTTTCGCATGCGGGCATCCCGGAGATCGGAAGTTTTCACCGCGCGCTGGCTGATGCCGAG
ATGACGGCGCATTTGTGGATGTCGATGATCGACAGGATTCGCCTGCAATACGGTATATCGATGATTTTTTTCGACCAGCT
TAGCGAACTCTCAAAAATCGACAAGCTCTATACTCACAGGTATCTTACCGCTCTGGCAGATGAACCCTTGAGAAAGGAGG
ACGGAGATGTTCGGTTCTGA

Upstream 100 bases:

>100_bases
GATAGTGACTCAACGGAAATTTCCGTTTTTTGGAGGGTGGCTTCGTGAAATCGGGGCGGCAATGAATGAGTGAACTGGTA
TCAAGATAACTGTTTATATT

Downstream 100 bases:

>100_bases
CCGGCTGCTCGATGTCGCAATCATGATGATCGAGCGTACGCATCGGGTGGAAAACCTGGAGACCAGCGAACTTGCTGCGA
TGCTTGCAGGGCCGGAACCT

Product: DNA polymerase III, epsilon subunit

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MHRTMADSVVVLDFETTGLSPQYGDRAIEIGAVLVEHGEIVDRYQKLMNPGFRISRFIESYTGITNEMLSGQPCCEEVMT
EFSEFIAGHNIVAHNASFDRRFLDFELKRAKRVYEGACCCSLLVSRRIYQDSPNHKLQTLVSHAGIPEIGSFHRALADAE
MTAHLWMSMIDRIRLQYGISMIFFDQLSELSKIDKLYTHRYLTALADEPLRKEDGDVRF

Sequences:

>Translated_219_residues
MHRTMADSVVVLDFETTGLSPQYGDRAIEIGAVLVEHGEIVDRYQKLMNPGFRISRFIESYTGITNEMLSGQPCCEEVMT
EFSEFIAGHNIVAHNASFDRRFLDFELKRAKRVYEGACCCSLLVSRRIYQDSPNHKLQTLVSHAGIPEIGSFHRALADAE
MTAHLWMSMIDRIRLQYGISMIFFDQLSELSKIDKLYTHRYLTALADEPLRKEDGDVRF
>Mature_219_residues
MHRTMADSVVVLDFETTGLSPQYGDRAIEIGAVLVEHGEIVDRYQKLMNPGFRISRFIESYTGITNEMLSGQPCCEEVMT
EFSEFIAGHNIVAHNASFDRRFLDFELKRAKRVYEGACCCSLLVSRRIYQDSPNHKLQTLVSHAGIPEIGSFHRALADAE
MTAHLWMSMIDRIRLQYGISMIFFDQLSELSKIDKLYTHRYLTALADEPLRKEDGDVRF

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2176

COG function: function code L; DNA polymerase III, alpha subunit (gram-positive type)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

Organism=Escherichia coli, GI1786409, Length=178, Percent_Identity=33.1460674157303, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR023223
- InterPro:   IPR016027
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 25091; Mature: 25091

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRTMADSVVVLDFETTGLSPQYGDRAIEIGAVLVEHGEIVDRYQKLMNPGFRISRFIES
CCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
YTGITNEMLSGQPCCEEVMTEFSEFIAGHNIVAHNASFDRRFLDFELKRAKRVYEGACCC
HHCHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
SLLVSRRIYQDSPNHKLQTLVSHAGIPEIGSFHRALADAEMTAHLWMSMIDRIRLQYGIS
HHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
MIFFDQLSELSKIDKLYTHRYLTALADEPLRKEDGDVRF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MHRTMADSVVVLDFETTGLSPQYGDRAIEIGAVLVEHGEIVDRYQKLMNPGFRISRFIES
CCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
YTGITNEMLSGQPCCEEVMTEFSEFIAGHNIVAHNASFDRRFLDFELKRAKRVYEGACCC
HHCHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
SLLVSRRIYQDSPNHKLQTLVSHAGIPEIGSFHRALADAEMTAHLWMSMIDRIRLQYGIS
HHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
MIFFDQLSELSKIDKLYTHRYLTALADEPLRKEDGDVRF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]