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The map label for this gene is msrAB [H]

Identifier: 119357267

GI number: 119357267

Start: 1660235

End: 1661236

Strand: Reverse

Name: msrAB [H]

Synonym: Cpha266_1459

Alternate gene names: 119357267

Gene position: 1661236-1660235 (Counterclockwise)

Preceding gene: 119357269

Following gene: 119357266

Centisome position: 53.01

GC content: 49.6

Gene sequence:

>1002_bases
ATGGTAAACAACAGAAAAACAGGAATTTCGGTTTCTGCTGCTCTGGCGGCAGTTCTTCTCGGTATCGCGCTCTTTCTGTT
TTACCAGTCGGGCACGGGTTCATTTCCCTTTACATCAAAGGCAACAAGTATTCAAAAGGAGACGCATATGACACAGAGAC
CACTGACACCCGAAGAGGAACGGGTGATCGTTCATAAAGGCACCGAGAGGCCATTCACCGGAGCATATTACAAAAACACG
GAAGATGGCGTCTATCATTGCAGGCGATGCGACGCACCGCTTTTTTCTTCAAAGGATAAATTCGATTCCGGTACCGGATG
GCCAAGTTTTGATGACGCTATTGCGGGCGCGGTAAAAGAGGTTCCCGATACCGATGGTCGGCGCACAGAAATAGTTTGTG
CCAGGTGCGGCGCCCATCTTGGTCACGTTTTTTTCAATGAGGGGATGACCGCAAAAAGCGTTCGGCATTGCGTTAACTCG
ATCTCTCTTCTTTTTCATCCTGATGCGGAAGCTGCTCCTGTAACTCAAAAAGCGGTATTTGCCGGCGGCTGTTTCTGGGG
CGTCGAGTACCATTTCAGTAAAACAAAAGGCGTGCTTTCCGTCACTTCGGGGTATACCGGAGGCTCAATCGAAAATCCAT
CCTATAAACAGGTCTGTTCGGGGCGCACTGGTCATGCAGAAGCTGTTGAGATTGCGTTCGACCCCCGTGTTGTCAGCTAC
GAAGCCCTTGCAAAGCTGTTTTTCGAGATTCACGATCCTACCCAGCTCAATCGGCAGGGGCCCGATATGGGAACGCAGTA
CCGATCGGCTGTGTTTTATTCCGATGAAGAACAGAAAAAAACAGCCGAAAAACTCATCGGGGAGTTGAAGGAAAAGGGGT
ACAATGTCGTTACCACCATTGAACCTGCCGGAACCTTCTGGAATGCCGAGGAGTACCATCAGGACTACTACCGGAAAACG
GGTCATCAGCCCTACTGTCACATCTATCAAAAGCGTTTTTAA

Upstream 100 bases:

>100_bases
AAGTGCAGAGGGGTTGAAGGTGCAGGAACAGAGAGGAAGAAAGAGAGCACGTTGCAAAGATGCCTCTTTCCGGGAACATA
AGGTAAAGGAGCGACCGAAA

Downstream 100 bases:

>100_bases
TTCGCGTTATGATAAAAAAAAGAGGGCCATCTGCTTGTCAGGCGGCTTTTTTTATTCTATATTATTAGCATATGCCAATA
ACAATGGCGAGATATGGTAT

Product: bifunctional methionine sulfoxide reductase B/A protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MVNNRKTGISVSAALAAVLLGIALFLFYQSGTGSFPFTSKATSIQKETHMTQRPLTPEEERVIVHKGTERPFTGAYYKNT
EDGVYHCRRCDAPLFSSKDKFDSGTGWPSFDDAIAGAVKEVPDTDGRRTEIVCARCGAHLGHVFFNEGMTAKSVRHCVNS
ISLLFHPDAEAAPVTQKAVFAGGCFWGVEYHFSKTKGVLSVTSGYTGGSIENPSYKQVCSGRTGHAEAVEIAFDPRVVSY
EALAKLFFEIHDPTQLNRQGPDMGTQYRSAVFYSDEEQKKTAEKLIGELKEKGYNVVTTIEPAGTFWNAEEYHQDYYRKT
GHQPYCHIYQKRF

Sequences:

>Translated_333_residues
MVNNRKTGISVSAALAAVLLGIALFLFYQSGTGSFPFTSKATSIQKETHMTQRPLTPEEERVIVHKGTERPFTGAYYKNT
EDGVYHCRRCDAPLFSSKDKFDSGTGWPSFDDAIAGAVKEVPDTDGRRTEIVCARCGAHLGHVFFNEGMTAKSVRHCVNS
ISLLFHPDAEAAPVTQKAVFAGGCFWGVEYHFSKTKGVLSVTSGYTGGSIENPSYKQVCSGRTGHAEAVEIAFDPRVVSY
EALAKLFFEIHDPTQLNRQGPDMGTQYRSAVFYSDEEQKKTAEKLIGELKEKGYNVVTTIEPAGTFWNAEEYHQDYYRKT
GHQPYCHIYQKRF
>Mature_333_residues
MVNNRKTGISVSAALAAVLLGIALFLFYQSGTGSFPFTSKATSIQKETHMTQRPLTPEEERVIVHKGTERPFTGAYYKNT
EDGVYHCRRCDAPLFSSKDKFDSGTGWPSFDDAIAGAVKEVPDTDGRRTEIVCARCGAHLGHVFFNEGMTAKSVRHCVNS
ISLLFHPDAEAAPVTQKAVFAGGCFWGVEYHFSKTKGVLSVTSGYTGGSIENPSYKQVCSGRTGHAEAVEIAFDPRVVSY
EALAKLFFEIHDPTQLNRQGPDMGTQYRSAVFYSDEEQKKTAEKLIGELKEKGYNVVTTIEPAGTFWNAEEYHQDYYRKT
GHQPYCHIYQKRF

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=151, Percent_Identity=48.3443708609272, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI208609995, Length=151, Percent_Identity=48.3443708609272, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI117606353, Length=126, Percent_Identity=47.6190476190476, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI301336164, Length=119, Percent_Identity=42.8571428571429, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI301336162, Length=119, Percent_Identity=42.8571428571429, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI73089054, Length=119, Percent_Identity=42.8571428571429, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI37620216, Length=119, Percent_Identity=42.8571428571429, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI208609993, Length=104, Percent_Identity=45.1923076923077, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1790665, Length=171, Percent_Identity=45.0292397660819, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788077, Length=107, Percent_Identity=49.5327102803738, Blast_Score=100, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17533973, Length=142, Percent_Identity=38.7323943661972, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17553450, Length=115, Percent_Identity=40, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI115532676, Length=115, Percent_Identity=40, Blast_Score=81, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=170, Percent_Identity=38.2352941176471, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6319816, Length=122, Percent_Identity=50.8196721311475, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24645799, Length=154, Percent_Identity=40.2597402597403, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45553335, Length=143, Percent_Identity=42.6573426573427, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21356369, Length=143, Percent_Identity=42.6573426573427, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI221378664, Length=131, Percent_Identity=44.2748091603053, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221378662, Length=138, Percent_Identity=42.7536231884058, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24645801, Length=165, Percent_Identity=36.3636363636364, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24645804, Length=154, Percent_Identity=38.3116883116883, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24664627, Length=151, Percent_Identity=39.0728476821192, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI45553131, Length=146, Percent_Identity=39.041095890411, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24664631, Length=151, Percent_Identity=38.4105960264901, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.12; =1.8.4.11 [H]

Molecular weight: Translated: 37036; Mature: 37036

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNNRKTGISVSAALAAVLLGIALFLFYQSGTGSFPFTSKATSIQKETHMTQRPLTPEEE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
RVIVHKGTERPFTGAYYKNTEDGVYHCRRCDAPLFSSKDKFDSGTGWPSFDDAIAGAVKE
EEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
VPDTDGRRTEIVCARCGAHLGHVFFNEGMTAKSVRHCVNSISLLFHPDAEAAPVTQKAVF
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCEEEECCCCCCCCCHHHHHE
AGGCFWGVEYHFSKTKGVLSVTSGYTGGSIENPSYKQVCSGRTGHAEAVEIAFDPRVVSY
ECCEEEEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCEECH
EALAKLFFEIHDPTQLNRQGPDMGTQYRSAVFYSDEEQKKTAEKLIGELKEKGYNVVTTI
HHHHHHHHHHCCCHHCCCCCCCCCHHHHHEEEECCHHHHHHHHHHHHHHHHCCCEEEEEE
EPAGTFWNAEEYHQDYYRKTGHQPYCHIYQKRF
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure
MVNNRKTGISVSAALAAVLLGIALFLFYQSGTGSFPFTSKATSIQKETHMTQRPLTPEEE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
RVIVHKGTERPFTGAYYKNTEDGVYHCRRCDAPLFSSKDKFDSGTGWPSFDDAIAGAVKE
EEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
VPDTDGRRTEIVCARCGAHLGHVFFNEGMTAKSVRHCVNSISLLFHPDAEAAPVTQKAVF
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCEEEECCCCCCCCCHHHHHE
AGGCFWGVEYHFSKTKGVLSVTSGYTGGSIENPSYKQVCSGRTGHAEAVEIAFDPRVVSY
ECCEEEEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCEECH
EALAKLFFEIHDPTQLNRQGPDMGTQYRSAVFYSDEEQKKTAEKLIGELKEKGYNVVTTI
HHHHHHHHHHCCCHHCCCCCCCCCHHHHHEEEECCHHHHHHHHHHHHHHHHCCCEEEEEE
EPAGTFWNAEEYHQDYYRKTGHQPYCHIYQKRF
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]