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The map label for this gene is hisC

Identifier: 119357221

GI number: 119357221

Start: 1607871

End: 1608953

Strand: Reverse

Name: hisC

Synonym: Cpha266_1412

Alternate gene names: 119357221

Gene position: 1608953-1607871 (Counterclockwise)

Preceding gene: 119357227

Following gene: 119357220

Centisome position: 51.34

GC content: 49.03

Gene sequence:

>1083_bases
ATGAAAAGAGATATACAGGAACTGCTCAATCCCGCATTGCGCGACCTCAAAGCCTATAACGTTGAGGGCGGTCAGCAGGC
AGGCATAAAGCTCAACCAGAATGAAAGCCCTTTTGATCTTCCCTTGTGGCTGAAGGAAGAGGTTCTTGAGGCATTTGAAA
AGGAGCCATGGAATCGCTATCCCGATATTCTGCCTTTCAGAGGGATGCGTTCCTATGCGAGCTTTGTTGGAGTGCCGGCC
GATGCCGTGATGATGAGCAATGGTTCGAACGAGATGCTCTATACCATATTTCTCGCCTGTCTCGGGCCCGGAAAGAAAAT
CCTTATTCCTGAGCCATCCTTCTCTCTTTATGAAAAGATTGCCCGGCTGCTTCATACCGAAGTGGTCTTTGTGCCCATGT
TGCCGGGGCTTGCGTTTGATGCCGACGCGATTATCCGGAAAGCCGGCGAGGAGCGTGTTGATTTTATTGTGCTCTCAACC
CCCAACAATCCTACGGGGATGTCTCTTGCCTCTGAAGAGGTCTGCCGGATTGCGGAAGCGGCGGACGCTCTCGTGCTTGT
CGATGAGGCCTATATTGAGTTTTCACGCCAGAAGAGCGTTGTTGCTGAAATTGCTCGTTTGAAAAATCTTATTGTGCTTC
GAACCATGTCGAAAGCACTTGCTCTTGCCGGCATGCGCATAGGCTTCGCTATAGCTGATCCGGCTTTGATGGCTGAGATA
GCAAAACCGAAAATTCCCTTTGCTTCGAGCAGACTTTCTGAAATCACCTTGCAGCGGGTACTTGCCAACTATTATCTGGT
GACCGATGCTGTTTCCTATATTCTCCATGAACGTGAACGGCTTTCGACCGAACTGAAGGGGATCGGTGGAGTTGAGCTTT
ATGAAAGCGATACCAATTTTATTATAATCAGGGTGCGTCATGCTCATGAGTTGTTCTGTGAGCTGAGTCGTCGGGACATT
CTTGTCAGGGATGTATCCGGATATCCTCTTATGGAGAACTGTCTTCGTTTCAATATCGGGCTCAGGGATGAAAACGATGC
TTTGCTTCAGCAACTCAGGCTTTTATGCGATGAGCCAGTTTAG

Upstream 100 bases:

>100_bases
TGAAAAAAGATGTTTTTTTATCTGAACTCATTCTGTCATCGCGTTACAATAGGTTATCTTCTTTCCGAACCGGTGTTCAA
AAAAACAGTAACGTTATTCT

Downstream 100 bases:

>100_bases
AAAGCTGTCAGGACTGGAGATGAACCGGTTGGACGCGAAGAGCGTTTTTGATGTACCAAGGCATCCGGTTACTCTTATGC
TCGATAATATCCGAAGCATG

Product: histidinol phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MKRDIQELLNPALRDLKAYNVEGGQQAGIKLNQNESPFDLPLWLKEEVLEAFEKEPWNRYPDILPFRGMRSYASFVGVPA
DAVMMSNGSNEMLYTIFLACLGPGKKILIPEPSFSLYEKIARLLHTEVVFVPMLPGLAFDADAIIRKAGEERVDFIVLST
PNNPTGMSLASEEVCRIAEAADALVLVDEAYIEFSRQKSVVAEIARLKNLIVLRTMSKALALAGMRIGFAIADPALMAEI
AKPKIPFASSRLSEITLQRVLANYYLVTDAVSYILHERERLSTELKGIGGVELYESDTNFIIIRVRHAHELFCELSRRDI
LVRDVSGYPLMENCLRFNIGLRDENDALLQQLRLLCDEPV

Sequences:

>Translated_360_residues
MKRDIQELLNPALRDLKAYNVEGGQQAGIKLNQNESPFDLPLWLKEEVLEAFEKEPWNRYPDILPFRGMRSYASFVGVPA
DAVMMSNGSNEMLYTIFLACLGPGKKILIPEPSFSLYEKIARLLHTEVVFVPMLPGLAFDADAIIRKAGEERVDFIVLST
PNNPTGMSLASEEVCRIAEAADALVLVDEAYIEFSRQKSVVAEIARLKNLIVLRTMSKALALAGMRIGFAIADPALMAEI
AKPKIPFASSRLSEITLQRVLANYYLVTDAVSYILHERERLSTELKGIGGVELYESDTNFIIIRVRHAHELFCELSRRDI
LVRDVSGYPLMENCLRFNIGLRDENDALLQQLRLLCDEPV
>Mature_360_residues
MKRDIQELLNPALRDLKAYNVEGGQQAGIKLNQNESPFDLPLWLKEEVLEAFEKEPWNRYPDILPFRGMRSYASFVGVPA
DAVMMSNGSNEMLYTIFLACLGPGKKILIPEPSFSLYEKIARLLHTEVVFVPMLPGLAFDADAIIRKAGEERVDFIVLST
PNNPTGMSLASEEVCRIAEAADALVLVDEAYIEFSRQKSVVAEIARLKNLIVLRTMSKALALAGMRIGFAIADPALMAEI
AKPKIPFASSRLSEITLQRVLANYYLVTDAVSYILHERERLSTELKGIGGVELYESDTNFIIIRVRHAHELFCELSRRDI
LVRDVSGYPLMENCLRFNIGLRDENDALLQQLRLLCDEPV

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=357, Percent_Identity=31.3725490196078, Blast_Score=161, Evalue=6e-41,
Organism=Escherichia coli, GI1788722, Length=175, Percent_Identity=27.4285714285714, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17567369, Length=212, Percent_Identity=27.3584905660377, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=385, Percent_Identity=28.5714285714286, Blast_Score=117, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_CHLPD (A1BGB4)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911865.1
- ProteinModelPortal:   A1BGB4
- SMR:   A1BGB4
- STRING:   A1BGB4
- GeneID:   4568497
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_1412
- NMPDR:   fig|290317.7.peg.1491
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   ILHERER
- ProtClustDB:   CLSK637673
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 40449; Mature: 40449

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRDIQELLNPALRDLKAYNVEGGQQAGIKLNQNESPFDLPLWLKEEVLEAFEKEPWNRY
CCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCC
PDILPFRGMRSYASFVGVPADAVMMSNGSNEMLYTIFLACLGPGKKILIPEPSFSLYEKI
CCCCCCCCHHHHHHHHCCCCHHEEECCCCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHH
ARLLHTEVVFVPMLPGLAFDADAIIRKAGEERVDFIVLSTPNNPTGMSLASEEVCRIAEA
HHHHHHHHHEEECCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHH
ADALVLVDEAYIEFSRQKSVVAEIARLKNLIVLRTMSKALALAGMRIGFAIADPALMAEI
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
AKPKIPFASSRLSEITLQRVLANYYLVTDAVSYILHERERLSTELKGIGGVELYESDTNF
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCE
IIIRVRHAHELFCELSRRDILVRDVSGYPLMENCLRFNIGLRDENDALLQQLRLLCDEPV
EEEEECCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKRDIQELLNPALRDLKAYNVEGGQQAGIKLNQNESPFDLPLWLKEEVLEAFEKEPWNRY
CCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCC
PDILPFRGMRSYASFVGVPADAVMMSNGSNEMLYTIFLACLGPGKKILIPEPSFSLYEKI
CCCCCCCCHHHHHHHHCCCCHHEEECCCCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHH
ARLLHTEVVFVPMLPGLAFDADAIIRKAGEERVDFIVLSTPNNPTGMSLASEEVCRIAEA
HHHHHHHHHEEECCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHH
ADALVLVDEAYIEFSRQKSVVAEIARLKNLIVLRTMSKALALAGMRIGFAIADPALMAEI
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
AKPKIPFASSRLSEITLQRVLANYYLVTDAVSYILHERERLSTELKGIGGVELYESDTNF
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCE
IIIRVRHAHELFCELSRRDILVRDVSGYPLMENCLRFNIGLRDENDALLQQLRLLCDEPV
EEEEECCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA