BacMap

Definition	Chlorobium phaeobacteroides DSM 266 chromosome, complete genome.
Accession	NC_008639
Length	3,133,902

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The map label for this gene is fabL [H]

Identifier: 119356922

GI number: 119356922

Start: 1246618

End: 1247370

Strand: Reverse

Name: fabL [H]

Synonym: Cpha266_1101

Alternate gene names: 119356922

Gene position: 1247370-1246618 (Counterclockwise)

Preceding gene: 119356923

Following gene: 119356921

Centisome position: 39.8

GC content: 49.4

Gene sequence:

>753_bases
ATGAAACATCTGACAAATAAAATCGCTGTCGTTACAGGGGGAACAAGAGGAATAGGGAGAGCCATATCGCTGCATCTTGC
CGAAAGCGGAGCCAGAGTGCTCGCGCTTTATGCAAGAAGCCGTAAAAGTGCCGAATCCCTTGAACATGAGGCTGCTGTCC
GGGGCCTCGATATCACAACCTTCAGAGGCGATCTTTCTCATGAAGAGAGCTTCATCCAGGTTGTGCAGCAACTTCATGAT
TCCTGCGAACATGTGGATATTCTTGTACACTCTGCTGCCAGCGGAGTACACCGGAAAGCCATGGAGCTTTCCGATAAACA
ACTGAAATGGACTTTTGAAATCAACTTCTTTGCTGTACACCGGTTGACAAGAGAGCTTATAGGAAAAATGGGAAGAGGAG
GCCGTATAATCGGAATCACCTCGCCTGGAGGAACCCGGGTTATTCCCGATTACGCCGCAGTAGGTTCTACAAAAGGCGCC
ATGGAGGCTTTATTCCGTCACTACAGCCGTGAGTTCGCTCCTGAAGGGATCGCGGTTAATCTTGTCTGCCCCGGCCTGGT
CATGACCGATGCAGCAAAGGCTTTACCGGAACTTGAACGTCTTTTAAACATCACCCTCGAGTATACGCCTTCCGGCAGAA
TGACAACGCCTCAAGATGTTGCTGAAGTGGTAAACTTTCTTACAACGGATGCAGGAGCCCAGATCGTCGGACAAACCATC
ACAATTGATGGCGGAAAAGGATTATTGGCCTAA

Upstream 100 bases:

>100_bases
TAGGTTCTCTCATTGCTTTTTTGTGTTCTGATGAGGCTCGCTACATAACCGGATCCGTCATTCCTGTTGATGGCGGAAGA
TCATTGGGAGACACCGGAAT

Downstream 100 bases:

>100_bases
GCTGACTTTGATCCGTTACGTCCGACGGCGTGCATATCAAGCTCCTGTTCCGGTTATCATTACTCAATGAACATGTGGAA
ATGCATGAAAAGAACCGTTT

Product: short-chain dehydrogenase/reductase SDR

Products: NA

Alternate protein names: Enoyl-acyl carrier protein reductase III; NADPH-dependent enoyl-ACP reductase [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MKHLTNKIAVVTGGTRGIGRAISLHLAESGARVLALYARSRKSAESLEHEAAVRGLDITTFRGDLSHEESFIQVVQQLHD
SCEHVDILVHSAASGVHRKAMELSDKQLKWTFEINFFAVHRLTRELIGKMGRGGRIIGITSPGGTRVIPDYAAVGSTKGA
MEALFRHYSREFAPEGIAVNLVCPGLVMTDAAKALPELERLLNITLEYTPSGRMTTPQDVAEVVNFLTTDAGAQIVGQTI
TIDGGKGLLA

Sequences:

>Translated_250_residues
MKHLTNKIAVVTGGTRGIGRAISLHLAESGARVLALYARSRKSAESLEHEAAVRGLDITTFRGDLSHEESFIQVVQQLHD
SCEHVDILVHSAASGVHRKAMELSDKQLKWTFEINFFAVHRLTRELIGKMGRGGRIIGITSPGGTRVIPDYAAVGSTKGA
MEALFRHYSREFAPEGIAVNLVCPGLVMTDAAKALPELERLLNITLEYTPSGRMTTPQDVAEVVNFLTTDAGAQIVGQTI
TIDGGKGLLA
>Mature_250_residues
MKHLTNKIAVVTGGTRGIGRAISLHLAESGARVLALYARSRKSAESLEHEAAVRGLDITTFRGDLSHEESFIQVVQQLHD
SCEHVDILVHSAASGVHRKAMELSDKQLKWTFEINFFAVHRLTRELIGKMGRGGRIIGITSPGGTRVIPDYAAVGSTKGA
MEALFRHYSREFAPEGIAVNLVCPGLVMTDAAKALPELERLLNITLEYTPSGRMTTPQDVAEVVNFLTTDAGAQIVGQTI
TIDGGKGLLA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=251, Percent_Identity=28.6852589641434, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI7705925, Length=246, Percent_Identity=28.8617886178862, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI5031737, Length=245, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI19923817, Length=254, Percent_Identity=24.8031496062992, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI126723750, Length=258, Percent_Identity=27.1317829457364, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI40254992, Length=250, Percent_Identity=29.6, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI66933014, Length=259, Percent_Identity=26.6409266409266, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI15277342, Length=261, Percent_Identity=26.8199233716475, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI10190704, Length=251, Percent_Identity=27.4900398406374, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI109715829, Length=258, Percent_Identity=30.2325581395349, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI33667109, Length=196, Percent_Identity=29.5918367346939, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1787335, Length=247, Percent_Identity=33.1983805668016, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI2367365, Length=248, Percent_Identity=32.258064516129, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI87082100, Length=259, Percent_Identity=30.8880308880309, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=29.6, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=29.3172690763052, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=29.2, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI2367175, Length=246, Percent_Identity=27.6422764227642, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1786812, Length=258, Percent_Identity=26.7441860465116, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI87082160, Length=252, Percent_Identity=26.1904761904762, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790717, Length=254, Percent_Identity=26.3779527559055, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787545, Length=259, Percent_Identity=25.8687258687259, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=23.7903225806452, Blast_Score=75, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17560332, Length=272, Percent_Identity=29.7794117647059, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17560676, Length=249, Percent_Identity=28.9156626506024, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17544670, Length=270, Percent_Identity=27.037037037037, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17562910, Length=265, Percent_Identity=26.7924528301887, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193204405, Length=269, Percent_Identity=28.996282527881, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=26.0377358490566, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI115534694, Length=252, Percent_Identity=26.984126984127, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17555706, Length=266, Percent_Identity=27.8195488721804, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71994604, Length=254, Percent_Identity=26.3779527559055, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17538486, Length=266, Percent_Identity=26.6917293233083, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17563726, Length=272, Percent_Identity=26.4705882352941, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=26.2745098039216, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=25.9398496240602, Blast_Score=80, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17560220, Length=266, Percent_Identity=26.6917293233083, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI72000259, Length=276, Percent_Identity=26.0869565217391, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17561402, Length=257, Percent_Identity=28.4046692607004, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17531453, Length=270, Percent_Identity=26.2962962962963, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=273, Percent_Identity=25.2747252747253, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=25.9398496240602, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI25147288, Length=264, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=272, Percent_Identity=25.7352941176471, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=254, Percent_Identity=27.5590551181102, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=274, Percent_Identity=27.007299270073, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=268, Percent_Identity=25.7462686567164, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=274, Percent_Identity=25.1824817518248, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355319, Length=252, Percent_Identity=30.952380952381, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI23397609, Length=250, Percent_Identity=28.8, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24643142, Length=250, Percent_Identity=28, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=25.4980079681275, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21357041, Length=254, Percent_Identity=25.1968503937008, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=25.3012048192771, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=24.0157480314961, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281364494, Length=202, Percent_Identity=29.2079207920792, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24648944, Length=212, Percent_Identity=28.3018867924528, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24644337, Length=121, Percent_Identity=29.7520661157025, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.10 [H]

Molecular weight: Translated: 26967; Mature: 26967

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHLTNKIAVVTGGTRGIGRAISLHLAESGARVLALYARSRKSAESLEHEAAVRGLDITT
CCCCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEE
FRGDLSHEESFIQVVQQLHDSCEHVDILVHSAASGVHRKAMELSDKQLKWTFEINFFAVH
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHH
RLTRELIGKMGRGGRIIGITSPGGTRVIPDYAAVGSTKGAMEALFRHYSREFAPEGIAVN
HHHHHHHHHCCCCCEEEEEECCCCCEECCCHHHHCCCHHHHHHHHHHHHHHCCCCCEEEE
LVCPGLVMTDAAKALPELERLLNITLEYTPSGRMTTPQDVAEVVNFLTTDAGAQIVGQTI
EECCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEECEEE
TIDGGKGLLA
EEECCCCCCC
>Mature Secondary Structure
MKHLTNKIAVVTGGTRGIGRAISLHLAESGARVLALYARSRKSAESLEHEAAVRGLDITT
CCCCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEE
FRGDLSHEESFIQVVQQLHDSCEHVDILVHSAASGVHRKAMELSDKQLKWTFEINFFAVH
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHH
RLTRELIGKMGRGGRIIGITSPGGTRVIPDYAAVGSTKGAMEALFRHYSREFAPEGIAVN
HHHHHHHHHCCCCCEEEEEECCCCCEECCCHHHHCCCHHHHHHHHHHHHHHCCCCCEEEE
LVCPGLVMTDAAKALPELERLLNITLEYTPSGRMTTPQDVAEVVNFLTTDAGAQIVGQTI
EECCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEECEEE
TIDGGKGLLA
EEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9202460; 9384377 [H]