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The map label for this gene is serA [H]

Identifier: 119356910

GI number: 119356910

Start: 1233048

End: 1234628

Strand: Reverse

Name: serA [H]

Synonym: Cpha266_1089

Alternate gene names: 119356910

Gene position: 1234628-1233048 (Counterclockwise)

Preceding gene: 119356914

Following gene: 119356906

Centisome position: 39.4

GC content: 47.25

Gene sequence:

>1581_bases
ATGAAAGTACTGATCACTGATGGTGTCGATCCGCAATGTGCTCAAATTCTCAAGCAGAATGGCTTTGAGGTCACTGAAAT
ACCTAAAATCAGCAAGGAAGAACTCAAAGAGATCATCGGGAACTTTGACAAACTTATCGTCAGAAGTGCAACAAAAGTTA
CGGCTGAAATCATTGAGCTGGGAAAAAAACTGAAATTGATCGGTCGAGCCGGAGCCGGAGTTGATAACATCGACATCGAA
GCCGCAACACGCAACGGCATTATTGTCATGAATACACCCGGAGGCAACACGATCTCTGCCGCAGAGCATACCTGCGGAAT
GATGCTTGCCGCTGCCCGCCAAATCCCGCAGGCAACCGCAGAATTAAAAAACGGTAAATGGGACAAGAAAAAATTCATGG
GAGTTGAGCTTGACGGAAAAACACTCTCCATTATCGGCCTGGGTAAAATCGGTCGTGAAGTTGCCTTCCGCATGCAGGCT
TTCGGAATGAAAACCATTGCATACGACCCCATGATCCCCGACGAATATGCAGCACATCTTAACATCGCACTGCTTCCGCT
GCATGAAAACTTCAAGCAGGCCGACTTCATTACCATTCACTCCTCTCTCAACGAATCAACGAGAAACCTTATTGCCAATG
ACACTTTTGCCCTGATGAAACAAGGGGTAATTATCGTCAATTGCGCACGGGGCGGCATCATCAATGAGGCGGATCTCGCT
GAGGCAATTGCGTCAGGAAAAGTCGGCGCCGCAGCTCTCGACGTTTTCGAAACAGAACCTGTTCAGCAGGATAATCCCCT
CTTAAAGCTCGAACGTGTTGTTGCAACGCCGCACATCGCAGCATCGACCAATGAAGCGCAGGTGAAAGTCGCCGTACAGA
TCGCCGAACAGATTGTTGAGTGGAAACAAAAAGGAAAACTCGAAGGCGCAGTCAATGCCTCGGCAGTTGAACTGGCACAA
ACACCCGGTGTCCGATCATACCTTGCACTTGCTGAAAAGCTTGGAGCAACGCTTGCCCAGCTTACTGCGATTCAAGCCAA
TAAAATCGTCGTCACAACATCCGGCGAATTTCTTCAAAAGTTCAGCGAGGTCATTACAGCCGCAGCATTGAAAGGATTTC
TCGATATCCGCCAGACAAAAGACACCAACTATATCAATGTCTTTACCATGGCTAAAGAAACCGGAATCACCCTTGAACAG
AAATTCGAAAAAGAAAACCCCGATTACACGAACCTTATCAGAATCGAACTTGAAAATGGAGCGACCAAGCGCATGATCGG
TGGCACTGTTTTTGGCGACAAGGAGCTGAGAATTGTGATGATCGACCGGTTTATTGTTGAGTTTAAACCAGAAGGCACCA
TTATCATATACAATAACATCGATCAACCCGGCGTTATTGCTCAGGTCACGCAACTGCTCCTGCTGCATAACCTGAACGTC
GCATCAATTGCGCTCTCAAGAGATGAAGAAAAGAAACTTGCCATAACCGCTATTGTTGTTGATGGCGGGGTGACAACGAC
TTTGCTCGATGAAATAAGTACGGTCAACGGAGTTTCAGACTCAACGCTTCTCTCTCTGTAA

Upstream 100 bases:

>100_bases
TATTATCACTATAAATAATGGTACCCTGAAACGAGGCCTGGCTGCTCCCTCATTTGAAAGCCGTGGTTAACGTTATCCGA
TAATTTTAATCCTGAAGAAC

Downstream 100 bases:

>100_bases
GCGCATATTCTGGCCACACAAAAAAACCTGCCTTTTCAGGCAGGTTTTTTTGTATAAAAGAAACAGATCCGTTTATCTGA
AAATCATCATGGCTTTGTAA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MKVLITDGVDPQCAQILKQNGFEVTEIPKISKEELKEIIGNFDKLIVRSATKVTAEIIELGKKLKLIGRAGAGVDNIDIE
AATRNGIIVMNTPGGNTISAAEHTCGMMLAAARQIPQATAELKNGKWDKKKFMGVELDGKTLSIIGLGKIGREVAFRMQA
FGMKTIAYDPMIPDEYAAHLNIALLPLHENFKQADFITIHSSLNESTRNLIANDTFALMKQGVIIVNCARGGIINEADLA
EAIASGKVGAAALDVFETEPVQQDNPLLKLERVVATPHIAASTNEAQVKVAVQIAEQIVEWKQKGKLEGAVNASAVELAQ
TPGVRSYLALAEKLGATLAQLTAIQANKIVVTTSGEFLQKFSEVITAAALKGFLDIRQTKDTNYINVFTMAKETGITLEQ
KFEKENPDYTNLIRIELENGATKRMIGGTVFGDKELRIVMIDRFIVEFKPEGTIIIYNNIDQPGVIAQVTQLLLLHNLNV
ASIALSRDEEKKLAITAIVVDGGVTTTLLDEISTVNGVSDSTLLSL

Sequences:

>Translated_526_residues
MKVLITDGVDPQCAQILKQNGFEVTEIPKISKEELKEIIGNFDKLIVRSATKVTAEIIELGKKLKLIGRAGAGVDNIDIE
AATRNGIIVMNTPGGNTISAAEHTCGMMLAAARQIPQATAELKNGKWDKKKFMGVELDGKTLSIIGLGKIGREVAFRMQA
FGMKTIAYDPMIPDEYAAHLNIALLPLHENFKQADFITIHSSLNESTRNLIANDTFALMKQGVIIVNCARGGIINEADLA
EAIASGKVGAAALDVFETEPVQQDNPLLKLERVVATPHIAASTNEAQVKVAVQIAEQIVEWKQKGKLEGAVNASAVELAQ
TPGVRSYLALAEKLGATLAQLTAIQANKIVVTTSGEFLQKFSEVITAAALKGFLDIRQTKDTNYINVFTMAKETGITLEQ
KFEKENPDYTNLIRIELENGATKRMIGGTVFGDKELRIVMIDRFIVEFKPEGTIIIYNNIDQPGVIAQVTQLLLLHNLNV
ASIALSRDEEKKLAITAIVVDGGVTTTLLDEISTVNGVSDSTLLSL
>Mature_526_residues
MKVLITDGVDPQCAQILKQNGFEVTEIPKISKEELKEIIGNFDKLIVRSATKVTAEIIELGKKLKLIGRAGAGVDNIDIE
AATRNGIIVMNTPGGNTISAAEHTCGMMLAAARQIPQATAELKNGKWDKKKFMGVELDGKTLSIIGLGKIGREVAFRMQA
FGMKTIAYDPMIPDEYAAHLNIALLPLHENFKQADFITIHSSLNESTRNLIANDTFALMKQGVIIVNCARGGIINEADLA
EAIASGKVGAAALDVFETEPVQQDNPLLKLERVVATPHIAASTNEAQVKVAVQIAEQIVEWKQKGKLEGAVNASAVELAQ
TPGVRSYLALAEKLGATLAQLTAIQANKIVVTTSGEFLQKFSEVITAAALKGFLDIRQTKDTNYINVFTMAKETGITLEQ
KFEKENPDYTNLIRIELENGATKRMIGGTVFGDKELRIVMIDRFIVEFKPEGTIIIYNNIDQPGVIAQVTQLLLLHNLNV
ASIALSRDEEKKLAITAIVVDGGVTTTLLDEISTVNGVSDSTLLSL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=407, Percent_Identity=48.1572481572482, Blast_Score=384, Evalue=1e-107,
Organism=Homo sapiens, GI6912396, Length=275, Percent_Identity=32.7272727272727, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4557497, Length=283, Percent_Identity=33.5689045936396, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI61743967, Length=283, Percent_Identity=33.5689045936396, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI145580578, Length=283, Percent_Identity=32.5088339222615, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI4557499, Length=283, Percent_Identity=32.5088339222615, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI145580575, Length=259, Percent_Identity=33.976833976834, Blast_Score=135, Evalue=8e-32,
Organism=Escherichia coli, GI1789279, Length=375, Percent_Identity=31.2, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI87082289, Length=296, Percent_Identity=29.7297297297297, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1787645, Length=247, Percent_Identity=31.9838056680162, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1788660, Length=302, Percent_Identity=28.476821192053, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87081824, Length=243, Percent_Identity=25.5144032921811, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=320, Percent_Identity=51.875, Blast_Score=314, Evalue=7e-86,
Organism=Caenorhabditis elegans, GI25147481, Length=296, Percent_Identity=30.7432432432432, Blast_Score=130, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320925, Length=332, Percent_Identity=30.7228915662651, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6322116, Length=332, Percent_Identity=30.421686746988, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324055, Length=237, Percent_Identity=32.0675105485232, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324964, Length=253, Percent_Identity=31.2252964426877, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324980, Length=185, Percent_Identity=29.7297297297297, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=156, Percent_Identity=32.6923076923077, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=49.8338870431894, Blast_Score=298, Evalue=6e-81,
Organism=Drosophila melanogaster, GI24646446, Length=264, Percent_Identity=37.1212121212121, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24646448, Length=264, Percent_Identity=37.1212121212121, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24646452, Length=264, Percent_Identity=37.1212121212121, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24646450, Length=264, Percent_Identity=37.1212121212121, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI62472511, Length=264, Percent_Identity=37.1212121212121, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI28574286, Length=301, Percent_Identity=31.2292358803987, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI45551003, Length=309, Percent_Identity=28.4789644012945, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24585514, Length=309, Percent_Identity=28.4789644012945, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28574282, Length=309, Percent_Identity=28.4789644012945, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28574284, Length=309, Percent_Identity=28.4789644012945, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI45552429, Length=309, Percent_Identity=28.4789644012945, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24585516, Length=307, Percent_Identity=26.7100977198697, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28571528, Length=276, Percent_Identity=31.8840579710145, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56915; Mature: 56915

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLITDGVDPQCAQILKQNGFEVTEIPKISKEELKEIIGNFDKLIVRSATKVTAEIIEL
CEEEEECCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
GKKLKLIGRAGAGVDNIDIEAATRNGIIVMNTPGGNTISAAEHTCGMMLAAARQIPQATA
CHHEEEEECCCCCCCCCEEEEECCCCEEEEECCCCCEECHHHHHHHHHHHHHHHCHHHHH
ELKNGKWDKKKFMGVELDGKTLSIIGLGKIGREVAFRMQAFGMKTIAYDPMIPDEYAAHL
HHCCCCCCHHHEEEEEECCCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCCHHCEE
NIALLPLHENFKQADFITIHSSLNESTRNLIANDTFALMKQGVIIVNCARGGIINEADLA
EEEEEECCCCCCCCCEEEEECCCCHHHHHHHCCCHHHHHHCCEEEEEECCCCCCCHHHHH
EAIASGKVGAAALDVFETEPVQQDNPLLKLERVVATPHIAASTNEAQVKVAVQIAEQIVE
HHHHCCCCCHHEEEHHCCCCCCCCCCHHHHHHHHCCCCEEECCCCCEEEHHHHHHHHHHH
WKQKGKLEGAVNASAVELAQTPGVRSYLALAEKLGATLAQLTAIQANKIVVTTSGEFLQK
HHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEECCEEEEEECHHHHHH
FSEVITAAALKGFLDIRQTKDTNYINVFTMAKETGITLEQKFEKENPDYTNLIRIELENG
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHCCCCCCCEEEEEEEECCC
ATKRMIGGTVFGDKELRIVMIDRFIVEFKPEGTIIIYNNIDQPGVIAQVTQLLLLHNLNV
CCEEEECCEEECCCCEEEEEEEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHCCCC
ASIALSRDEEKKLAITAIVVDGGVTTTLLDEISTVNGVSDSTLLSL
EEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCEECC
>Mature Secondary Structure
MKVLITDGVDPQCAQILKQNGFEVTEIPKISKEELKEIIGNFDKLIVRSATKVTAEIIEL
CEEEEECCCCHHHHHHHHHCCCEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
GKKLKLIGRAGAGVDNIDIEAATRNGIIVMNTPGGNTISAAEHTCGMMLAAARQIPQATA
CHHEEEEECCCCCCCCCEEEEECCCCEEEEECCCCCEECHHHHHHHHHHHHHHHCHHHHH
ELKNGKWDKKKFMGVELDGKTLSIIGLGKIGREVAFRMQAFGMKTIAYDPMIPDEYAAHL
HHCCCCCCHHHEEEEEECCCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCCHHCEE
NIALLPLHENFKQADFITIHSSLNESTRNLIANDTFALMKQGVIIVNCARGGIINEADLA
EEEEEECCCCCCCCCEEEEECCCCHHHHHHHCCCHHHHHHCCEEEEEECCCCCCCHHHHH
EAIASGKVGAAALDVFETEPVQQDNPLLKLERVVATPHIAASTNEAQVKVAVQIAEQIVE
HHHHCCCCCHHEEEHHCCCCCCCCCCHHHHHHHHCCCCEEECCCCCEEEHHHHHHHHHHH
WKQKGKLEGAVNASAVELAQTPGVRSYLALAEKLGATLAQLTAIQANKIVVTTSGEFLQK
HHHCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEECCEEEEEECHHHHHH
FSEVITAAALKGFLDIRQTKDTNYINVFTMAKETGITLEQKFEKENPDYTNLIRIELENG
HHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHCCCCCCCEEEEEEEECCC
ATKRMIGGTVFGDKELRIVMIDRFIVEFKPEGTIIIYNNIDQPGVIAQVTQLLLLHNLNV
CCEEEECCEEECCCCEEEEEEEEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHCCCC
ASIALSRDEEKKLAITAIVVDGGVTTTLLDEISTVNGVSDSTLLSL
EEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]