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The map label for this gene is accC [H]

Identifier: 119356886

GI number: 119356886

Start: 1204781

End: 1206238

Strand: Reverse

Name: accC [H]

Synonym: Cpha266_1064

Alternate gene names: 119356886

Gene position: 1206238-1204781 (Counterclockwise)

Preceding gene: 119356888

Following gene: 119356885

Centisome position: 38.49

GC content: 53.29

Gene sequence:

>1458_bases
ATGGATAAAAAAATCAAAAAAGTTCTTGTAGCCAATCGGAGCGTTCCGGCCGTACGGGTTATTCAAACATGCAAAGACAG
AAAAATCCCCACAACGGCAGTCTACAGTACTCCGGACCGTCTTGCCGCTCACGTGTTCATGGCAACTGACGCGGTTCATA
TCGGCGAAGCGCCGCCTGTCGAATCGTACCTGAACATGGAAAAGATTATCGCGGCAGCCCGCAAGAGCGGCGCCAATGCC
ATACATCCGGGCTGGGGCTTTCTTTCCGAAAATGCGAAATTCGCCCAAATGGTGCAGGATTCCGACCTGATCTGGATCGG
CCCAAGCCCCGAAGTCATCCATAAAATGGGCGACAAAATCGAGTCGAAAAAGATCGCCAAAGAAGCCAAAGTCCCCACCA
TCCCGGGCATCAACTCCCCGAAAACCGCCGAGGAAATCCGCACGTGGATGCAGGAGGAGGACGTTGCTCTTCCGATTATC
ATCAAAGCCTCCTCGGGCGGCGGCGGCAAAGGAATGGTCAGGGTCACTCACGATTCGGAGCTTGAGAACGCCCTGGCACA
GGCTCGATCGGAAGCGAAAAAATCATTCGGCAACGACGAAATTCTCGTTGAAAAGTTTATCGAAAAAGGTCGACACATCG
AAGTGCAGATCATCGCCGACCAGCATGGCAATGTGATTCATCTCTTCGAGCGCGAATGCACGCTCCAGCGCCGCAACCAG
AAAATCATCGAAGAAGCCCCGTCGCCCAGCATTGACGACGACATCCGTCAATCCATTTGCGAGACAGCCGTCCAGCTCAT
GCGCACAATCGGCTACTCGTCTGCTGGCACAGTTGAATTTCTGCTTGATGCCGCGACCGGCAAATTCTACTTCCTCGAAG
TAAACACCCGCCTTCAGGTAGAGCATGGCATTACCGAGCTGATAACCGGCGTGGATATCGTCAGCCTGATGCTCGACATA
GCACAAGGAGACCCTCTCGGCTTCCTGCAGGAAGACATCCGCCCGAACCGCTGGGCGCTGGAAGTCCGACTAAACGCGGA
AGATCCGGCAACATTCAGCCCTTCATTCGGCAACATCAGCCGCCTGCACCTGAACCTCTATCCCGGTACCAGGGTATCGC
AAGGCGTCTATGAAGGCTCTGAAATCCCGCCCTATTACGACTCGCTGATCATGCTCCTGATGACATCCGGACCGGACAGG
GAAACCGCCATTATGAAAATGGAAAGCATTCTCTGCCGCAACCTCAGGGTTGAAGGCGTTAAAACCCTTGCGCCGATGCT
TTTGAGCATCATCCGGCACCACAATTTCATCAGGGGCGATTTCTCGACGCGCTTTATCGAAGAGCATATGGACGAACTCG
TCTCCATGTTCCCGGAGGGCGACAGCGAAGAAGATGTGCTGAAAATCGCCAAATATATAGCTGAAATTTCTGCTCTTGGA
ACACCGAACTGGATTTAA

Upstream 100 bases:

>100_bases
TGCGAAATCTCTTGCAACCATGTTTTCAAATAGGTATGATGCTCTGTATATCAGGCTTTACCATCAAAAATCGCGAATTA
CTTAAGTCGGAAAAGGCATA

Downstream 100 bases:

>100_bases
GAACCATGACCAATTCTGTCTTCGTCAAACCGGGAATGAGCCCGAAAGAAATCATCAATAACGTTCGTCATTTAGATGCG
ATAGCCCTGACTTCGACCGG

Product: carbamoyl-phosphate synthase L chain, ATP-binding

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MDKKIKKVLVANRSVPAVRVIQTCKDRKIPTTAVYSTPDRLAAHVFMATDAVHIGEAPPVESYLNMEKIIAAARKSGANA
IHPGWGFLSENAKFAQMVQDSDLIWIGPSPEVIHKMGDKIESKKIAKEAKVPTIPGINSPKTAEEIRTWMQEEDVALPII
IKASSGGGGKGMVRVTHDSELENALAQARSEAKKSFGNDEILVEKFIEKGRHIEVQIIADQHGNVIHLFERECTLQRRNQ
KIIEEAPSPSIDDDIRQSICETAVQLMRTIGYSSAGTVEFLLDAATGKFYFLEVNTRLQVEHGITELITGVDIVSLMLDI
AQGDPLGFLQEDIRPNRWALEVRLNAEDPATFSPSFGNISRLHLNLYPGTRVSQGVYEGSEIPPYYDSLIMLLMTSGPDR
ETAIMKMESILCRNLRVEGVKTLAPMLLSIIRHHNFIRGDFSTRFIEEHMDELVSMFPEGDSEEDVLKIAKYIAEISALG
TPNWI

Sequences:

>Translated_485_residues
MDKKIKKVLVANRSVPAVRVIQTCKDRKIPTTAVYSTPDRLAAHVFMATDAVHIGEAPPVESYLNMEKIIAAARKSGANA
IHPGWGFLSENAKFAQMVQDSDLIWIGPSPEVIHKMGDKIESKKIAKEAKVPTIPGINSPKTAEEIRTWMQEEDVALPII
IKASSGGGGKGMVRVTHDSELENALAQARSEAKKSFGNDEILVEKFIEKGRHIEVQIIADQHGNVIHLFERECTLQRRNQ
KIIEEAPSPSIDDDIRQSICETAVQLMRTIGYSSAGTVEFLLDAATGKFYFLEVNTRLQVEHGITELITGVDIVSLMLDI
AQGDPLGFLQEDIRPNRWALEVRLNAEDPATFSPSFGNISRLHLNLYPGTRVSQGVYEGSEIPPYYDSLIMLLMTSGPDR
ETAIMKMESILCRNLRVEGVKTLAPMLLSIIRHHNFIRGDFSTRFIEEHMDELVSMFPEGDSEEDVLKIAKYIAEISALG
TPNWI
>Mature_485_residues
MDKKIKKVLVANRSVPAVRVIQTCKDRKIPTTAVYSTPDRLAAHVFMATDAVHIGEAPPVESYLNMEKIIAAARKSGANA
IHPGWGFLSENAKFAQMVQDSDLIWIGPSPEVIHKMGDKIESKKIAKEAKVPTIPGINSPKTAEEIRTWMQEEDVALPII
IKASSGGGGKGMVRVTHDSELENALAQARSEAKKSFGNDEILVEKFIEKGRHIEVQIIADQHGNVIHLFERECTLQRRNQ
KIIEEAPSPSIDDDIRQSICETAVQLMRTIGYSSAGTVEFLLDAATGKFYFLEVNTRLQVEHGITELITGVDIVSLMLDI
AQGDPLGFLQEDIRPNRWALEVRLNAEDPATFSPSFGNISRLHLNLYPGTRVSQGVYEGSEIPPYYDSLIMLLMTSGPDR
ETAIMKMESILCRNLRVEGVKTLAPMLLSIIRHHNFIRGDFSTRFIEEHMDELVSMFPEGDSEEDVLKIAKYIAEISALG
TPNWI

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=463, Percent_Identity=47.5161987041037, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI295821183, Length=463, Percent_Identity=47.5161987041037, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI189095269, Length=462, Percent_Identity=47.6190476190476, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI116805327, Length=456, Percent_Identity=43.859649122807, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI106049528, Length=479, Percent_Identity=43.8413361169102, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI106049295, Length=479, Percent_Identity=43.8413361169102, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI106049292, Length=479, Percent_Identity=43.8413361169102, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI38679971, Length=538, Percent_Identity=29.9256505576208, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI38679977, Length=538, Percent_Identity=29.9256505576208, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI38679967, Length=538, Percent_Identity=29.9256505576208, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI38679960, Length=538, Percent_Identity=29.9256505576208, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI38679974, Length=538, Percent_Identity=29.9256505576208, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI134142062, Length=521, Percent_Identity=30.5182341650672, Blast_Score=219, Evalue=7e-57,
Organism=Homo sapiens, GI18105007, Length=191, Percent_Identity=24.0837696335079, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1789654, Length=446, Percent_Identity=44.6188340807175, Blast_Score=382, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17567343, Length=463, Percent_Identity=46.8682505399568, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI71987519, Length=455, Percent_Identity=45.0549450549451, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17562816, Length=485, Percent_Identity=41.0309278350515, Blast_Score=350, Evalue=8e-97,
Organism=Caenorhabditis elegans, GI133931226, Length=492, Percent_Identity=29.6747967479675, Blast_Score=213, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71997168, Length=515, Percent_Identity=30.0970873786408, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71997163, Length=515, Percent_Identity=30.0970873786408, Blast_Score=212, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6319695, Length=484, Percent_Identity=40.702479338843, Blast_Score=340, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6321376, Length=484, Percent_Identity=41.1157024793388, Blast_Score=333, Evalue=4e-92,
Organism=Saccharomyces cerevisiae, GI6319685, Length=446, Percent_Identity=38.5650224215247, Blast_Score=309, Evalue=8e-85,
Organism=Saccharomyces cerevisiae, GI6323863, Length=501, Percent_Identity=31.3373253493014, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6324343, Length=513, Percent_Identity=29.6296296296296, Blast_Score=209, Evalue=9e-55,
Organism=Drosophila melanogaster, GI24652212, Length=481, Percent_Identity=43.035343035343, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652210, Length=481, Percent_Identity=43.035343035343, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652214, Length=481, Percent_Identity=43.035343035343, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI19921944, Length=481, Percent_Identity=43.035343035343, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652216, Length=481, Percent_Identity=43.035343035343, Blast_Score=374, Evalue=1e-103,
Organism=Drosophila melanogaster, GI281363050, Length=481, Percent_Identity=43.035343035343, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652224, Length=481, Percent_Identity=43.035343035343, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652222, Length=481, Percent_Identity=43.035343035343, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652220, Length=481, Percent_Identity=43.035343035343, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652218, Length=481, Percent_Identity=43.035343035343, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24651757, Length=458, Percent_Identity=40.174672489083, Blast_Score=344, Evalue=6e-95,
Organism=Drosophila melanogaster, GI24651759, Length=417, Percent_Identity=40.2877697841727, Blast_Score=314, Evalue=7e-86,
Organism=Drosophila melanogaster, GI161076407, Length=512, Percent_Identity=30.2734375, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24586460, Length=512, Percent_Identity=30.2734375, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24586458, Length=512, Percent_Identity=30.2734375, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI161076409, Length=512, Percent_Identity=30.2734375, Blast_Score=217, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 53955; Mature: 53955

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS50975 ATP_GRASP ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKIKKVLVANRSVPAVRVIQTCKDRKIPTTAVYSTPDRLAAHVFMATDAVHIGEAPPV
CCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHEECCEECCCCCCH
ESYLNMEKIIAAARKSGANAIHPGWGFLSENAKFAQMVQDSDLIWIGPSPEVIHKMGDKI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCHHHHHHHHHHH
ESKKIAKEAKVPTIPGINSPKTAEEIRTWMQEEDVALPIIIKASSGGGGKGMVRVTHDSE
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEECCHH
LENALAQARSEAKKSFGNDEILVEKFIEKGRHIEVQIIADQHGNVIHLFERECTLQRRNQ
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEECCCCCEEEEEHHHHHHHHHHH
KIIEEAPSPSIDDDIRQSICETAVQLMRTIGYSSAGTVEFLLDAATGKFYFLEVNTRLQV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEECCCCEEEEEEECCEEEE
EHGITELITGVDIVSLMLDIAQGDPLGFLQEDIRPNRWALEVRLNAEDPATFSPSFGNIS
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCEE
RLHLNLYPGTRVSQGVYEGSEIPPYYDSLIMLLMTSGPDRETAIMKMESILCRNLRVEGV
EEEEEECCCCCHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHH
KTLAPMLLSIIRHHNFIRGDFSTRFIEEHMDELVSMFPEGDSEEDVLKIAKYIAEISALG
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
TPNWI
CCCCC
>Mature Secondary Structure
MDKKIKKVLVANRSVPAVRVIQTCKDRKIPTTAVYSTPDRLAAHVFMATDAVHIGEAPPV
CCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHEECCEECCCCCCH
ESYLNMEKIIAAARKSGANAIHPGWGFLSENAKFAQMVQDSDLIWIGPSPEVIHKMGDKI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCHHHHHHHHHHH
ESKKIAKEAKVPTIPGINSPKTAEEIRTWMQEEDVALPIIIKASSGGGGKGMVRVTHDSE
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEECCHH
LENALAQARSEAKKSFGNDEILVEKFIEKGRHIEVQIIADQHGNVIHLFERECTLQRRNQ
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEECCCCCEEEEEHHHHHHHHHHH
KIIEEAPSPSIDDDIRQSICETAVQLMRTIGYSSAGTVEFLLDAATGKFYFLEVNTRLQV
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHEEECCCCEEEEEEECCEEEE
EHGITELITGVDIVSLMLDIAQGDPLGFLQEDIRPNRWALEVRLNAEDPATFSPSFGNIS
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCEE
RLHLNLYPGTRVSQGVYEGSEIPPYYDSLIMLLMTSGPDRETAIMKMESILCRNLRVEGV
EEEEEECCCCCHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHH
KTLAPMLLSIIRHHNFIRGDFSTRFIEEHMDELVSMFPEGDSEEDVLKIAKYIAEISALG
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCC
TPNWI
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]