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The map label for this gene is hisB

Identifier: 119356757

GI number: 119356757

Start: 1058618

End: 1059220

Strand: Reverse

Name: hisB

Synonym: Cpha266_0929

Alternate gene names: 119356757

Gene position: 1059220-1058618 (Counterclockwise)

Preceding gene: 119356758

Following gene: 119356751

Centisome position: 33.8

GC content: 49.59

Gene sequence:

>603_bases
ATGCCTGAAAACGTAGTCAACCCTGTCCGTACCGCGACTGTATCAAGAAAAACAAAAGAAACCGATATCACCGTAACGGT
TCTGATAGATGGAACCGGTCACGGATCCATCAATTCGGGTGTCGCATTTCTTGACCATATGCTTGCCAACTTCTGCCGGC
ATTCCGGATTTGATATGTCGCTTGTATGCAACGGAGATCTCGATGTTGATGACCACCACAGCGTTGAAGATGTCGCTCTT
GTCATCGGCAGCGCCATCAGCGAAGCGCTGCTCGACAAAACAGGCTTGCAGCGGTATGGCTGGGCTATCATCCCGATGGA
TGAAGCTCTGGCTCGTTGTGCCCTTGATCTTGGAGGCAGAAGTTACTGCGTCTTCAATGCGGAGTTCAAGCGGCCTGTTA
TCGAGGGATTTTCAACAGAGATGGTGGAGCATTTTTTTGTTTCGCTCTCAAGAACCATGCAGGCCAACATCCATCTTGCC
ATTCTGGAGGGAAAAAACACGCACCACAAGATCGAAGCACTGTTCAAGTCGTTTGCCTATGCCATGAAGGATGCCGTGAG
AATTACAGGAACAACAATCCCCTCAACCAAGGGAAAGCTGTAG

Upstream 100 bases:

>100_bases
AGGTTCAGTTTTTATTTTCCACTTGGCTCCTCACTGCTTCTTTCGGCAGTACTGAGCATTCTCTTTTACTTTTTCAATAA
ATTTATCCGGTAACGCTTCC

Downstream 100 bases:

>100_bases
GCTCTCCCCCGGCATCGGTGCAAACCGTTTACTTTGCGTAGGCGATTGAACGTCTTTCGCGAATAATCGATACCTTTATC
TGTCCGGGGTACTGAACCTC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MPENVVNPVRTATVSRKTKETDITVTVLIDGTGHGSINSGVAFLDHMLANFCRHSGFDMSLVCNGDLDVDDHHSVEDVAL
VIGSAISEALLDKTGLQRYGWAIIPMDEALARCALDLGGRSYCVFNAEFKRPVIEGFSTEMVEHFFVSLSRTMQANIHLA
ILEGKNTHHKIEALFKSFAYAMKDAVRITGTTIPSTKGKL

Sequences:

>Translated_200_residues
MPENVVNPVRTATVSRKTKETDITVTVLIDGTGHGSINSGVAFLDHMLANFCRHSGFDMSLVCNGDLDVDDHHSVEDVAL
VIGSAISEALLDKTGLQRYGWAIIPMDEALARCALDLGGRSYCVFNAEFKRPVIEGFSTEMVEHFFVSLSRTMQANIHLA
ILEGKNTHHKIEALFKSFAYAMKDAVRITGTTIPSTKGKL
>Mature_199_residues
PENVVNPVRTATVSRKTKETDITVTVLIDGTGHGSINSGVAFLDHMLANFCRHSGFDMSLVCNGDLDVDDHHSVEDVALV
IGSAISEALLDKTGLQRYGWAIIPMDEALARCALDLGGRSYCVFNAEFKRPVIEGFSTEMVEHFFVSLSRTMQANIHLAI
LEGKNTHHKIEALFKSFAYAMKDAVRITGTTIPSTKGKL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=198, Percent_Identity=48.989898989899, Blast_Score=195, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324776, Length=166, Percent_Identity=39.7590361445783, Blast_Score=142, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_CHLPD (A1BF00)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911401.1
- ProteinModelPortal:   A1BF00
- SMR:   A1BF00
- STRING:   A1BF00
- GeneID:   4570624
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0929
- NMPDR:   fig|290317.7.peg.987
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- ProtClustDB:   PRK00951
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21869; Mature: 21738

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPENVVNPVRTATVSRKTKETDITVTVLIDGTGHGSINSGVAFLDHMLANFCRHSGFDMS
CCCCCCCHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCEE
LVCNGDLDVDDHHSVEDVALVIGSAISEALLDKTGLQRYGWAIIPMDEALARCALDLGGR
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCEEEEEHHHHHHHHHHHCCCC
SYCVFNAEFKRPVIEGFSTEMVEHFFVSLSRTMQANIHLAILEGKNTHHKIEALFKSFAY
EEEEEECHHCCHHHHCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHH
AMKDAVRITGTTIPSTKGKL
HHHHCEEEECCCCCCCCCCC
>Mature Secondary Structure 
PENVVNPVRTATVSRKTKETDITVTVLIDGTGHGSINSGVAFLDHMLANFCRHSGFDMS
CCCCCCHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCEE
LVCNGDLDVDDHHSVEDVALVIGSAISEALLDKTGLQRYGWAIIPMDEALARCALDLGGR
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCEEEEEHHHHHHHHHHHCCCC
SYCVFNAEFKRPVIEGFSTEMVEHFFVSLSRTMQANIHLAILEGKNTHHKIEALFKSFAY
EEEEEECHHCCHHHHCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHH
AMKDAVRITGTTIPSTKGKL
HHHHCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA