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The map label for this gene is glmU [H]

Identifier: 119356751

GI number: 119356751

Start: 1051458

End: 1052435

Strand: Reverse

Name: glmU [H]

Synonym: Cpha266_0923

Alternate gene names: 119356751

Gene position: 1052435-1051458 (Counterclockwise)

Preceding gene: 119356757

Following gene: 119356750

Centisome position: 33.58

GC content: 47.85

Gene sequence:

>978_bases
ATGAAAGCCATCATTCCTGTTGCAGGCGTTGGAACCCGTCTGCGTCCTCACACCTACTCGCACCCGAAAGTTCTTTTAAA
TGTTGCCGGCAAACCGATCATCGGCCACATCATGGACAAGCTTATTGATGCCGGAATCGATGAAGCTATTGTCATTGTAG
GTTATCTCGGCAGTATGGTCGAAGATTGGCTGCGCAAACACTACACCATAAAGTTCACCTTTGTCGATCAGACTGAAATG
CTTGGTCTTGCCCATGCGGTCTGGATGTGTAAAGACCATGTCGATAAAACCGATCCCCTGCTTATCATTCTTGGCGACAC
GGTTTTCGATGTCGATCTTTCCCCCGTGCTTCAGAGCCCCTGCTCAACGCTGGGAGTCAAGGAGGTCGAAGACCCTCGAC
GGTTCGGAGTGGCGGTGATGGAAGAAAACCGCATTAAAAAACTTGTTGAAAAACCTGATACGCCTGTAAGCAATCTGGCC
ATTGTCGGCCTCTATTTTCTTTACAAGGCGCAGCCGCTTTTTGAGTGCATCGATCACCTGATCAGCAATGAGATAAAAAC
CAAAGGAGAGTACCAGCTTACCGATGCGCTCCAACTCATGATTGAACGGGGTGAACCGTTTACAACATTTCCTGTTGAAG
GGTGGTATGATTGCGGCAAACCTGAAACGCTTCTCTCTACCAACGAAATTCTCCTGCAGAAAACAGTGTCAGGAAAAACG
TTTCCAGGATGCATCATCAACGAACCCGTATTCATAGCCGACAGCGCCACGCTTGAAAATGCCATTATCGGACCAAACAC
ATCCGTCGCTGAACATGCCGTCATAACTGATGCCGTCGTAAAAAACTCCATTATCGGCAGTGAGGCCCAGGTAACCGGTG
TAATGCTCACCCAATCGATTGTAGGCAACAACGCATCCATTAACGGGTCCTTCCATAAAATCAATATCGGCGATTACTCG
GAAATAATGATTGGATAA

Upstream 100 bases:

>100_bases
TGCAAGAAAGAGAGTCATGAATCACTAAATTTCCTTCAGCGCAAGAAGAGAAAAAAAATGCGTGACCCGGGCACCTTACA
ATCTAACCCGACAGACCATT

Downstream 100 bases:

>100_bases
CACGCTCTTGCAAGTCAGCGGACGAATGCTTACATTTTAGCTTTATTTTTGTTCGGCATCCCCATTACCTATGGACACGG
TGCCCCGGACTCAGAAATAA

Product: nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MKAIIPVAGVGTRLRPHTYSHPKVLLNVAGKPIIGHIMDKLIDAGIDEAIVIVGYLGSMVEDWLRKHYTIKFTFVDQTEM
LGLAHAVWMCKDHVDKTDPLLIILGDTVFDVDLSPVLQSPCSTLGVKEVEDPRRFGVAVMEENRIKKLVEKPDTPVSNLA
IVGLYFLYKAQPLFECIDHLISNEIKTKGEYQLTDALQLMIERGEPFTTFPVEGWYDCGKPETLLSTNEILLQKTVSGKT
FPGCIINEPVFIADSATLENAIIGPNTSVAEHAVITDAVVKNSIIGSEAQVTGVMLTQSIVGNNASINGSFHKINIGDYS
EIMIG

Sequences:

>Translated_325_residues
MKAIIPVAGVGTRLRPHTYSHPKVLLNVAGKPIIGHIMDKLIDAGIDEAIVIVGYLGSMVEDWLRKHYTIKFTFVDQTEM
LGLAHAVWMCKDHVDKTDPLLIILGDTVFDVDLSPVLQSPCSTLGVKEVEDPRRFGVAVMEENRIKKLVEKPDTPVSNLA
IVGLYFLYKAQPLFECIDHLISNEIKTKGEYQLTDALQLMIERGEPFTTFPVEGWYDCGKPETLLSTNEILLQKTVSGKT
FPGCIINEPVFIADSATLENAIIGPNTSVAEHAVITDAVVKNSIIGSEAQVTGVMLTQSIVGNNASINGSFHKINIGDYS
EIMIG
>Mature_325_residues
MKAIIPVAGVGTRLRPHTYSHPKVLLNVAGKPIIGHIMDKLIDAGIDEAIVIVGYLGSMVEDWLRKHYTIKFTFVDQTEM
LGLAHAVWMCKDHVDKTDPLLIILGDTVFDVDLSPVLQSPCSTLGVKEVEDPRRFGVAVMEENRIKKLVEKPDTPVSNLA
IVGLYFLYKAQPLFECIDHLISNEIKTKGEYQLTDALQLMIERGEPFTTFPVEGWYDCGKPETLLSTNEILLQKTVSGKT
FPGCIINEPVFIADSATLENAIIGPNTSVAEHAVITDAVVKNSIIGSEAQVTGVMLTQSIVGNNASINGSFHKINIGDYS
EIMIG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=327, Percent_Identity=28.1345565749235, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI11761621, Length=326, Percent_Identity=28.2208588957055, Blast_Score=116, Evalue=4e-26,
Organism=Escherichia coli, GI1790224, Length=242, Percent_Identity=30.5785123966942, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787488, Length=266, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788351, Length=247, Percent_Identity=27.5303643724696, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1788355, Length=268, Percent_Identity=25, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790168, Length=318, Percent_Identity=24.8427672955975, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=344, Percent_Identity=27.0348837209302, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17509979, Length=339, Percent_Identity=28.023598820059, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17509981, Length=326, Percent_Identity=27.6073619631902, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320148, Length=331, Percent_Identity=27.7945619335347, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21355443, Length=330, Percent_Identity=28.1818181818182, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24644084, Length=330, Percent_Identity=28.1818181818182, Blast_Score=111, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 35618; Mature: 35618

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIIPVAGVGTRLRPHTYSHPKVLLNVAGKPIIGHIMDKLIDAGIDEAIVIVGYLGSMV
CCCEEECCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
EDWLRKHYTIKFTFVDQTEMLGLAHAVWMCKDHVDKTDPLLIILGDTVFDVDLSPVLQSP
HHHHHCCEEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEECCCHHHHHCH
CSTLGVKEVEDPRRFGVAVMEENRIKKLVEKPDTPVSNLAIVGLYFLYKAQPLFECIDHL
HHHCCCCCCCCHHHHCEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
ISNEIKTKGEYQLTDALQLMIERGEPFTTFPVEGWYDCGKPETLLSTNEILLQKTVSGKT
HHHHHCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCHHHEEEECCCCC
FPGCIINEPVFIADSATLENAIIGPNTSVAEHAVITDAVVKNSIIGSEAQVTGVMLTQSI
CCCEEECCCEEEECCCHHCCCEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHEEEHHH
VGNNASINGSFHKINIGDYSEIMIG
HCCCCEECCCEEEEECCCCHHEECC
>Mature Secondary Structure
MKAIIPVAGVGTRLRPHTYSHPKVLLNVAGKPIIGHIMDKLIDAGIDEAIVIVGYLGSMV
CCCEEECCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
EDWLRKHYTIKFTFVDQTEMLGLAHAVWMCKDHVDKTDPLLIILGDTVFDVDLSPVLQSP
HHHHHCCEEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEECCCHHHHHCH
CSTLGVKEVEDPRRFGVAVMEENRIKKLVEKPDTPVSNLAIVGLYFLYKAQPLFECIDHL
HHHCCCCCCCCHHHHCEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
ISNEIKTKGEYQLTDALQLMIERGEPFTTFPVEGWYDCGKPETLLSTNEILLQKTVSGKT
HHHHHCCCCCCHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCHHHEEEECCCCC
FPGCIINEPVFIADSATLENAIIGPNTSVAEHAVITDAVVKNSIIGSEAQVTGVMLTQSI
CCCEEECCCEEEECCCHHCCCEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHEEEHHH
VGNNASINGSFHKINIGDYSEIMIG
HCCCCEECCCEEEEECCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]