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The map label for this gene is ahcY

Identifier: 119356749

GI number: 119356749

Start: 1048461

End: 1049876

Strand: Reverse

Name: ahcY

Synonym: Cpha266_0921

Alternate gene names: 119356749

Gene position: 1049876-1048461 (Counterclockwise)

Preceding gene: 119356750

Following gene: 119356748

Centisome position: 33.5

GC content: 51.34

Gene sequence:

>1416_bases
ATGACCATTGAAGCTGAAGTTCTTGCATATAAAGTTGCGGATATGTCTCTTGCAGAGTGGGGTCGCAAAGAGATCGATAT
TGCAGAAAAAGAGATGCCGGGTCTCATGGCTACCCGAAAAAAATATGCGGGCCAAAAACCCCTGAAGGGTGCAAGAATTG
CAGGCTCCCTGCACATGACCATCCAGACCGCTGTCTTGATCGAAACCCTCGTTGAGCTTGGCGCTGATGTGCGCTGGGCA
AGCTGTAATATTTTTTCCACGCAGGATCATGCCGCTGCCGCAATTGCGAAAGCAGGCATCCCGGTCTTCGCATGGAAAGG
TGAAACCCTTGACGAATACTGGTGGTGTACCCGCCAGATTCTCGAATTTGAAGGCGGCAAGGGACCTCACCTCATTGTTG
ACGACGGCGGCGATGCAACGCTGATGATCCATCTCGGCTACAAAATCGAAATCGATCCATCGCTGCTTGATAAAACTCCG
GGCAACATTGAAGAAAAAGCGCTTTTCCAGCAACTGCGCGAGGTCTATGAAGAAGACAGCCAGAGATGGCACAACGTCGC
TGCGGAAATGAAAGGTGTATCTGAAGAAACTACCACCGGCGTACACCGTCTCTACCAGATGATGGAAAAAGAGGAACTGC
TGTTTCCTGCCATCAACGTCAACGATTCGGTGACAAAATCAAAATTCGACAACCTCTATGGATGCCGCGAGTCACTTGCT
GACGGTATCAAACGCGCGACTGACGTCATGGTTGCAGGCAAAGTAGTTGTTGTTCTTGGCTATGGTGATGTTGGCAAAGG
TTCCGCCAGATCCATGCGGGCTTATGGCGCAAGGGTCATCGTTACTGAAATCGATCCGATCTGTGCACTGCAGGCCGCCA
TGGAAGGTTATGAGGTCAACACCATGGATGAAGCGGTCACAGAAGGCAATATCTTTGTTACCACAACAGGAAACAAGGAT
GTCATCACGCTTGAGCACATGAAAAAGATGAAGGGCGAAGCCATCATCTGCAACATCGGTCACTTCGACAACGAAATCCA
GGTCGAACCGCTCAACAACTATGCCGGCGCAACCAAGCTCAACATCAAGCCGCAGGTCGACAAATACACCTTTGAGGACG
GTCACGCCATCTATCTGCTTGCCGAAGGCCGACTCGTCAATCTTGGCTGTGCCACTGGCCATCCATCGTTTGTGATGAGC
AACTCCTTCACCAACCAGACGCTCGCCCAGCTCGAGCTCTGGACACGCGACTATGCAATCGATGTCTATCGTCTGCCGAA
ACAGCTTGACGAAGAGGTCGCCAGACTGCATCTTGAGCAGCTTGGAGTCAAACTGACCACGCTGACCAACGAACAGGCTG
AGTATATCGGTGTTCCTCTTGAAGGGCCCTACAAGCCTGAGCACTACCGCTACTGA

Upstream 100 bases:

>100_bases
TTACCGGCAAGCGACTGGCGGAGTACCGACCCGTCTGAAAATCGAGCATGTAATAAAGAGAGGTTCCCGTTCCTCTGAAC
CTTTTAACAATCATGGCGAA

Downstream 100 bases:

>100_bases
GAGGTAATGGTGCGCAAAAAGACAAACAAAAAAGGCAGCTCTTCAAAGAGCTGCCTTTTTTATTGCTGGGGCGGCAGGAT
TCGAACCTGCGAATGTCGGC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTIEAEVLAYKVADMSLAEWGRKEIDIAEKEMPGLMATRKKYAGQKPLKGARIAGSLHMTIQTAVLIETLVELGADVRWA
SCNIFSTQDHAAAAIAKAGIPVFAWKGETLDEYWWCTRQILEFEGGKGPHLIVDDGGDATLMIHLGYKIEIDPSLLDKTP
GNIEEKALFQQLREVYEEDSQRWHNVAAEMKGVSEETTTGVHRLYQMMEKEELLFPAINVNDSVTKSKFDNLYGCRESLA
DGIKRATDVMVAGKVVVVLGYGDVGKGSARSMRAYGARVIVTEIDPICALQAAMEGYEVNTMDEAVTEGNIFVTTTGNKD
VITLEHMKKMKGEAIICNIGHFDNEIQVEPLNNYAGATKLNIKPQVDKYTFEDGHAIYLLAEGRLVNLGCATGHPSFVMS
NSFTNQTLAQLELWTRDYAIDVYRLPKQLDEEVARLHLEQLGVKLTTLTNEQAEYIGVPLEGPYKPEHYRY

Sequences:

>Translated_471_residues
MTIEAEVLAYKVADMSLAEWGRKEIDIAEKEMPGLMATRKKYAGQKPLKGARIAGSLHMTIQTAVLIETLVELGADVRWA
SCNIFSTQDHAAAAIAKAGIPVFAWKGETLDEYWWCTRQILEFEGGKGPHLIVDDGGDATLMIHLGYKIEIDPSLLDKTP
GNIEEKALFQQLREVYEEDSQRWHNVAAEMKGVSEETTTGVHRLYQMMEKEELLFPAINVNDSVTKSKFDNLYGCRESLA
DGIKRATDVMVAGKVVVVLGYGDVGKGSARSMRAYGARVIVTEIDPICALQAAMEGYEVNTMDEAVTEGNIFVTTTGNKD
VITLEHMKKMKGEAIICNIGHFDNEIQVEPLNNYAGATKLNIKPQVDKYTFEDGHAIYLLAEGRLVNLGCATGHPSFVMS
NSFTNQTLAQLELWTRDYAIDVYRLPKQLDEEVARLHLEQLGVKLTTLTNEQAEYIGVPLEGPYKPEHYRY
>Mature_470_residues
TIEAEVLAYKVADMSLAEWGRKEIDIAEKEMPGLMATRKKYAGQKPLKGARIAGSLHMTIQTAVLIETLVELGADVRWAS
CNIFSTQDHAAAAIAKAGIPVFAWKGETLDEYWWCTRQILEFEGGKGPHLIVDDGGDATLMIHLGYKIEIDPSLLDKTPG
NIEEKALFQQLREVYEEDSQRWHNVAAEMKGVSEETTTGVHRLYQMMEKEELLFPAINVNDSVTKSKFDNLYGCRESLAD
GIKRATDVMVAGKVVVVLGYGDVGKGSARSMRAYGARVIVTEIDPICALQAAMEGYEVNTMDEAVTEGNIFVTTTGNKDV
ITLEHMKKMKGEAIICNIGHFDNEIQVEPLNNYAGATKLNIKPQVDKYTFEDGHAIYLLAEGRLVNLGCATGHPSFVMSN
SFTNQTLAQLELWTRDYAIDVYRLPKQLDEEVARLHLEQLGVKLTTLTNEQAEYIGVPLEGPYKPEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=469, Percent_Identity=63.9658848614073, Blast_Score=574, Evalue=1e-164,
Organism=Homo sapiens, GI239937451, Length=442, Percent_Identity=64.027149321267, Blast_Score=539, Evalue=1e-153,
Organism=Homo sapiens, GI298286489, Length=465, Percent_Identity=48.8172043010753, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI195539337, Length=465, Percent_Identity=48.8172043010753, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI24308043, Length=465, Percent_Identity=48.8172043010753, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI195539349, Length=465, Percent_Identity=48.8172043010753, Blast_Score=444, Evalue=1e-125,
Organism=Homo sapiens, GI21361647, Length=465, Percent_Identity=47.5268817204301, Blast_Score=423, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17506425, Length=468, Percent_Identity=63.034188034188, Blast_Score=586, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6320882, Length=479, Percent_Identity=58.2463465553236, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24642172, Length=465, Percent_Identity=64.3010752688172, Blast_Score=580, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24656245, Length=455, Percent_Identity=49.6703296703297, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45553387, Length=464, Percent_Identity=48.7068965517241, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI45553385, Length=463, Percent_Identity=48.5961123110151, Blast_Score=411, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_CHLPD (A1BEZ2)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911393.1
- ProteinModelPortal:   A1BEZ2
- SMR:   A1BEZ2
- STRING:   A1BEZ2
- GeneID:   4570555
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0921
- NMPDR:   fig|290317.7.peg.978
- eggNOG:   COG0499
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- ProtClustDB:   PRK05476
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 52434; Mature: 52303

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 60-60 BINDING 135-135 BINDING 196-196 BINDING 226-226 BINDING 230-230 BINDING 231-231 BINDING 283-283 BINDING 318-318 BINDING 387-387

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIEAEVLAYKVADMSLAEWGRKEIDIAEKEMPGLMATRKKYAGQKPLKGARIAGSLHMT
CEEEHHEEEEEHHCCHHHHCCCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCEEECEEEEH
IQTAVLIETLVELGADVRWASCNIFSTQDHAAAAIAKAGIPVFAWKGETLDEYWWCTRQI
HHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
LEFEGGKGPHLIVDDGGDATLMIHLGYKIEIDPSLLDKTPGNIEEKALFQQLREVYEEDS
HHCCCCCCCEEEEECCCCEEEEEEECEEEEECHHHHCCCCCCHHHHHHHHHHHHHHHHHH
QRWHNVAAEMKGVSEETTTGVHRLYQMMEKEELLFPAINVNDSVTKSKFDNLYGCRESLA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHH
DGIKRATDVMVAGKVVVVLGYGDVGKGSARSMRAYGARVIVTEIDPICALQAAMEGYEVN
HHHHHHHHEEEECEEEEEEECCCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHCCCCCC
TMDEAVTEGNIFVTTTGNKDVITLEHMKKMKGEAIICNIGHFDNEIQVEPLNNYAGATKL
CHHHHHCCCCEEEEECCCCCEEEHHHHHHHCCCEEEEECCCCCCEEEEEECCCCCCCEEE
NIKPQVDKYTFEDGHAIYLLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQLELWTRDYAI
ECCCCCCCEEECCCCEEEEEECCEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHEE
DVYRLPKQLDEEVARLHLEQLGVKLTTLTNEQAEYIGVPLEGPYKPEHYRY
HHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCHHEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
TIEAEVLAYKVADMSLAEWGRKEIDIAEKEMPGLMATRKKYAGQKPLKGARIAGSLHMT
EEEHHEEEEEHHCCHHHHCCCCCCCCHHHHCCCHHHHHHHHCCCCCCCCCEEECEEEEH
IQTAVLIETLVELGADVRWASCNIFSTQDHAAAAIAKAGIPVFAWKGETLDEYWWCTRQI
HHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
LEFEGGKGPHLIVDDGGDATLMIHLGYKIEIDPSLLDKTPGNIEEKALFQQLREVYEEDS
HHCCCCCCCEEEEECCCCEEEEEEECEEEEECHHHHCCCCCCHHHHHHHHHHHHHHHHHH
QRWHNVAAEMKGVSEETTTGVHRLYQMMEKEELLFPAINVNDSVTKSKFDNLYGCRESLA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHH
DGIKRATDVMVAGKVVVVLGYGDVGKGSARSMRAYGARVIVTEIDPICALQAAMEGYEVN
HHHHHHHHEEEECEEEEEEECCCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHCCCCCC
TMDEAVTEGNIFVTTTGNKDVITLEHMKKMKGEAIICNIGHFDNEIQVEPLNNYAGATKL
CHHHHHCCCCEEEEECCCCCEEEHHHHHHHCCCEEEEECCCCCCEEEEEECCCCCCCEEE
NIKPQVDKYTFEDGHAIYLLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQLELWTRDYAI
ECCCCCCCEEECCCCEEEEEECCEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHEE
DVYRLPKQLDEEVARLHLEQLGVKLTTLTNEQAEYIGVPLEGPYKPEHYRY
HHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCHHEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA