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The map label for this gene is kefBC [H]

Identifier: 119356745

GI number: 119356745

Start: 1044157

End: 1045914

Strand: Direct

Name: kefBC [H]

Synonym: Cpha266_0917

Alternate gene names: 119356745

Gene position: 1044157-1045914 (Clockwise)

Preceding gene: 119356744

Following gene: 119356747

Centisome position: 33.32

GC content: 47.38

Gene sequence:

>1758_bases
ATGCACGATTTTGATTTTCTTGGCGAACTGGCTCTTATTGGCGCAATGGCCATTGCCATTATTCTGATCTTCCAGAAGCT
GAGGATTCCCCCTGTTATCGGCCTTATTTTTACCGGTATTGTGCTCGGTCCGTCCGGGATCGGTGTCGTTTACGATGAAA
AACTTATTGCCACCCTTGCCGAGCTTGGCGTTGTTCTGTTGCTGTTTACTATCGGACTTGAGTTTTCGGTTGACGATCTT
AAACGATTGAAAAAGATTGTGCTGGTCGGCGGTTTTGTTCAGATCGTGCTGACCGGTCTGGCGTTGAGTTTTCTTGCCTA
CTGGTTCATGTTCATGATCGGAAAGCATATCAGCGTTGAAGCCGGCATATTTCTCGGTTTTGCATTTTCGGTGAGCAGCA
CGGCTATCTGTCTGAAAATTCTTTCCGATCGGGAAGAGCTTGGAATGCCTCATGGTCGAATAGCTCTTGGAATTCTGATT
TTTCAGGATATCGCCATTGTTCCCTTGATGGTGGGTATCAATTTTCTTGCTCCTGACGCAATTTTTTCATTTGAAGTGTT
CCTGAAAAAAGTCGGTTTTATTCTTTTGTTCGGTGCGGCCCTGGTTGCCGGTTTCAGGGTGCTTATGCCCAGGATAGTCC
GCCTTATTGCCTCGTTGCACGCACGTGAAGTGCTTGTTATCGGCGCACTGGTCATCTGTTTTGGTGCGGCGTATCTTACC
TCTCTTGCCGGTCTCTCTCTTGCGCTTGGTTCATTTGTTGCCGAGATGATTATTGCAAGTACGGATGAAAGTCACCAGAT
CAGTGCGACCATCGATCCCTTTCGTGAGGCCTTTTCAAGTATCTTTTTTATTTCCGTCGGTCTACTGCTCGATATCAGAG
TAATAAATCTTCCGCTTTTCATTTCCATCGCTCTTGGAGTGCTGCTTGTCAAGGGAATGCTTGTTACCGGTGTGTCGCTT
TTTCTTGGCTACTCCATGCGTGTCAGCATGATGGCCGGCATGGCTCTTGCCCAGATAGGGGAGTTTTCCTTTGTGCTTGC
CCAGACGGGCATGAAGAGTCATTTGATCAATCAGGAGGTCTTTCAGGCCATGCTTGCCATCATTGTTGTCACGATGATTG
TTACGCCGGCCATGATTGCTGTTGCACCTAAAGTAGCTGATCAGGTGGTTCCTGTTCTCGGGTTTATTCCGCTGGTTTCA
AAAGATGCATCAGGCATTCCGTCCCGCCCGCCTGACAGTACCATTATCTGCGCTGGCGAGATTCATGCGGCTATTATCGG
ATTTGGCGTGAACGGTCAGAACGTTGCCGCGGTGCTGCATGCCACCAATATCTCCTATTCTGTTCTTGAAATTGATCGTG
AAATTGTCAAAACCATGAGGCGCAGCGGTGAACCTATCTATTATGGGGACTGTACGGAAAAAAAATCGTTACTGCGAGCC
GGTATTGATCATGCCAGAGCAGTGGTTCTCTGTGTTTCGGATAATATGGCTGTACGCAAGAGTATTGCCGTTATTCGTGA
AATCAATAACAAAACATTTATTATCGTCAGGGCAAGAACGCTTGATGAGGTCGATACGCTCTACAAGGCCGGAGCCGATG
TTGTCGTGACCGAAAAATTTGAAACCTCCATTCAGATTTTTTCGCAGCTTCTCAATCACTTTACCGTTGATCCCGAGCTG
ATTCTCGGTCAGCAGGAGATCATCCGCCGTGAATGCGAAAAAATATTTCTCAAGCCGCTTTCCTCACCCATCCGGTAA

Upstream 100 bases:

>100_bases
TAAAGGCGGTTCGGGTAACCGCCTTTTTTATTGTGTACCTTCAACTACTTTTTGTACTTAGTAGGAAGGAGATATTTCTT
TTTTTTAACCCCCCGGTTGT

Downstream 100 bases:

>100_bases
GCAGGAACATCATTCGGCTATTTCAAGCCAGGCCGATATTTTTCCCTGCATGGCGTCGCGTACTTCGCGGAAAACGGCAA
GCTGCTCCTCTTCGCTGCCC

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MHDFDFLGELALIGAMAIAIILIFQKLRIPPVIGLIFTGIVLGPSGIGVVYDEKLIATLAELGVVLLLFTIGLEFSVDDL
KRLKKIVLVGGFVQIVLTGLALSFLAYWFMFMIGKHISVEAGIFLGFAFSVSSTAICLKILSDREELGMPHGRIALGILI
FQDIAIVPLMVGINFLAPDAIFSFEVFLKKVGFILLFGAALVAGFRVLMPRIVRLIASLHAREVLVIGALVICFGAAYLT
SLAGLSLALGSFVAEMIIASTDESHQISATIDPFREAFSSIFFISVGLLLDIRVINLPLFISIALGVLLVKGMLVTGVSL
FLGYSMRVSMMAGMALAQIGEFSFVLAQTGMKSHLINQEVFQAMLAIIVVTMIVTPAMIAVAPKVADQVVPVLGFIPLVS
KDASGIPSRPPDSTIICAGEIHAAIIGFGVNGQNVAAVLHATNISYSVLEIDREIVKTMRRSGEPIYYGDCTEKKSLLRA
GIDHARAVVLCVSDNMAVRKSIAVIREINNKTFIIVRARTLDEVDTLYKAGADVVVTEKFETSIQIFSQLLNHFTVDPEL
ILGQQEIIRRECEKIFLKPLSSPIR

Sequences:

>Translated_585_residues
MHDFDFLGELALIGAMAIAIILIFQKLRIPPVIGLIFTGIVLGPSGIGVVYDEKLIATLAELGVVLLLFTIGLEFSVDDL
KRLKKIVLVGGFVQIVLTGLALSFLAYWFMFMIGKHISVEAGIFLGFAFSVSSTAICLKILSDREELGMPHGRIALGILI
FQDIAIVPLMVGINFLAPDAIFSFEVFLKKVGFILLFGAALVAGFRVLMPRIVRLIASLHAREVLVIGALVICFGAAYLT
SLAGLSLALGSFVAEMIIASTDESHQISATIDPFREAFSSIFFISVGLLLDIRVINLPLFISIALGVLLVKGMLVTGVSL
FLGYSMRVSMMAGMALAQIGEFSFVLAQTGMKSHLINQEVFQAMLAIIVVTMIVTPAMIAVAPKVADQVVPVLGFIPLVS
KDASGIPSRPPDSTIICAGEIHAAIIGFGVNGQNVAAVLHATNISYSVLEIDREIVKTMRRSGEPIYYGDCTEKKSLLRA
GIDHARAVVLCVSDNMAVRKSIAVIREINNKTFIIVRARTLDEVDTLYKAGADVVVTEKFETSIQIFSQLLNHFTVDPEL
ILGQQEIIRRECEKIFLKPLSSPIR
>Mature_585_residues
MHDFDFLGELALIGAMAIAIILIFQKLRIPPVIGLIFTGIVLGPSGIGVVYDEKLIATLAELGVVLLLFTIGLEFSVDDL
KRLKKIVLVGGFVQIVLTGLALSFLAYWFMFMIGKHISVEAGIFLGFAFSVSSTAICLKILSDREELGMPHGRIALGILI
FQDIAIVPLMVGINFLAPDAIFSFEVFLKKVGFILLFGAALVAGFRVLMPRIVRLIASLHAREVLVIGALVICFGAAYLT
SLAGLSLALGSFVAEMIIASTDESHQISATIDPFREAFSSIFFISVGLLLDIRVINLPLFISIALGVLLVKGMLVTGVSL
FLGYSMRVSMMAGMALAQIGEFSFVLAQTGMKSHLINQEVFQAMLAIIVVTMIVTPAMIAVAPKVADQVVPVLGFIPLVS
KDASGIPSRPPDSTIICAGEIHAAIIGFGVNGQNVAAVLHATNISYSVLEIDREIVKTMRRSGEPIYYGDCTEKKSLLRA
GIDHARAVVLCVSDNMAVRKSIAVIREINNKTFIIVRARTLDEVDTLYKAGADVVVTEKFETSIQIFSQLLNHFTVDPEL
ILGQQEIIRRECEKIFLKPLSSPIR

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=383, Percent_Identity=28.4595300261097, Blast_Score=108, Evalue=2e-23,
Organism=Escherichia coli, GI1786685, Length=554, Percent_Identity=30.6859205776173, Blast_Score=203, Evalue=3e-53,
Organism=Escherichia coli, GI1789749, Length=572, Percent_Identity=28.3216783216783, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1786232, Length=572, Percent_Identity=27.7972027972028, Blast_Score=182, Evalue=7e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 63339; Mature: 63339

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDFDFLGELALIGAMAIAIILIFQKLRIPPVIGLIFTGIVLGPSGIGVVYDEKLIATLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHH
ELGVVLLLFTIGLEFSVDDLKRLKKIVLVGGFVQIVLTGLALSFLAYWFMFMIGKHISVE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
AGIFLGFAFSVSSTAICLKILSDREELGMPHGRIALGILIFQDIAIVPLMVGINFLAPDA
HHHHEEEHHHHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCHH
IFSFEVFLKKVGFILLFGAALVAGFRVLMPRIVRLIASLHAREVLVIGALVICFGAAYLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLAGLSLALGSFVAEMIIASTDESHQISATIDPFREAFSSIFFISVGLLLDIRVINLPLF
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISIALGVLLVKGMLVTGVSLFLGYSMRVSMMAGMALAQIGEFSFVLAQTGMKSHLINQEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHCCHHH
FQAMLAIIVVTMIVTPAMIAVAPKVADQVVPVLGFIPLVSKDASGIPSRPPDSTIICAGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECC
IHAAIIGFGVNGQNVAAVLHATNISYSVLEIDREIVKTMRRSGEPIYYGDCTEKKSLLRA
CEEEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHH
GIDHARAVVLCVSDNMAVRKSIAVIREINNKTFIIVRARTLDEVDTLYKAGADVVVTEKF
CCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHCCCCEEEEHHH
ETSIQIFSQLLNHFTVDPELILGQQEIIRRECEKIFLKPLSSPIR
HHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MHDFDFLGELALIGAMAIAIILIFQKLRIPPVIGLIFTGIVLGPSGIGVVYDEKLIATLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEHHHHHHHHH
ELGVVLLLFTIGLEFSVDDLKRLKKIVLVGGFVQIVLTGLALSFLAYWFMFMIGKHISVE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
AGIFLGFAFSVSSTAICLKILSDREELGMPHGRIALGILIFQDIAIVPLMVGINFLAPDA
HHHHEEEHHHHHHHHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCHH
IFSFEVFLKKVGFILLFGAALVAGFRVLMPRIVRLIASLHAREVLVIGALVICFGAAYLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLAGLSLALGSFVAEMIIASTDESHQISATIDPFREAFSSIFFISVGLLLDIRVINLPLF
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISIALGVLLVKGMLVTGVSLFLGYSMRVSMMAGMALAQIGEFSFVLAQTGMKSHLINQEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHCCHHH
FQAMLAIIVVTMIVTPAMIAVAPKVADQVVPVLGFIPLVSKDASGIPSRPPDSTIICAGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECC
IHAAIIGFGVNGQNVAAVLHATNISYSVLEIDREIVKTMRRSGEPIYYGDCTEKKSLLRA
CEEEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHH
GIDHARAVVLCVSDNMAVRKSIAVIREINNKTFIIVRARTLDEVDTLYKAGADVVVTEKF
CCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHCCCCEEEEHHH
ETSIQIFSQLLNHFTVDPELILGQQEIIRRECEKIFLKPLSSPIR
HHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]