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The map label for this gene is dut

Identifier: 119356656

GI number: 119356656

Start: 938197

End: 938658

Strand: Direct

Name: dut

Synonym: Cpha266_0825

Alternate gene names: 119356656

Gene position: 938197-938658 (Clockwise)

Preceding gene: 119356654

Following gene: 119356662

Centisome position: 29.94

GC content: 46.97

Gene sequence:

>462_bases
ATGCTTAAGGTAAAGATTGTTCGGTTAAACGAGAAAGCTCTTTTGCCGGTTTATGCAACAACGCATGCCGCAGGTATGGA
CGTTGCCGCATGTCTTGAGGAAAATGTTGTGGTACTGCCCTTTGAAACGGCACTGATTCCTTCCGGATTTGCCATTGAAC
TTCCCGAAGGATATGAAGCTCAGCTTCGTCCGAGAAGTGGTTTGGCACTTCGTCATCTGATTTCGCTGCCGAATACTCCT
GCAACCATCGATGCCGATTATCGGGGAGAGGTTAAAATCATTCTCATCAATTATGGACAAGAGCCTTTTGTTGTACATCA
TGGCGACAGGGTGGCTCAGATGGTCGTGGCAAAAGTGGAAAGGGTGTTTTTTGATGAAGTATTAACGCTTGCCTCATCGT
CAAGAGCGGATGGTGGATTTGGTCATACCGGAATAGCGGGAAATCCGGAATCGAAAGCGTAA

Upstream 100 bases:

>100_bases
TAGACTTTTTCAGACGATCTCTCCATTCGGGCTGTGATTTTAATTTCTATATTGGGTGCAACGAACCGGTAACATAATGT
CAAGATAACCCATATTTCTG

Downstream 100 bases:

>100_bases
CCGCGCTCTATAAGGGTGTCCTGTAAAACAGCAAACGAAAAGAGCGCTGTTGTCAGGTCAGGGACAAAGCGCTCTTCAGA
TTTATTTCAGGGAACAGGCT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MLKVKIVRLNEKALLPVYATTHAAGMDVAACLEENVVVLPFETALIPSGFAIELPEGYEAQLRPRSGLALRHLISLPNTP
ATIDADYRGEVKIILINYGQEPFVVHHGDRVAQMVVAKVERVFFDEVLTLASSSRADGGFGHTGIAGNPESKA

Sequences:

>Translated_153_residues
MLKVKIVRLNEKALLPVYATTHAAGMDVAACLEENVVVLPFETALIPSGFAIELPEGYEAQLRPRSGLALRHLISLPNTP
ATIDADYRGEVKIILINYGQEPFVVHHGDRVAQMVVAKVERVFFDEVLTLASSSRADGGFGHTGIAGNPESKA
>Mature_153_residues
MLKVKIVRLNEKALLPVYATTHAAGMDVAACLEENVVVLPFETALIPSGFAIELPEGYEAQLRPRSGLALRHLISLPNTP
ATIDADYRGEVKIILINYGQEPFVVHHGDRVAQMVVAKVERVFFDEVLTLASSSRADGGFGHTGIAGNPESKA

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family

Homologues:

Organism=Homo sapiens, GI4503423, Length=146, Percent_Identity=37.6712328767123, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI70906444, Length=146, Percent_Identity=37.6712328767123, Blast_Score=104, Evalue=2e-23,
Organism=Homo sapiens, GI70906441, Length=146, Percent_Identity=37.6712328767123, Blast_Score=104, Evalue=4e-23,
Organism=Escherichia coli, GI1790071, Length=146, Percent_Identity=39.7260273972603, Blast_Score=113, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI71988561, Length=143, Percent_Identity=37.7622377622378, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319729, Length=142, Percent_Identity=32.3943661971831, Blast_Score=83, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583610, Length=153, Percent_Identity=33.9869281045752, Blast_Score=96, Evalue=6e-21,
Organism=Drosophila melanogaster, GI19921126, Length=153, Percent_Identity=33.9869281045752, Blast_Score=96, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DUT_CHLPD (A1BEP9)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911300.1
- ProteinModelPortal:   A1BEP9
- SMR:   A1BEP9
- STRING:   A1BEP9
- GeneID:   4570323
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0825
- NMPDR:   fig|290317.7.peg.875
- eggNOG:   COG0756
- HOGENOM:   HBG436079
- OMA:   LDLRACI
- ProtClustDB:   CLSK637750
- HAMAP:   MF_00116
- InterPro:   IPR008180
- InterPro:   IPR008181
- TIGRFAMs:   TIGR00576

Pfam domain/function: PF00692 dUTPase

EC number: =3.6.1.23

Molecular weight: Translated: 16520; Mature: 16520

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: BINDING 78-78 BINDING 92-92

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKVKIVRLNEKALLPVYATTHAAGMDVAACLEENVVVLPFETALIPSGFAIELPEGYEA
CEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHCCEEEEEEHHHCCCCCCEEECCCCCCE
QLRPRSGLALRHLISLPNTPATIDADYRGEVKIILINYGQEPFVVHHGDRVAQMVVAKVE
EECCCCCHHHHHHHHCCCCCCEEECCCCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHH
RVFFDEVLTLASSSRADGGFGHTGIAGNPESKA
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLKVKIVRLNEKALLPVYATTHAAGMDVAACLEENVVVLPFETALIPSGFAIELPEGYEA
CEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHCCEEEEEEHHHCCCCCCEEECCCCCCE
QLRPRSGLALRHLISLPNTPATIDADYRGEVKIILINYGQEPFVVHHGDRVAQMVVAKVE
EECCCCCHHHHHHHHCCCCCCEEECCCCCCEEEEEEECCCCCEEEECCHHHHHHHHHHHH
RVFFDEVLTLASSSRADGGFGHTGIAGNPESKA
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA