Click here to switch to the map view.

The map label for this gene is nadB1 [H]

Identifier: 119356642

GI number: 119356642

Start: 924239

End: 925834

Strand: Reverse

Name: nadB1 [H]

Synonym: Cpha266_0811

Alternate gene names: 119356642

Gene position: 925834-924239 (Counterclockwise)

Preceding gene: 119356643

Following gene: 119356638

Centisome position: 29.54

GC content: 48.37

Gene sequence:

>1596_bases
ATGACCGAATCGATCAATACAGACGTCCTTGTCATCGGAAGTGGAATCGGAGGGCTTTATTTCGCCATCCATATGGCTGA
CCATGCAAAAGTGACCATCATCACAAAAAAGGAAAGCTCCACCTCAAATACAAACTGGGCGCAAGGAGGCATTGCCGCAA
CCATTGACAGTAGTGACAGTGCGGAACTGCATATTGCCGATACGCTTGATGCCGGGGCCGGCCTGTGCGACAAGACGATG
GTTTCTTTCATGGTGCATGAAGGTCCCCGACACATCCAGCGCCTGATTGAACTCGGCGTTCAGTTCACAACCACCGACCA
TGATCATCTGCATCTGGGAAAAGAGGGTGGCCATTCACGCAGCAGAATTGTTCATGCGCAGGATCTTACCGGACGCGAAG
TTGAAAACGCCCTTCTCAATCGGGTAAACAGCCATCCGAACATTACCATTCTCGAACACCACTTTGCCATTGAGCTGCTC
ACAGAGCACCATCTTGGCATAAAAACCAACGACATAACCTGTTATGGCGCTTATGTGCTTGATTCGAAACAGAGAATACC
AAAAAAAATCCTGTCGAAAGTAACCATGCTTGCTTCAGGAGGACTTGGTCAGATCTATCCCTATACCACCAATCCTGATA
TTGCAACCGGAGACGGGGTTGCCATGGCATACCGTGCCGGCGCGGAAATCTCCAATATGGAGTTCATTCAGTTTCATCCG
ACATCCCTCTGCCACCCTAAAGCCAAATCATATCTCATCTCTGAAGCAGTCAGGGGGTTCGGCGGCATTCTCAAGCTGAA
AAACGGACAGGAGTTCATGCATAAATACGACAAACGCCTGAACCTTGCACCCAGAGACATTGTTGCGCGAGCAATAGATT
CTGAAATAAAAAAATCAGGAGAAGAGTGCGTTTTTCTTGACGTTACCCATATTGATCCAGAAAAAACAAAAGAACACTTC
CCCAATATTTACGAAACCTGCCTGCACTACGGCATCGACATGACCAGAGAGATGATCCCCGTCGTTCCTGCTGCACACTA
CTCCTGCGGAGGAATACGAATCGATGCGGAGGGAAGAAGCACCATCAACCGCCTTTATGCCTGCGGCGAAACAAGCTGCA
CAGGCGTCCACGGAGCAAACCGCCTGGCAAGCAACTCTCTGCTCGAAGCGCTTGTGTTCTCGTATCGTGCTTTTCAGAAC
ATCTGTACCCAGCTCAATGAGATCACGCTCAATGTTGAGGTTCCCGACTGGGATGATACGGGAACCGTCAATCCGGAAGA
GTGGATACTTGTTTCGCATAATAAAAAAGAGGCCCAGCAGGTGATGAACGACTATGTGGGCATTGTGCGCAGCGACTTGC
GTTTGCAGCGGGCAAAACGAAGAATGGACTTTCTGAAGGATGAAACCGAAGCCTATTATAAAAAGACCAAAATAACCACC
CAGATTCTTGAGCTGAGAAACATCATCAAGGTGTCAAGCCTGATTATTGAAGGCGCAATCAAACGAAGGGAATCAAGAGG
CCTGCACTTCACAACGGATTATCCGAAAAGTGATAACAAGCATTTTCTTATCGATACCGTTCTCAGATCGTTCTGA

Upstream 100 bases:

>100_bases
CACTCCATCATACTCGTAGGGATAGTGCTGATAATCCTCAGCGCGCTGCGCCAACTCAGACCGGTAAAAAATTCATGAAC
ATTTTTTTAACAACTGCGAT

Downstream 100 bases:

>100_bases
ACTGATCCCGAGCAGAACTACTTCACCTCCTGCCAATCCCTTGCATAGCGAAAATCTATTCCGGGAGTTCTTGAGGAAAT
TTTTGCAATAACAGGCATCA

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO 1; Quinolinate synthase B 1 [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MTESINTDVLVIGSGIGGLYFAIHMADHAKVTIITKKESSTSNTNWAQGGIAATIDSSDSAELHIADTLDAGAGLCDKTM
VSFMVHEGPRHIQRLIELGVQFTTTDHDHLHLGKEGGHSRSRIVHAQDLTGREVENALLNRVNSHPNITILEHHFAIELL
TEHHLGIKTNDITCYGAYVLDSKQRIPKKILSKVTMLASGGLGQIYPYTTNPDIATGDGVAMAYRAGAEISNMEFIQFHP
TSLCHPKAKSYLISEAVRGFGGILKLKNGQEFMHKYDKRLNLAPRDIVARAIDSEIKKSGEECVFLDVTHIDPEKTKEHF
PNIYETCLHYGIDMTREMIPVVPAAHYSCGGIRIDAEGRSTINRLYACGETSCTGVHGANRLASNSLLEALVFSYRAFQN
ICTQLNEITLNVEVPDWDDTGTVNPEEWILVSHNKKEAQQVMNDYVGIVRSDLRLQRAKRRMDFLKDETEAYYKKTKITT
QILELRNIIKVSSLIIEGAIKRRESRGLHFTTDYPKSDNKHFLIDTVLRSF

Sequences:

>Translated_531_residues
MTESINTDVLVIGSGIGGLYFAIHMADHAKVTIITKKESSTSNTNWAQGGIAATIDSSDSAELHIADTLDAGAGLCDKTM
VSFMVHEGPRHIQRLIELGVQFTTTDHDHLHLGKEGGHSRSRIVHAQDLTGREVENALLNRVNSHPNITILEHHFAIELL
TEHHLGIKTNDITCYGAYVLDSKQRIPKKILSKVTMLASGGLGQIYPYTTNPDIATGDGVAMAYRAGAEISNMEFIQFHP
TSLCHPKAKSYLISEAVRGFGGILKLKNGQEFMHKYDKRLNLAPRDIVARAIDSEIKKSGEECVFLDVTHIDPEKTKEHF
PNIYETCLHYGIDMTREMIPVVPAAHYSCGGIRIDAEGRSTINRLYACGETSCTGVHGANRLASNSLLEALVFSYRAFQN
ICTQLNEITLNVEVPDWDDTGTVNPEEWILVSHNKKEAQQVMNDYVGIVRSDLRLQRAKRRMDFLKDETEAYYKKTKITT
QILELRNIIKVSSLIIEGAIKRRESRGLHFTTDYPKSDNKHFLIDTVLRSF
>Mature_530_residues
TESINTDVLVIGSGIGGLYFAIHMADHAKVTIITKKESSTSNTNWAQGGIAATIDSSDSAELHIADTLDAGAGLCDKTMV
SFMVHEGPRHIQRLIELGVQFTTTDHDHLHLGKEGGHSRSRIVHAQDLTGREVENALLNRVNSHPNITILEHHFAIELLT
EHHLGIKTNDITCYGAYVLDSKQRIPKKILSKVTMLASGGLGQIYPYTTNPDIATGDGVAMAYRAGAEISNMEFIQFHPT
SLCHPKAKSYLISEAVRGFGGILKLKNGQEFMHKYDKRLNLAPRDIVARAIDSEIKKSGEECVFLDVTHIDPEKTKEHFP
NIYETCLHYGIDMTREMIPVVPAAHYSCGGIRIDAEGRSTINRLYACGETSCTGVHGANRLASNSLLEALVFSYRAFQNI
CTQLNEITLNVEVPDWDDTGTVNPEEWILVSHNKKEAQQVMNDYVGIVRSDLRLQRAKRRMDFLKDETEAYYKKTKITTQ
ILELRNIIKVSSLIIEGAIKRRESRGLHFTTDYPKSDNKHFLIDTVLRSF

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=524, Percent_Identity=30.5343511450382, Blast_Score=207, Evalue=3e-53,
Organism=Escherichia coli, GI1788928, Length=515, Percent_Identity=46.4077669902913, Blast_Score=499, Evalue=1e-142,
Organism=Escherichia coli, GI1790597, Length=540, Percent_Identity=30.5555555555556, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1786942, Length=537, Percent_Identity=28.4916201117318, Blast_Score=193, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17550100, Length=529, Percent_Identity=29.1115311909263, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17505833, Length=526, Percent_Identity=29.0874524714829, Blast_Score=195, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI71986328, Length=430, Percent_Identity=28.1395348837209, Blast_Score=112, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6322701, Length=543, Percent_Identity=29.8342541436464, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6322416, Length=539, Percent_Identity=29.6846011131725, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6322511, Length=490, Percent_Identity=25.5102040816327, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320788, Length=322, Percent_Identity=26.7080745341615, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137288, Length=544, Percent_Identity=29.9632352941176, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24655642, Length=544, Percent_Identity=29.9632352941176, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24655647, Length=544, Percent_Identity=29.9632352941176, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24663005, Length=530, Percent_Identity=28.4905660377358, Blast_Score=188, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 59285; Mature: 59154

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESINTDVLVIGSGIGGLYFAIHMADHAKVTIITKKESSTSNTNWAQGGIAATIDSSDS
CCCCCCCCEEEEECCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCC
AELHIADTLDAGAGLCDKTMVSFMVHEGPRHIQRLIELGVQFTTTDHDHLHLGKEGGHSR
CEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCEEEECCCCCEECCCCCCCCH
SRIVHAQDLTGREVENALLNRVNSHPNITILEHHFAIELLTEHHLGIKTNDITCYGAYVL
HEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEHHHEEEEHHHCCCCEEECCEEEEEEEEE
DSKQRIPKKILSKVTMLASGGLGQIYPYTTNPDIATGDGVAMAYRAGAEISNMEFIQFHP
CCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCEEEEEECC
TSLCHPKAKSYLISEAVRGFGGILKLKNGQEFMHKYDKRLNLAPRDIVARAIDSEIKKSG
CCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
EECVFLDVTHIDPEKTKEHFPNIYETCLHYGIDMTREMIPVVPAAHYSCGGIRIDAEGRS
CCEEEEEEECCCHHHHHHHCCHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCEEEECCCHH
TINRLYACGETSCTGVHGANRLASNSLLEALVFSYRAFQNICTQLNEITLNVEVPDWDDT
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCC
GTVNPEEWILVSHNKKEAQQVMNDYVGIVRSDLRLQRAKRRMDFLKDETEAYYKKTKITT
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QILELRNIIKVSSLIIEGAIKRRESRGLHFTTDYPKSDNKHFLIDTVLRSF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEHHHHHHHHC
>Mature Secondary Structure 
TESINTDVLVIGSGIGGLYFAIHMADHAKVTIITKKESSTSNTNWAQGGIAATIDSSDS
CCCCCCCEEEEECCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCCC
AELHIADTLDAGAGLCDKTMVSFMVHEGPRHIQRLIELGVQFTTTDHDHLHLGKEGGHSR
CEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCEEEECCCCCEECCCCCCCCH
SRIVHAQDLTGREVENALLNRVNSHPNITILEHHFAIELLTEHHLGIKTNDITCYGAYVL
HEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEHHHEEEEHHHCCCCEEECCEEEEEEEEE
DSKQRIPKKILSKVTMLASGGLGQIYPYTTNPDIATGDGVAMAYRAGAEISNMEFIQFHP
CCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCCCEEEEEECC
TSLCHPKAKSYLISEAVRGFGGILKLKNGQEFMHKYDKRLNLAPRDIVARAIDSEIKKSG
CCCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
EECVFLDVTHIDPEKTKEHFPNIYETCLHYGIDMTREMIPVVPAAHYSCGGIRIDAEGRS
CCEEEEEEECCCHHHHHHHCCHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCEEEECCCHH
TINRLYACGETSCTGVHGANRLASNSLLEALVFSYRAFQNICTQLNEITLNVEVPDWDDT
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCC
GTVNPEEWILVSHNKKEAQQVMNDYVGIVRSDLRLQRAKRRMDFLKDETEAYYKKTKITT
CCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QILELRNIIKVSSLIIEGAIKRRESRGLHFTTDYPKSDNKHFLIDTVLRSF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]