Click here to switch to the map view.

The map label for this gene is acnB [H]

Identifier: 119356634

GI number: 119356634

Start: 915157

End: 917727

Strand: Direct

Name: acnB [H]

Synonym: Cpha266_0803

Alternate gene names: 119356634

Gene position: 915157-917727 (Clockwise)

Preceding gene: 119356633

Following gene: 119356639

Centisome position: 29.2

GC content: 50.8

Gene sequence:

>2571_bases
ATGAGTCTTGTAAGCCAGTATCGCGCACATAGTGAAGAAAGAGAACAACTCGGCATTCCGCCGCTGCCGCTTACCGCTGA
ACAGACCCGTTCACTGATTGAGCTTTTAATGCAGGGTCAGGTTCAGGAGCAGGAGTATCTCCTTGAACTCTTCAATGAAC
ATATCAGTCCCGGTGTTGACGATGCTGCTTTTGAAAAGGCCGCTTTTCTTGACAGTATCATAAAAGGGGAGTGCACGTGT
GCCGCGATCAGCCCTGTCGATGCGGTCGCCATTCTTGGAACGATGCTTGGCGGGTATAATGTAAAACCCCTGACCGACGC
ATTGAGTCATGCCGATGAACATATATGCCGCGCAGCAGCCGATGTGCTCAAGAAAATTCTGCTTGTGTACGACTCATTTG
ATGTGGTTGTGGAACTCTCGTCATCCAACGCCTATGCAAAAGAGGTTCTTCAATCCTGGGCGGATGCTGAGTGGTTTACC
ACAAGACCACTGCTTCCTGAAAAAATGACGCTTACGGTTTTCAAGGTACCCGGCGAAACCAACACTGATGATCTCTCGCC
GGCAAGCGAGGCCTTTACCCGAAGCGATATTCCCCTGCACGCGCGCTGCATGCTTGGATCGAAAATGGACGATCCGATCG
GGACCATTACCCGGCTCAAAGCCAAAGGTTATCCTCTCGCGTATGTCGGTGATGTGGTCGGTACCGGTTCGAGCAGAAAA
TCAGGAATCAATTCGGTGCAGTGGCATCTTGGTGAGGATATTCCGGCAGTGCCGAACAAAAGAACAGGCAGTGTTGTGAT
CGGCGGTATTGTTGCGCCTATTTTTTTCAATACTGCGGAAGATTCCGGTGCCTTGCCGATTCAGACGGATGTTACCGCCA
TGGAAATGGGCGATGTGATTGATCTTTACGTATACAAGGGGATCATTGAAAAAAACGGTGCTGTTATAGCGGAATTTTCG
ATTTCTCCCAAAACGCTTATTGATGAGGTGCGGGCAGGAGGAAGAATTCCTCTTATTATCGGCAGAAATCTTACCAGAAA
AGCAAGAAAGACGCTTGGTCTTGGCGAGGATAGTGTTTTTCAGCGTCCCGAGCAGCCCGAAGATACCGGAAAAGGTTACA
CCCTTGCCCAGAAAATGATCGGGAAGGCATGTGGAATGAAAGGGGTAAGGCCAGGTATGTATGTTGAACCTGAAACCCTT
ACGGTTGGCTCACAGGATACGACAGGAGCCATGACCCGTGATGAGGTCAAGGAGCTTGCGGCATTGAGTTTCAGCGCGGA
TCTTGCCATGCAGAGCTTTTGCCATACCGCAGCCTATCCGAAACCATCGGATGTGAAGCTTCACCGAACGCTTCCGTACT
TTATGATGAGCAGGGGAGGGGTCGCGCTCAGGCCTGGCGACGGTGTTATTCATACATGGCTGAACCGCATGGCGCTTCCC
GACACGCTGGGTACCGGTGCTGATTCCCATACCCGGTTTCCTATCGGCATTTCCTTCCCCGGAGGGTCAGGTCTTGTTGC
ATTTACCGCAGTGACGGGCACCATGCCGTTGAACGTTCCTGAATCCGTACTTGTTCGTTTTACCGGTAAACTGCAGCCAG
GCATTACCTTGCGCGATCTTGTCAATGCCATACCCTATGTTGCATTGAAAAAGGGTCTTTTAACCGTTGAGAAAAAAGGG
AAGAAAAATATCTTCGCAGGCCGCATCCTTGAAATCGAGGGATTGCCGGATCTCAAGGTAGAGCAGGCATTCGAGCTCAG
CGATGCGTCTGCAGAACGAAGCGCAGCAGCCTGTACGGTACGTCTTTCGAAAGAACCGGTTATCGAGTACCTCAGCTCGA
ATATCAAGCTGCTCGAGCAGATGATTGAAGAGGGGTACGGGGATGCCGGGACCCTTCGTCGTCGTATCGGGAAGATGGAG
GAGTGGCTTCAAAATCCGGTGCTTCTTGAACCCGATTCCGACGCTGAATATGCCGCTGTGATCGATATTGATATGAACAC
GATCAAGGAGCCTGTTCTTGCCTGTCCGAATGATCCTGATGATGTGATGACGCTCAGCGAAGTGCTGCTCGATGATGCCA
GACCTAAAACCATCAACGAAGTATTTGTAGGGAGCTGTATGACCAATATCGGTCATTTCCGCGCACTTGGCGAGGTGCTC
AGAAACAAGGGCGTTGCTGCTGCCCGCCTCTGGGTGGTTCCTCCAACCAAGATGGATATGAAAAAGCTTATAGAGGAGGG
TTATTATGCCGTTTTCGGTGCTGCGGGAGCCCGAACCGAGCTGCCTGGATGTTCTCTTTGCATGGGTAACCAGGCGCGAG
TTGCCGATAATGCCGTTGTGTTTTCAACAAGCACAAGAAACTTTGATAACCGCATGGGTACGGGCGCCCAGGTCTATCTT
GGCTCTGCTGAGCTTGCTGCCGTTTGCGCCCTTCTTGGTCATCTGCCGAACCGTGACGAATATCTGGAGATCTTTAACCG
GCAGCTCTCGGGCGATAAGGCACAAAACGTTTATCGTTATTTGAAGTTCAATGAGATCGAAAAAGAAGAATTACAGTTGC
TTGTTGACTAA

Upstream 100 bases:

>100_bases
TTTTACTGTCTTTGCTTTTTTTCGGAAATCGCAAAGATTTTCCTTTCCCGTTTATCAAACCGAACTATTCATTCAAACGC
AACCCAGGGAGATTGACCTT

Downstream 100 bases:

>100_bases
AAAAAGCATTTATTAAGGCGGGATATGAAAATATTTTTTCCTATCCCGTTATACGGTGGGCTTTTGAAAACTCACTGTTT
TTTGTTAATATTCGGAAGCT

Product: bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase

Products: NA

Alternate protein names: Aconitase 2; 2-methylisocitrate dehydratase; Citrate hydro-lyase 2 [H]

Number of amino acids: Translated: 856; Mature: 855

Protein sequence:

>856_residues
MSLVSQYRAHSEEREQLGIPPLPLTAEQTRSLIELLMQGQVQEQEYLLELFNEHISPGVDDAAFEKAAFLDSIIKGECTC
AAISPVDAVAILGTMLGGYNVKPLTDALSHADEHICRAAADVLKKILLVYDSFDVVVELSSSNAYAKEVLQSWADAEWFT
TRPLLPEKMTLTVFKVPGETNTDDLSPASEAFTRSDIPLHARCMLGSKMDDPIGTITRLKAKGYPLAYVGDVVGTGSSRK
SGINSVQWHLGEDIPAVPNKRTGSVVIGGIVAPIFFNTAEDSGALPIQTDVTAMEMGDVIDLYVYKGIIEKNGAVIAEFS
ISPKTLIDEVRAGGRIPLIIGRNLTRKARKTLGLGEDSVFQRPEQPEDTGKGYTLAQKMIGKACGMKGVRPGMYVEPETL
TVGSQDTTGAMTRDEVKELAALSFSADLAMQSFCHTAAYPKPSDVKLHRTLPYFMMSRGGVALRPGDGVIHTWLNRMALP
DTLGTGADSHTRFPIGISFPGGSGLVAFTAVTGTMPLNVPESVLVRFTGKLQPGITLRDLVNAIPYVALKKGLLTVEKKG
KKNIFAGRILEIEGLPDLKVEQAFELSDASAERSAAACTVRLSKEPVIEYLSSNIKLLEQMIEEGYGDAGTLRRRIGKME
EWLQNPVLLEPDSDAEYAAVIDIDMNTIKEPVLACPNDPDDVMTLSEVLLDDARPKTINEVFVGSCMTNIGHFRALGEVL
RNKGVAAARLWVVPPTKMDMKKLIEEGYYAVFGAAGARTELPGCSLCMGNQARVADNAVVFSTSTRNFDNRMGTGAQVYL
GSAELAAVCALLGHLPNRDEYLEIFNRQLSGDKAQNVYRYLKFNEIEKEELQLLVD

Sequences:

>Translated_856_residues
MSLVSQYRAHSEEREQLGIPPLPLTAEQTRSLIELLMQGQVQEQEYLLELFNEHISPGVDDAAFEKAAFLDSIIKGECTC
AAISPVDAVAILGTMLGGYNVKPLTDALSHADEHICRAAADVLKKILLVYDSFDVVVELSSSNAYAKEVLQSWADAEWFT
TRPLLPEKMTLTVFKVPGETNTDDLSPASEAFTRSDIPLHARCMLGSKMDDPIGTITRLKAKGYPLAYVGDVVGTGSSRK
SGINSVQWHLGEDIPAVPNKRTGSVVIGGIVAPIFFNTAEDSGALPIQTDVTAMEMGDVIDLYVYKGIIEKNGAVIAEFS
ISPKTLIDEVRAGGRIPLIIGRNLTRKARKTLGLGEDSVFQRPEQPEDTGKGYTLAQKMIGKACGMKGVRPGMYVEPETL
TVGSQDTTGAMTRDEVKELAALSFSADLAMQSFCHTAAYPKPSDVKLHRTLPYFMMSRGGVALRPGDGVIHTWLNRMALP
DTLGTGADSHTRFPIGISFPGGSGLVAFTAVTGTMPLNVPESVLVRFTGKLQPGITLRDLVNAIPYVALKKGLLTVEKKG
KKNIFAGRILEIEGLPDLKVEQAFELSDASAERSAAACTVRLSKEPVIEYLSSNIKLLEQMIEEGYGDAGTLRRRIGKME
EWLQNPVLLEPDSDAEYAAVIDIDMNTIKEPVLACPNDPDDVMTLSEVLLDDARPKTINEVFVGSCMTNIGHFRALGEVL
RNKGVAAARLWVVPPTKMDMKKLIEEGYYAVFGAAGARTELPGCSLCMGNQARVADNAVVFSTSTRNFDNRMGTGAQVYL
GSAELAAVCALLGHLPNRDEYLEIFNRQLSGDKAQNVYRYLKFNEIEKEELQLLVD
>Mature_855_residues
SLVSQYRAHSEEREQLGIPPLPLTAEQTRSLIELLMQGQVQEQEYLLELFNEHISPGVDDAAFEKAAFLDSIIKGECTCA
AISPVDAVAILGTMLGGYNVKPLTDALSHADEHICRAAADVLKKILLVYDSFDVVVELSSSNAYAKEVLQSWADAEWFTT
RPLLPEKMTLTVFKVPGETNTDDLSPASEAFTRSDIPLHARCMLGSKMDDPIGTITRLKAKGYPLAYVGDVVGTGSSRKS
GINSVQWHLGEDIPAVPNKRTGSVVIGGIVAPIFFNTAEDSGALPIQTDVTAMEMGDVIDLYVYKGIIEKNGAVIAEFSI
SPKTLIDEVRAGGRIPLIIGRNLTRKARKTLGLGEDSVFQRPEQPEDTGKGYTLAQKMIGKACGMKGVRPGMYVEPETLT
VGSQDTTGAMTRDEVKELAALSFSADLAMQSFCHTAAYPKPSDVKLHRTLPYFMMSRGGVALRPGDGVIHTWLNRMALPD
TLGTGADSHTRFPIGISFPGGSGLVAFTAVTGTMPLNVPESVLVRFTGKLQPGITLRDLVNAIPYVALKKGLLTVEKKGK
KNIFAGRILEIEGLPDLKVEQAFELSDASAERSAAACTVRLSKEPVIEYLSSNIKLLEQMIEEGYGDAGTLRRRIGKMEE
WLQNPVLLEPDSDAEYAAVIDIDMNTIKEPVLACPNDPDDVMTLSEVLLDDARPKTINEVFVGSCMTNIGHFRALGEVLR
NKGVAAARLWVVPPTKMDMKKLIEEGYYAVFGAAGARTELPGCSLCMGNQARVADNAVVFSTSTRNFDNRMGTGAQVYLG
SAELAAVCALLGHLPNRDEYLEIFNRQLSGDKAQNVYRYLKFNEIEKEELQLLVD

Specific function: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate as well as the dehydration of 2-methylisocitrate to cis-2-methylaconitate [H]

COG id: COG1049

COG function: function code C; Aconitase B

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aconitase/IPM isomerase family [H]

Homologues:

Organism=Escherichia coli, GI2367097, Length=860, Percent_Identity=62.6744186046512, Blast_Score=1045, Evalue=0.0,
Organism=Escherichia coli, GI1786259, Length=391, Percent_Identity=25.8312020460358, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323335, Length=376, Percent_Identity=25.7978723404255, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015931
- InterPro:   IPR015937
- InterPro:   IPR001030
- InterPro:   IPR015928
- InterPro:   IPR015932
- InterPro:   IPR018136
- InterPro:   IPR004406
- InterPro:   IPR015930
- InterPro:   IPR015933
- InterPro:   IPR015929 [H]

Pfam domain/function: PF00330 Aconitase; PF06434 Aconitase_2_N; PF11791 Aconitase_B_N [H]

EC number: =4.2.1.3; =4.2.1.99 [H]

Molecular weight: Translated: 93077; Mature: 92946

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00450 ACONITASE_1 ; PS01244 ACONITASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVSQYRAHSEEREQLGIPPLPLTAEQTRSLIELLMQGQVQEQEYLLELFNEHISPGVD
CCHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC
DAAFEKAAFLDSIIKGECTCAAISPVDAVAILGTMLGGYNVKPLTDALSHADEHICRAAA
HHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
DVLKKILLVYDSFDVVVELSSSNAYAKEVLQSWADAEWFTTRPLLPEKMTLTVFKVPGET
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCEECCCCCCCCEEEEEEECCCCC
NTDDLSPASEAFTRSDIPLHARCMLGSKMDDPIGTITRLKAKGYPLAYVGDVVGTGSSRK
CCCCCCCHHHHHHCCCCCEEEHEECCCCCCCCHHHHHHHHCCCCCEEEECHHHCCCCCCC
SGINSVQWHLGEDIPAVPNKRTGSVVIGGIVAPIFFNTAEDSGALPIQTDVTAMEMGDVI
CCCCCHHHCCCCCCCCCCCCCCCCEEECCCHHHHHEECCCCCCCCCEECCCHHHHHCCHH
DLYVYKGIIEKNGAVIAEFSISPKTLIDEVRAGGRIPLIIGRNLTRKARKTLGLGEDSVF
HHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCHHHH
QRPEQPEDTGKGYTLAQKMIGKACGMKGVRPGMYVEPETLTVGSQDTTGAMTRDEVKELA
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEECCCEEEECCCCCCCCCCHHHHHHHH
ALSFSADLAMQSFCHTAAYPKPSDVKLHRTLPYFMMSRGGVALRPGDGVIHTWLNRMALP
HHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHCCCCEEECCCCCHHHHHHHHHCCC
DTLGTGADSHTRFPIGISFPGGSGLVAFTAVTGTMPLNVPESVLVRFTGKLQPGITLRDL
CCCCCCCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHCCCCCCCCCCHHHH
VNAIPYVALKKGLLTVEKKGKKNIFAGRILEIEGLPDLKVEQAFELSDASAERSAAACTV
HHHHHHHHHHHCCEEEECCCCCCEEECEEEEECCCCCCCHHHHHCCCCCCHHHCCEEEEE
RLSKEPVIEYLSSNIKLLEQMIEEGYGDAGTLRRRIGKMEEWLQNPVLLEPDSDAEYAAV
EECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEE
IDIDMNTIKEPVLACPNDPDDVMTLSEVLLDDARPKTINEVFVGSCMTNIGHFRALGEVL
EEECHHHHHCCCEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RNKGVAAARLWVVPPTKMDMKKLIEEGYYAVFGAAGARTELPGCSLCMGNQARVADNAVV
HCCCCEEEEEEEECCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCEECCCCCEECCCEEE
FSTSTRNFDNRMGTGAQVYLGSAELAAVCALLGHLPNRDEYLEIFNRQLSGDKAQNVYRY
EEECCCCCHHHCCCCCEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHH
LKFNEIEKEELQLLVD
HHHCCCCHHHHHEECC
>Mature Secondary Structure 
SLVSQYRAHSEEREQLGIPPLPLTAEQTRSLIELLMQGQVQEQEYLLELFNEHISPGVD
CHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCC
DAAFEKAAFLDSIIKGECTCAAISPVDAVAILGTMLGGYNVKPLTDALSHADEHICRAAA
HHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
DVLKKILLVYDSFDVVVELSSSNAYAKEVLQSWADAEWFTTRPLLPEKMTLTVFKVPGET
HHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCEECCCCCCCCEEEEEEECCCCC
NTDDLSPASEAFTRSDIPLHARCMLGSKMDDPIGTITRLKAKGYPLAYVGDVVGTGSSRK
CCCCCCCHHHHHHCCCCCEEEHEECCCCCCCCHHHHHHHHCCCCCEEEECHHHCCCCCCC
SGINSVQWHLGEDIPAVPNKRTGSVVIGGIVAPIFFNTAEDSGALPIQTDVTAMEMGDVI
CCCCCHHHCCCCCCCCCCCCCCCCEEECCCHHHHHEECCCCCCCCCEECCCHHHHHCCHH
DLYVYKGIIEKNGAVIAEFSISPKTLIDEVRAGGRIPLIIGRNLTRKARKTLGLGEDSVF
HHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCHHHH
QRPEQPEDTGKGYTLAQKMIGKACGMKGVRPGMYVEPETLTVGSQDTTGAMTRDEVKELA
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEECCCEEEECCCCCCCCCCHHHHHHHH
ALSFSADLAMQSFCHTAAYPKPSDVKLHRTLPYFMMSRGGVALRPGDGVIHTWLNRMALP
HHHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHCCCCEEECCCCCHHHHHHHHHCCC
DTLGTGADSHTRFPIGISFPGGSGLVAFTAVTGTMPLNVPESVLVRFTGKLQPGITLRDL
CCCCCCCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHCCCCCCCCCCHHHH
VNAIPYVALKKGLLTVEKKGKKNIFAGRILEIEGLPDLKVEQAFELSDASAERSAAACTV
HHHHHHHHHHHCCEEEECCCCCCEEECEEEEECCCCCCCHHHHHCCCCCCHHHCCEEEEE
RLSKEPVIEYLSSNIKLLEQMIEEGYGDAGTLRRRIGKMEEWLQNPVLLEPDSDAEYAAV
EECCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEE
IDIDMNTIKEPVLACPNDPDDVMTLSEVLLDDARPKTINEVFVGSCMTNIGHFRALGEVL
EEECHHHHHCCCEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RNKGVAAARLWVVPPTKMDMKKLIEEGYYAVFGAAGARTELPGCSLCMGNQARVADNAVV
HCCCCEEEEEEEECCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCEECCCCCEECCCEEE
FSTSTRNFDNRMGTGAQVYLGSAELAAVCALLGHLPNRDEYLEIFNRQLSGDKAQNVYRY
EEECCCCCHHHCCCCCEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHH
LKFNEIEKEELQLLVD
HHHCCCCHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]