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The map label for this gene is hisD [H]

Identifier: 119356632

GI number: 119356632

Start: 912494

End: 913777

Strand: Direct

Name: hisD [H]

Synonym: Cpha266_0801

Alternate gene names: 119356632

Gene position: 912494-913777 (Clockwise)

Preceding gene: 119356630

Following gene: 119356633

Centisome position: 29.12

GC content: 50.7

Gene sequence:

>1284_bases
GTGTTAAAAATATTCTGTTTTGCCCAGGATGGTGAGGCTCTGAAAAAACAGTTGAGCCGTAGCGTTTCTTTTGATTCCGG
AGTTCAGGATGTCGTCAATGATATTCTTGAACAGGTTCGCACCCGGGGTGACGCAGCACTTCTTGAGTATACCGAGCGCT
TTCAGGGAGCCCGGCTTAATGAAATGATGGTTTCCGGCGAAGAGATCAGAAGTGCTTATGAGCAGGTGGATTCCGGATTT
CTTGAGGTGATGCATGAGGCCTATCGCAATATTACCCGATTTCACCAGCACGAGGTGGAAAACAGTTTTTTTTATGAAGG
CGCGGGGGGCGTAATTCTCGGCCAGAGGGTTACTCCGATGCAGCGGGCACTCCTGTATGTTCCCGGAGGGATGGCCTCTT
ATCCTTCATCGCTCTTGATGAATGCTGCGCCTGCAAAGGTTGCCGGCGTGAGGGATATTGTTGTTACCACCCCTTGCGAT
CCGGATGGACGTGTGAATCCGCATATTCTTGCGGCTGCCGCAGTTGCCGGAATTGACTCTGTTTACAAACTTGGAGGGGC
TCAGGCAATCGCCGCGTTTGCCTATGGTACGGAGAGCATTCCGAAAGTGGATATTATTACCGGACCTGGTAACAAGTATG
TTGCGCTTGCAAAAAAACAGGTGTTTGGACATGTCTCCATCGACAGCATTGCCGGTCCGTCAGAAGTTGTTGTGATTGCC
GATGAAACAGCAAACCCGGACTTTATCGTTCTTGATATGTTTGCACAGGCAGAGCATGATGCGGATGCTTCGGCGGTGCT
TATTACTCCATCCGAATCGCTTGCAGCAGCCGTTCGCGAGACTGCCCGCCGGAGGATCGGCTCGATGCTGCGCAAGGATA
TCATCGGTTCAGCTCTTGAAAAAAACGGCGCTATCGTGATCGTTCAATCAATAGAGGAGGCCTGTTTGGTGTCGGATATG
ATTGCGCCGGAACATCTCGAACTGCATGTCGACCGTCCATGGGATCTGCTGCCGAGCATCAATCATGCCGGGGCAGTGTT
CATAGGGAGTTACTCCTGTGAAACGGTAGGGGATTATTTCGCAGGCCCGAACCACACGCTTCCGACCAACGGGACGGCCC
GATTTTTTTCTCCGCTTTCTGTTCGTGATTTTGTCAAGCACACCTCAATTATTTCCTACTCAAAAAAACAGCTTCAGGAA
TGTGGTAAAAAAATTGCCGCATTTGCCGATTATGAGGGTCTTCAGGCTCATGCTGAGGCTGTCCGCGTAAGACTTGATTC
GTGA

Upstream 100 bases:

>100_bases
GTCGCACACTTTTTTTTGCCCTGTTTCTATTCCGAGCCTCATTGAGTACATTAAAGAACGAGGTCGCTATGCTTTTTGAA
CTTAATTCACTACTGATAAC

Downstream 100 bases:

>100_bases
TGAAGGTCAGTGATTTCGATTATGAACTTCCGGAGTCGCACATTGCCCGGTATCCTCCGGATGAGAGGGGCTCAACCAGA
CTGCTTGTACTGCAAAGATC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MLKIFCFAQDGEALKKQLSRSVSFDSGVQDVVNDILEQVRTRGDAALLEYTERFQGARLNEMMVSGEEIRSAYEQVDSGF
LEVMHEAYRNITRFHQHEVENSFFYEGAGGVILGQRVTPMQRALLYVPGGMASYPSSLLMNAAPAKVAGVRDIVVTTPCD
PDGRVNPHILAAAAVAGIDSVYKLGGAQAIAAFAYGTESIPKVDIITGPGNKYVALAKKQVFGHVSIDSIAGPSEVVVIA
DETANPDFIVLDMFAQAEHDADASAVLITPSESLAAAVRETARRRIGSMLRKDIIGSALEKNGAIVIVQSIEEACLVSDM
IAPEHLELHVDRPWDLLPSINHAGAVFIGSYSCETVGDYFAGPNHTLPTNGTARFFSPLSVRDFVKHTSIISYSKKQLQE
CGKKIAAFADYEGLQAHAEAVRVRLDS

Sequences:

>Translated_427_residues
MLKIFCFAQDGEALKKQLSRSVSFDSGVQDVVNDILEQVRTRGDAALLEYTERFQGARLNEMMVSGEEIRSAYEQVDSGF
LEVMHEAYRNITRFHQHEVENSFFYEGAGGVILGQRVTPMQRALLYVPGGMASYPSSLLMNAAPAKVAGVRDIVVTTPCD
PDGRVNPHILAAAAVAGIDSVYKLGGAQAIAAFAYGTESIPKVDIITGPGNKYVALAKKQVFGHVSIDSIAGPSEVVVIA
DETANPDFIVLDMFAQAEHDADASAVLITPSESLAAAVRETARRRIGSMLRKDIIGSALEKNGAIVIVQSIEEACLVSDM
IAPEHLELHVDRPWDLLPSINHAGAVFIGSYSCETVGDYFAGPNHTLPTNGTARFFSPLSVRDFVKHTSIISYSKKQLQE
CGKKIAAFADYEGLQAHAEAVRVRLDS
>Mature_427_residues
MLKIFCFAQDGEALKKQLSRSVSFDSGVQDVVNDILEQVRTRGDAALLEYTERFQGARLNEMMVSGEEIRSAYEQVDSGF
LEVMHEAYRNITRFHQHEVENSFFYEGAGGVILGQRVTPMQRALLYVPGGMASYPSSLLMNAAPAKVAGVRDIVVTTPCD
PDGRVNPHILAAAAVAGIDSVYKLGGAQAIAAFAYGTESIPKVDIITGPGNKYVALAKKQVFGHVSIDSIAGPSEVVVIA
DETANPDFIVLDMFAQAEHDADASAVLITPSESLAAAVRETARRRIGSMLRKDIIGSALEKNGAIVIVQSIEEACLVSDM
IAPEHLELHVDRPWDLLPSINHAGAVFIGSYSCETVGDYFAGPNHTLPTNGTARFFSPLSVRDFVKHTSIISYSKKQLQE
CGKKIAAFADYEGLQAHAEAVRVRLDS

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=410, Percent_Identity=37.8048780487805, Blast_Score=275, Evalue=6e-75,
Organism=Saccharomyces cerevisiae, GI6319819, Length=426, Percent_Identity=36.6197183098592, Blast_Score=271, Evalue=1e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46177; Mature: 46177

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIFCFAQDGEALKKQLSRSVSFDSGVQDVVNDILEQVRTRGDAALLEYTERFQGARLN
CEEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHH
EMMVSGEEIRSAYEQVDSGFLEVMHEAYRNITRFHQHEVENSFFYEGAGGVILGQRVTPM
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEECCCCCHH
QRALLYVPGGMASYPSSLLMNAAPAKVAGVRDIVVTTPCDPDGRVNPHILAAAAVAGIDS
HHEEEECCCCHHHCCHHHHHCCCCCHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
VYKLGGAQAIAAFAYGTESIPKVDIITGPGNKYVALAKKQVFGHVSIDSIAGPSEVVVIA
HHHHCCHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEHHHHHCCCCHHCCCCCCEEEEEE
DETANPDFIVLDMFAQAEHDADASAVLITPSESLAAAVRETARRRIGSMLRKDIIGSALE
ECCCCCCEEEEEEHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KNGAIVIVQSIEEACLVSDMIAPEHLELHVDRPWDLLPSINHAGAVFIGSYSCETVGDYF
CCCCEEEEECHHHHHHHHHCCCCCCEEEEECCCHHHCCCCCCCCEEEEECCCHHHHHHHC
AGPNHTLPTNGTARFFSPLSVRDFVKHTSIISYSKKQLQECGKKIAAFADYEGLQAHAEA
CCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
VRVRLDS
HEEEECC
>Mature Secondary Structure
MLKIFCFAQDGEALKKQLSRSVSFDSGVQDVVNDILEQVRTRGDAALLEYTERFQGARLN
CEEEEEEECCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHH
EMMVSGEEIRSAYEQVDSGFLEVMHEAYRNITRFHQHEVENSFFYEGAGGVILGQRVTPM
HHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEECCCCCHH
QRALLYVPGGMASYPSSLLMNAAPAKVAGVRDIVVTTPCDPDGRVNPHILAAAAVAGIDS
HHEEEECCCCHHHCCHHHHHCCCCCHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHH
VYKLGGAQAIAAFAYGTESIPKVDIITGPGNKYVALAKKQVFGHVSIDSIAGPSEVVVIA
HHHHCCHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEHHHHHCCCCHHCCCCCCEEEEEE
DETANPDFIVLDMFAQAEHDADASAVLITPSESLAAAVRETARRRIGSMLRKDIIGSALE
ECCCCCCEEEEEEHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KNGAIVIVQSIEEACLVSDMIAPEHLELHVDRPWDLLPSINHAGAVFIGSYSCETVGDYF
CCCCEEEEECHHHHHHHHHCCCCCCEEEEECCCHHHCCCCCCCCEEEEECCCHHHHHHHC
AGPNHTLPTNGTARFFSPLSVRDFVKHTSIISYSKKQLQECGKKIAAFADYEGLQAHAEA
CCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
VRVRLDS
HEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]