Click here to switch to the map view.

The map label for this gene is pgsA [H]

Identifier: 119356504

GI number: 119356504

Start: 763754

End: 764401

Strand: Direct

Name: pgsA [H]

Synonym: Cpha266_0669

Alternate gene names: 119356504

Gene position: 763754-764401 (Clockwise)

Preceding gene: 119356503

Following gene: 119356505

Centisome position: 24.37

GC content: 47.38

Gene sequence:

>648_bases
ATGGAGGGAATTGTGACGTTACAACGGGTGGTGAACCTGATTTCAAGCCATATGACCATACCGAACCAGCTCACGATGCT
CCGTATCGTGCTTGTTCCTGTATTTGTCGCGCTTCTCTTGCAGGATGAGCCTTATGTGAAGTTGCTTGGCGTTTTTGTTT
TTGTCGTAGCATCTCTTACCGACGCCTATGATGGATACCATGCAAGAAAGTATGGCGAGACTACCCGTCTTGGCGCCTTT
CTTGATCCGCTTGCCGATAAACTGTTGATTACAGCGGCTTTTCTGCTCTATGTGCGAATGGGTTATCTTGTGCTGTGGAT
GGTTATTCTTGTTGCTGTTCGTGATGTCGTGATTACGGCACTGCGAATATATGCCGAAATGAAAGACCGGCCAGTGGTGA
CCAGCAAGGAGGCCAAGTACAAGACACTCATGCAGAACGTGTTTGCCTATATCATCATGGCGTTGCTTCTTCTGAGGGAA
CCGGTGTTTTTCGGCAGCAGCATTGCATCAGCAGTCAACGGCTTTCTGGTTTCAGATTACCTGGACTATATGATGCTTGT
CGTTACGATTTTTACGGTTTATACAGGGATTTCCTACCTCACCAGCAACTGGAGAGCATCGTTTCAGAGCTCTTCGGATG
AACATTGA

Upstream 100 bases:

>100_bases
GGAGGGGGGCTGCAGCACGGAGATCGAGCCACTGTTACCGGATTCAGTGCGCTCATAAATGGATTGATGGTATGAAAAAT
GAGGTGAGTGTGACACTTGA

Downstream 100 bases:

>100_bases
GCGCATGAAACTGTTTTTGGCAAAAGTTCTCTCTACCTGTGGCGGTTTGGGTTATTTTCCGGCTGCACCCGGTACTTTTG
TGAGTTTTATCGCTGTTCTG

Product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MEGIVTLQRVVNLISSHMTIPNQLTMLRIVLVPVFVALLLQDEPYVKLLGVFVFVVASLTDAYDGYHARKYGETTRLGAF
LDPLADKLLITAAFLLYVRMGYLVLWMVILVAVRDVVITALRIYAEMKDRPVVTSKEAKYKTLMQNVFAYIIMALLLLRE
PVFFGSSIASAVNGFLVSDYLDYMMLVVTIFTVYTGISYLTSNWRASFQSSSDEH

Sequences:

>Translated_215_residues
MEGIVTLQRVVNLISSHMTIPNQLTMLRIVLVPVFVALLLQDEPYVKLLGVFVFVVASLTDAYDGYHARKYGETTRLGAF
LDPLADKLLITAAFLLYVRMGYLVLWMVILVAVRDVVITALRIYAEMKDRPVVTSKEAKYKTLMQNVFAYIIMALLLLRE
PVFFGSSIASAVNGFLVSDYLDYMMLVVTIFTVYTGISYLTSNWRASFQSSSDEH
>Mature_215_residues
MEGIVTLQRVVNLISSHMTIPNQLTMLRIVLVPVFVALLLQDEPYVKLLGVFVFVVASLTDAYDGYHARKYGETTRLGAF
LDPLADKLLITAAFLLYVRMGYLVLWMVILVAVRDVVITALRIYAEMKDRPVVTSKEAKYKTLMQNVFAYIIMALLLLRE
PVFFGSSIASAVNGFLVSDYLDYMMLVVTIFTVYTGISYLTSNWRASFQSSSDEH

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI10092647, Length=124, Percent_Identity=38.7096774193548, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI188536108, Length=117, Percent_Identity=41.025641025641, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1788220, Length=152, Percent_Identity=36.1842105263158, Blast_Score=88, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320059, Length=127, Percent_Identity=40.9448818897638, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 24273; Mature: 24273

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGIVTLQRVVNLISSHMTIPNQLTMLRIVLVPVFVALLLQDEPYVKLLGVFVFVVASLT
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
DAYDGYHARKYGETTRLGAFLDPLADKLLITAAFLLYVRMGYLVLWMVILVAVRDVVITA
HHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRIYAEMKDRPVVTSKEAKYKTLMQNVFAYIIMALLLLREPVFFGSSIASAVNGFLVSDY
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHH
LDYMMLVVTIFTVYTGISYLTSNWRASFQSSSDEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEGIVTLQRVVNLISSHMTIPNQLTMLRIVLVPVFVALLLQDEPYVKLLGVFVFVVASLT
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
DAYDGYHARKYGETTRLGAFLDPLADKLLITAAFLLYVRMGYLVLWMVILVAVRDVVITA
HHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRIYAEMKDRPVVTSKEAKYKTLMQNVFAYIIMALLLLREPVFFGSSIASAVNGFLVSDY
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHH
LDYMMLVVTIFTVYTGISYLTSNWRASFQSSSDEH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7750561; 9384377 [H]