Click here to switch to the map view.

The map label for this gene is mutS2 [H]

Identifier: 119356503

GI number: 119356503

Start: 761185

End: 763569

Strand: Direct

Name: mutS2 [H]

Synonym: Cpha266_0668

Alternate gene names: 119356503

Gene position: 761185-763569 (Clockwise)

Preceding gene: 119356494

Following gene: 119356504

Centisome position: 24.29

GC content: 51.99

Gene sequence:

>2385_bases
ATGAATCCCGTCAGTCTGAAAAAACTTGAATTCGATAAAGTAGCCAATTATGCCGCGCAGTTCTGCCTTTCGGCGATGGG
GCGCGACAGGCTTCTTGCTGCGGAACCGGAGGTGGGGCGCCGGGAGCTTGTGGCGGAACTTGAACGGGTGCTTGAGTTGC
GCAATATGCTTCAGGAGGGGAGTGCGCTTCCTTTTTCATGGTTGCCGGATACACGGCCTCTTCTGAAAAAGCTTGAAATC
CTTGAGAGTTATCTTGAGCCGGAGGAGTTGCAGGATATTTATCATCTCCTTTTTTCATCGGTTCAGTTGCGCAAGTTCAT
GTTTTTTAACCGCGAGGTCTATCCTCTGCTGAATGAGTTTACCATCAGGCTCTGGCTTGAAAAGAGCCTTCAGACCTCGA
TTCGTCGTATTATCGATGAGCAGTCGAGGGTGCGCGATACGGCAAGCGAGGAGCTTCTGTTGATCCGGCGTGAGCTCGGC
GGCAGCCGTGAGCTGATTCGAAGGAAGATGGAGCGGCTACAGAGGCGTTGTCAGGAGAGCGGATGGCTGATGGAGGATAC
GATAGCGATCAAGAACGGGCGCCTGACGCTTGGTCTTCGGGTGGAGTACAAATACAAAATTGCCGGCTATATACAGGATT
ACTCCGGTAGCGGACAGACGGTTTTTATCGAGCCTGCCGAAACGCTTGAGATCAGTAACCGCATTCAGGATCTGGAGATC
AGCGAGCGAAGGGAGATCGAGCGAATTCTGAAGGAGATGTCGGGAGCGTTGCGCCTTGAACTTGAAAATCTGAGGTATAA
CGAGATCATTCTTGGTGATTTTGATTCGCTCTACGCGCGGGCACGCTTTGCCGTTGAAACGAACTCGGTGCTTCCGGGTA
TTGCCGATGGACAGTCCTTGCGAATTATCAGAGGGTTTCATCCCTGGCTCCTGATTTCGCATCATCATAAAGAGGTTATG
CCTCTCGATCTTGATCTGGATGAAACTGACCGGGTGCTCGTAATTTCCGGTCCCAATGCGGGCGGTAAATCGGTGGCGAT
GAAGACCGCCGGTCTGCTCTGCTGCATGCTGGTGCATGGTTACCTGCTGCCTTGCAGCGAGAGTTCCGTGTTCCCTCTTT
TCAGTGATATTTTTATCGAGATCGGCGACGATCAGTCTATTGAAAATGATCTCTCCACCTTCAGCTCCCATCTTGGCGCG
ATCAGAACCATCCTTGACGTTGCAGGGAGCGGCGATCTGGTGCTGATTGACGAGCTTTGCGCCGGCACGGATGTTGAGGA
GGGCGGGGCCATTGCTCGAGCAGTGATGGAGGAACTGCTCAATCGCGGGACAAAAACCATTGTTACCACTCATCTCGGCG
ACCTGAAGGCCTATGCTCATGAGCGTGAGGGAGTGCTTAACGGCGCCATGGAGTTTGACCGGGCTGGTCTGGTGCCGACT
TTCCGTTTTGTCAAGGGATTGCCGGGTAACAGTTTTGCCTTTGCGATGATGAAGCGGATGGGTTTTCCTGTGAAAATGGT
TGAGCGGGCTTCGGAATTTATGATGGATGAGCGTATCGGGCTTGACCGGATGCTTGATGACTTGAGTCGTCTCTTTGAAG
AGAATCGTCTGCTGAAGCAGCAGCTTGAGGGTGAACGGGCTGATCTTGCTGAACGGGTTATTGCTCTTCGCGCCGAGGAG
GCCGGTGTTGAACGGAAGCAGAGAGAACTGAGACTTGGTGCTGCAAGAGAGTTGCAGAAAGAGGTAGAACATGCACGAAA
AGAGATCAGGGAGATTGTTCAGGAGGTGAGGAACGCTCCAGCTGATGCAAAAACTGTACAGGATTCGAGAAAAAAACTTG
GTCTGAAAAAGCAGGAAGCTGAAAAGAGTGAATCAGTTCTGGATGCTGAAGCTGAGAGTGCAGTTCATCTTGATCGTTCC
ATCCGAGAGGGTGATCTGGTCAGGATTCTTGACAGCACGGCCTCAGGCGAGGTCGAGAGCGTCAATGGAGAGAGTGTTGT
GGTGCAATGTGGTCATTTCAGGTTGACCACGTCGCTTAAAAACCTTGAGAAAACTTCGAAAACGCAGGTTAAAAAAAATC
TCAGAGAGCCTCTGCTCCGGCAGCAAAAGGGCTCCTGGTCAGCAATCACCTCTGAGGTGGATTCGACAAAACTTGACTTG
CGGGGGCTCAGTGGTGATGAGGCGATCATGAAAATCGACAGGTTTATCGATACCATGCGTCTTAATCGTATTCATTCAGC
GATGATTCTTCACGGCAAGGGAACCGGATCGCTGCGGCAGCGAACGGCGGAATTTCTCCAGCAGCATGGCTCGGTCAAAA
GTTTTCGACTGGGAGAGTGGGGCGAGGGAGGAGCAGGCGTGACCATCGTCGAGATTGAATCGTGA

Upstream 100 bases:

>100_bases
GTTGATTTTTAACGTGATGCTTATGAACAGTTGCCTGTTTCTGTGTATCGATTATTCATGACCCAATTGCCGTAAAGGCT
TATAGAATTACCGTGTATCA

Downstream 100 bases:

>100_bases
TGAAGCGGCACCCTTCATACGGGTTTCGTTGAAAAAACGCCTTCAATAGCGTATCTTATGCCGAAGAAGGGCCGAATATG
AACGGGAGGGGGGCTGCAGC

Product: Smr protein/MutS2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 794; Mature: 794

Protein sequence:

>794_residues
MNPVSLKKLEFDKVANYAAQFCLSAMGRDRLLAAEPEVGRRELVAELERVLELRNMLQEGSALPFSWLPDTRPLLKKLEI
LESYLEPEELQDIYHLLFSSVQLRKFMFFNREVYPLLNEFTIRLWLEKSLQTSIRRIIDEQSRVRDTASEELLLIRRELG
GSRELIRRKMERLQRRCQESGWLMEDTIAIKNGRLTLGLRVEYKYKIAGYIQDYSGSGQTVFIEPAETLEISNRIQDLEI
SERREIERILKEMSGALRLELENLRYNEIILGDFDSLYARARFAVETNSVLPGIADGQSLRIIRGFHPWLLISHHHKEVM
PLDLDLDETDRVLVISGPNAGGKSVAMKTAGLLCCMLVHGYLLPCSESSVFPLFSDIFIEIGDDQSIENDLSTFSSHLGA
IRTILDVAGSGDLVLIDELCAGTDVEEGGAIARAVMEELLNRGTKTIVTTHLGDLKAYAHEREGVLNGAMEFDRAGLVPT
FRFVKGLPGNSFAFAMMKRMGFPVKMVERASEFMMDERIGLDRMLDDLSRLFEENRLLKQQLEGERADLAERVIALRAEE
AGVERKQRELRLGAARELQKEVEHARKEIREIVQEVRNAPADAKTVQDSRKKLGLKKQEAEKSESVLDAEAESAVHLDRS
IREGDLVRILDSTASGEVESVNGESVVVQCGHFRLTTSLKNLEKTSKTQVKKNLREPLLRQQKGSWSAITSEVDSTKLDL
RGLSGDEAIMKIDRFIDTMRLNRIHSAMILHGKGTGSLRQRTAEFLQQHGSVKSFRLGEWGEGGAGVTIVEIES

Sequences:

>Translated_794_residues
MNPVSLKKLEFDKVANYAAQFCLSAMGRDRLLAAEPEVGRRELVAELERVLELRNMLQEGSALPFSWLPDTRPLLKKLEI
LESYLEPEELQDIYHLLFSSVQLRKFMFFNREVYPLLNEFTIRLWLEKSLQTSIRRIIDEQSRVRDTASEELLLIRRELG
GSRELIRRKMERLQRRCQESGWLMEDTIAIKNGRLTLGLRVEYKYKIAGYIQDYSGSGQTVFIEPAETLEISNRIQDLEI
SERREIERILKEMSGALRLELENLRYNEIILGDFDSLYARARFAVETNSVLPGIADGQSLRIIRGFHPWLLISHHHKEVM
PLDLDLDETDRVLVISGPNAGGKSVAMKTAGLLCCMLVHGYLLPCSESSVFPLFSDIFIEIGDDQSIENDLSTFSSHLGA
IRTILDVAGSGDLVLIDELCAGTDVEEGGAIARAVMEELLNRGTKTIVTTHLGDLKAYAHEREGVLNGAMEFDRAGLVPT
FRFVKGLPGNSFAFAMMKRMGFPVKMVERASEFMMDERIGLDRMLDDLSRLFEENRLLKQQLEGERADLAERVIALRAEE
AGVERKQRELRLGAARELQKEVEHARKEIREIVQEVRNAPADAKTVQDSRKKLGLKKQEAEKSESVLDAEAESAVHLDRS
IREGDLVRILDSTASGEVESVNGESVVVQCGHFRLTTSLKNLEKTSKTQVKKNLREPLLRQQKGSWSAITSEVDSTKLDL
RGLSGDEAIMKIDRFIDTMRLNRIHSAMILHGKGTGSLRQRTAEFLQQHGSVKSFRLGEWGEGGAGVTIVEIES
>Mature_794_residues
MNPVSLKKLEFDKVANYAAQFCLSAMGRDRLLAAEPEVGRRELVAELERVLELRNMLQEGSALPFSWLPDTRPLLKKLEI
LESYLEPEELQDIYHLLFSSVQLRKFMFFNREVYPLLNEFTIRLWLEKSLQTSIRRIIDEQSRVRDTASEELLLIRRELG
GSRELIRRKMERLQRRCQESGWLMEDTIAIKNGRLTLGLRVEYKYKIAGYIQDYSGSGQTVFIEPAETLEISNRIQDLEI
SERREIERILKEMSGALRLELENLRYNEIILGDFDSLYARARFAVETNSVLPGIADGQSLRIIRGFHPWLLISHHHKEVM
PLDLDLDETDRVLVISGPNAGGKSVAMKTAGLLCCMLVHGYLLPCSESSVFPLFSDIFIEIGDDQSIENDLSTFSSHLGA
IRTILDVAGSGDLVLIDELCAGTDVEEGGAIARAVMEELLNRGTKTIVTTHLGDLKAYAHEREGVLNGAMEFDRAGLVPT
FRFVKGLPGNSFAFAMMKRMGFPVKMVERASEFMMDERIGLDRMLDDLSRLFEENRLLKQQLEGERADLAERVIALRAEE
AGVERKQRELRLGAARELQKEVEHARKEIREIVQEVRNAPADAKTVQDSRKKLGLKKQEAEKSESVLDAEAESAVHLDRS
IREGDLVRILDSTASGEVESVNGESVVVQCGHFRLTTSLKNLEKTSKTQVKKNLREPLLRQQKGSWSAITSEVDSTKLDL
RGLSGDEAIMKIDRFIDTMRLNRIHSAMILHGKGTGSLRQRTAEFLQQHGSVKSFRLGEWGEGGAGVTIVEIES

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=266, Percent_Identity=28.1954887218045, Blast_Score=90, Evalue=1e-17,
Organism=Homo sapiens, GI36949366, Length=222, Percent_Identity=31.981981981982, Blast_Score=87, Evalue=8e-17,
Organism=Homo sapiens, GI4504191, Length=189, Percent_Identity=29.6296296296296, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI26638666, Length=246, Percent_Identity=29.2682926829268, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4505253, Length=246, Percent_Identity=29.2682926829268, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4557761, Length=273, Percent_Identity=24.5421245421245, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI26638664, Length=247, Percent_Identity=29.1497975708502, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1789089, Length=269, Percent_Identity=27.8810408921933, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17534743, Length=204, Percent_Identity=30.3921568627451, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17508445, Length=210, Percent_Identity=26.1904761904762, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17539736, Length=306, Percent_Identity=26.1437908496732, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321912, Length=269, Percent_Identity=26.7657992565056, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319935, Length=312, Percent_Identity=26.6025641025641, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320302, Length=267, Percent_Identity=28.8389513108614, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324482, Length=280, Percent_Identity=24.6428571428571, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24664545, Length=338, Percent_Identity=27.2189349112426, Blast_Score=87, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24584320, Length=253, Percent_Identity=28.0632411067194, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 89783; Mature: 89783

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPVSLKKLEFDKVANYAAQFCLSAMGRDRLLAAEPEVGRRELVAELERVLELRNMLQEG
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
SALPFSWLPDTRPLLKKLEILESYLEPEELQDIYHLLFSSVQLRKFMFFNREVYPLLNEF
CCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TIRLWLEKSLQTSIRRIIDEQSRVRDTASEELLLIRRELGGSRELIRRKMERLQRRCQES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
GWLMEDTIAIKNGRLTLGLRVEYKYKIAGYIQDYSGSGQTVFIEPAETLEISNRIQDLEI
CCEEEEEEEEECCEEEEEEEEEEEEEEEEEEECCCCCCCEEEECCHHHHHHHHHHHCCCH
SERREIERILKEMSGALRLELENLRYNEIILGDFDSLYARARFAVETNSVLPGIADGQSL
HHHHHHHHHHHHHCCCEEEEECCCCCCEEEECCHHHHHHHHHHEEECCCCCCCCCCCCCE
RIIRGFHPWLLISHHHKEVMPLDLDLDETDRVLVISGPNAGGKSVAMKTAGLLCCMLVHG
EEEECCCCEEEEECCCCCCCCEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHC
YLLPCSESSVFPLFSDIFIEIGDDQSIENDLSTFSSHLGAIRTILDVAGSGDLVLIDELC
EEECCCCCCCCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHH
AGTDVEEGGAIARAVMEELLNRGTKTIVTTHLGDLKAYAHEREGVLNGAMEFDRAGLVPT
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
FRFVKGLPGNSFAFAMMKRMGFPVKMVERASEFMMDERIGLDRMLDDLSRLFEENRLLKQ
HHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QLEGERADLAERVIALRAEEAGVERKQRELRLGAARELQKEVEHARKEIREIVQEVRNAP
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ADAKTVQDSRKKLGLKKQEAEKSESVLDAEAESAVHLDRSIREGDLVRILDSTASGEVES
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEE
VNGESVVVQCGHFRLTTSLKNLEKTSKTQVKKNLREPLLRQQKGSWSAITSEVDSTKLDL
CCCCEEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEE
RGLSGDEAIMKIDRFIDTMRLNRIHSAMILHGKGTGSLRQRTAEFLQQHGSVKSFRLGEW
CCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHCCCCCEEECCCC
GEGGAGVTIVEIES
CCCCCCEEEEEECC
>Mature Secondary Structure
MNPVSLKKLEFDKVANYAAQFCLSAMGRDRLLAAEPEVGRRELVAELERVLELRNMLQEG
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
SALPFSWLPDTRPLLKKLEILESYLEPEELQDIYHLLFSSVQLRKFMFFNREVYPLLNEF
CCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
TIRLWLEKSLQTSIRRIIDEQSRVRDTASEELLLIRRELGGSRELIRRKMERLQRRCQES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
GWLMEDTIAIKNGRLTLGLRVEYKYKIAGYIQDYSGSGQTVFIEPAETLEISNRIQDLEI
CCEEEEEEEEECCEEEEEEEEEEEEEEEEEEECCCCCCCEEEECCHHHHHHHHHHHCCCH
SERREIERILKEMSGALRLELENLRYNEIILGDFDSLYARARFAVETNSVLPGIADGQSL
HHHHHHHHHHHHHCCCEEEEECCCCCCEEEECCHHHHHHHHHHEEECCCCCCCCCCCCCE
RIIRGFHPWLLISHHHKEVMPLDLDLDETDRVLVISGPNAGGKSVAMKTAGLLCCMLVHG
EEEECCCCEEEEECCCCCCCCEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHC
YLLPCSESSVFPLFSDIFIEIGDDQSIENDLSTFSSHLGAIRTILDVAGSGDLVLIDELC
EEECCCCCCCCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHH
AGTDVEEGGAIARAVMEELLNRGTKTIVTTHLGDLKAYAHEREGVLNGAMEFDRAGLVPT
CCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
FRFVKGLPGNSFAFAMMKRMGFPVKMVERASEFMMDERIGLDRMLDDLSRLFEENRLLKQ
HHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QLEGERADLAERVIALRAEEAGVERKQRELRLGAARELQKEVEHARKEIREIVQEVRNAP
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ADAKTVQDSRKKLGLKKQEAEKSESVLDAEAESAVHLDRSIREGDLVRILDSTASGEVES
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEE
VNGESVVVQCGHFRLTTSLKNLEKTSKTQVKKNLREPLLRQQKGSWSAITSEVDSTKLDL
CCCCEEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEE
RGLSGDEAIMKIDRFIDTMRLNRIHSAMILHGKGTGSLRQRTAEFLQQHGSVKSFRLGEW
CCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHCCCCCEEECCCC
GEGGAGVTIVEIES
CCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA