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The map label for this gene is hemN [H]

Identifier: 119356450

GI number: 119356450

Start: 685133

End: 686551

Strand: Direct

Name: hemN [H]

Synonym: Cpha266_0614

Alternate gene names: 119356450

Gene position: 685133-686551 (Clockwise)

Preceding gene: 119356442

Following gene: 119356451

Centisome position: 21.86

GC content: 45.45

Gene sequence:

>1419_bases
ATGGCAGCAAATCTTGCGGTGAAGTACAGTAATCCCGGCCCTCGTTATACCAGTTATCCGACCATTCCTTCATGGAGCAC
AGACGGTGTTACCCAGGAACAATGGAAGGAGGCTATGGTCAAAGGGTTCAATGACAGCAATGAGAGCACCGGCATCAGTT
TGTATATTCATATTCCTTTTTGCGAAAATTACTGTTATTTTTGCGGATGTAACGCTCATCGTACTCAGGATCACTCTTTT
GAAGCTCCTTACCTTGACGCGTTGCTCAAGGAATGGCAGATGTATCTCGATGTTTTTCCCGGAACGCTTAATGTTAAGGA
GATGCATATCGGTGGAGGGACGCCAACTTTTTTCAGTCCTGAAAACCTGATCAAGCTTGTTGACGGTCTCTACAAGCATG
TCAATACGATGGATGATTATATTTTCAGTTTTGAAACAAATCCGCGATCAACATCGAGAGAGCACCTTGAGGCGCTCTAC
AGTGTGGGTTTCAGACGCATGAGCTTCGGTATCCAGGATTTTGATCCGATTGTGCAGCAGGAGATCAATCGTCCGCAGTC
CTTCGAGCTTGTAAGGGAAAAAGTTGAACTTGCACGAGAGATCGGCTTTACTTCGCTGAATTTTGATCTTGTTTACGGTT
TACCCAAACAGACACTTGCCACTATAACCGATACCATTCAGAAAGTGATGGAGTTGAAGCCCGACAGGCTTGCTTTTTAT
GCCTACGGGCACAATCCTCACATGTATGAAGGTCAGAGGAAGTTCAAGGAATCGGATCTTCCTGTTGGCGATGTCAAGCA
GGAACTCTATGACAAAGGACGAGCAATGCTTGAGTCGATAGGCTATCATGAAATCGGCATGGATCATTTTGCCATTGAAG
GTGATGCCCTGTATGAAGCAGCTAAAAACGGAACTCTGCATAGAAACTTCATGGGGTACACCGAAAATACCACTCAAATG
ATGCTTGCGCTTGGAGCATCATCCATCAGTGATACATGGTATGCATTTGCTCAGAATGAAAGGCACGATGATGCCTATAT
CAAGGCTGTAAATGAAGGACGTTTTCCGCTTTTGCGCGGTCATCTGCTCACCGATGAGGATCTTGTGCTGCGTCGACATA
TTCTCAATCTGATGTGCAAGCAGGAGACCTCATGGGAAGATCCCAAACTCTATTGCGACGAGCTTGATATTGCCAGATAC
AGGCTGGAGGATATGGAAAGTGACGGTATGGTGGTACTTCTTGAGCATGGAGTCAGGGTTACCGATGTCGGTATTCCGTT
TCTGCGTAATATTTGCATGGCGTTTGACGCAAGACTCTGGCGATCGGACAGCCTTTCCAAAGCATATAATGTATCAAGGG
ATATTCAGAAAACATATATTGAAAAAGCCCGTCAGGCAAAAGCTCAACAGGTTGAGTAA

Upstream 100 bases:

>100_bases
GCGGTCTGTTTGTAAGATGGGATGAATTTATGAAATTGTCGAGTTTTATGTATTTTCCACAGTATCAGACAAAAAATAAC
ACTTGTTGAGGAAGTTTACA

Downstream 100 bases:

>100_bases
CGGTCTGAATAAGTATAATGCAAAGGGTGATTTTGATCACCCTTTTTTTGTGTCGTTTTTATGAAAAAAAAAGTAAAAAT
AGGGTTTCTTGGGAGCGGAT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MAANLAVKYSNPGPRYTSYPTIPSWSTDGVTQEQWKEAMVKGFNDSNESTGISLYIHIPFCENYCYFCGCNAHRTQDHSF
EAPYLDALLKEWQMYLDVFPGTLNVKEMHIGGGTPTFFSPENLIKLVDGLYKHVNTMDDYIFSFETNPRSTSREHLEALY
SVGFRRMSFGIQDFDPIVQQEINRPQSFELVREKVELAREIGFTSLNFDLVYGLPKQTLATITDTIQKVMELKPDRLAFY
AYGHNPHMYEGQRKFKESDLPVGDVKQELYDKGRAMLESIGYHEIGMDHFAIEGDALYEAAKNGTLHRNFMGYTENTTQM
MLALGASSISDTWYAFAQNERHDDAYIKAVNEGRFPLLRGHLLTDEDLVLRRHILNLMCKQETSWEDPKLYCDELDIARY
RLEDMESDGMVVLLEHGVRVTDVGIPFLRNICMAFDARLWRSDSLSKAYNVSRDIQKTYIEKARQAKAQQVE

Sequences:

>Translated_472_residues
MAANLAVKYSNPGPRYTSYPTIPSWSTDGVTQEQWKEAMVKGFNDSNESTGISLYIHIPFCENYCYFCGCNAHRTQDHSF
EAPYLDALLKEWQMYLDVFPGTLNVKEMHIGGGTPTFFSPENLIKLVDGLYKHVNTMDDYIFSFETNPRSTSREHLEALY
SVGFRRMSFGIQDFDPIVQQEINRPQSFELVREKVELAREIGFTSLNFDLVYGLPKQTLATITDTIQKVMELKPDRLAFY
AYGHNPHMYEGQRKFKESDLPVGDVKQELYDKGRAMLESIGYHEIGMDHFAIEGDALYEAAKNGTLHRNFMGYTENTTQM
MLALGASSISDTWYAFAQNERHDDAYIKAVNEGRFPLLRGHLLTDEDLVLRRHILNLMCKQETSWEDPKLYCDELDIARY
RLEDMESDGMVVLLEHGVRVTDVGIPFLRNICMAFDARLWRSDSLSKAYNVSRDIQKTYIEKARQAKAQQVE
>Mature_471_residues
AANLAVKYSNPGPRYTSYPTIPSWSTDGVTQEQWKEAMVKGFNDSNESTGISLYIHIPFCENYCYFCGCNAHRTQDHSFE
APYLDALLKEWQMYLDVFPGTLNVKEMHIGGGTPTFFSPENLIKLVDGLYKHVNTMDDYIFSFETNPRSTSREHLEALYS
VGFRRMSFGIQDFDPIVQQEINRPQSFELVREKVELAREIGFTSLNFDLVYGLPKQTLATITDTIQKVMELKPDRLAFYA
YGHNPHMYEGQRKFKESDLPVGDVKQELYDKGRAMLESIGYHEIGMDHFAIEGDALYEAAKNGTLHRNFMGYTENTTQMM
LALGASSISDTWYAFAQNERHDDAYIKAVNEGRFPLLRGHLLTDEDLVLRRHILNLMCKQETSWEDPKLYCDELDIARYR
LEDMESDGMVVLLEHGVRVTDVGIPFLRNICMAFDARLWRSDSLSKAYNVSRDIQKTYIEKARQAKAQQVE

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=260, Percent_Identity=26.9230769230769, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI87082341, Length=441, Percent_Identity=39.2290249433107, Blast_Score=295, Evalue=6e-81,
Organism=Escherichia coli, GI1789325, Length=243, Percent_Identity=27.9835390946502, Blast_Score=112, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 54353; Mature: 54222

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00304 SASP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAANLAVKYSNPGPRYTSYPTIPSWSTDGVTQEQWKEAMVKGFNDSNESTGISLYIHIPF
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEE
CENYCYFCGCNAHRTQDHSFEAPYLDALLKEWQMYLDVFPGTLNVKEMHIGGGTPTFFSP
ECCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCH
ENLIKLVDGLYKHVNTMDDYIFSFETNPRSTSREHLEALYSVGFRRMSFGIQDFDPIVQQ
HHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
EINRPQSFELVREKVELAREIGFTSLNFDLVYGLPKQTLATITDTIQKVMELKPDRLAFY
HCCCCHHHHHHHHHHHHHHHCCCCEECEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEE
AYGHNPHMYEGQRKFKESDLPVGDVKQELYDKGRAMLESIGYHEIGMDHFAIEGDALYEA
EECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCEEECCHHHHHH
AKNGTLHRNFMGYTENTTQMMLALGASSISDTWYAFAQNERHDDAYIKAVNEGRFPLLRG
HCCCCEEECCCCCCCCHHHHHHHHCCCHHCHHHHHHHCCCCCCCHHEEEECCCCCCEEEC
HLLTDEDLVLRRHILNLMCKQETSWEDPKLYCDELDIARYRLEDMESDGMVVLLEHGVRV
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHCCCCCEEEEEECCCEE
TDVGIPFLRNICMAFDARLWRSDSLSKAYNVSRDIQKTYIEKARQAKAQQVE
EECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AANLAVKYSNPGPRYTSYPTIPSWSTDGVTQEQWKEAMVKGFNDSNESTGISLYIHIPF
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEEEE
CENYCYFCGCNAHRTQDHSFEAPYLDALLKEWQMYLDVFPGTLNVKEMHIGGGTPTFFSP
ECCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCH
ENLIKLVDGLYKHVNTMDDYIFSFETNPRSTSREHLEALYSVGFRRMSFGIQDFDPIVQQ
HHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
EINRPQSFELVREKVELAREIGFTSLNFDLVYGLPKQTLATITDTIQKVMELKPDRLAFY
HCCCCHHHHHHHHHHHHHHHCCCCEECEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEE
AYGHNPHMYEGQRKFKESDLPVGDVKQELYDKGRAMLESIGYHEIGMDHFAIEGDALYEA
EECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCEEECCHHHHHH
AKNGTLHRNFMGYTENTTQMMLALGASSISDTWYAFAQNERHDDAYIKAVNEGRFPLLRG
HCCCCEEECCCCCCCCHHHHHHHHCCCHHCHHHHHHHCCCCCCCHHEEEECCCCCCEEEC
HLLTDEDLVLRRHILNLMCKQETSWEDPKLYCDELDIARYRLEDMESDGMVVLLEHGVRV
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHHHHHHHHCCCCCEEEEEECCCEE
TDVGIPFLRNICMAFDARLWRSDSLSKAYNVSRDIQKTYIEKARQAKAQQVE
EECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]