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The map label for this gene is glyA

Identifier: 119356437

GI number: 119356437

Start: 673670

End: 674992

Strand: Direct

Name: glyA

Synonym: Cpha266_0601

Alternate gene names: 119356437

Gene position: 673670-674992 (Clockwise)

Preceding gene: 119356436

Following gene: 119356439

Centisome position: 21.5

GC content: 49.96

Gene sequence:

>1323_bases
ATGGATACCGATATCCTTCAGATGCAGGATAAAGAAGTTTTTGAAGCGGTGGTCAACGAGACGGTAAGGCAGACCGAAAC
GCTGGAACTTATCGCTTCCGAGAATTTTACCAGTCGTGCGGTTATGCAGGCATGCGGCTCGGTGATGACCAACAAATACG
CCGAGGGCTATCCCGGAAAGAGGTATTACGGCGGGTGCGAATTTGTTGATGTTGCCGAAAACCTTGCGCGTGATCGGGCA
AAAAAACTCTTTAACTGTTCATATGTCAACGTGCAGCCGCATTCCGGCTCAAGTGCCAATATGGCAGTACTGTTCTCGGT
ACTCAAGCCTGGTGACCGGATCATGGGTCTTGATCTGTCTCACGGCGGTCATCTTACCCATGGCAGTCCGGTGAACTTTT
CGGGTCAACTTTATGAGGCTCACTCATATGGTGTTCGGAGAGAAACCGGCTGTATTGACATGAATATGGTTGAGGAACTG
GCTAATAAGGTTCGTCCGAAACTTATCATCTGCGGTGCAAGCGCCTATTCTCAGGGATTCGATTTCAAGGCTTTCAGGGA
GATTGCCGATAGGATCGGTGCTCTGCTCATGGCTGATATTGCGCATCCGGCAGGACTTATTGTCGCAGGGCTTTTAAGCG
ATCCTGTTCCGCATTGTCATTTTGTGACCACAACCACACACAAGACGCTTCGCGGACCAAGGGGCGGAATGATCATGATG
GGCAGTGATTTTGAGAATCCACTCGGGATTACCATCAAAACAAAAACCGGCTCACGGGTGAAAATGATGACGGAGGTAAT
GGATGCAGAGGTTATGCCCGGCATTCAGGGCGGCCCGCTGATGCATATTATTGCAGGAAAGGCAGTTGCATTTGCTGAGG
CGCTTCGCCCGGAGTTCAGGGATTATGCGCTGCAGGTAAAAAAGAATGCTGCCGTTATGGCGGATAAATTTTCGAGTCTC
GGTTACACCATTGTCAGCGGTGGCACCAAGAACCATCTCATGCTGCTTGACTTGCGCAACAAGAACGTAAATGGAAAGGT
TGCTGAAAATCTGTTGCATCAAGCAGGTATTACCGTTAACAAGAATATGGTACCGTTCGACGACAAGTCTCCCTTTGTTA
CCAGCGGAATCAGAATCGGGACTCCGGCAATGACGACCAGAGGGATGAAAGAGAGCGACAGCGAGCGTATCGTCGAGTTG
ATCGATCGTGTTGTTTCCGCGGCTGAAACTCCTGCTGTTGATGATGTGTGTCGTTTGGTGCGTCAGGAAATCAGGGAGCT
CTGTCTTCAGCACCCGATGGATGGATATGAGATGACGCCATAA

Upstream 100 bases:

>100_bases
TGAATCTCTTTTTTTTGAACAGATAACTGAAAATCATTTGAATAAAAGTCAACAACCTCCCAACCAGTAAACTTCCGTCA
GGAAAAGGAACGATACAACG

Downstream 100 bases:

>100_bases
GCTGCCGTGCTCTTTTCGGATTTTTTTTTGCCGCCTTTCGGAGCTTTCGCTTCTGAGGCGGCTTTTTTTTCGCGTTACCT
CTGTTTATCGGTTATCAATA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MDTDILQMQDKEVFEAVVNETVRQTETLELIASENFTSRAVMQACGSVMTNKYAEGYPGKRYYGGCEFVDVAENLARDRA
KKLFNCSYVNVQPHSGSSANMAVLFSVLKPGDRIMGLDLSHGGHLTHGSPVNFSGQLYEAHSYGVRRETGCIDMNMVEEL
ANKVRPKLIICGASAYSQGFDFKAFREIADRIGALLMADIAHPAGLIVAGLLSDPVPHCHFVTTTTHKTLRGPRGGMIMM
GSDFENPLGITIKTKTGSRVKMMTEVMDAEVMPGIQGGPLMHIIAGKAVAFAEALRPEFRDYALQVKKNAAVMADKFSSL
GYTIVSGGTKNHLMLLDLRNKNVNGKVAENLLHQAGITVNKNMVPFDDKSPFVTSGIRIGTPAMTTRGMKESDSERIVEL
IDRVVSAAETPAVDDVCRLVRQEIRELCLQHPMDGYEMTP

Sequences:

>Translated_440_residues
MDTDILQMQDKEVFEAVVNETVRQTETLELIASENFTSRAVMQACGSVMTNKYAEGYPGKRYYGGCEFVDVAENLARDRA
KKLFNCSYVNVQPHSGSSANMAVLFSVLKPGDRIMGLDLSHGGHLTHGSPVNFSGQLYEAHSYGVRRETGCIDMNMVEEL
ANKVRPKLIICGASAYSQGFDFKAFREIADRIGALLMADIAHPAGLIVAGLLSDPVPHCHFVTTTTHKTLRGPRGGMIMM
GSDFENPLGITIKTKTGSRVKMMTEVMDAEVMPGIQGGPLMHIIAGKAVAFAEALRPEFRDYALQVKKNAAVMADKFSSL
GYTIVSGGTKNHLMLLDLRNKNVNGKVAENLLHQAGITVNKNMVPFDDKSPFVTSGIRIGTPAMTTRGMKESDSERIVEL
IDRVVSAAETPAVDDVCRLVRQEIRELCLQHPMDGYEMTP
>Mature_440_residues
MDTDILQMQDKEVFEAVVNETVRQTETLELIASENFTSRAVMQACGSVMTNKYAEGYPGKRYYGGCEFVDVAENLARDRA
KKLFNCSYVNVQPHSGSSANMAVLFSVLKPGDRIMGLDLSHGGHLTHGSPVNFSGQLYEAHSYGVRRETGCIDMNMVEEL
ANKVRPKLIICGASAYSQGFDFKAFREIADRIGALLMADIAHPAGLIVAGLLSDPVPHCHFVTTTTHKTLRGPRGGMIMM
GSDFENPLGITIKTKTGSRVKMMTEVMDAEVMPGIQGGPLMHIIAGKAVAFAEALRPEFRDYALQVKKNAAVMADKFSSL
GYTIVSGGTKNHLMLLDLRNKNVNGKVAENLLHQAGITVNKNMVPFDDKSPFVTSGIRIGTPAMTTRGMKESDSERIVEL
IDRVVSAAETPAVDDVCRLVRQEIRELCLQHPMDGYEMTP

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI19923315, Length=460, Percent_Identity=42.8260869565217, Blast_Score=351, Evalue=6e-97,
Organism=Homo sapiens, GI261862352, Length=460, Percent_Identity=42.8260869565217, Blast_Score=351, Evalue=6e-97,
Organism=Homo sapiens, GI261862350, Length=460, Percent_Identity=42.8260869565217, Blast_Score=351, Evalue=6e-97,
Organism=Homo sapiens, GI261862348, Length=460, Percent_Identity=42.8260869565217, Blast_Score=351, Evalue=6e-97,
Organism=Homo sapiens, GI22547186, Length=431, Percent_Identity=44.7795823665893, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI261862346, Length=455, Percent_Identity=42.1978021978022, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI22547189, Length=430, Percent_Identity=41.6279069767442, Blast_Score=300, Evalue=2e-81,
Organism=Escherichia coli, GI1788902, Length=424, Percent_Identity=54.0094339622642, Blast_Score=431, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI25144729, Length=417, Percent_Identity=45.8033573141487, Blast_Score=340, Evalue=6e-94,
Organism=Caenorhabditis elegans, GI25144732, Length=417, Percent_Identity=45.8033573141487, Blast_Score=340, Evalue=7e-94,
Organism=Saccharomyces cerevisiae, GI6319739, Length=437, Percent_Identity=42.3340961098398, Blast_Score=345, Evalue=7e-96,
Organism=Saccharomyces cerevisiae, GI6323087, Length=423, Percent_Identity=44.9172576832151, Blast_Score=343, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24640005, Length=462, Percent_Identity=43.7229437229437, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221329721, Length=462, Percent_Identity=43.7229437229437, Blast_Score=366, Evalue=1e-101,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_CHLPD (A1BE30)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_911081.1
- ProteinModelPortal:   A1BE30
- SMR:   A1BE30
- STRING:   A1BE30
- GeneID:   4568721
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0601
- NMPDR:   fig|290317.7.peg.634
- eggNOG:   COG0112
- HOGENOM:   HBG301263
- OMA:   EAHSYGV
- ProtClustDB:   PRK00011
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 48142; Mature: 48142

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTDILQMQDKEVFEAVVNETVRQTETLELIASENFTSRAVMQACGSVMTNKYAEGYPGK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHCCCCCCC
RYYGGCEFVDVAENLARDRAKKLFNCSYVNVQPHSGSSANMAVLFSVLKPGDRIMGLDLS
CCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEEEC
HGGHLTHGSPVNFSGQLYEAHSYGVRRETGCIDMNMVEELANKVRPKLIICGASAYSQGF
CCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECHHHCCCC
DFKAFREIADRIGALLMADIAHPAGLIVAGLLSDPVPHCHFVTTTTHKTLRGPRGGMIMM
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCHHHHCCCCCCEEEE
GSDFENPLGITIKTKTGSRVKMMTEVMDAEVMPGIQGGPLMHIIAGKAVAFAEALRPEFR
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEHHCHHHHHHHHHCHHHH
DYALQVKKNAAVMADKFSSLGYTIVSGGTKNHLMLLDLRNKNVNGKVAENLLHQAGITVN
HHHHHHHCCHHHHHHHHHHCCEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEC
KNMVPFDDKSPFVTSGIRIGTPAMTTRGMKESDSERIVELIDRVVSAAETPAVDDVCRLV
CCCCCCCCCCCCEECCEEECCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
RQEIRELCLQHPMDGYEMTP
HHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDTDILQMQDKEVFEAVVNETVRQTETLELIASENFTSRAVMQACGSVMTNKYAEGYPGK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHCCCCCCC
RYYGGCEFVDVAENLARDRAKKLFNCSYVNVQPHSGSSANMAVLFSVLKPGDRIMGLDLS
CCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEEEC
HGGHLTHGSPVNFSGQLYEAHSYGVRRETGCIDMNMVEELANKVRPKLIICGASAYSQGF
CCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECHHHCCCC
DFKAFREIADRIGALLMADIAHPAGLIVAGLLSDPVPHCHFVTTTTHKTLRGPRGGMIMM
CHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCHHHHCCCCCCEEEE
GSDFENPLGITIKTKTGSRVKMMTEVMDAEVMPGIQGGPLMHIIAGKAVAFAEALRPEFR
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCEEEEHHCHHHHHHHHHCHHHH
DYALQVKKNAAVMADKFSSLGYTIVSGGTKNHLMLLDLRNKNVNGKVAENLLHQAGITVN
HHHHHHHCCHHHHHHHHHHCCEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEC
KNMVPFDDKSPFVTSGIRIGTPAMTTRGMKESDSERIVELIDRVVSAAETPAVDDVCRLV
CCCCCCCCCCCCEECCEEECCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
RQEIRELCLQHPMDGYEMTP
HHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA