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The map label for this gene is ribBA [H]

Identifier: 119356436

GI number: 119356436

Start: 672350

End: 673639

Strand: Direct

Name: ribBA [H]

Synonym: Cpha266_0600

Alternate gene names: 119356436

Gene position: 672350-673639 (Clockwise)

Preceding gene: 119356434

Following gene: 119356437

Centisome position: 21.45

GC content: 47.05

Gene sequence:

>1290_bases
ATGGACAAAAAGATTTTTGATACAATCGAAGCGGCTGTTGAAGATATACGGCAGGGCAAGCTGGTTATCGTGATTGATGA
TGAAGATCGTGAAGATGAGGGTGATTTTATTGCTGCTGCTGATGTTGTGACCACCGAAATGGTTAATTTTATCACCAAGG
AGGCTCGCGGTCTGTTATGTGTGGCACTCACCATGGGTCGGGCCAGAGAGTTGCAGCTTGATCCTATGGTACAGAGAAAC
ACCTCTCAGCACGAGACCAATTTTACGGTATCTGTTGACGCGATTGCCGTAGGGGTGACTACCGGTATTTCTGTTTCTGA
CAGGACAATGACGATAAAAATGCTTGGCGATCCGCTTTCCATGGCTGACGATTTTTCTCGTCCGGGACATATTTTTCCAT
TGCGCGCCATGGATGGCGGAGTGCTCAGACGAGTGGGACATACTGAGGCCGCCGTTGATCTTGCCCGGCTTGCCGGATGT
AGTCCTGTGGGGCTTCTGTGCGAAATTCTGAATGATGACGGAAGTATGGCAAGGCTTCCCGAACTGATACGCTTGAAGGA
GAAATTCGGATTGAAGCTGATTACCATCAAGGATCTTGTCGCTTATCAGATGCAGCGTAACAAGCTGGTCTTTCGGGCTG
TAGAGACAAAGCTTCCTACGATCTATGGTGATTTCAGGTTAATAGCTTATGAGTCGTTTATTGACCATCAGAACCACATG
GCTTTTGTCAAAGGGGATGTTTCTACCGACGAACCGGTGCTCGTCAGGGTTCACTCCCAGTGCGCGACAGGGGACACGTT
CGCTTCGCTGAGGTGCGACTGCGGTAACCAGCTTGCATCCGCCCTGACGATGATTGAAAATGAAGGTCGCGGTGTGCTGG
TTTATCTTATGCAGGAAGGTAGGGGTATCGGGCTTATCAACAAGCTGAAAGCTTACAATCTGCAGGATGAAGGCTTTGAT
ACGGTGGAGGCAAATGAAAAGCTCGGTTTCAAGGCTGATTTGCGCGACTATGGCATTGGCGCCCAGATTCTCAAGGATCT
TGGAGTTAAAAAAATGAAACTGCTTACCAATAATCCGAAAAAAATTGTTGGACTCGAAGGGTATGGCCTCGAGATTACCG
AAAGAGTTTCCATTGAAATTGCCCCCAATTCCATCAACAAGAGCTATCTGGATACAAAACGAGATAAAATGGGCCACATG
ATCGGACGTTCGTGCGGAAATGAATCTCTTTTTTTTGAACAGATAACTGAAAATCATTTGAATAAAAGTCAACAACCTCC
CAACCAGTAA

Upstream 100 bases:

>100_bases
GATGCCCTTTTGAGAAGCAGTGCAAACCGACCAGGTTTTTTTTTACATTACATTCTTTACGTTAAACTATTCGTTCTGAT
AACAAGGTTGAACAACGTGT

Downstream 100 bases:

>100_bases
ACTTCCGTCAGGAAAAGGAACGATACAACGATGGATACCGATATCCTTCAGATGCAGGATAAAGAAGTTTTTGAAGCGGT
GGTCAACGAGACGGTAAGGC

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MDKKIFDTIEAAVEDIRQGKLVIVIDDEDREDEGDFIAAADVVTTEMVNFITKEARGLLCVALTMGRARELQLDPMVQRN
TSQHETNFTVSVDAIAVGVTTGISVSDRTMTIKMLGDPLSMADDFSRPGHIFPLRAMDGGVLRRVGHTEAAVDLARLAGC
SPVGLLCEILNDDGSMARLPELIRLKEKFGLKLITIKDLVAYQMQRNKLVFRAVETKLPTIYGDFRLIAYESFIDHQNHM
AFVKGDVSTDEPVLVRVHSQCATGDTFASLRCDCGNQLASALTMIENEGRGVLVYLMQEGRGIGLINKLKAYNLQDEGFD
TVEANEKLGFKADLRDYGIGAQILKDLGVKKMKLLTNNPKKIVGLEGYGLEITERVSIEIAPNSINKSYLDTKRDKMGHM
IGRSCGNESLFFEQITENHLNKSQQPPNQ

Sequences:

>Translated_429_residues
MDKKIFDTIEAAVEDIRQGKLVIVIDDEDREDEGDFIAAADVVTTEMVNFITKEARGLLCVALTMGRARELQLDPMVQRN
TSQHETNFTVSVDAIAVGVTTGISVSDRTMTIKMLGDPLSMADDFSRPGHIFPLRAMDGGVLRRVGHTEAAVDLARLAGC
SPVGLLCEILNDDGSMARLPELIRLKEKFGLKLITIKDLVAYQMQRNKLVFRAVETKLPTIYGDFRLIAYESFIDHQNHM
AFVKGDVSTDEPVLVRVHSQCATGDTFASLRCDCGNQLASALTMIENEGRGVLVYLMQEGRGIGLINKLKAYNLQDEGFD
TVEANEKLGFKADLRDYGIGAQILKDLGVKKMKLLTNNPKKIVGLEGYGLEITERVSIEIAPNSINKSYLDTKRDKMGHM
IGRSCGNESLFFEQITENHLNKSQQPPNQ
>Mature_429_residues
MDKKIFDTIEAAVEDIRQGKLVIVIDDEDREDEGDFIAAADVVTTEMVNFITKEARGLLCVALTMGRARELQLDPMVQRN
TSQHETNFTVSVDAIAVGVTTGISVSDRTMTIKMLGDPLSMADDFSRPGHIFPLRAMDGGVLRRVGHTEAAVDLARLAGC
SPVGLLCEILNDDGSMARLPELIRLKEKFGLKLITIKDLVAYQMQRNKLVFRAVETKLPTIYGDFRLIAYESFIDHQNHM
AFVKGDVSTDEPVLVRVHSQCATGDTFASLRCDCGNQLASALTMIENEGRGVLVYLMQEGRGIGLINKLKAYNLQDEGFD
TVEANEKLGFKADLRDYGIGAQILKDLGVKKMKLLTNNPKKIVGLEGYGLEITERVSIEIAPNSINKSYLDTKRDKMGHM
IGRSCGNESLFFEQITENHLNKSQQPPNQ

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=192, Percent_Identity=54.1666666666667, Blast_Score=221, Evalue=6e-59,
Organism=Escherichia coli, GI1789420, Length=203, Percent_Identity=46.7980295566502, Blast_Score=194, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6320695, Length=207, Percent_Identity=44.4444444444444, Blast_Score=172, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6319438, Length=171, Percent_Identity=45.0292397660819, Blast_Score=128, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 47518; Mature: 47518

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKIFDTIEAAVEDIRQGKLVIVIDDEDREDEGDFIAAADVVTTEMVNFITKEARGLLC
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCEEE
VALTMGRARELQLDPMVQRNTSQHETNFTVSVDAIAVGVTTGISVSDRTMTIKMLGDPLS
EEEECCCCCEEECCCHHHCCCCCCCCEEEEEEEEEEEEEECCCEECCCEEEEEEECCCHH
MADDFSRPGHIFPLRAMDGGVLRRVGHTEAAVDLARLAGCSPVGLLCEILNDDGSMARLP
HHHCCCCCCCEEEEECCCCHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHH
ELIRLKEKFGLKLITIKDLVAYQMQRNKLVFRAVETKLPTIYGDFRLIAYESFIDHQNHM
HHHHHHHHHCEEEEEHHHHHHHHHHCCCEEEEEHHHCCCEEECCEEEEEEHHHHCCCCCE
AFVKGDVSTDEPVLVRVHSQCATGDTFASLRCDCGNQLASALTMIENEGRGVLVYLMQEG
EEEECCCCCCCCEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEEEECC
RGIGLINKLKAYNLQDEGFDTVEANEKLGFKADLRDYGIGAQILKDLGVKKMKLLTNNPK
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEECHHHCCCHHHHHHHCCCCEEEHHCCCCC
KIVGLEGYGLEITERVSIEIAPNSINKSYLDTKRDKMGHMIGRSCGNESLFFEQITENHL
EEEEECCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
NKSQQPPNQ
CCCCCCCCC
>Mature Secondary Structure
MDKKIFDTIEAAVEDIRQGKLVIVIDDEDREDEGDFIAAADVVTTEMVNFITKEARGLLC
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCEEE
VALTMGRARELQLDPMVQRNTSQHETNFTVSVDAIAVGVTTGISVSDRTMTIKMLGDPLS
EEEECCCCCEEECCCHHHCCCCCCCCEEEEEEEEEEEEEECCCEECCCEEEEEEECCCHH
MADDFSRPGHIFPLRAMDGGVLRRVGHTEAAVDLARLAGCSPVGLLCEILNDDGSMARLP
HHHCCCCCCCEEEEECCCCHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHH
ELIRLKEKFGLKLITIKDLVAYQMQRNKLVFRAVETKLPTIYGDFRLIAYESFIDHQNHM
HHHHHHHHHCEEEEEHHHHHHHHHHCCCEEEEEHHHCCCEEECCEEEEEEHHHHCCCCCE
AFVKGDVSTDEPVLVRVHSQCATGDTFASLRCDCGNQLASALTMIENEGRGVLVYLMQEG
EEEECCCCCCCCEEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCEEEEEEEECC
RGIGLINKLKAYNLQDEGFDTVEANEKLGFKADLRDYGIGAQILKDLGVKKMKLLTNNPK
CCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEECHHHCCCHHHHHHHCCCCEEEHHCCCCC
KIVGLEGYGLEITERVSIEIAPNSINKSYLDTKRDKMGHMIGRSCGNESLFFEQITENHL
EEEEECCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
NKSQQPPNQ
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA