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The map label for this gene is pyrD [H]

Identifier: 119356429

GI number: 119356429

Start: 663774

End: 664718

Strand: Reverse

Name: pyrD [H]

Synonym: Cpha266_0593

Alternate gene names: 119356429

Gene position: 664718-663774 (Counterclockwise)

Preceding gene: 119356430

Following gene: 119356427

Centisome position: 21.21

GC content: 50.69

Gene sequence:

>945_bases
ATGACAGACCACATTCCTGTAGAGAAAACATCCATAACAGGCATATCACTTGGCAGAGGACTCGAACTGCGCTCACCGGT
TCTCCTTGCTTCAGGAACGGTCTCTTATGGCGAAGAGCTCAATACGCTTTGCGATCTCGGAAAAATCGGCGGTCTGGTAA
CCAAGGCAATTTCACTGGAACCCAGAACCGGCAACCCGCCACAGCGTATCGCTGAAACGCCATCAGGCATGGTCAACGCC
ATCGGGCTGGCCAATGTCGGTGTGAAAAAGTTCATCACTGAAAAAGCGCCTTTTCTCCGGAAACTCAACACCGCGATTAT
CGTTAATATTGCCGGAAGATCCATCGACGAGTACGCTGAGGTTATTGCAAGACTCGACGACGTTGAGGGTATCGGAGGTT
ATGAAATCAACCTTTCATGTCCGAACGTCAAGGGAGAGTGCATGATCATGGGAGTAAGCCGCAGTGCTACCCATGAAATC
GTTTCCGTGCTTCGCAAGATCACAAACAGGCACCTCATGATCAAACTAACGCCAAACGTCACGTCGATCAGCTCGATAGC
TCTGGCGGCAGAAGAGGCTGGCGCCGACTCGGTATCACTGATCAACACCCTGGTCGGAATGGCTGTAAACTATAAAACCC
GGAAACCGTTGTTGCGAAATGTTACCGGAGGACTTTCCGGTCCGGCAATCAAGCCGATAGCTCTGGCGAAAGTATGGGAG
GTGTTCAATGCTGTCAACATCCCTGTTGTCGGCATGGGCGGGATTACGGGATTTGAAGATGCCATGGAGTTTCTCCTTGT
CGGAGCAACGGCAATCCAGATCGGCACCATGAATTTCGTCTACCCTGATATCGGCGAAAAAACCGCAGTTGCTCTTGAAA
AACACTTTTCCATGCCGGACGCACCGAACATCAAAGAGTATATCGGTAGTCTCATCACAGAGTAG

Upstream 100 bases:

>100_bases
TAACCCTTCCTTCCTGGAGAAGGGTTATGCAGGGGAGACCTGTGAATGAGTCTCCCCTGCGCCCTCTTCCGAGAACAGAG
AAAGAAACGATGAACCAATC

Downstream 100 bases:

>100_bases
TTCCTGCGACATGAAAACCTATCTTCCCCACCCCCGTTTGTTTGACAGGTATTTTTTTGCTCTCCTGCCTCCGATTTTTG
AACCCATAATCCGGTATTCA

Product: dihydroorotate oxidase B, catalytic subunit

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MTDHIPVEKTSITGISLGRGLELRSPVLLASGTVSYGEELNTLCDLGKIGGLVTKAISLEPRTGNPPQRIAETPSGMVNA
IGLANVGVKKFITEKAPFLRKLNTAIIVNIAGRSIDEYAEVIARLDDVEGIGGYEINLSCPNVKGECMIMGVSRSATHEI
VSVLRKITNRHLMIKLTPNVTSISSIALAAEEAGADSVSLINTLVGMAVNYKTRKPLLRNVTGGLSGPAIKPIALAKVWE
VFNAVNIPVVGMGGITGFEDAMEFLLVGATAIQIGTMNFVYPDIGEKTAVALEKHFSMPDAPNIKEYIGSLITE

Sequences:

>Translated_314_residues
MTDHIPVEKTSITGISLGRGLELRSPVLLASGTVSYGEELNTLCDLGKIGGLVTKAISLEPRTGNPPQRIAETPSGMVNA
IGLANVGVKKFITEKAPFLRKLNTAIIVNIAGRSIDEYAEVIARLDDVEGIGGYEINLSCPNVKGECMIMGVSRSATHEI
VSVLRKITNRHLMIKLTPNVTSISSIALAAEEAGADSVSLINTLVGMAVNYKTRKPLLRNVTGGLSGPAIKPIALAKVWE
VFNAVNIPVVGMGGITGFEDAMEFLLVGATAIQIGTMNFVYPDIGEKTAVALEKHFSMPDAPNIKEYIGSLITE
>Mature_313_residues
TDHIPVEKTSITGISLGRGLELRSPVLLASGTVSYGEELNTLCDLGKIGGLVTKAISLEPRTGNPPQRIAETPSGMVNAI
GLANVGVKKFITEKAPFLRKLNTAIIVNIAGRSIDEYAEVIARLDDVEGIGGYEINLSCPNVKGECMIMGVSRSATHEIV
SVLRKITNRHLMIKLTPNVTSISSIALAAEEAGADSVSLINTLVGMAVNYKTRKPLLRNVTGGLSGPAIKPIALAKVWEV
FNAVNIPVVGMGGITGFEDAMEFLLVGATAIQIGTMNFVYPDIGEKTAVALEKHFSMPDAPNIKEYIGSLITE

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=279, Percent_Identity=31.1827956989247, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI45006951, Length=300, Percent_Identity=26, Blast_Score=78, Evalue=9e-15,
Organism=Escherichia coli, GI87082059, Length=309, Percent_Identity=26.8608414239482, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71984108, Length=150, Percent_Identity=34, Blast_Score=78, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6322633, Length=267, Percent_Identity=32.2097378277154, Blast_Score=105, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24640763, Length=156, Percent_Identity=39.1025641025641, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI18858217, Length=156, Percent_Identity=39.1025641025641, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 33296; Mature: 33165

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDHIPVEKTSITGISLGRGLELRSPVLLASGTVSYGEELNTLCDLGKIGGLVTKAISLE
CCCCCCCCCCEECEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHEEEC
PRTGNPPQRIAETPSGMVNAIGLANVGVKKFITEKAPFLRKLNTAIIVNIAGRSIDEYAE
CCCCCCHHHHHCCCCCHHHHHHHHHCCHHHHHHHCCHHHHHCCCEEEEEECCCCHHHHHH
VIARLDDVEGIGGYEINLSCPNVKGECMIMGVSRSATHEIVSVLRKITNRHLMIKLTPNV
HHHHHHCCCCCCCEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCC
TSISSIALAAEEAGADSVSLINTLVGMAVNYKTRKPLLRNVTGGLSGPAIKPIALAKVWE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHCCHHHHHCCCCCCCCCCHHHHHHHHH
VFNAVNIPVVGMGGITGFEDAMEFLLVGATAIQIGTMNFVYPDIGEKTAVALEKHFSMPD
HHHHCCCCEEECCCCCCHHHHHHHHHHHHHHEEECCCEEECCCCCCHHHHHHHHHCCCCC
APNIKEYIGSLITE
CCCHHHHHHHHHCC
>Mature Secondary Structure 
TDHIPVEKTSITGISLGRGLELRSPVLLASGTVSYGEELNTLCDLGKIGGLVTKAISLE
CCCCCCCCCEECEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHEEEC
PRTGNPPQRIAETPSGMVNAIGLANVGVKKFITEKAPFLRKLNTAIIVNIAGRSIDEYAE
CCCCCCHHHHHCCCCCHHHHHHHHHCCHHHHHHHCCHHHHHCCCEEEEEECCCCHHHHHH
VIARLDDVEGIGGYEINLSCPNVKGECMIMGVSRSATHEIVSVLRKITNRHLMIKLTPNV
HHHHHHCCCCCCCEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCC
TSISSIALAAEEAGADSVSLINTLVGMAVNYKTRKPLLRNVTGGLSGPAIKPIALAKVWE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHCCHHHHHCCCCCCCCCCHHHHHHHHH
VFNAVNIPVVGMGGITGFEDAMEFLLVGATAIQIGTMNFVYPDIGEKTAVALEKHFSMPD
HHHHCCCCEEECCCCCCHHHHHHHHHHHHHHEEECCCEEECCCCCCHHHHHHHHHCCCCC
APNIKEYIGSLITE
CCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA