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The map label for this gene is appB [H]

Identifier: 119356404

GI number: 119356404

Start: 635866

End: 636831

Strand: Direct

Name: appB [H]

Synonym: Cpha266_0568

Alternate gene names: 119356404

Gene position: 635866-636831 (Clockwise)

Preceding gene: 119356403

Following gene: 119356405

Centisome position: 20.29

GC content: 46.07

Gene sequence:

>966_bases
ATGCTGACTTACATTATTAAACGGCTGCTGATAGCCGTACCGCTAATTTTTGGTGTACTCACACTTACGTTTTTTATCAT
CAGGCTCGCTCCTGGTGATCCGGCGGCATATTTCATCCAGCCTGGTATCAGTCCTCATGTAGCAGAACAGATCAGGGAGC
AGTATGGCCTTAACGATCCCTTGCCTGTTCAGTATATCAAGTGGATTTCAAGTGTGCTTCATGGTGATTTCGGACGCAGT
TTCAGCCGTGCTCAACAGCCGGTTTTTGATGTTATAGCAGAGGCTCTTCCTGTTACCGTAACCATAGCGCTTTTAACGCT
TATTGCGAATTTCATTTTTGGCATTATCATCGGAATTATTTCTGCTGTGCGTCAGAACAGCGTGCTTGACAGGGTACTGA
CGGTAATTGCGCTGTTTTTTTATTCGATGCCGGAGTTCTGGTTTGCGTTGATGATGATCATTATGTTTTCTCTGAAGCTG
CCACTATTCCCAGCCTCAGGACTGAATGAAATCGGAGCGGAAAGCTTCGGAACGGTCGGCTTTATTCTTGACAGGCTCTG
GCACCTTGTCCTGCCGGTAACAGTGCTGAGTATTAACGGCGCTGCCGGCATTGCCCGTTATGTCAGAGGAAGCATGCTTG
AGGTTATCAGGCAGGATTATATCAGAACAGCAAGGGCAAAAGGTCTGAAGGAACGAGTCGTTATTTTTAAACACGCGCTC
CGCAATGCGCTCCTGCCGGTGATAACGCTTATGGGGAGCTCATTGCCTTTTATTTTTAGTGGGGCACTATTTATTGAGGT
CATTTTTGCATTTCCCGGTATGGGGAGAGTGACTGTCGAGGCCATATTTTCAAGGGATTATCCCTTGATTATAGCAAATA
CCTTTATTTCCGGATCTCTTATTGTCCTCGGAAACCTTGTTGCTGATGTGTTCTATGCTGTTGCGGATCCGAGAATCAAG
CTTTAA

Upstream 100 bases:

>100_bases
AAGAATTCAGGGCGAAGAGCTTAATATTTCAGGAACCTTTTACAATATTGACGACTGGACTCTTAACCCTTCGGCAACTG
TGGCTCTTTAAGATGATACC

Downstream 100 bases:

>100_bases
ATTATTCCGAGAGGAACTCTTTGGCCAGTGAAAATCGAATTGTTAAATACCCCTGCTGATGCTCTTGAAATTCGTTATGA
AGAGCAGATCCGTCCGCTGA

Product: binding-protein-dependent transport systems inner membrane component

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MLTYIIKRLLIAVPLIFGVLTLTFFIIRLAPGDPAAYFIQPGISPHVAEQIREQYGLNDPLPVQYIKWISSVLHGDFGRS
FSRAQQPVFDVIAEALPVTVTIALLTLIANFIFGIIIGIISAVRQNSVLDRVLTVIALFFYSMPEFWFALMMIIMFSLKL
PLFPASGLNEIGAESFGTVGFILDRLWHLVLPVTVLSINGAAGIARYVRGSMLEVIRQDYIRTARAKGLKERVVIFKHAL
RNALLPVITLMGSSLPFIFSGALFIEVIFAFPGMGRVTVEAIFSRDYPLIIANTFISGSLIVLGNLVADVFYAVADPRIK
L

Sequences:

>Translated_321_residues
MLTYIIKRLLIAVPLIFGVLTLTFFIIRLAPGDPAAYFIQPGISPHVAEQIREQYGLNDPLPVQYIKWISSVLHGDFGRS
FSRAQQPVFDVIAEALPVTVTIALLTLIANFIFGIIIGIISAVRQNSVLDRVLTVIALFFYSMPEFWFALMMIIMFSLKL
PLFPASGLNEIGAESFGTVGFILDRLWHLVLPVTVLSINGAAGIARYVRGSMLEVIRQDYIRTARAKGLKERVVIFKHAL
RNALLPVITLMGSSLPFIFSGALFIEVIFAFPGMGRVTVEAIFSRDYPLIIANTFISGSLIVLGNLVADVFYAVADPRIK
L
>Mature_321_residues
MLTYIIKRLLIAVPLIFGVLTLTFFIIRLAPGDPAAYFIQPGISPHVAEQIREQYGLNDPLPVQYIKWISSVLHGDFGRS
FSRAQQPVFDVIAEALPVTVTIALLTLIANFIFGIIIGIISAVRQNSVLDRVLTVIALFFYSMPEFWFALMMIIMFSLKL
PLFPASGLNEIGAESFGTVGFILDRLWHLVLPVTVLSINGAAGIARYVRGSMLEVIRQDYIRTARAKGLKERVVIFKHAL
RNALLPVITLMGSSLPFIFSGALFIEVIFAFPGMGRVTVEAIFSRDYPLIIANTFISGSLIVLGNLVADVFYAVADPRIK
L

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG0601

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789965, Length=337, Percent_Identity=36.7952522255193, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI1787497, Length=320, Percent_Identity=37.5, Blast_Score=222, Evalue=2e-59,
Organism=Escherichia coli, GI1787053, Length=320, Percent_Identity=38.4375, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1789888, Length=323, Percent_Identity=35.2941176470588, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1788504, Length=361, Percent_Identity=31.3019390581717, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1787761, Length=300, Percent_Identity=35.6666666666667, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1787550, Length=269, Percent_Identity=31.5985130111524, Blast_Score=151, Evalue=5e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 35520; Mature: 35520

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTYIIKRLLIAVPLIFGVLTLTFFIIRLAPGDPAAYFIQPGISPHVAEQIREQYGLNDP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCC
LPVQYIKWISSVLHGDFGRSFSRAQQPVFDVIAEALPVTVTIALLTLIANFIFGIIIGII
CHHHHHHHHHHHHHCHHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAVRQNSVLDRVLTVIALFFYSMPEFWFALMMIIMFSLKLPLFPASGLNEIGAESFGTVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCHHHCCHHH
FILDRLWHLVLPVTVLSINGAAGIARYVRGSMLEVIRQDYIRTARAKGLKERVVIFKHAL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RNALLPVITLMGSSLPFIFSGALFIEVIFAFPGMGRVTVEAIFSRDYPLIIANTFISGSL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEHHHHCCHH
IVLGNLVADVFYAVADPRIKL
HHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLTYIIKRLLIAVPLIFGVLTLTFFIIRLAPGDPAAYFIQPGISPHVAEQIREQYGLNDP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCC
LPVQYIKWISSVLHGDFGRSFSRAQQPVFDVIAEALPVTVTIALLTLIANFIFGIIIGII
CHHHHHHHHHHHHHCHHCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAVRQNSVLDRVLTVIALFFYSMPEFWFALMMIIMFSLKLPLFPASGLNEIGAESFGTVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCHHHCCHHH
FILDRLWHLVLPVTVLSINGAAGIARYVRGSMLEVIRQDYIRTARAKGLKERVVIFKHAL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RNALLPVITLMGSSLPFIFSGALFIEVIFAFPGMGRVTVEAIFSRDYPLIIANTFISGSL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEEHHHHCCHH
IVLGNLVADVFYAVADPRIKL
HHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]