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The map label for this gene is nudG [H]

Identifier: 119356350

GI number: 119356350

Start: 563148

End: 563564

Strand: Direct

Name: nudG [H]

Synonym: Cpha266_0513

Alternate gene names: 119356350

Gene position: 563148-563564 (Clockwise)

Preceding gene: 119356349

Following gene: 119356351

Centisome position: 17.97

GC content: 48.2

Gene sequence:

>417_bases
TTGAAAGCGCGTCCGCATATCGGTGATGTTGTCTGTGCTATTATTGAGCGCAATGGCAGATTTTTGATAGCCAGGAGGCC
TGAGGGAAAAACGCTTGCTCTGAAGTGGGAGTTTCCAGGCGGTAAGGTCGAGTCGGGTGAATCACCCCGGGATGCTTTAC
ATCGTGAACTTGCCGAGGAGCTCGGGATTGTTGTTGAGATACTCCAGCGCCTGAGTCCTGTTGTTTATTCCTATTCCGAT
TTTTCGTTACGTCTTATTCCTTATCGTTGCCTGATTGTGAGCGGTGAGCCGGTTCCTGTTGAACATACTGCGCTTGAGTG
GATCAGCGTTGATGATGCGGTTTTTTATGACTTTCCTGAAGCAGATATACCGATTCTTGAAGAGTACAGGATGTTGGTGA
GTGGTGAGAGCTTTTGA

Upstream 100 bases:

>100_bases
TGGATACGGAGTATGCGTGAGATGATAAGGGTGGGCAAAATGTCCGCCCTTTTATTATTTTTGTCGGAATTCGTGGAGTT
TTTTTTCCGGGGGGCCCCAC

Downstream 100 bases:

>100_bases
TCTCTGAATTCTTCAAATGGTTATCTCTTTTTTTTGTTCCGAAGCTCTATTGCTGCGTTGTCCCGACATGTCGGGATGCT
GTCTGACTGTCACGAATACT

Product: NUDIX hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 138; Mature: 138

Protein sequence:

>138_residues
MKARPHIGDVVCAIIERNGRFLIARRPEGKTLALKWEFPGGKVESGESPRDALHRELAEELGIVVEILQRLSPVVYSYSD
FSLRLIPYRCLIVSGEPVPVEHTALEWISVDDAVFYDFPEADIPILEEYRMLVSGESF

Sequences:

>Translated_138_residues
MKARPHIGDVVCAIIERNGRFLIARRPEGKTLALKWEFPGGKVESGESPRDALHRELAEELGIVVEILQRLSPVVYSYSD
FSLRLIPYRCLIVSGEPVPVEHTALEWISVDDAVFYDFPEADIPILEEYRMLVSGESF
>Mature_138_residues
MKARPHIGDVVCAIIERNGRFLIARRPEGKTLALKWEFPGGKVESGESPRDALHRELAEELGIVVEILQRLSPVVYSYSD
FSLRLIPYRCLIVSGEPVPVEHTALEWISVDDAVFYDFPEADIPILEEYRMLVSGESF

Specific function: Specific for pyrimidine substrates. Acts on 5-methyl- dCTP, CTP and dCTP in decreasing order [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=124, Percent_Identity=41.9354838709677, Blast_Score=84, Evalue=3e-18,
Organism=Escherichia coli, GI1786288, Length=123, Percent_Identity=34.1463414634146, Blast_Score=69, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 15629; Mature: 15629

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKARPHIGDVVCAIIERNGRFLIARRPEGKTLALKWEFPGGKVESGESPRDALHRELAEE
CCCCCCHHHHEEEEEECCCCEEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHH
LGIVVEILQRLSPVVYSYSDFSLRLIPYRCLIVSGEPVPVEHTALEWISVDDAVFYDFPE
HHHHHHHHHHHHHHEEECCCCEEEEEEEEEEEECCCCCCCCCCEEEEEECCCEEEEECCC
ADIPILEEYRMLVSGESF
CCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MKARPHIGDVVCAIIERNGRFLIARRPEGKTLALKWEFPGGKVESGESPRDALHRELAEE
CCCCCCHHHHEEEEEECCCCEEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHH
LGIVVEILQRLSPVVYSYSDFSLRLIPYRCLIVSGEPVPVEHTALEWISVDDAVFYDFPE
HHHHHHHHHHHHHHEEECCCCEEEEEEEEEEEECCCCCCCCCCEEEEEECCCEEEEECCC
ADIPILEEYRMLVSGESF
CCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 11053429 [H]