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The map label for this gene is ppx [H]

Identifier: 119356335

GI number: 119356335

Start: 546143

End: 547708

Strand: Direct

Name: ppx [H]

Synonym: Cpha266_0498

Alternate gene names: 119356335

Gene position: 546143-547708 (Clockwise)

Preceding gene: 119356332

Following gene: 119356336

Centisome position: 17.43

GC content: 49.11

Gene sequence:

>1566_bases
ATGGGTTCTGACGCATTGAGAGTTGCCGCGATTGATCTCGGCACCAACTCTTTTCACATGGTTGTCGTTGAGATTGATCG
TGTCAAGGGTATTATTGAGATTGACCGGGTGAAGGATATGATCTGTATCGGGCGCGGCAGCATATCGTCTAAAATGCTTG
ACGAATCGGCCATGCTGTCGGGTATTGCGGCATTGAGGAACTTTCTTGTTCTTGCCGGTCAGCACGGCGTCAAGTCTGAA
CAGGTTATAGCTTTTGCCACCAGTGCCATACGGGAGGCGAAAAACAGGGATGTGTTTATCCGGAGGGTGAGGGAGGAGAC
CGGACTGAAGGTCAGGGTGATTTCAGGCAAGGAGGAGGCCGAGTTTATTTATTACGGAGTACGAAATGCCGTCAAGCTTG
GAAATTCATTTGATCTGCTGTTCGATATCGGAGGCGGTTCTGTAGAGTTCGTTATTGCGAACAATAAAGAGGTGAAGTTG
CTTGAGAGCCGTAAAATCGGTGTGGCAAGAATGCATGAGCGGTTTATTGGTACCGATCCGGTTTCGGCGCATGAGATCAA
GCTTCTTGAGCAGTTTTATGCTGCGGAGATGGTCTCTTCGCTTGAAAAAGCGACACTTCTTGGGGTCAGGAGGGGGATAG
CCTCTTCAGGGACCGCTCAGAACATAGCGCGAATGATTCGTTCGTTTGAGGCGCGCGAGAGCGATGTTTCGCTCAATAAC
AGCGTGGTTACCCGTCGGGAGTTTCAGCGGTTGTATAAAGCGGTTGTTCCCCTTGGTTCGGTTGACAGGAGGAGGATGAC
CGGACTTGACGAGAAACGGGTCGATCTGATTTTACCCGGTCTGATTCTTGTTGACATGATTTTCCGCAAGTTCAATCTTG
AAGAGATTGTCATATCGGATTATGCTCTTCGTGAAGGTATGGTGCTTAACTATTTGCAGCGGGGATTTCATCCGCTTTCT
GATAACGGCGGCCAGCCGGATATCAGAAGAGAGAGCGTCTATGAACTCGGTTTCCGGTGTGGCTGGAACAGGGAGCATTC
AGAACATGTGGCCAAACTTGCCATGCAGTTTTTTGACCAGCTTCGCCTTCTTCATGGTCTTGGTCCGGAGTATCGCGAAC
TGCTTGAGTATGCTGCGCTTTTGCACAATATCGGTATTTTTATATCGAATTCTTCTCACCACAAGCATAGTCAATATATT
ATCATGAATGGCGAATTGAGGGGATTTTCGCCATCCGAAACGGAGATTATCGGTCATGTTGCACGGTATCACCGCAAGTC
CCCCCCATCTGAAAAACACTCCCCCTACAATCAGTTAAAGCCGAAGTACCGCAATGTTGTCGATGTGCTTTCAGGGATTC
TTCGTCTTGCCAATGGACTTGAACGGGGTCACCGCCAGAATATCTATGCTGTAAGCACAGCAATAAGCGATCGTGTTATT
TCCGTCAGGCTTGAGAGTCACCTTGAACCCGATATCGAGATCTGGGCTGCCGATCAACTGAAGTCCTGGCTTGAAATGGT
TTTGTCGCGTTCAATCGTTATCCGCCCCCGCTCTGAGCATGCGTGA

Upstream 100 bases:

>100_bases
ACATTACTTAACGCCGGGATAAGGGGAACATTCGCTTTTTCCTTTTCTTTTTTAAACATGTATTTTAAAAGGCGCTTTTT
CAACTTTTCCGGTTTACAGT

Downstream 100 bases:

>100_bases
TCGGGAATCTTGCAGGATTCAGCGGCTTCTTCTCCATGAGGGGACAGTCTGGCTGGACGAATCGTATGGTGCTCGACATG
AGGGCGAAAGCCTGCTTTTT

Product: Ppx/GppA phosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 521; Mature: 520

Protein sequence:

>521_residues
MGSDALRVAAIDLGTNSFHMVVVEIDRVKGIIEIDRVKDMICIGRGSISSKMLDESAMLSGIAALRNFLVLAGQHGVKSE
QVIAFATSAIREAKNRDVFIRRVREETGLKVRVISGKEEAEFIYYGVRNAVKLGNSFDLLFDIGGGSVEFVIANNKEVKL
LESRKIGVARMHERFIGTDPVSAHEIKLLEQFYAAEMVSSLEKATLLGVRRGIASSGTAQNIARMIRSFEARESDVSLNN
SVVTRREFQRLYKAVVPLGSVDRRRMTGLDEKRVDLILPGLILVDMIFRKFNLEEIVISDYALREGMVLNYLQRGFHPLS
DNGGQPDIRRESVYELGFRCGWNREHSEHVAKLAMQFFDQLRLLHGLGPEYRELLEYAALLHNIGIFISNSSHHKHSQYI
IMNGELRGFSPSETEIIGHVARYHRKSPPSEKHSPYNQLKPKYRNVVDVLSGILRLANGLERGHRQNIYAVSTAISDRVI
SVRLESHLEPDIEIWAADQLKSWLEMVLSRSIVIRPRSEHA

Sequences:

>Translated_521_residues
MGSDALRVAAIDLGTNSFHMVVVEIDRVKGIIEIDRVKDMICIGRGSISSKMLDESAMLSGIAALRNFLVLAGQHGVKSE
QVIAFATSAIREAKNRDVFIRRVREETGLKVRVISGKEEAEFIYYGVRNAVKLGNSFDLLFDIGGGSVEFVIANNKEVKL
LESRKIGVARMHERFIGTDPVSAHEIKLLEQFYAAEMVSSLEKATLLGVRRGIASSGTAQNIARMIRSFEARESDVSLNN
SVVTRREFQRLYKAVVPLGSVDRRRMTGLDEKRVDLILPGLILVDMIFRKFNLEEIVISDYALREGMVLNYLQRGFHPLS
DNGGQPDIRRESVYELGFRCGWNREHSEHVAKLAMQFFDQLRLLHGLGPEYRELLEYAALLHNIGIFISNSSHHKHSQYI
IMNGELRGFSPSETEIIGHVARYHRKSPPSEKHSPYNQLKPKYRNVVDVLSGILRLANGLERGHRQNIYAVSTAISDRVI
SVRLESHLEPDIEIWAADQLKSWLEMVLSRSIVIRPRSEHA
>Mature_520_residues
GSDALRVAAIDLGTNSFHMVVVEIDRVKGIIEIDRVKDMICIGRGSISSKMLDESAMLSGIAALRNFLVLAGQHGVKSEQ
VIAFATSAIREAKNRDVFIRRVREETGLKVRVISGKEEAEFIYYGVRNAVKLGNSFDLLFDIGGGSVEFVIANNKEVKLL
ESRKIGVARMHERFIGTDPVSAHEIKLLEQFYAAEMVSSLEKATLLGVRRGIASSGTAQNIARMIRSFEARESDVSLNNS
VVTRREFQRLYKAVVPLGSVDRRRMTGLDEKRVDLILPGLILVDMIFRKFNLEEIVISDYALREGMVLNYLQRGFHPLSD
NGGQPDIRRESVYELGFRCGWNREHSEHVAKLAMQFFDQLRLLHGLGPEYRELLEYAALLHNIGIFISNSSHHKHSQYII
MNGELRGFSPSETEIIGHVARYHRKSPPSEKHSPYNQLKPKYRNVVDVLSGILRLANGLERGHRQNIYAVSTAISDRVIS
VRLESHLEPDIEIWAADQLKSWLEMVLSRSIVIRPRSEHA

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=425, Percent_Identity=29.6470588235294, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI48994966, Length=460, Percent_Identity=28.2608695652174, Blast_Score=153, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 58826; Mature: 58694

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSDALRVAAIDLGTNSFHMVVVEIDRVKGIIEIDRVKDMICIGRGSISSKMLDESAMLS
CCCCCEEEEEEEECCCCEEEEEEEEECCCCCEEHHHHHHHHEECCCCHHHHHHHHHHHHH
GIAALRNFLVLAGQHGVKSEQVIAFATSAIREAKNRDVFIRRVREETGLKVRVISGKEEA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCC
EFIYYGVRNAVKLGNSFDLLFDIGGGSVEFVIANNKEVKLLESRKIGVARMHERFIGTDP
EEEEEEHHHHHHCCCCEEEEEEECCCEEEEEEECCCCEEEECCCCCCHHHHHHHHCCCCC
VSAHEIKLLEQFYAAEMVSSLEKATLLGVRRGIASSGTAQNIARMIRSFEARESDVSLNN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
SVVTRREFQRLYKAVVPLGSVDRRRMTGLDEKRVDLILPGLILVDMIFRKFNLEEIVISD
HHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
YALREGMVLNYLQRGFHPLSDNGGQPDIRRESVYELGFRCGWNREHSEHVAKLAMQFFDQ
HHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LRLLHGLGPEYRELLEYAALLHNIGIFISNSSHHKHSQYIIMNGELRGFSPSETEIIGHV
HHHHHCCCHHHHHHHHHHHHHHHCCEEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHH
ARYHRKSPPSEKHSPYNQLKPKYRNVVDVLSGILRLANGLERGHRQNIYAVSTAISDRVI
HHHHCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCEE
SVRLESHLEPDIEIWAADQLKSWLEMVLSRSIVIRPRSEHA
EEEEHHCCCCCCEEEEHHHHHHHHHHHHCCCEEEECCCCCC
>Mature Secondary Structure 
GSDALRVAAIDLGTNSFHMVVVEIDRVKGIIEIDRVKDMICIGRGSISSKMLDESAMLS
CCCCEEEEEEEECCCCEEEEEEEEECCCCCEEHHHHHHHHEECCCCHHHHHHHHHHHHH
GIAALRNFLVLAGQHGVKSEQVIAFATSAIREAKNRDVFIRRVREETGLKVRVISGKEEA
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCC
EFIYYGVRNAVKLGNSFDLLFDIGGGSVEFVIANNKEVKLLESRKIGVARMHERFIGTDP
EEEEEEHHHHHHCCCCEEEEEEECCCEEEEEEECCCCEEEECCCCCCHHHHHHHHCCCCC
VSAHEIKLLEQFYAAEMVSSLEKATLLGVRRGIASSGTAQNIARMIRSFEARESDVSLNN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
SVVTRREFQRLYKAVVPLGSVDRRRMTGLDEKRVDLILPGLILVDMIFRKFNLEEIVISD
HHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
YALREGMVLNYLQRGFHPLSDNGGQPDIRRESVYELGFRCGWNREHSEHVAKLAMQFFDQ
HHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LRLLHGLGPEYRELLEYAALLHNIGIFISNSSHHKHSQYIIMNGELRGFSPSETEIIGHV
HHHHHCCCHHHHHHHHHHHHHHHCCEEEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHH
ARYHRKSPPSEKHSPYNQLKPKYRNVVDVLSGILRLANGLERGHRQNIYAVSTAISDRVI
HHHHCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCEE
SVRLESHLEPDIEIWAADQLKSWLEMVLSRSIVIRPRSEHA
EEEEHHCCCCCCEEEEHHHHHHHHHHHHCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]