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The map label for this gene is modD [H]

Identifier: 119356293

GI number: 119356293

Start: 500853

End: 501698

Strand: Reverse

Name: modD [H]

Synonym: Cpha266_0455

Alternate gene names: 119356293

Gene position: 501698-500853 (Counterclockwise)

Preceding gene: 119356294

Following gene: 119356292

Centisome position: 16.01

GC content: 54.14

Gene sequence:

>846_bases
ATGCTGTATCAACTGCCCGACACCGATATTGAACGATTTATTGAAGAGGATATGCCTTATGGCGACCTCACCACCTCGCT
CCTTGGTATTGGAAATGCGCAGGGCTCCATTACTTTTACCAGCAGGCATCTTACGGTACTCTCCTGCACGGAAGAGGCCT
GTCGCGTTCTTGAACGTTGCGGGGCGCGGGTTACCTCGTCGATGCCGAGCGGAACAAGCGTTGAGGCGGGAGTCATGTTT
CTTTCGGCTGAAGGGTCGGCTGCAAGCCTGCATGCCGGATGGAAGGTTGCCCTCAACCTGCTTGAATATGCTTCGGGCAT
CGCAACACGTACCGCAGCAATCGTCAACAGTGCCCGGGCCGTAAACCCTGCTGTTTCTGTTGTCACCACCCGAAAGTCGT
TTCCGGGAACAAAAAAAGTTGCCATCAAGGCTATCATGGCCGGGGGAGCAATGCCTCACCGGCTTGGCCTGTCGGAATCC
ATTCTGGTATTCCGTCACCATACCGCTTTTCAGGGCGGGCTTGAGAGCTTTCTTGAAACCCTTTCGTCACTTAAACAACG
TGCTCCTGAAAACAGGGTTATTGTTGAGGCCGACACCGCAAAAGAGGCTCTGCAAATCGCTGCTGCAGGAGCCGATGTCG
TGCAGGTTGACAAGATGCCGTCTGAAGAGCTCGCGATACTTGTCGCCGGAATTCACCGCCAGTTCCCCGGGGTAAAGGTT
TCTGCCGCCGGAGGCATCAATGCCGACAATGCCGCTATCTATGCATCTACAGGTGTTGACATCCTCGTTCTCTCATCGGT
CTATTTCGGAAAGCCCTCGGACATTGCCGCACTCATTAACCCATAA

Upstream 100 bases:

>100_bases
TCTTATTTATTTAATTATTATCTTATTTTTCCTTATTATTTAATGTTTTCAGGTTTAACCGAAATACCTTTACTCATATA
ACGAACGAGAACGAAGAACC

Downstream 100 bases:

>100_bases
TCCTGACAACGTAAAACAGATACCATCATGATGATATCAATGAGAAAAACGCTCCTTCTGTTTTTTGCGCTGCTCACCAT
CTCAGTTCCTGCGATGGCTG

Product: modD protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MLYQLPDTDIERFIEEDMPYGDLTTSLLGIGNAQGSITFTSRHLTVLSCTEEACRVLERCGARVTSSMPSGTSVEAGVMF
LSAEGSAASLHAGWKVALNLLEYASGIATRTAAIVNSARAVNPAVSVVTTRKSFPGTKKVAIKAIMAGGAMPHRLGLSES
ILVFRHHTAFQGGLESFLETLSSLKQRAPENRVIVEADTAKEALQIAAAGADVVQVDKMPSEELAILVAGIHRQFPGVKV
SAAGGINADNAAIYASTGVDILVLSSVYFGKPSDIAALINP

Sequences:

>Translated_281_residues
MLYQLPDTDIERFIEEDMPYGDLTTSLLGIGNAQGSITFTSRHLTVLSCTEEACRVLERCGARVTSSMPSGTSVEAGVMF
LSAEGSAASLHAGWKVALNLLEYASGIATRTAAIVNSARAVNPAVSVVTTRKSFPGTKKVAIKAIMAGGAMPHRLGLSES
ILVFRHHTAFQGGLESFLETLSSLKQRAPENRVIVEADTAKEALQIAAAGADVVQVDKMPSEELAILVAGIHRQFPGVKV
SAAGGINADNAAIYASTGVDILVLSSVYFGKPSDIAALINP
>Mature_281_residues
MLYQLPDTDIERFIEEDMPYGDLTTSLLGIGNAQGSITFTSRHLTVLSCTEEACRVLERCGARVTSSMPSGTSVEAGVMF
LSAEGSAASLHAGWKVALNLLEYASGIATRTAAIVNSARAVNPAVSVVTTRKSFPGTKKVAIKAIMAGGAMPHRLGLSES
ILVFRHHTAFQGGLESFLETLSSLKQRAPENRVIVEADTAKEALQIAAAGADVVQVDKMPSEELAILVAGIHRQFPGVKV
SAAGGINADNAAIYASTGVDILVLSSVYFGKPSDIAALINP

Specific function: NAD biosynthesis; aspartate to NaMN; third (last) step. [C]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=265, Percent_Identity=29.4339622641509, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1786299, Length=193, Percent_Identity=26.9430051813472, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321162, Length=273, Percent_Identity=24.1758241758242, Blast_Score=89, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006242
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: 2.4.2.-

Molecular weight: Translated: 29458; Mature: 29458

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYQLPDTDIERFIEEDMPYGDLTTSLLGIGNAQGSITFTSRHLTVLSCTEEACRVLERC
CCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECEEEEEECCHHHHHHHHHC
GARVTSSMPSGTSVEAGVMFLSAEGSAASLHAGWKVALNLLEYASGIATRTAAIVNSARA
CCHHHCCCCCCCCEEEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNPAVSVVTTRKSFPGTKKVAIKAIMAGGAMPHRLGLSESILVFRHHTAFQGGLESFLET
CCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCHHCCCCCCEEEEEECHHHHHHHHHHHHH
LSSLKQRAPENRVIVEADTAKEALQIAAAGADVVQVDKMPSEELAILVAGIHRQFPGVKV
HHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCEEEECCCCCHHHHHHEEHHHHCCCCEEE
SAAGGINADNAAIYASTGVDILVLSSVYFGKPSDIAALINP
EECCCCCCCCCEEEEECCCEEEEEEHHHCCCCCCCEEECCC
>Mature Secondary Structure
MLYQLPDTDIERFIEEDMPYGDLTTSLLGIGNAQGSITFTSRHLTVLSCTEEACRVLERC
CCCCCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECEEEEEECCHHHHHHHHHC
GARVTSSMPSGTSVEAGVMFLSAEGSAASLHAGWKVALNLLEYASGIATRTAAIVNSARA
CCHHHCCCCCCCCEEEEEEEEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VNPAVSVVTTRKSFPGTKKVAIKAIMAGGAMPHRLGLSESILVFRHHTAFQGGLESFLET
CCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCHHCCCCCCEEEEEECHHHHHHHHHHHHH
LSSLKQRAPENRVIVEADTAKEALQIAAAGADVVQVDKMPSEELAILVAGIHRQFPGVKV
HHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCEEEECCCCCHHHHHHEEHHHHCCCCEEE
SAAGGINADNAAIYASTGVDILVLSSVYFGKPSDIAALINP
EECCCCCCCCCEEEEECCCEEEEEEHHHCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]