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The map label for this gene is apt

Identifier: 119356261

GI number: 119356261

Start: 467760

End: 468293

Strand: Direct

Name: apt

Synonym: Cpha266_0423

Alternate gene names: 119356261

Gene position: 467760-468293 (Clockwise)

Preceding gene: 119356260

Following gene: 119356265

Centisome position: 14.93

GC content: 43.82

Gene sequence:

>534_bases
ATGACTATTAAATCGCGTATCCGTTCAATTCCCGATTACCCGAAAAAAGGGATCATGTTTCGTGATATTACAACGCTTAT
CAAAGATCCGGTTGGTTTTCGTCTGGTAATCGATAATCTTACCCAGCACTATCTTCAGAACGGAGTTGATTTTGATGTGA
TTGTCGGCATAGAAGCAAGAGGATTTATTATCGGCGGTGCATTATCCTATGCGCTTGGAAAAGGTTTTGTTCCGGTAAGA
AAACCGGGAAAATTGCCTGCTGATGTTGCTTCCCAGAAATATGAACTTGAATATGGAAGCGATACCATAGAAATACATAT
TGATGCTCTCGAAGAGGGAAGCAGGGTGCTTTTGGTTGATGACCTTCTGGCAACAGGCGGAACGGCGCTTGCGGCTGCAG
CATTGGTTGAAAAAGTTGGCGGGGTTGTTGCTGAAATGGCCTTTATTGTCAATCTGCCTGATGTTGGCGGTGAACAGCGT
ATCCTTGACAAAGGGTACAGTATCTTTTCCCTTACAGATTTTGAAGGCGATTAG

Upstream 100 bases:

>100_bases
TTGAGGGGATTGACGATGATTTGAATTTAATGGGCAGACTGTTATTTTAAACCCATCTTGTCGCCTGCATCATCTTACCA
ACACTCAAATCATTCAGTTC

Downstream 100 bases:

>100_bases
CCGTATTCTTCCCTGTTCCGTAAGGGGGGCTTATGAATAAAACTGCTCCCCTTACCGTTTTGAGTGTCGTTCTGCAGTTG
TTTTCGCCATTCGTGTGCTG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MTIKSRIRSIPDYPKKGIMFRDITTLIKDPVGFRLVIDNLTQHYLQNGVDFDVIVGIEARGFIIGGALSYALGKGFVPVR
KPGKLPADVASQKYELEYGSDTIEIHIDALEEGSRVLLVDDLLATGGTALAAAALVEKVGGVVAEMAFIVNLPDVGGEQR
ILDKGYSIFSLTDFEGD

Sequences:

>Translated_177_residues
MTIKSRIRSIPDYPKKGIMFRDITTLIKDPVGFRLVIDNLTQHYLQNGVDFDVIVGIEARGFIIGGALSYALGKGFVPVR
KPGKLPADVASQKYELEYGSDTIEIHIDALEEGSRVLLVDDLLATGGTALAAAALVEKVGGVVAEMAFIVNLPDVGGEQR
ILDKGYSIFSLTDFEGD
>Mature_176_residues
TIKSRIRSIPDYPKKGIMFRDITTLIKDPVGFRLVIDNLTQHYLQNGVDFDVIVGIEARGFIIGGALSYALGKGFVPVRK
PGKLPADVASQKYELEYGSDTIEIHIDALEEGSRVLLVDDLLATGGTALAAAALVEKVGGVVAEMAFIVNLPDVGGEQRI
LDKGYSIFSLTDFEGD

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=174, Percent_Identity=43.1034482758621, Blast_Score=138, Evalue=3e-33,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=48.8, Blast_Score=120, Evalue=7e-28,
Organism=Escherichia coli, GI1786675, Length=174, Percent_Identity=52.8735632183908, Blast_Score=187, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17509087, Length=161, Percent_Identity=41.6149068322981, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323619, Length=161, Percent_Identity=41.6149068322981, Blast_Score=114, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=170, Percent_Identity=37.0588235294118, Blast_Score=101, Evalue=7e-23,
Organism=Drosophila melanogaster, GI17136334, Length=166, Percent_Identity=42.1686746987952, Blast_Score=133, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_CHLPD (A1BDK4)

Other databases:

- EMBL:   CP000492
- RefSeq:   YP_910905.1
- ProteinModelPortal:   A1BDK4
- SMR:   A1BDK4
- STRING:   A1BDK4
- GeneID:   4570977
- GenomeReviews:   CP000492_GR
- KEGG:   cph:Cpha266_0423
- NMPDR:   fig|290317.7.peg.434
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19114; Mature: 18983

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKSRIRSIPDYPKKGIMFRDITTLIKDPVGFRLVIDNLTQHYLQNGVDFDVIVGIEAR
CCHHHHHHCCCCCCCCCEEHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCEEEEEEECCC
GFIIGGALSYALGKGFVPVRKPGKLPADVASQKYELEYGSDTIEIHIDALEEGSRVLLVD
CEEEEHHHHHHHCCCCCCCCCCCCCCHHHCCCEEEEEECCCEEEEEEEECCCCCEEEEEE
DLLATGGTALAAAALVEKVGGVVAEMAFIVNLPDVGGEQRILDKGYSIFSLTDFEGD
HHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHCCCEEEEEECCCCC
>Mature Secondary Structure 
TIKSRIRSIPDYPKKGIMFRDITTLIKDPVGFRLVIDNLTQHYLQNGVDFDVIVGIEAR
CHHHHHHCCCCCCCCCEEHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCEEEEEEECCC
GFIIGGALSYALGKGFVPVRKPGKLPADVASQKYELEYGSDTIEIHIDALEEGSRVLLVD
CEEEEHHHHHHHCCCCCCCCCCCCCCHHHCCCEEEEEECCCEEEEEEEECCCCCEEEEEE
DLLATGGTALAAAALVEKVGGVVAEMAFIVNLPDVGGEQRILDKGYSIFSLTDFEGD
HHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA